Tenapanor Side Effects
Medically reviewed by Drugs.com. Last updated on Mar 13, 2025.
Applies to tenapanor: oral tablet.
Important warnings
This medicine can cause some serious health issues
Oral route (tablet)
Tenapanor is contraindicated in patients less than 6 years of age; in nonclinical studies in young juvenile rats administration of tenapanor caused deaths presumed to be due to dehydration.Avoid use of tenapanor in patients 6 years to less than 12 years of age.The safety and effectiveness of tenapanor have not been established in patients less than 18 years of age.
Precautions
It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects.
Call your doctor right away if you have severe diarrhea.
Serious side effects of tenapanor
Along with its needed effects, tenapanor may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking tenapanor:
More common side effects
- diarrhea
Less common or rare side effects
- bleeding in the rectum
Rare side effects
Other side effects of tenapanor
Some side effects of tenapanor may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common side effects
- dizziness
- excess air or gas in the stomach or intestines
- full or bloated feeling
- passing gas
- pressure in the stomach
- swelling of abdominal or stomach area
For healthcare professionals
Applies to tenapanor: oral tablet.
General adverse events
The most commonly reported side effects included diarrhea, abdominal distention, flatulence, and dizziness.[Ref]
Gastrointestinal
- Very common (10% or more): Diarrhea (up to 20%)
- Common (1% to 10%): Abdominal distention, flatulence, severe diarrhea
- Frequency not reported: Abnormal gastrointestinal sounds, rectal bleeding[Ref]
Diarrhea occurred in 20% of patients with renal dysfunction (estimated glomerular function rate [eGFR] less than 90 mL/min/1.73 m2), compared to 16% of patients without renal dysfunction.[Ref]
Metabolic
- Frequency not reported: Hyperkalemia resulting in hospitalization[Ref]
In a clinical trial with patients with type 2 diabetes mellitus and chronic kidney disease (eGFR 25 to 70 mL/min/1.73 m2), hyperkalemia resulting in hospitalization was reported in 2 patients given this drug and 1 patient given placebo.[Ref]
Nervous system
- Common (1% to 10%): Dizziness[Ref]
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References
1. (2019) "Product Information. Ibsrela (tenapanor)." Ardelyx, Inc
More about tenapanor
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- Reviews (21)
- Dosage information
- During pregnancy
- Drug class: NHE3 inhibitors
- Breastfeeding
- En español
Patient resources
Other brands
Professional resources
- Tenapanor Hydrochloride monograph
- Tenapanor Hydrochloride (Phosphate-Removing Agent) (AHFS Monograph)
Other brands
Related treatment guides
Further information
Tenapanor side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.