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Lubiprostone Side Effects

Medically reviewed by Last updated on Apr 30, 2023.

Applies to lubiprostone: oral capsule liquid filled.

Serious side effects of Lubiprostone

Along with its needed effects, lubiprostone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lubiprostone:

More common

Less common

Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking lubiprostone:

Symptoms of overdose

Other side effects of Lubiprostone

Some side effects of lubiprostone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to lubiprostone: oral capsule.


Very common (10% or more): Nausea (up to 29%), diarrhea (up to 12%)

Common (1% to 10%): Abdominal pain, abdominal distention, flatulence, vomiting, loose stools, abdominal discomfort, dyspepsia, dry mouth

Frequency not reported: Intestinal functional disorder, constipation, eructation, fecal incontinence, defecation urgency, frequent bowel movements, gastroesophageal reflux disease, gastritis, hard feces, rectal hemorrhage, pollakiuria

Postmarketing reports: Ischemic colitis[Ref]

Nervous system

Very common (10% or more): Headache (up to 11%)

Common (1% to 10%): Dizziness

Uncommon (0.1% to 1%): Syncope

Frequency not reported: Dysgeusia, tremor, lethargy[Ref]


Common (1% to 10%): Palpitations, hot flush

Postmarketing reports: Tachycardia/increased heart rate, hypotension[Ref]


Common (1% to 10%): Hyperhidrosis

Frequency not reported: Cold sweat, erythema

Postmarketing reports: Rash/urticaria[Ref]


Common (1% to 10%): Edema, fatigue, chest discomfort/pain, peripheral edema

Frequency not reported: Influenza, pain

Postmarketing reports: Malaise, asthenia, swelling[Ref]


Common (1% to 10%): Dyspnea

Frequency not reported: Pharyngolaryngeal pain, cough

Postmarketing reports: Throat tightness[Ref]


Uncommon (0.1% to 1%): Muscle spasms

Frequency not reported: Muscle cramps, joint swelling, myalgia, fibromyalgia[Ref]


Frequency not reported: Urinary tract infection[Ref]


Frequency not reported: Increased ALT and AST[Ref]


Frequency not reported: Electrolyte imbalance, decreased appetite, decreased blood potassium, increased weight, anorexia[Ref]


Frequency not reported: Anxiety, depression[Ref]


Postmarketing reports: Hypersensitivity/allergic-type reactions[Ref]

Frequently asked questions


1. Product Information. Amitiza (lubiprostone). Sucampo Pharmaceuticals Inc. 2006.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.