Prucalopride Side Effects

Medically reviewed by Drugs.com. Last updated on Sep 19, 2024.

Applies to prucalopride: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects.

This medicine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. Make sure the doctor knows if you have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. Also tell the doctor if you have sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. If you or your caregiver notice any of these side effects, tell your doctor right away.

Common side effects of prucalopride

Some side effects of prucalopride may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects of prucalopride

Along with its needed effects, prucalopride may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking prucalopride:

For healthcare professionals

Applies to prucalopride: oral tablet.

General adverse events

The most commonly reported side effects included headache, abdominal pain, nausea, and diarrhea.^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (up to 19.6%), Abdominal pain (up to 16%), diarrhea (up to 13%)
• Common (1% to 10%): Abdominal distention, abnormal bowel sounds, abnormal gastrointestinal sounds, dyspepsia, flatulence, rectal hemorrhage, upper abdominal pain, vomiting

Uncommon (0.1% to 1%):

• Frequency not reported: Abdominal discomfort, abdominal tenderness, epigastric discomfort, lower abdominal pain^[Ref]

Diarrhea occurred within the first week in 70% of those reporting the side effect, and usually resolved within a few days in 73% of the patients. Severe diarrhea occurred in approximately 1.3% of patients.^[Ref]

Nervous system

• Very common (10% or more): Headache (up to 24.2%)
• Common (1% to 10%): Dizziness
• Uncommon (0.1% to 1%): Tremors
• Frequency not reported: Migraine^[Ref]

Headache occurred within the first 2 days in 66% of patients who reported the side effect, and usually resolved within a few days in 65% of the patients.^[Ref]

Respiratory

• Common (1% to 10%): Nasopharyngitis, sinusitis
• Postmarketing reports: Dyspnea^[Ref]

Other

• Common (1% to 10%): Fatigue
• Uncommon (0.1% to 1%): Fever/pyrexia, malaise^[Ref]

Metabolic

• Common (1% to 10%): Decreased appetite
• Uncommon (0.1% to 1%): Anorexia^[Ref]

Musculoskeletal

• Common (1% to 10%): Back pain^[Ref]

Immunologic

• Common (1% to 10%): Influenza^[Ref]

Cardiovascular

• Uncommon (0.1% to 1%): Palpitations^[Ref]

Dermatologic

• Postmarketing reports: Facial edema, pruritus, rash, urticaria^[Ref]

Genitourinary

• Common (1% to 10%): Polyuria, urinary tract infection
• Uncommon (0.1% to 1%): Pollakiuria^[Ref]

See also:

Frequently asked questions

• Which drugs cause opioid-induced constipation?
• What type of drug is Motegrity?

Further information

Prucalopride side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer