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Prucalopride Side Effects

Medically reviewed by Last updated on Mar 23, 2024.

Applies to prucalopride: oral tablet.

Serious side effects of Prucalopride

Along with its needed effects, prucalopride may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking prucalopride:

Less common


Incidence not known

Other side effects of Prucalopride

Some side effects of prucalopride may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to prucalopride: oral tablet.


The most commonly reported side effects included headache, abdominal pain, nausea, and diarrhea.[Ref]


Very common (10% or more): Nausea (up to 19.6%), Abdominal pain (up to 16%), diarrhea (up to 13%)

Common (1% to 10%): Abdominal distention, abnormal bowel sounds, abnormal gastrointestinal sounds, dyspepsia, flatulence, rectal hemorrhage, upper abdominal pain, vomiting

Uncommon (0.1% to 1%):

Frequency not reported: Abdominal discomfort, abdominal tenderness, epigastric discomfort, lower abdominal pain[Ref]

Diarrhea occurred within the first week in 70% of those reporting the side effect, and usually resolved within a few days in 73% of the patients. Severe diarrhea occurred in approximately 1.3% of patients.[Ref]

Nervous system

Very common (10% or more): Headache (up to 24.2%)

Common (1% to 10%): Dizziness

Uncommon (0.1% to 1%): Tremors

Frequency not reported: Migraine[Ref]

Headache occurred within the first 2 days in 66% of patients who reported the side effect, and usually resolved within a few days in 65% of the patients.[Ref]


Common (1% to 10%): Nasopharyngitis, sinusitis

Postmarketing reports: Dyspnea[Ref]


Common (1% to 10%): Fatigue

Uncommon (0.1% to 1%): Fever/pyrexia, malaise[Ref]


Common (1% to 10%): Decreased appetite

Uncommon (0.1% to 1%): Anorexia[Ref]


Common (1% to 10%): Back pain[Ref]


Common (1% to 10%): Influenza[Ref]


Uncommon (0.1% to 1%): Palpitations[Ref]


Postmarketing reports: Facial edema, pruritus, rash, urticaria[Ref]


Common (1% to 10%): Polyuria, urinary tract infection

Uncommon (0.1% to 1%): Pollakiuria[Ref]

Frequently asked questions


1. Cerner Multum, Inc. "UK Summary of Product Characteristics."

2. Cerner Multum, Inc. "Australian Product Information."

3. (2012) "Product Information. Resotran (prucalopride)." Janssen Pharmaceuticals

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.