Lubiprostone Alternatives Compared
| Lubiprostone | Trulance (plecanatide) | Linzess (linaclotide) |
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| Lubiprostone | Trulance (plecanatide) | Linzess (linaclotide) |
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Prescription only
Prescribed for Irritable Bowel Syndrome with Constipation, Chronic Idiopathic Constipation, Opioid-Induced Constipation, Constipation, Irritable Bowel Syndrome. Lubiprostone may also be used for... View more |
Prescription only
Prescribed for Irritable Bowel Syndrome with Constipation, Chronic Idiopathic Constipation. Trulance may also be used for purposes not listed in this medication guide. |
Prescription only
Prescribed for Chronic Idiopathic Constipation, Irritable Bowel Syndrome with Constipation, Functional Constipation, Irritable Bowel Syndrome. Linzess may also be used for purposes not listed in this... View more |
Related suggestions Chronic Idiopathic Constipation
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| More about Lubiprostone | More about Trulance (plecanatide) | More about Linzess (linaclotide) | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Lubiprostone has an average rating of 5.6 out of 10 from a total of 280 ratings on Drugs.com. 43% of reviewers reported a positive effect, while 38% reported a negative effect. |
Trulance has an average rating of 6.1 out of 10 from a total of 279 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 34% reported a negative effect. |
Linzess has an average rating of 6.7 out of 10 from a total of 885 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 26% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||||||||||
View all Lubiprostone side effects |
View all Trulance side effects |
View all Linzess side effects |
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| Drug Class | ||||||||||||||||||||||||||
| Generic Availability | ||||||||||||||||||||||||||
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Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Lubiprostone prices |
View all Trulance prices |
View all Linzess prices |
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| Dosage Forms | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Amitiza |
N/A |
N/A |
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| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 1 drugs are known to interact with Lubiprostone:
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A total of 1 drugs are known to interact with Trulance:
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A total of 59 drugs are known to interact with Linzess:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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January 31, 2006 |
January 19, 2017 |
August 30, 2012 |
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| WADA Class View classifications | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
| Patient Resources | ||||||||||||||||||||||||||
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| Related Treatment Guide | ||||||||||||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.