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User Reviews for Lubiprostone

Also known as: Amitiza

The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.

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Condition Avg. Ratings Reviews Compare
Irritable Bowel Syndrome
6.7
   
50 reviews 136 medications
Constipation, Chronic
6.7
   
121 reviews 30 medications
Constipation, Drug Induced
5.8
   
14 reviews 3 medications
Constipation
4.0
   
6 reviews 248 medications
Opioid-Induced Constipation
3.0
   
6 reviews 4 medications
Summary of Lubiprostone reviews 6.4 197 reviews

Reviews for Lubiprostone

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Amitiza (lubiprostone) for Constipation, Chronic: "Have suffered from Chronic Constipation for many years. 'Specialists' may label it "Idiopathic", which sounds technical, but really means "I don't know why, either, so just take this pill, or this other pill", etc. (So WHY not do more research, instead of just prescribing different pills????) Was prescribed LOW-dose Amitiza, and the side effects were absolutely awful !!!! Spent the night in the bathroom! Incredible pain, cramps, bloating, nausea all night! and NO BM! Eventually had a very painful BM at 4:00 A.M., which left me with an inflamed, painful, distended GI system. My doctor says that I should "try Amitiza AGAIN"??? Really? ! This is insane, and unacceptable; and hopefully, in spite of this terrible experience, I think I am still sane! Will keep looking for something that does not include torture as a side effect! God bless!"

   
1.0

RetiredMBA (taken for less than 1 month) April 26, 2018

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Amitiza (lubiprostone) for Irritable Bowel Syndrome: "I have IBS with constipation. I take amatiza twice a day. I lost 52 pounds in one year. It has been wonderful! No bloating anymore."

linds (taken for 1 to 2 years) April 12, 2018

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Amitiza (lubiprostone) for Constipation, Chronic: "During surgery to correct a prolapsed bladder May 2017, my urogynocologist tightened the vaginal area (cestocele?) and then did a rectocele without my permission as he never mentioned it when I was diagnosed. This has led to severe constipation and nausea, so my family doctor prescribed Amitiza 24 MCG two per day. It helped me have a bowel movement within 24 hours, but now I feel somewhat dizzy and my blood pressure is up. Has anyone else had a rectocele that caused constipation?"

Manny (taken for less than 1 month) April 6, 2018

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Amitiza (lubiprostone) for Opioid-Induced Constipation: "I recently had back surgery and was given Dilaudid for pain. I have lymphocytic colitis also which usually means lots of watery diarrhea but I had been having constipation before my back surgery. After surgery the constipation has been awful. My doctor gave me samples of Amitiza and I took one 24mcg pill a day and after the 3rd day it was somewhat easier to have a bowel movement. It’s now been about 2 weeks and my doctor increased it to 2 pills a day. It is not working AT ALL. I am more constipated than I was before surgery. I don’t know whether to continue on it or not. I hate this bloated full feeling all the time. Any suggestions?"

   
2.0

Nursietj (taken for less than 1 month) March 12, 2018

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Amitiza (lubiprostone) for Constipation, Chronic: "I have been severely constipated for years after 20 years of chronic diarrhea. Have had to resort to enemas and laxatives just to get some relief. Was on linzess 290 for year and a half and it was so inconsistent when it worked. Started amitiza 24 mcg couple of months ago. You definitely have to eat while taking it literally. I only have to take it once a day now and I feel like it is a miracle. I just hope it doesn't stop working. I am finally feeling normal and not sluggish and miserable anymore. It is quite expensive as my insurance pays very little and I'm out $259 per month. It's definitely worth it to me. I was probably spending more than that on OTC stuff anyway."

   
10

FINALLY RELIEF February 12, 2018

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For Constipation, Chronic: "I have tried Bisacodyl and Senna in the past. They initially worked but then they eventually became ineffective. At about the time the Senna started to lose its effectiveness, I began to do daily enemas in the morning with about one quart of body temperature mineral water. But the Internet is full of people saying not to do daily enemas, so when my doctor said he had a new medicine for chronic constipation that I should try, I went for it. I immediately recognized the 24m Amistiza pills as the same ones my 90 year old father is taking. They work for him but not for me. I went three days, taking 2 pills a day, without any discernible effect, perhaps just more gas and I thought I had to urinate more often. Imagine how uncomfortable it was to not have a BM for those three days. I certainly admire the comment-giver who gave the drug 17 days before he gave up! I am back to the daily enemas. They make me feel refreshed and very healthy. I hope I can go along like this forever."

   
1.0

SteveWa January 27, 2018

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Amitiza (lubiprostone) for Constipation, Chronic: "just awful!"

   
3.0

sarajbl (taken for 1 to 6 months) December 20, 2017

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Amitiza (lubiprostone) for Irritable Bowel Syndrome: "I’ve been on Amitiza 24mg for 2 years. At first it was 2 pills a day, but the side effects were horrible. The doctor then reduced it to 1 pill a day and at first it worked great. But in the last year I’ve had constant, explosive diarrhea with constant stomach pains. Last Saturday was the last straw and I stopped taking it. Now I’m a little constipated and have some stomach pain but no explosive diarrhea. The medicine they give you to stop the diarrhea, while on amitiza, constipates me for a week and makes me feel extremely uncomfortable and full. I’ll take IBS constipation over that any day."

