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Amitiza Dosage

Generic name: lubiprostone 8ug
Dosage form: capsule, gelatin coated
Drug class: Chloride channel activators

Medically reviewed by Last updated on Mar 25, 2024.

Recommended Dosage

The recommended oral dosage of Amitiza by indication and adjustments for patients with moderate (Child Pugh Class B) and severe (Child Pugh Class C) hepatic impairment are shown in Table 1.

Table 1. Recommended Dosage Regimen
If the dose is tolerated and an adequate response has not been obtained after an appropriate interval, doses can then be escalated to full dosing with appropriate monitoring of patient response.
Recommended Adult Dosage Regimen 24 mcg twice daily 8 mcg twice daily
Dosage Adjustment for Hepatic Impairment [see Use in Specific Populations (8.6)] Moderate Impairment (Child-Pugh Class B):
16 mcg twice daily*
Moderate Impairment (Child-Pugh Class B):
No adjustment necessary
Severe Impairment (Child-Pugh Class C):
8 mcg twice daily*
Severe Impairment (Child-Pugh Class C):
8 mcg once daily*

Administration Instructions

  • Take Amitiza orally with food and water.
  • Swallow capsules whole and do not break apart or chew.
  • Physicians and patients should periodically assess the need for continued therapy.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.