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Plecanatide Dosage

Medically reviewed by Last updated on Nov 13, 2023.

Applies to the following strengths: 3 mg

Usual Adult Dose for Chronic Idiopathic Constipation

3 mg orally once a day

Use: Treatment of chronic idiopathic constipation (CIC)

Usual Pediatric Dose for Chronic Idiopathic Constipation

  • Under Age 6 Years: Contraindicated.
  • Age 6 to Under 18 Years: Not recommended.

Renal Dose Adjustments

Data not available.

Liver Dose Adjustments

Data not available.


US BOXED WARNING: RISK OF SERIOUS DEHYDRATION IN PEDIATRIC PATIENTS. This drug is contraindicated in patients less than 6 years of age due to animal studies that revealed a single oral dose of this drug caused deaths from dehydration in young juvenile mice. Use of this drug should be avoided in patients age 6 years to less than 18 years.

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available.

Other Comments

Administration Advice:

  • Administer this drug with or without food.
  • Advise patients to swallow a drug tablet whole for each dose.
  • Consult the manufacturer product information for instructions on administering a crushed tablet in either applesauce or water or administering it with water via a nasogastric or gastric feeding tube to patients with swallowing difficulties; mixing this drug in other soft foods and liquids has not been tested.

Storage Requirements:
  • Store this drug at room temperature (20 to 25 Celsius/68 to 77 Fahrenheit).
  • Keep this drug in its original bottle; do not subdivide or repackage.
  • Keep this drug in a dry place and protect from moisture; do not remove the desiccant from the drug bottle.

Patient Advice:
  • If you miss a dose, skip it and take the next dose at the regular time. Do not take two doses at the same time.
  • If you experience severe diarrhea during treatment, stop taking this drug and contact your healthcare provider.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.