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Mesalamine User Reviews & Ratings

Brand names: Lialda, Pentasa, Asacol, Apriso, Asacol HD, Delzicol, Canasa, Rowasa, Zaldyon Canasa Pac Rowasa Sulfite Free …show all brand names

Mesalamine has an average rating of 7.1 out of 10 from a total of 420 reviews on Drugs.com. 62% of reviewers reported a positive experience, while 20% reported a negative experience.

Reviews for Mesalamine

  • Fano
  • October 1, 2018

Apriso (mesalamine) for Ulcerative Colitis "I’ve had UC for 30 years now. Life was hell for the first 15 years, and I tried everything that is out there, including energy healing and experimental cell therapy in Mexico! I was ready to have my colon removed before I finally learned how to get in remission and stay in remission by watching what I eat. I have not been on any medication for 15 years now. I keep a variety of meds handy just in case. Twice I had mild flare-ups, and both times I took Apriso, and within 5 days, I went back to remission, and then I stopped taking the med again. I stay away from milk, spicy food, alcohol when my stomach feels sensitive, certain fruits such as strawberries and cantaloupe, and greasy food. Pay attention to what you eat and keep a chart. You’ll be able to pinpoint what irritates your body."

10 / 10
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  • Regai...
  • Taken for 1 to 6 months
  • July 24, 2019

Pentasa (mesalamine) for Crohn's Disease, Maintenance "I'm 24 years old and my Crohn's is continuously getting worse. Every year I look more pale and more like a skeleton. When I eat food, it goes through me within an hour. I use the bathroom every time I eat. I've been dizzy with no energy. I started taking Pentasa 2 months ago. I have never felt dizzy since, the color is coming back to my skin. I've gained a little bit of weight, and I only use the bathroom once a day. I haven't been taking the drug very long, but so far it seems to be my lifesaver!"

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  • QuisU...
  • Taken for 5 to 10 years
  • November 4, 2017

Lialda (mesalamine) for Ulcerative Colitis, Active "I was diagnosed with moderate to severe ulcerative colitis in 2008. I’ve been on all kinds of medication including Asacol, 6MP, Remicade, Humira, prednisone, amitriptyline, Lialda, and others. I also had surgery to remove my gallbladder due to stones - which I regret now since I don’t think it made any difference with the BMs and bleeding. I finally had good results with Lialda. I used to take 4 pills a day but managed to wean down to 2. I also realized that part of the healing process came from spiritual healing and mental attitude. The stress from a job played a major role in my flare-ups. Prayer helped me spiritually which, in turn, helped me with my mind, which then helped with my gut alongside Lialda and a less stressful job."

10 / 10
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Frequently asked questions

  • Char
  • Taken for 10 years or more
  • May 2, 2019

Rowasa (mesalamine) for Ulcerative Colitis, Active "I have had Ulcerative Colitis for 30 plus years, and I have been on multiple meds. Prednisone working the best. But you can't stay on prednisone forever, nasty side affects. Rowasa, Enemas are great for me, I have no mess, no problems at all. They take away the urge to go, and the spasms in my lower rectum. They are a dream medicine. I can actually feel the medicine coating my colon and it feels so much better, when I use these enemas. But you have to be diligent. Stay on your left side all night for the best results so it stays in the correct place. Don't worry about being ashamed to use these, your significant other will understand. Good luck to all."

10 / 10
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  • Michael
  • Taken for 10 years or more
  • November 25, 2023

Pentasa (mesalamine) for Ulcerative Colitis "I was first diagnosed with ulcerative colitis 27 years ago. I was put on Pentasa 500mg twice daily. My GP took me off it after 10 years as he felt it was no longer needed. This was a big mistake. I suffered numerous diarrhea occasions over the 5 years I was off it. This then resulted in needing multiple periods on steroids. My consultant put me back on Pentasa then and I've never had to take steroids since. Pentasa has brought normality back into my life. However, I do find I am very prone to picking up infections. I'm not sure if this is linked to the Pentasa or ulcerative colitis. Overall, it has been a lifesaver in that I no longer miss work and can live a normal lifestyle."

10 / 10
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Are you taking this medicine?

