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Trulance Disease Interactions

There are 2 disease interactions with Trulance (plecanatide).


Plecanatide (applies to Trulance) dehydration

Major Potential Hazard, Moderate plausibility. Applicable conditions: Electrolyte Abnormalities

Plecanatide should be used with caution in dehydrated patients and patients with severe diarrhea. Plecanatide is contraindicated in patients less than 6 years of age as these patients may be more likely to develop severe diarrhea and its potentially serious consequences. Care is recommended when using this agent in adult patients with electrolyte abnormalities or with severe diarrhea. It is recommended to suspend dosing and rehydrate the patient if such symptoms occur during therapy.


  1. "Product Information. Trulance (plecanatide)." Synergy Pharmaceuticals Inc. (2017):

Plecanatide (applies to Trulance) gastrointestinal obstruction

Major Potential Hazard, Moderate plausibility.

The use of plecanatide is contraindicated in patients with known or suspected mechanical gastrointestinal obstruction.


  1. "Product Information. Trulance (plecanatide)." Synergy Pharmaceuticals Inc. (2017):

Trulance drug interactions

There is 1 drug interaction with Trulance (plecanatide).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.