What type of drug is Motegrity?
What type of constipation is Motegrity used to treat?
Motegrity (prucalopride) is a selective serotonin type 4 (5-HT4) receptor agonist. It works by enhancing colonic peristalsis to increase bowel motility in adults with chronic idiopathic constipation (CIC).
Chronic idiopathic constipation is constipation that is long-lasting and does not have any identifiable cause. It is thought that as many as 35 million adults in the U.S. may suffer from CIC. People with CIC frequently report symptoms such as hard or lumpy stools, straining during bowel movements, and incomplete bowel movements.
Motegrity (prucalopride) is the first selective serotonin type 4 (5-HT4) receptor agonist approved for CIC. Other treatments for CIC include Linzess (linaclotide) and Trulance (plecanatide). Both of these drugs are guanylate cyclase-C agonists that work by binding to intestinal epithelial cells to stimulate the secretion of water into the intestinal lumen. Linzess and Trulance are also approved for use in the treatment of irritable bowel syndrome with constipation (IBS-C).
Read next
Which drugs cause opioid-induced constipation?
Any drug that is classified as an "opioid" can cause constipation. Examples of commonly prescribed opioids that may cause this side effect include morphine, tramadol, fentanyl, methadone, hydrocodone, codeine and oxycodone. Continue reading
When is the best time to take MiraLAX?
For relief of constipation, you can take one dose of MiraLAX at any time of the day for up to 7 days. You may prefer to take it early in the day so that it’s less likely you will have a bowel movement during bedtime or late at night. MiraLAX usually produces a bowel movement in 1 to 3 days. If your constipation worsens or does not improve after one week, contact your healthcare provider. Continue reading
Can ibuprofen cause constipation?
Yes, ibuprofen may cause constipation in 1% to 10% of patients, but it is more likely to cause other stomach side effects like nausea (57%), vomiting (22%), flatulence / gas (16%), diarrhea (10%) and stomach pain or heartburn (1% to 10%). Continue reading
Related medical questions
- Can antibiotics cause constipation?
- Is psyllium husk an affordable weight loss option to Ozempic?
- Does gabapentin cause constipation?
- The Do's and Don'ts of Treating Constipation
- What is the maximum dosage for Colace stool softener at one time?
- Does tramadol cause constipation?
- How long does it take for Linzess to work?
- Linzess or Trulance - which is better for constipation?
- What is the best way to take Linzess?
- Can Adderall cause constipation?
- Fleet Enema - What is the difference between constipation and fecal impaction?
- Amitiza - how long does it take to work? Is it better to take after dinner?
- Why does Aimovig cause constipation?
- Can Farxiga cause constipation?
- Over the Counter Medication for Pets
- What type of pain does fibromyalgia cause?
- How do you to treat hemorrhoids at home?
- What do I need to know about Medications/Vaccinations before I Travel?
- How often does diarrhea occur with Linzess?
Drug information
Related support groups
- Motegrity (3 questions, 7 members)
- Prucalopride (3 questions, 6 members)
- Constipation (221 questions, 603 members)
- Chronic Idiopathic Constipation (12 questions, 22 members)