  • Made...
  • Taken for 1 to 6 months
  • September 19, 2019

Lialda (mesalamine) for Ulcerative Colitis, Maintenance "I’ve tried taking Lialda 1.2g several times in a 3 months time frame. It really seems to help with my ulcerative colitis. It improved my diarrhea (7/10) and stomach pain (8/10). It pretty much does it’s job of keeping me in remission. But, Every time I take this, my mood changes, my jaws and cheek hurt, I can’t speak properly, I can’t focus, and I just don’t feel like doing anything. At first I thought it was all in my head (pigeon superstition). And so I experimented with it about 6 times and it happened every single time. Even as I’m writing this my jaws hurt, I can’t focus, don’t wanna talk and I’m avoiding doing my homework and I have a 3 hour class to go to! Maybe I’m an exception to the common side effects. I think it’s worth writing this review just in case someone else have the similar side effects."

3 / 10
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  • Mack
  • Taken for 6 months to 1 year
  • February 26, 2019

Pentasa (mesalamine) for Crohn's Disease, Maintenance "I’m 19 and turning 20. I was diagnosed with Crohn’s last March and was taking Pentasa, and it works great, but when I switched to United Healthcare, they wouldn’t cover it. They then prescribed me Apriso. If your Crohn’s is specific to your small intestine and not your colon, please don’t take Apriso. Apriso is meant to target your colon. I went back to the hospital for the third time because of it, so it was decided that I should go back onto Pentasa. It really works for those who aren’t sure about it. It really does. I was in severe pain for months until Pentasa. It’s kept the pain away and let me get back to a normal diet. For those who were on Pentasa and were forced to change medication due to insurance, you can dispute to your insurance that you need it. It took 2 months to do it, for me, but it worked out. My insurance now will cover it. Good luck to those with Crohn’s and/or are having trouble finding medication or can’t take Pentasa, anymore."

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  • Trish
  • Taken for 10 years or more
  • February 13, 2020

Pentasa (mesalamine) for Crohn's Disease, Maintenance "Pentasa for Crohn's I was diagnosed with Crohn's in 2001. I have been taking Pentasa for over ten years and I find it works well. I was taking Asacol, but I found them hard to swallow. I could not swallow Pentasa either and dissolving in my throat was a real problem, so a few years ago I started dissolving them in water and adding yogurt or jam. Amazingly, it did the trick. I haven't had any problems with my Crohn's for many years."

10 / 10
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  • Chad
  • September 9, 2014

Lialda (mesalamine) for Ulcerative Colitis, Active "My doctor switched me from Asacol HD to Lialda after I lost my insurance and needed a less expensive substitute. I was worried because I had grown accustomed to Asacol and did very well on that medicine. After a few days of adjusting to Lialda, with no real problems or side effects (just a little gas during the first 48 hours), I feel fantastic on Lialda. I've been on Lialda for about 5 months now and feel as good, if not better than I did on Asacol. I have fewer headaches than I did on Asacol and feel great with fewer stomach cramps. Best of all, for me or anyone who is on the go during the day, I now take one Lialda tablet, twice daily (once in the morning, once at night). This is compared to two Asacol tablets THREE times daily."

8 / 10
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  • GTano
  • March 12, 2021

Salofalk (mesalamine) for Ulcerative Colitis, Maintenance "I've used both the Salofalk Foam & the liquid Salofalk enema & recommend trying this if you are struggling. It takes longer to administer, but is easier to keep in. If you're having issues with the foam, I recommend the following: - Make sure to release the foam slowly. It's less of a shock to the system & helps reduce that reflex muscle action that makes you want to evacuate it. - Wait at least 30 secs before the 2nd dose otherwise you just feel too full when the 2nd dose is released. - After the 2nd dose, don't withdraw the nozzle immediately. Wait at least 30 secs. When you withdraw it, do so as fast as possible. This stops any residual foam coming into contact with (for want of a better word) your anus & causing a burning sensation. - Finally it doesn't say this on the foam instructions, consider lying on your left side for 30 mins after your treatment. This helps the foam get to where it needs to go & makes it easier to keep in. Hope this helps someone & good luck!"

6 / 10
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  • Acem
  • Taken for 1 to 6 months
  • October 2, 2019

Pentasa (mesalamine) for Crohn's Disease, Maintenance "I was diagnosed in 1983 with Crohn’s at age 19. That triggered a “preexisting condition” which led to me being uninsured for 30 yrs. As my disease progressed it felt like I was going thru a colonoscopy prep every day of my life. Bloody diarrhea constantly so much I had to stop working. I started on Pentasa about a month ago and for the 1st time in 30 yrs have had solid BMs and no bleeding. It’s like a miracle drug for me. Dr wants me to take it as a suppository at night along with 500 mg capsules 3x/day. The capsules cost $250/m copay ($2,500 reg price) but medicare won’t cover the suppositories which are $9,000! Who can afford that? The main side effect of this drug, for me, is bankruptcy. Other than that it works great."

