Prucalopride

Generic name: prucalopride [ proo-KAL-oh-pride ]
Brand name: Motegrity
Dosage form: oral tablet (1 mg; 2 mg)
Drug class: Serotoninergic neuroenteric modulators

Medically reviewed by Drugs.com on Feb 3, 2025. Written by Cerner Multum.

What is prucalopride?

Prucalopride is used to treat chronic idiopathic constipation (constipation without a known cause).

Prucalopride may also be used for purposes not listed in this medication guide.

Prucalopride side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Prucalopride may cause serious side effects. Stop using prucalopride and call your doctor at once if you have:

• unusual changes in mood or behavior;

• ongoing or worsening depression;

• thoughts about suicide or hurting yourself; or

• if you feel sad or hopeless.

Common side effects of prucalopride may include:

• nausea, vomiting, diarrhea;

• stomach pain, bloating, gas;

• headache;

• dizziness; or

• feeling tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

Warnings

You should not use prucalopride if you have a blockage in your intestines, Crohn's disease, ulcerative colitis, or intestinal perforation.

Before taking this medicine

You should not use prucalopride if you are allergic to it, or if you have:

• a blockage in your intestines;

• severe constipation;

• inflammatory bowel disease (Crohn's disease, ulcerative colitis);

• toxic megacolon; or

• perforation (a hole or tear) of your intestines.

Tell your doctor if you have ever had:

• kidney disease;

• depression;

• a mood disorder; or

• suicidal thoughts.

Tell your doctor if you are pregnant or breast-feeding.

Prucalopride is not approved for use by anyone younger than 18 years old.

How should I take prucalopride?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

You may take prucalopride with or without food.

Store prucalopride in the original container at room temperature, away from moisture and heat.

Prucalopride dosing information

Usual Adult Dose for Chronic Idiopathic Constipation:

2 mg orally once a day

Use: Treatment of chronic idiopathic constipation (CIC)

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose may cause severe diarrhea.

What should I avoid while taking prucalopride?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect prucalopride?

Other drugs may affect prucalopride, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Popular FAQ

More FAQ

• What type of drug is Motegrity?

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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