Prucalopride Dosage

Medically reviewed by Drugs.com. Last updated on Feb 4, 2025.

Usual Adult Dose for Chronic Idiopathic Constipation

2 mg orally once a day

Use: Treatment of chronic idiopathic constipation (CIC)

Renal Dose Adjustments

Mild to moderate renal dysfunction (CrCl at least 30 mL/min): No adjustment recommended.
Severe renal dysfunction (CrCl less than 30 mL/min): 1 mg orally once a day
End-stage renal disease requiring dialysis: Not recommended.

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:

• Hypersensitivity to the active component or any of the ingredients
• Intestinal perforation or obstruction due to structural/functional disorder of the gut wall, obstructive ileus, severe inflammatory conditions of the intestinal tract (e.g., Crohn's disease ulcerative colitis, toxic megacolon/megarectum)

Safety and efficacy have not been established in patients younger than pediatric patients.

Consult WARNINGS section for additional precautions.

Dialysis

End-stage renal disease requiring dialysis: Not recommended.

Other Comments

Administration advice:

• This drug may be taken without regard to food.

Storage requirements:

• Protect from moisture.

General:

• Doses exceeding 2 mg/day are not expected to increase efficacy.
• Safety and efficacy have been demonstrated in patients with chronic functional constipation; safety and efficacy have not been assessed in those with secondary causes of constipation (e.g., endocrine, metabolic, and/or neurologic disorders) or mediation-related constipation (e.g., opioid use). Some experts recommend that this drug should be avoided in patients with secondary causes of constipation.

Patient advice:

• Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.
• Inform patients that this drug may cause dizziness and fatigue, and they should avoid driving or operating machinery if these side effects occur.

Frequently asked questions

• Which drugs cause opioid-induced constipation?
• What type of drug is Motegrity?

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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