10 / 10
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  • mymya...
  • Taken for 1 to 6 months
  • September 12, 2014

Lialda (mesalamine) for Ulcerative Colitis, Active "Starting taking Lialda about a month and a half ago, and it took a couple of weeks to start working. As soon as it started working, I felt great - no more stomach pain, no more blood, no more diarrhea. Oh, finally something that helps take the pain away. I was shocked at how good it worked. But then I should have known it was too good to be true. About four weeks into it, my beautiful hair started falling out in clumps every time I washed it or even brushed it. I mean, it was a lot; every time I would cry. Also, the muscle aches were the worst. I would sit for maybe 10 minutes and go to get up and almost fall over because my legs almost gave out. Other than that, it works great for the pain, but I can't take the side effects, so I'm going to be switching medicines."

7 / 10
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  • Debbie
  • January 3, 2021

Pentasa (mesalamine) for Ulcerative Colitis "Received diagnosed last year of ulcerative colitis when I stopped smoking, 2 months later all the symptoms hit: bloated, pains in the stomach, constipation and lots of blood! I went for a colonoscopy and was diagnosed with ulcerative colitis. At first I was given the rectal foam...I found the process awful, once inserted you couldn’t move otherwise it triggered a bowel movement, also caused awful cramps. I then tried the Pentasa tablets, taking 2 a day for 8 weeks now and what a difference. The bloating and pain in the stomach has gone down loads, bowel movements more regular and much less bleeding. I still get the odd niggly feelings and a small amount of blood so the doctor has recommend to up the does to 4 a day. So far though these tablets have massively improved my ulcerative colitis. I’m in the UK and fortunate enough to have the NHS so I pay £9 for three big boxes. It’s crazy to think people have to pay hundreds for no fault of their own!"

8 / 10
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  • hotbo...
  • Taken for 1 to 6 months
  • September 1, 2017

Lialda (mesalamine) for Ulcerative Colitis, Active "Developed UC after I stopped smoking about 10 years ago. Have tried everything including Lialda and Canasa. The only thing that works for me is smoking cigarettes. I've also tried nicotine gum and patch and even E-cigs. Only real cigarettes work. I have to smoke about 5 per day. Symptoms go away after 1-2 weeks. Then I stop smoking. Sometimes the symptoms will come back after a month, sometimes 6. Hate smoking but what's the alternative?"

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  • Anonymous
  • December 16, 2016

Lialda (mesalamine) for Ulcerative Colitis "My husband died from taking Lialda. He had been taking it for 3 months and it totally depleted his white blood cells. When he was admitted to the hospital, he was taken to ICU ISOLATION on a Fri. and died Wed. Autopsy confirmed he died from the Lialda!"

4 / 10
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  • Jenni...
  • Taken for 1 to 6 months
  • October 14, 2013

Lialda (mesalamine) for Ulcerative Colitis, Active "I take two Lialda pills every morning (1.2gm). Lialda helped my stomach pains and bleeding tremendously! I recommend it to everyone! It took a good 2 months to really show a big difference, but I am so happy I finally found something that helps. It has taken me years to finally find something. Also, contact your doctor or Lialda because it's really expensive, but you can get their coupon card and only pay $10 a month."

10 / 10
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  • Noneya
  • Taken for 1 to 6 months
  • November 1, 2019

Apriso (mesalamine) for Ulcerative Colitis "I suffered for almost a year before I was diagnosed with Ulcerative colitis (UC). It got so severe all I did was work and come home and sleep on the bathroom floor. I would make 40-50 trips to the bathroom a day. I just wished I’d die some days. It was truly debilitating. I’m so thankful my employer was very understanding and supportive! I can not take steroids so my options were very limited. My doctor put me on this medication Apriso and it has been life changing for me. The medication is very expensive, but luckily my insurance covers it! When I initially called the pharmacy they told me my cost was over $800 for a 1 month supply, because my insurance denied it. I fixed that issue right away. Out of pocket from a pharmacy is about $30 for a 1 month supply. But I found a home delivery service that had a 3 month supply for only $24!!! Most insurance companies will only cover 1-2 months of this medication so ask. I highly recommend this medication if you have UC."

