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Amitiza Side Effects

Generic name: lubiprostone

Medically reviewed by Drugs.com. Last updated on Aug 10, 2023.

Note: This document contains side effect information about lubiprostone. Some dosage forms listed on this page may not apply to the brand name Amitiza.

Applies to lubiprostone: oral capsule liquid filled.

Serious side effects of Amitiza

Along with its needed effects, lubiprostone (the active ingredient contained in Amitiza) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lubiprostone:

More common

Less common

Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking lubiprostone:

Symptoms of overdose

Other side effects of Amitiza

Some side effects of lubiprostone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to lubiprostone: oral capsule.

Gastrointestinal

Very common (10% or more): Nausea (up to 29%), diarrhea (up to 12%)

Common (1% to 10%): Abdominal pain, abdominal distention, flatulence, vomiting, loose stools, abdominal discomfort, dyspepsia, dry mouth

Frequency not reported: Intestinal functional disorder, constipation, eructation, fecal incontinence, defecation urgency, frequent bowel movements, gastroesophageal reflux disease, gastritis, hard feces, rectal hemorrhage, pollakiuria

Postmarketing reports: Ischemic colitis[Ref]

Nervous system

Very common (10% or more): Headache (up to 11%)

Common (1% to 10%): Dizziness

Uncommon (0.1% to 1%): Syncope

Frequency not reported: Dysgeusia, tremor, lethargy[Ref]

Cardiovascular

Common (1% to 10%): Palpitations, hot flush

Postmarketing reports: Tachycardia/increased heart rate, hypotension[Ref]

Dermatologic

Common (1% to 10%): Hyperhidrosis

Frequency not reported: Cold sweat, erythema

Postmarketing reports: Rash/urticaria[Ref]

Other

Common (1% to 10%): Edema, fatigue, chest discomfort/pain, peripheral edema

Frequency not reported: Influenza, pain

Postmarketing reports: Malaise, asthenia, swelling[Ref]

Respiratory

Common (1% to 10%): Dyspnea

Frequency not reported: Pharyngolaryngeal pain, cough

Postmarketing reports: Throat tightness[Ref]

Musculoskeletal

Uncommon (0.1% to 1%): Muscle spasms

Frequency not reported: Muscle cramps, joint swelling, myalgia, fibromyalgia[Ref]

Genitourinary

Frequency not reported: Urinary tract infection[Ref]

Hepatic

Frequency not reported: Increased ALT and AST[Ref]

Metabolic

Frequency not reported: Electrolyte imbalance, decreased appetite, decreased blood potassium, increased weight, anorexia[Ref]

Psychiatric

Frequency not reported: Anxiety, depression[Ref]

Hypersensitivity

Postmarketing reports: Hypersensitivity/allergic-type reactions[Ref]

Frequently asked questions

References

1. Product Information. Amitiza (lubiprostone). Sucampo Pharmaceuticals Inc. 2006.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.