Motegrity and Cramps: What Users Say

• Anonymous
• Taken for 1 to 2 years
• March 15, 2021

For Chronic Idiopathic Constipation "Motegrity is the ONLY treatment that has worked for my chronic idiopathic constipation. Before Motegrity, I was on Amitiza, Linzess, Trulance (no response to any of them), plus every OTC option you could think of, every diet, test, etc. With Motegrity, I have BMs 4/7 days a week which is a vast improvement from my previous quality of life. I will say the first week I had significant side effects. Expect the first 24-48 hours especially to be full of diarrhea, abdominal cramping, sweats. But stick it out! After that first week I have not had a single side effect in over a year of taking 2mg per day."

• Do...
• Taken for 1 to 6 months
• February 15, 2022

For Chronic Idiopathic Constipation "I started taking Motegrity after failing with many other medications following problems with slow gastric motility, recurring SIBO, and chronic constipation. At first, I was taking it every few days because, while effective, it caused cramping and stomachaches. I went back to my GI feeling at a loss because I felt like I’ve tried everything, and she said, of course it’s going to cause cramping if I haven’t had a BM in a week! She recommended cleaning myself out with magnesium citrate for a day, then taking Motegrity daily. This has helped! I’ve actually had normal BMs for the first time in a long time!"

• Ful...
• April 16, 2021

For Chronic Idiopathic Constipation "I have chronic constipation, and it's absolutely a life of misery. My doctor prescribed Motegrity, and it works. However, the horrific cramps and headache I could do without. The warning sign that I need to stay put close to a bathroom are the cramps and nausea. The headache starts about 30 minutes after taking it. When you live with idiopathic chronic constipation as severely as I do, then you kind of have to go with what works. Nevertheless, I could definitely live without the side effects."

• Me ...
• July 19, 2021

For Chronic Idiopathic Constipation "This medication made me sick as heck! My GI told me to try it, and wow, my stomach is still having cramps on and off! I was vomiting, sweating, and cramping all at once! That’s alright, I’ll stick to Linzess."

• San...
• Taken for less than 1 month
• February 10, 2021

For Chronic Idiopathic Constipation "After suddenly developing abdominal pain and infrequent BMs four years ago without consistent relief from diet changes or OTC products, or Amitiza and Linzess, I'm trying this (and one other which is less effective). This "worked" initially with soft and loose stool, lots of gas, and cramping. Added my OTC again, but ineffective. Tried the other sample drug, even less effective. Back on Motegrity, same experience and have concluded it's exacerbating neck and back pain to intolerable levels, possible wrist and ankle pain, fatigue, and the blues. Totally interfering with sleep. The only temporary relief I get is swimming or exercising."