10 / 10
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38 Report
  • Nous
  • Taken for 2 to 5 years
  • March 29, 2021

Pentasa (mesalamine) for Ulcerative Colitis "I was diagnosed with UC in 2018 due to high levels of stress causing serious diarrhea, sharp stomach pain, bloating and bleeding. I got various tests until the doctors were able to diagnose me with UC. Starting off with steroids for a couple weeks, I then began taking 4 tablets daily and the improvements were amazing. I am able to eat any food without any complications. When I find myself stressed out, I do see little flare ups but they go away after a day or two max. I would 100% for anyone to try this medication if you have these symptoms due to stress."

10 / 10
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  • happy...
  • Taken for 10 years or more
  • December 5, 2012

Pentasa (mesalamine) for Crohn's Disease, Maintenance "Totally awesome. I was diagnosed over 25 years ago with Crohn's. I take 1000mg 3 times a day of Pentasa and 50mg of mercaptopurine once a day, and I have only had 2 flare-ups. With proper diet, exercise, and medications taken as directed daily on a regular schedule, remission and a normal life are possible."

9 / 10
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  • PCano
  • Taken for less than 1 month
  • January 16, 2020

Lialda (mesalamine) for Ulcerative Colitis, Active "In 2009 I developed pneumonitis, pericarditis, pancreatitis, and ARDS after 3 weeks on Lialda. My GI doc told me and the other docs on my case that I probably had swine flu, and refused to consider Lialda as a possible culprit. The early-onset signs that you're reacting to this drug are that your colitis doesn't improve or gets worse. Having 0 experience (this was a first-line treatment upon my UC diagnosis), I trusted things would improve eventually, as the doctor told me to give it a month. But before that month was up, I was in ICU on full ventilation for 2 weeks & had a cup of bloody fluid drained off of my heart. A pulmonologist noted that my lungs looked like I’d "inhaled pure lye" (which I hadn't). Another doctor on my case eventually intervened and gave me a megadose of steroids, which was the only thing that reversed my condition and imminent death. It was a very long, physically painful, and emotionally devastating recovery, something I never should have had to experience."

1 / 10
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  • no...
  • Taken for 1 to 2 years
  • November 19, 2015

Lialda (mesalamine) for Ulcerative Colitis, Active "Glad to say , I am no longer taking this product that really never worked anyway. Have no symptoms for 5 years, everyone said I would be taking prescription medication for life. I just change my eating and drinking habits and you to can win the battle. Good Luck."

1 / 10
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56 Report
  • MissT
  • December 2, 2015

Pentasa (mesalamine) for Crohn's Disease, Maintenance "This medicine is the best thing that ever could happened for me .I'm able to eat without it running back out the next 10 min. I have gained weight now I'm worry about gaining to much weight from all the eating I do. I should have started taking it last year but I was worried about the side effects. But no side effects."

10 / 10
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  • Anonymous
  • Taken for 10 years or more
  • April 13, 2013

Asacol (mesalamine) for Ulcerative Colitis, Maintenance "I have had Ulcerative Colitis for 30 years, on Asacol for 17. Took it during 2 pregnancies with no ill effects. This medicine has helped me stay in remission for the past 17 years, at a low dose (would like 4 400mg/day, but too expensive, so making due with 2). A lifesaver."

10 / 10
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  • colten
  • Taken for less than 1 month
  • April 14, 2016

Pentasa (mesalamine) for Crohn's Disease, Maintenance "I was recently diagnosed with crohns, having painful cramps, bloody stool, and diarrhea. My 2nd day being on Pentasa I ate Taco Bell (which most people with crohns will tell you, almost kills you haha!) I had absolutely no cramps or diarrhea!!! I'm on week 2 taking 500mg 4 times a day and I'm still feeling great! No cramps what so ever! The only symptoms I've noticed was slight chest tightness the first couple of days, slight weight loss, increased appetite, and a little bit of my hair falling out. I started taking folic acid to help with the hair loss."

10 / 10
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  • kbbaby
  • March 22, 2016

Lialda (mesalamine) for Ulcerative Colitis, Active "This drug almost killed me. I started during a flare up in my 2nd trimester. My hair would fall out and kept reporting unexplained protein in my urine at every doc appointment...I lost 15 lbs during pregnancy and was determine high risk. 6 months post term, I started to get severe chills to fever, couldn't eat, had full colitis symptoms...was hospitalized with cardiac distress, severe anemia and dehydration and stage 4 kidney failure caused by Lialda...mayo clinic detected that the protein in my urine was in fact a side effect from the lialda. I was immediately taken off and my creatin and iron levels began to stabilize and my hair stopped falling out."

1 / 10
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Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.