Motegrity and Nausea: What Users Say

• Hig...
• Taken for 1 to 6 months
• November 30, 2019

For Chronic Idiopathic Constipation "Overall, Motegrity is extremely effective. I’ve been on it for four and a half weeks and have had little to no intestinal side effects as experienced with Linzess (severe bloat, gas, and incontinence) and have been able to feel pretty normal. The only issue I’ve experienced is pretty frequent headaches (about every other day) and nausea (every day). I take Excedrin Migraine for the headaches and Ondansetron for the nausea and seem to do well. This drug has saved me from my many nights awake with severe pain from my CIC and gastroparesis, so the benefits outweigh the side effects."

• MBa...
• August 10, 2019

For Chronic Idiopathic Constipation "I started out with a whole pill and immediately experienced nausea and a pounding headache. The next day I took a half a pill, felt great but had little stool. That evening, took the second half of the pill, and depression started to settle in on me. By the 4th day, just taking half a pill, depression was heavy on me. I’ve decided to stop taking the medication after the 5th day of half a pill and go to a nutrition store to find something similar and try that also add more fiber to my diet. I’ve tried Linzess, severe weight gain. I’ve also tried Amitiza, nauseated all the time."

• Jus...
• Taken for less than 1 month
• May 10, 2021

For Chronic Idiopathic Constipation "I’ve been on Motegrity for 3 days, and it’s been a miracle drug so far! Been on Linzess, Trulance, Miralax, and EVERY OTC laxative on the market. Nothing worked until I used Motegrity. Yes, it causes severe nausea, but I just take it at night before I go to bed. The nausea wears off before I wake up. The first time I’ve had a proper BM in months!! Fingers crossed!!!"

• nnb...
• Taken for 1 to 2 years
• May 24, 2021

For Chronic Idiopathic Constipation "Since I was not sure how my body would react to Motegrity, I started by cutting the 2 mg pill into 4 pieces. The results were excellent with only 1/4 of a pill. Did not experience nausea or headaches that were noted in the reviews. Was told to expect flatus (gas), and that was true. Even though I took it at bedtime, flatus continued to be annoying sometimes throughout the day, especially an hour or so after eating. Have taken up to 1 mg and after, never needed the full dose. In spite of some of the undesired effects, I would recommend this medication!"

• Ksa...
• July 4, 2021

For Chronic Idiopathic Constipation "I can't poop. Laxatives, stool softeners, Amitiza, Linzess, every other drug you can think of either worked a few times and just stopped. I had high hopes for Motegrity. I took Motegrity three times, just to be sure my symptoms were actually caused by the drug. Motegrity produced a bowel movement for me within a day of taking the drug, each time. My third bowel movement on Motegrity was a bloodbath. Anyway, within 15 minutes of taking the drug, each time, my stomach severely bloated. As time passed, my abdomen would hurt even more and horribly burn-if anyone has ever had bowel obstructions or intussusceptions, the pain and burning felt like this. Then began the migraine, nausea, and vomiting/dry heaving. My abdomen felt as if I was getting lit on fire and ripped to shreds; screaming pain. Of course, I felt the need to take this godforsaken drug two more times, you know, just to be sure-as if the first round of torture wasn't enough. Now I have bloody stools."

• Deb...
• September 7, 2020

For Chronic Idiopathic Constipation "One Motegrity pill, and had side effect of a horrible headache, and it made my stomach so upset, and one day out still feeling like I'm going to throw up and bloating. Never again. I will no longer be ever taking this pill. I'm so sick from just this one pill."

• Ful...
• April 16, 2021

For Chronic Idiopathic Constipation "I have chronic constipation, and it's absolutely a life of misery. My doctor prescribed Motegrity, and it works. However, the horrific cramps and headache I could do without. The warning sign that I need to stay put close to a bathroom are the cramps and nausea. The headache starts about 30 minutes after taking it. When you live with idiopathic chronic constipation as severely as I do, then you kind of have to go with what works. Nevertheless, I could definitely live without the side effects."

• Kok...
• Taken for less than 1 month
• March 15, 2021

For Chronic Idiopathic Constipation "I took just a 1/2 yesterday morning. Got a crazy pounding headache within 10 minutes, then was constantly going to the bathroom. Nauseated and pounding heart. I have postural tachycardia syndrome and was flaring with adrenaline surges after taking this 1/2 once. It said it lasts 24 hours. Nope, it’s been 36 hours, and I’m still feeling sick to my stomach and nauseated. I could just sip my water. I am trying to push Gatorade as I’m dehydrated. I’ve been massaging my stomach as it’s in pain and gurgling still! I guess I’ll stick to Miralax in my water and stool softeners. This is not for me!"

• Ser...
• Taken for less than 1 month
• October 13, 2021

For Chronic Idiopathic Constipation "Motegrity does work, but the effect on me is harsh, and I have many side effects. I took 2 mg about six hours ago. It hit within 15 minutes. Since then, I have gone to the bathroom about 15 times. I didn't make it to the toilet a few times. I'm experiencing a racing heart, pounding headache, a jittery/shaky feeling, and intense nausea. I'm dizzy, weak, and achy. I take many other meds for other conditions, and for all I know, they've left my body. There's no way I could deal with this every day. Not sure if I'll try it again, definitely not anytime soon."

• sun...
• Taken for 1 to 6 months
• January 1, 2022

For Chronic Idiopathic Constipation "I was originally given Motegrity without trying the others because I had been following all the lifestyle advice typically given to start off. I had printouts of my daily meals, water consumption, fiber intake, macros. I was also already on a modified diet to avoid allergens. (I like data.) And it was clear movement for water like Linzess wasn’t going to do it. The first two months, I had to take it with Miralax, 1000 mg of magnesium, and senna at 8.6 mg? It took all four to go. I went every day, but it was explosive and miserable. So she reduced it down to 1 mg, and now things are manageable (every two days ish), but I’m constantly boiling. Y’all, I’m not at menopause age yet. I shouldn’t be sweating like this. But I’ve been in undershirts in 50-degree weather, and I sweat enough to completely stink in a few hours. I also regained all the sudden weight I lost prior to Motegrity in about two months (50 lbs, about 1/4 of my body). I'm also queasy all the time."

• Anonymous
• Taken for less than 1 month
• February 26, 2022

For Chronic Idiopathic Constipation "I have taken it 3 times, and each time the same side effects, all within 15 minutes of taking the medication. Bloating was the worst, along with stomach ache, nausea, and severe headache!! No thanks."