Tenapanor Side Effects
Medically reviewed by Drugs.com. Last updated on July 29, 2020.
For the Consumer
Applies to tenapanor: oral tablets
Warning
- Contraindicated in pediatric patients <6 years of age; avoid use in children 6 to <12 years of age.1 Tenapanor caused deaths, presumably due to dehydration, in young juvenile rats.1 (See Pediatric Use under Cautions.)
- Safety and efficacy not established in patients <18 years of age.1
Side effects include:
Diarrhea, abdominal distension, flatulence, dizziness.
For Healthcare Professionals
Applies to tenapanor: oral tablet
General
The most commonly reported side effects included diarrhea, abdominal distention, flatulence, and dizziness.[Ref]
Gastrointestinal
Very common (10% or more): Diarrhea (up to 20%)
Common (1% to 10%): Abdominal distention, flatulence, severe diarrhea
Frequency not reported: Abnormal gastrointestinal sounds, rectal bleeding[Ref]
Diarrhea occurred in 20% of patients with renal dysfunction (estimated glomerular function rate [eGFR] less than 90 mL/min/1.73 m2), compared to 16% of patients without renal dysfunction.[Ref]
Metabolic
Frequency not reported: Hyperkalemia resulting in hospitalization[Ref]
In a clinical trial with patients with type 2 diabetes mellitus and chronic kidney disease (eGFR 25 to 70 mL/min/1.73 m2), hyperkalemia resulting in hospitalization was reported in 2 patients given this drug and 1 patient given placebo.[Ref]
Nervous system
Common (1% to 10%): Dizziness[Ref]
References
1. "Product Information. Ibsrela (tenapanor)." Ardelyx, Inc, Fremont, CA.
More about tenapanor
Consumer resources
- Other brands
- Ibsrela
Professional resources
Related treatment guides
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.