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Motegrity (prucalopride) Disease Interactions

There are 4 disease interactions with Motegrity (prucalopride):

Major

Prucalopride (applies to Motegrity) intestinal inflammation

Major Potential Hazard, Moderate plausibility. Applicable conditions: Inflammatory Bowel Disease

The use of prucalopride is contraindicated in patients with severe inflammatory conditions of the intestinal tract such as Crohn's disease, ulcerative colitis, and toxic megacolon/megarectum.

Major

Prucalopride (applies to Motegrity) intestinal perforation

Major Potential Hazard, Moderate plausibility. Applicable conditions: Gastrointestinal Perforation, Gastrointestinal Obstruction

The use of prucalopride is contraindicated in patients with obstructive ileus, and intestinal perforation or obstruction due to structural or functional disorder of the gut wall.

Major

Prucalopride (applies to Motegrity) renal dysfunction

Major Potential Hazard, Moderate plausibility.

Prucalopride is known to be substantially excreted by the kidney, and the risk of adverse reactions may be greater in patients with impaired renal function. No dosage adjustment is required for patients with mild and moderate renal impairment. A decreased dosage is recommended in patients with severe renal impairment. Avoid the use of prucalopride in patients with end-stage renal disease requiring dialysis.

Moderate

Prucalopride (applies to Motegrity) depression

Moderate Potential Hazard, Moderate plausibility.

Suicides, suicide attempts, and suicidal ideation have been reported with the use of prucalopride. It is recommended to monitor all patients for persistent worsening of depression or the emergence of suicidal thoughts and behaviors. Patients should discontinue prucalopride immediately if they experience any of these symptoms.

Motegrity (prucalopride) drug interactions

There are 95 drug interactions with Motegrity (prucalopride)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.