Tenapanor Dosage
Medically reviewed by Drugs.com. Last updated on Nov 28, 2023.
Applies to the following strengths: 50 mg; 20 mg; 30 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Constipation
50 mg orally 2 times a day
Use: Treatment of irritable bowel syndrome with constipation (IBS-C)
Usual Adult Dose for Irritable Bowel Syndrome
50 mg orally 2 times a day
Use: Treatment of irritable bowel syndrome with constipation (IBS-C)
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
CONTRAINDICATIONS:
- Patients less than 6 years of age
- Patients with known/suspected mechanical gastrointestinal obstruction
US BOXED WARNINGS:
RISK OF SERIOUS DEHYDRATION IN PEDIATRIC PATIENTS:
- This drug is contraindicated in patients less than 6 years of age.
- In nonclinical studies in young juvenile rats, administration of this drug caused deaths presumed to be due to dehydration.
- Avoid use of this drug in patients 6 years to less than 12 years of age.
- The safety and effectiveness of this drug have not been established in patients less than 18 years of age
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
- The morning dose of this drug should be taken immediately prior to breakfast/first meal of the day; the second dose should be taken immediately prior to dinner.
- If a dose is missed, the missed dose should be skipped, and the next dose should be taken at the regular time. Patients should not take 2 doses at the same time.
Storage requirements:
- Protect from moisture; store in a dry area, and keep the bottle tightly closed when not in use.
- Avoid subdividing or repackaging this drug.
Monitoring:
- GASTROINTESTINAL: Signs/symptoms of severe diarrhea
Patient advice:
- Patients should be instructed to read the US FDA-approved patient labeling (Patient Information and Instructions for Use).
- Patients should be told to protect this drug from moisture (e.g., storing in a dry area, keeping the desiccant in the bottle, covering the bottle when not in use).
- Patients should be instructed to report episodes of severe diarrhea to their healthcare provider.
- Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.