Amitiza Dosage
Generic name: lubiprostone 8ug
Dosage form: capsule, gelatin coated
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Administration Instructions
- Take Amitiza orally with food and water.
- Swallow capsules whole and do not break apart or chew.
- Physicians and patients should periodically assess the need for continued therapy.
Chronic Idiopathic Constipation and Opioid-Induced Constipation
The recommended dose is 24 mcg twice daily.
Dosage in patients with hepatic impairment
For patients with moderately impaired hepatic function (Child-Pugh Class B), the recommended starting dose is 16 mcg twice daily. For patients with severely impaired hepatic function (Child-Pugh Class C), the recommended starting dose is 8 mcg twice daily. If this dose is tolerated and an adequate response has not been obtained after an appropriate interval, doses can then be escalated to full dosing with appropriate monitoring of patient response [see Use in Specific Populations (8.7) and Clinical Pharmacology (12.3)].
Irritable Bowel Syndrome with Constipation
The recommended dose is 8 mcg twice daily.
Dosage in patients with hepatic impairment
For patients with severely impaired hepatic function (Child-Pugh Class C), the recommended starting dose is 8 mcg once daily. If this dose is tolerated and an adequate response has not been obtained after an appropriate interval, doses can then be escalated to full dosing with appropriate monitoring of patient response. Dosage adjustment is not required for patients with moderately impaired hepatic function (Child-Pugh Class B) [see Use in Specific Populations (8.7) and Clinical Pharmacology (12.3)].
More about Amitiza (lubiprostone)
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- Drug class: chloride channel activators
