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Prucalopride Dosage

Medically reviewed by Last updated on Feb 6, 2023.

Applies to the following strengths: 1 mg; 2 mg

Usual Adult Dose for Chronic Idiopathic Constipation

2 mg orally once a day

Use: Treatment of chronic idiopathic constipation (CIC)

Renal Dose Adjustments

Mild to moderate renal dysfunction (CrCl at least 30 mL/min): No adjustment recommended.
Severe renal dysfunction (CrCl less than 30 mL/min): 1 mg orally once a day
End-stage renal disease requiring dialysis: Not recommended.

Liver Dose Adjustments

Data not available



  • Hypersensitivity to the active component or any of the ingredients
  • Intestinal perforation or obstruction due to structural/functional disorder of the gut wall, obstructive ileus, severe inflammatory conditions of the intestinal tract (e.g., Crohn's disease ulcerative colitis, toxic megacolon/megarectum)

Safety and efficacy have not been established in patients younger than pediatric patients.

Consult WARNINGS section for additional precautions.


End-stage renal disease requiring dialysis: Not recommended.

Other Comments

Administration advice:

  • This drug may be taken without regard to food.

Storage requirements:
  • Protect from moisture.

  • Doses exceeding 2 mg/day are not expected to increase efficacy.
  • Safety and efficacy have been demonstrated in patients with chronic functional constipation; safety and efficacy have not been assessed in those with secondary causes of constipation (e.g., endocrine, metabolic, and/or neurologic disorders) or mediation-related constipation (e.g., opioid use). Some experts recommend that this drug should be avoided in patients with secondary causes of constipation.

Patient advice:
  • Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.
  • Inform patients that this drug may cause dizziness and fatigue, and they should avoid driving or operating machinery if these side effects occur.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.