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Plecanatide Side Effects

For the Consumer

Applies to plecanatide: oral tablet

Along with its needed effects, plecanatide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking plecanatide:

  • Severe diarrhea

Some side effects of plecanatide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Mild diarrhea
Less common or rare
  • Body aches or pain
  • chills
  • cough
  • difficulty with breathing
  • ear congestion
  • excess air or gas in the stomach or intestines
  • fever
  • full or bloated feeling
  • headache
  • loss of voice
  • pain or tenderness around the eyes and cheekbones
  • passing gas
  • pressure in the stomach
  • runny nose
  • sneezing
  • sore throat
  • stuffy or runny nose
  • swelling of the abdominal or stomach area
  • tightness of the chest
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to plecanatide: oral tablet


Common (1% to 10%): Diarrhea
Frequency not reported: Abdominal distention, flatulence, abdominal tenderness[Ref]


In clinical trials, there were 2 patients with ALT greater than 5 to 15 times the upper limit of normal (ULN) and 3 patients with AST greater than 5 x ULN.[Ref]

Frequency not reported: Increased liver biochemical tests[Ref]


Frequency not reported: Sinusitis, upper respiratory tract infection[Ref]


1. "Product Information. Trulance (plecanatide)." Synergy Pharmaceuticals Inc., New York, NY.

Some side effects of plecanatide may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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