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Linaclotide Dosage

Applies to the following strength(s): 145 mcg ; 290 mcg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Irritable Bowel Syndrome

290 mcg orally once a day

Comments:
-Take on an empty stomach, at least 30 minutes prior to the first meal of the day
-Swallow capsules whole; do not break apart or chew

Use: Irritable bowel syndrome with constipation

Usual Adult Dose for Constipation

145 mcg orally once a day

Comments:
-Take on an empty stomach, at least 30 minutes prior to the first meal of the day
-Swallow capsules whole; do not break apart or chew

Use: Chronic idiopathic constipation

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

No adjustment recommended

Precautions

US BOXED WARNING:
Pediatric Warning: Linaclotide is contraindicated in pediatric patients up to 6 years of age; in nonclinical studies, administration of a single, clinically relevant adult oral dose of linaclotide caused deaths due to dehydration in young juvenile mice. Avoid use of linaclotide in pediatric patients 6 through 17 years of age.

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Storage requirements:
-Keep the drug in the original container to protect from moisture.
-Do not remove desiccant from the container.
-Once the container is opened, the drug should be used within 18 weeks.

Patient advice:
-Do not give this drug to children under 18 years of age. It may harm them.
-If you miss a dose, skip the missed dose and take the next dose at your regular time. Do not take 2 doses at the same time.
-Seek immediate medical attention if you develop unusual or severe stomach pain, especially if you also have bright red bloody stools or black stools that look like tar.
-This drug may cause side effects such as diarrhea, gas, and stomach pain. Tell your doctor if you have any side effect that bothers you or does not go away.

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