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Tenapanor Side Effects

Medically reviewed by Drugs.com. Last updated on July 29, 2020.

For the Consumer

Applies to tenapanor: oral tablets

Warning

  • Contraindicated in pediatric patients <6 years of age; avoid use in children 6 to <12 years of age.1 Tenapanor caused deaths, presumably due to dehydration, in young juvenile rats.1 (See Pediatric Use under Cautions.)

  • Safety and efficacy not established in patients <18 years of age.1

Side effects include:

Diarrhea, abdominal distension, flatulence, dizziness.

For Healthcare Professionals

Applies to tenapanor: oral tablet

General

The most commonly reported side effects included diarrhea, abdominal distention, flatulence, and dizziness.[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (up to 20%)

Common (1% to 10%): Abdominal distention, flatulence, severe diarrhea

Frequency not reported: Abnormal gastrointestinal sounds, rectal bleeding[Ref]

Diarrhea occurred in 20% of patients with renal dysfunction (estimated glomerular function rate [eGFR] less than 90 mL/min/1.73 m2), compared to 16% of patients without renal dysfunction.[Ref]

Metabolic

Frequency not reported: Hyperkalemia resulting in hospitalization[Ref]

In a clinical trial with patients with type 2 diabetes mellitus and chronic kidney disease (eGFR 25 to 70 mL/min/1.73 m2), hyperkalemia resulting in hospitalization was reported in 2 patients given this drug and 1 patient given placebo.[Ref]

Nervous system

Common (1% to 10%): Dizziness[Ref]

References

1. "Product Information. Ibsrela (tenapanor)." Ardelyx, Inc, Fremont, CA.

More about tenapanor

Consumer resources

Other brands
Ibsrela

Professional resources

Related treatment guides

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.