Lubiprostone Dosage
Medically reviewed by Drugs.com. Last updated on Oct 15, 2024.
Applies to the following strengths: 8 mcg; 24 mcg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Constipation - Chronic
24 mcg orally 2 times a day
Comments: The effectiveness of this drug in the treatment of opioid-induced constipation in patients taking diphenylheptane opioids (e.g., methadone) has not been established.
Use: Treatment of chronic idiopathic constipation and of opioid-induced constipation in adults with chronic non-cancer pain.
Usual Adult Dose for Irritable Bowel Syndrome
8 mcg orally 2 times a day
Use: Treatment of irritable bowel syndrome with constipation (IBS-C) in women age 18 years and older.
Renal Dose Adjustments
No adjustment recommended.
Liver Dose Adjustments
Patients with Chronic Idiopathic Constipation or Opioid-Induced Constipation:
Initial Dose:
- Mild Liver Dysfunction (Child-Pugh A): Dose adjustment not required.
- Moderate Liver Dysfunction (Child-Pugh B): 16 mcg orally 2 times a day
- Severe Liver Dysfunction (Child-Pugh C): 8 mcg orally 2 times a day
Patients with IBS-C:
- Mild (Child-Pugh A) and Moderate (Child-Pugh B) Liver Dysfunction: Dose adjustment not required.
- Severe Liver Dysfunction (Child-Pugh C): 8 mcg orally once a day
Maintenance Dose: If the initial dose is tolerated and an adequate response has not been obtained after an appropriate interval, escalate dose to full dosing with appropriate monitoring of patient response.
Precautions
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Dialysis
No adjustment recommended.
Other Comments
Administration Advice:
- Take doses with food and water.
- Swallow drug capsules whole; do not break apart or chew them.
Storage Requirements:
- Store at 25 degrees Celsius (77 degrees Fahrenheit); excursions permitted to 15 to 30 degrees Celsius (59 to 86 degrees Fahrenheit).
- Store in the original container to protect from light and moisture.
- Use drug within 4 weeks after opening the original container.
General:
- Following 4 weeks of twice-daily treatment, withdrawal of this drug did not result in a rebound effect.
Monitoring:
- Assessment of need for continued therapy (periodically)
Patient Advice:
- Contact your healthcare provider immediately if you experience severe nausea, diarrhea, or dyspnea during treatment.
Frequently asked questions
More about lubiprostone
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (280)
- Drug images
- Side effects
- During pregnancy
- Drug class: chloride channel activators
- Breastfeeding
- En español
Patient resources
Other brands
Professional resources
Other brands
Related treatment guides
See also:
MiraLAX
MiraLAX (polyethylene glycol) is used as a laxative to treat occasional constipation or irregular ...
Colace
Colace makes bowel movements softer and is used to treat or prevent constipation. Includes Colace ...
Tavneos
Tavneos (avacopan) is a C5a receptor antagonist used for severe active ANCA-associated vasculitis ...
Linzess
Linzess (linaclotide) is used to treat chronic idiopathic constipation, irritable bowel syndrome ...
Bentyl
Bentyl is used to treat functional bowel or irritable bowel syndrome. Bentyl may also be used for ...
Xifaxan
Xifaxan (rifaximin) is used to treat travelers' diarrhea, irritable bowel syndrome with diarrhea ...
Dulcolax
Dulcolax (bisacodyl) is a laxative used to treat constipation. Includes Dulcolax side effects ...
Polyethylene glycol 3350
Polyethylene glycol 3350 systemic is used for bowel preparation, constipation, constipation, acute ...
Hyoscyamine
Hyoscyamine systemic is used for anesthesia, anticholinesterase poisoning, crohn's disease ...
Magnesium oxide
Magnesium oxide systemic is used for constipation, duodenal ulcer, GERD, hypomagnesemia ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.