Polyethylene Glycol 3350 Dosage

Usual Adult Dose for Bowel Preparation

Constipation:
17 g (diluted in 8 fluid ounces water, juice, soda or coffee) orally once a day

Bowel Preparation (off-label use):
Whole dose: Mix 255 g with 64 oz of low -calorie Gatorade (G2 lemon-lime) and drink at a rate of 8 oz every 10 minutes starting at 6 PM the evening before the procedure.
Split dose: Mix 255 g with 64 oz of low-calorie Gatorade (G2 lemon-lime) and drink 32 oz at a rate of 8 oz every 10 minutes starting at 6 PM on the evening before the procedure. Drink the remaining 32 oz starting 5 hours before the procedure at a rate of 8 oz every 10 minutes.

Usual Adult Dose for Constipation

Constipation:
17 g (diluted in 8 fluid ounces water, juice, soda or coffee) orally once a day

Bowel Preparation (off-label use):
Whole dose: Mix 255 g with 64 oz of low -calorie Gatorade (G2 lemon-lime) and drink at a rate of 8 oz every 10 minutes starting at 6 PM the evening before the procedure.
Split dose: Mix 255 g with 64 oz of low-calorie Gatorade (G2 lemon-lime) and drink 32 oz at a rate of 8 oz every 10 minutes starting at 6 PM on the evening before the procedure. Drink the remaining 32 oz starting 5 hours before the procedure at a rate of 8 oz every 10 minutes.

Usual Pediatric Dose for Bowel Preparation

Occasional constipation:
Children greater than 6 months of age: 0.5 to 1.5 g/kg daily (initial dose 0.5 g/kg; titrate to effect)
Maximum dose: 17 g/day

Fecal impaction:
Children greater than 3 years of age: 1 to 1.5 g/kg daily for 3 days
Maximum dose: 100 g daily

Bowel preparation:
Children greater than 2 years of age: 1.5 g/kg/day
Maximum dose: 100 g daily

Usual Pediatric Dose for Constipation - Acute

Occasional constipation:
Children greater than 6 months of age: 0.5 to 1.5 g/kg daily (initial dose 0.5 g/kg; titrate to effect)
Maximum dose: 17 g/day

Fecal impaction:
Children greater than 3 years of age: 1 to 1.5 g/kg daily for 3 days
Maximum dose: 100 g daily

Bowel preparation:
Children greater than 2 years of age: 1.5 g/kg/day
Maximum dose: 100 g daily

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

No adjustment recommended

Precautions

Polyethylene glycol is contraindicated in patients with a known or suspected bowel obstruction.

Patients who present with nausea, vomiting, abdominal pain or distention should be evaluated for possible bowel obstruction prior to initiating therapy with polyethylene glycol.

Electrolyte imbalance and laxative dependence may be seen with prolonged, frequent or excessive polyethylene glycol therapy.

Dialysis

No adjustment recommended