   
2.0

Anonymous150 (taken for 2 to 5 years) December 4, 2017

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Amitiza (lubiprostone) for Constipation, Chronic: "I've recently started taking Amitiza 24 mcg twice daily for chronic constipation. I wasn't having any luck with OTC remedies. It took me 3 days to finally start have things move. I did experience slight nausea after taking each dose. Tolerable though. Hopefully as the next few days come and go things move along much better."

   
7.0

AnonymouslyfromPa December 2, 2017

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Amitiza (lubiprostone) for Irritable Bowel Syndrome: "I'm a woman who's had IBS for 50 years. A male GI was no help—his notes said I was "too concerned with my bowel movements". Apparently a skeptic about IBS. I saw a PA, who prescribed Amitiza. I took 24 mcg 2x daily more than a year, which worked well until I started having episodes of thin diarrhea without warning. I discontinued Amitiza and my bowels worked normally for a couple of months, but the old familiar constipation is back. I will try 24 mcg once a day. I have no idea if that will work, and realize that my PA would prefer monitoring me. However, I feel at this point that I have enough sense about my own body to make this decision myself. Just be aware: even if the drug works well, your response to it may change."

   
7.0

Aniche (taken for 1 to 2 years) November 18, 2017

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Amitiza (lubiprostone) for Constipation, Chronic: "If I could give a 0- I would! 22, chronic, idiopathic constipation since I was 14. Given 24mcg of amitiza twice daily for 1 month. NOTHING HAPPENED. Very very frustrating! Was really looking forward to it working so I could stop taking laxatives in bulk but no dice. Very disheartened. Onto Linaclotide (linzess)...."

   
1.0

Young&constipated (taken for 1 to 6 months) November 16, 2017

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Amitiza (lubiprostone) for Opioid-Induced Constipation: "Doctor gave me 24mcg samples in February for OIC and the resulting anal fissures. We started at once daily, but it worked a little TOO well! Once we reduced it to every other day, things seem to be working properly."

   
8.0

Silent Wolf (taken for 6 months to 1 year) October 22, 2017

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Amitiza (lubiprostone) for Constipation, Drug Induced: "I have been on opioid medications for 7 years for sensory neuropathy. I took Amitiza for one month and no effect. when I took movantik and Amitiza together 9 weeks now I've been almost normal in bowel movements it's tremendous."

   
10

Vince San Antonio TX (taken for 1 to 6 months) September 21, 2017

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Amitiza (lubiprostone) for Opioid-Induced Constipation: "It works great, however, it did stop working for me after the first month. Apparently. I was on a low dosage once per day, but now I have put on the appropriate dosage, but because I am "backed up" I am taking Miralax to get things moving again, hopefully. Then I am to start back on Amatiza at this dosage which is appropriate for OIC. 24mcg 2 times per day with a full glass of water. So I hope it works again. When it was working, it was great. I went to the bathroom like normal!"

   
7.0

cvdixon29 (taken for 1 to 6 months) September 20, 2017

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Amitiza (lubiprostone) for Constipation: "I have taken two doses and it didn't work at all. Was it placebo? I have no idea. What happened was that I experienced strange psychotropic effects: lessened ability to judge distances, lessened ability to follow conversations, slower reading speed, headache, facial muscle spasm, clenching my jaw, and then a crying episode after 4-5 hours after the dose. At least I know it didn't cause my acne. I am scared to try the higher dose after reading everyone's comments and the fact that my blood pressure runs low to begin with. And the fact that my stomach is prone to nausea."

   
1.0

Elaine64764008060 September 13, 2017

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Amitiza (lubiprostone) for Opioid-Induced Constipation: "Tried this medication for opioid induced constipation. Have been on opioids for chronic pain issues for about 7 years. Have also had rectal cancer and have a permanent colostomy bag. This medication did nothing to help my constipation. It caused severe stomach cramping after about one hour after I took it. With a colostomy bag you should never be constipated. I do take four capfuls of marilax daily. This does make me have a very runny stool. It is expensive though and doesn't taste the greatest. In fact I can hardly get the Marilax down at this point. I can't seem to find anything really to help. I also take 4 Sennakot tablets every day. I wouldn't recommend this medication."

   
1.0

Bren from MI (taken for less than 1 month) September 7, 2017

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For Constipation, Chronic: "I have suffered with chronic constipation for the last 9 years- it has got got progressively worse and I have literally tried EVERYTHING treatment and drug wise and nothing works anymore. I only pass BM when I have a weekly colonic irrigation which even now is taking over 90 mins to work. Lubiprostone was a last resort- I am 7 days into 24mg twice a day and nothing except nausea sickness the worst bloating I have ever had to the point I can't breathe by the evening. My chest is tight and my arms are having muscle spasms. I am dispairing....."

