Plecanatide Side Effects

Medically reviewed by Drugs.com. Last updated on Mar 17, 2022.

Summary

More frequently reported side effects include: diarrhea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to plecanatide: oral tablet

Warning

Oral route (Tablet)

Plecanatide is contraindicated in patients less than 6 years of age; in nonclinical studies in young juvenile mice administration of a single oral dose of plecanatide caused deaths due to dehydration. Avoid use of plecanatide in patients 6 years to less than 18 years of age. The safety and effectiveness of plecanatide have not been established in patients less than 18 years of age.

Side effects requiring immediate medical attention

Along with its needed effects, plecanatide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking plecanatide:

Less common

Severe diarrhea

Side effects not requiring immediate medical attention

Some side effects of plecanatide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Bladder pain
bloody or cloudy urine
body aches or pain
chills
cough
difficult, burning, or painful urination
difficulty with breathing
dizziness
ear congestion
excess air or gas in the stomach or bowels
fever
full or bloated feeling
headache
loss of voice
lower back or side pain
muscle aches
nasal congestion
nausea
pain or tenderness around the eyes and cheekbones
passing gas
pressure in the stomach
sneezing
sore throat
stuffy or runny nose
swelling of the abdominal or stomach area
tightness of the chest
unusual tiredness or weakness

For Healthcare Professionals

Applies to plecanatide: oral tablet

Gastrointestinal

Common (1% to 10%): Diarrhea

Frequency not reported: Abdominal distention, flatulence, abdominal tenderness^[Ref]

Hepatic

In clinical trials, there were 2 patients with ALT greater than 5 to 15 times the upper limit of normal (ULN) and 3 patients with AST greater than 5 x ULN.^[Ref]

Frequency not reported: Increased liver biochemical tests^[Ref]