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Lubiprostone Side Effects

For the Consumer

Applies to lubiprostone: oral capsule, oral capsule liquid filled

Along with its needed effects, lubiprostone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lubiprostone:

More common
  • Diarrhea
  • full or bloated feeling or pressure in the stomach
  • nausea
  • stomach pain
  • swelling of the abdominal or stomach area
Less common
  • Abdominal or stomach discomfort
  • black, tarry stools
  • blood in the stools
  • chest discomfort or pain
  • chills
  • cold or flu-like symptoms
  • cough
  • difficult or labored breathing
  • fever
  • general feeling of discomfort or illness
  • headache
  • increased sweating
  • joint pain
  • loss of appetite
  • loss of bowel control
  • muscle aches and pains
  • runny nose
  • shivering
  • sore throat
  • sweating
  • tightness in the chest
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting
Incidence not known
  • Abdominal or stomach tenderness
  • blurred vision
  • confusion
  • difficulty with swallowing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • hives or skin rash
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • swelling

Get emergency help immediately if any of the following symptoms of overdose occur while taking lubiprostone:

Symptoms of overdose
  • Dry heaves
  • dry mouth
  • feeling of warmth
  • lack or loss of strength
  • paleness of the skin
  • redness of the face, neck, arms, and occasionally, upper chest
  • severe, unusual tiredness or weakness
  • weight loss

Some side effects of lubiprostone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Excess air or gas in the stomach or intestines
  • passing gas
Less common
  • Acid or sour stomach
  • belching
  • bladder pain
  • bloody or cloudy urine
  • change in taste
  • cold sweats
  • difficult, burning, or painful urination
  • difficulty with moving
  • discouragement
  • dizziness
  • fear or nervousness
  • feeling sad or empty
  • frequent urge to urinate
  • heartburn
  • increased weight
  • indigestion
  • irritability
  • loss of interest or pleasure
  • loss of taste
  • lower back or side pain
  • muscle cramps
  • muscle stiffness
  • sore throat
  • stomach upset
  • swollen joints
  • tingling of the hands or feet
  • unusual drowsiness, dullness, tiredness, or feeling of sluggishness

For Healthcare Professionals

Applies to lubiprostone: oral capsule

Gastrointestinal

Very common (10% or more): Nausea (up to 29%), diarrhea (up to 12%)
Common (1% to 10%): Abdominal pain, abdominal distention, flatulence, vomiting, loose stools, abdominal discomfort, dyspepsia, dry mouth
Frequency not reported: Intestinal functional disorder, constipation, eructation, fecal incontinence, defecation urgency, frequent bowel movements, gastroesophageal reflux disease, gastritis, hard feces, rectal hemorrhage, pollakiuria
Postmarketing reports: Ischemic colitis[Ref]

Nervous system

Very common (10% or more): Headache (up to 11%)
Common (1% to 10%): Dizziness
Uncommon (0.1% to 1%): Syncope
Frequency not reported: Dysgeusia, tremor, lethargy[Ref]

Cardiovascular

Common (1% to 10%): Palpitations, hot flush
Postmarketing reports: Tachycardia/increased heart rate, hypotension[Ref]

Dermatologic

Common (1% to 10%): Hyperhidrosis
Frequency not reported: Cold sweat, erythema
Postmarketing reports: Rash/urticaria[Ref]

Other

Common (1% to 10%): Edema, fatigue, chest discomfort/pain, peripheral edema
Frequency not reported: Influenza, pain
Postmarketing reports: Malaise, asthenia, swelling[Ref]

Respiratory

Common (1% to 10%): Dyspnea
Frequency not reported: Pharyngolaryngeal pain, cough
Postmarketing reports: Throat tightness[Ref]

Musculoskeletal

Uncommon (0.1% to 1%): Muscle spasms
Frequency not reported: Muscle cramps, joint swelling, myalgia, fibromyalgia[Ref]

Genitourinary

Frequency not reported: Urinary tract infection[Ref]

Hepatic

Frequency not reported: Increased ALT and AST[Ref]

Metabolic

Frequency not reported: Electrolyte imbalance, decreased appetite, decreased blood potassium, increased weight, anorexia[Ref]

Psychiatric

Frequency not reported: Anxiety, depression[Ref]

Hypersensitivity

Postmarketing reports: Hypersensitivity/allergic-type reactions[Ref]

References

1. "Product Information. Amitiza (lubiprostone)." Sucampo Pharmaceuticals Inc, Bethesda, MD.

Some side effects of lubiprostone may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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