   
1.0

HaniB1990 (taken for less than 1 month) August 30, 2017

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Amitiza (lubiprostone) for Opioid-Induced Constipation: "The first time I took this it worked in less than a half hour. The second and third day, a little over an hour. The fourth day, nothing happened. So I took a second pill at bedtime, but nothing happened. I'm so disappointed. I really needed this to work."

   
1.0

EeyoreLover (taken for less than 1 month) August 16, 2017

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Amitiza (lubiprostone) for Constipation, Chronic: "I've been on Amitiza for about a year, and while it works, it doesn't work as well as If like it to. I tried the 24 mcg dose at first but it was way too strong, definitely makes you run to the bathroom all day. I then switched to the 8mcg capsules twice a day. If I take them on an empty stomach, I get really nauseated, so I usually take them with a meal. I still had to use Miralax and fiber along with the Amitiza to ensure I stayed regular. Sometimes with all of this, I still got constipated, so I would take a 24mcg dosage and deal with the aftermath. When I did have a BM with Amitiza, it wasn't a "complete " one. It would make me poop out water, but it felt like the bulk of the stool was still left inside. I stopped taking it."

   
5.0

Nurse87lin (taken for 1 to 2 years) August 5, 2017

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Amitiza (lubiprostone) for Constipation, Chronic: "In the first week I took Amitiza, I thought it was going to be a miracle answer to my chronic constipation. But I had a side effect of severe headaches almost every day....and sometimes all day long. Since I already have migraines, I blamed it on them getting worse.....even though the symptoms were different. First the headache would start, and within 5-10 minutes a gush of uncontrollable diarrhea. I kept blaming it all on migraines and seeking treatment for them. Finally, because of the expense of this one medication and having to take so many more, I had to stop taking Amitiza. Within just a few days, the headaches with diarrhea stopped. This is an excellent product if you don't have the side effects."

   
4.0

Bunky O June 23, 2017

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Amitiza (lubiprostone) for Constipation, Chronic: "Incredible experience. I started having chronic constipation shortly after joining the military. I had intense constipation all the time and was completely dependent on laxatives. After one year, I had a colonoscopy to see what was the problem, but there was nothing. I've met with a dietician, made a food log, tried tons of fiber, supplements, but nothing worked. After one more year, Miralax stopped working, and I was prescribed Amitiza. Amitiza immediately made me regular, I've only taken four pills total, after 3 weeks, and I've been the most regular ever in two years. Only fault is it makes me nauseous for a couple hours. I wish I had this years ago!"

Owen111111 May 30, 2017

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Amitiza (lubiprostone) for Opioid-Induced Constipation: "Did not help my OIC at all. In my opinion it is no better than an otc stool softener."

   
1.0

Katmom7 (taken for 1 to 6 months) May 30, 2017

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Amitiza (lubiprostone) for Irritable Bowel Syndrome: "I started taking Amitiza 8mcg twice a day about a year ago. At first I didn't notice anything. I have really bad bloating issues due to slow motility in large intestines. He then increased my dosage to 24 mcg twice a day and that's when my bloating decreased. Im able to eat foods I couldn't eat before. It does give me diarrhea badly at times but it doesn't bother me. I would give it a 10 but I still feel like there is something in my low intestines. Like it's not completely moving everything out of me. If I don't take it for a few days I do notice the bloating get worse. I definitely feel a whole lot better taking it than if I don't."

   
9.0

Atlantissummerset (taken for 1 to 2 years) May 27, 2017

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Amitiza (lubiprostone) for Constipation, Chronic: "I have been using amitza for a week. You need to take this LITERALLY WITH FOOD. If you have eaten lets say an hour before, do not take it. It will cause you severe painful stomach type of nausea. I feel after taking this. It causes me some type of stomach cramps. Not severely painful that will cause you to curl up in a fetal position but uncomfortable enough that you know its there the weird feeling in your stomach area. I have called my doctor to see if its even worth one more week to try despite the side effects. I have not seen any improvement in my bowel movement."

Angels1111 May 16, 2017

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Amitiza (lubiprostone) for Constipation, Chronic: "55 yr old female, chronic constipation my whole life. I have tried everything, OTC to Linzess which did nothing. I am thin, exercise, high fiber, flax, metamucil, probiotic, and nothing. I go 4-5 days then take 3 ducolax, magnesium citrate and pray. Now that doesn't work. Colonoscopy ruled out anything "serious". Prescribed 24mcg Amitiza. Ate breakfast took the pill and within an hour I was SO SICK. I had explosive diarrhea, felt faint, nauseous, cold chills and sweating. Laying on my bathroom floor going back and forth to the toilet, thought I would throw up too. But I went! I did not take it again because of the side effects. Doc gave me 8mcg. I'm scared to take it. It's awful that I would even think of taking it again just to go to the bathroom"

   
4.0

coach17 May 11, 2017

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