Generic Name: mesalamine (oral) (me SAL a meen)
Brand Names: Apriso, Asacol HD, Delzicol, Lialda, Pentasa
Medically reviewed on Nov 9, 2018
What is Apriso?
Apriso is used to treat mild to moderate ulcerative colitis in patients 18 years of age and older.
Apriso is also used to prevent the symptoms of ulcerative colitis from recurring.
Call your doctor at once if you have severe stomach pain, cramping, bloody diarrhea (may occur with fever, headache, and skin rash).
Before taking this medicine
You should not use Apriso if you are allergic to mesalamine, aspirin, sulfasalazine, or salicylates (such as Nuprin Backache Caplet, Kaopectate, KneeRelief, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, Trilisate, and others).
To make sure Apriso is safe for you, tell your doctor if you have:
a stomach condition called pyloric stenosis;
liver disease; or
a history of blockage in your digestive tract (stomach or intestines).
Apriso extended-release capsules contain phenylalanine. Talk to your doctor before using this form of mesalamine if you have phenylketonuria (PKU).
It is not known whether Apriso will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Mesalamine can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Do not give this medicine to a child without medical advice.
How should I take Apriso?
Take Apriso exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Take Apriso with a full glass of water.
Apriso can be taken with or without food. Follow your doctor's instructions or the directions on your medicine label.
Do not crush, break, or chew an Apriso extended-release capsule. Swallow the capsule whole.
The extended-release capsule is specially formulated to release the medicine after it has passed through your stomach into your intestines. Breaking open the capsule may cause the medicine to be released too early in the digestive tract.
Call your doctor if your ulcerative colitis symptoms do not improve, or if they get worse.
Apriso can cause unusual results with certain medical tests. Tell any doctor who treats you that you are taking mesalamine.
Store at room temperature away from moisture and heat.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking Apriso?
Ask your doctor before using an antacid, and use only the type your doctor recommends. Some antacids can make it harder for your body to absorb mesalamine.
Apriso side effects
Get emergency medical help if you have signs of an allergic reaction to Apriso: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using Apriso and call your doctor at once if you have:
severe stomach pain, cramping, bloody diarrhea;
fever, headache, skin rash;
bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
kidney problems - little or no urination, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath; or
liver problems - loss of appetite, upper stomach pain, tiredness, easy bruising or bleeding, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Common Apriso side effects may include:
nausea, stomach pain, diarrhea, constipation;
runny or stuffy nose, sinus pain, sore throat;
headache, back pain;
abnormal liver function tests.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Apriso?
Tell your doctor about all your current medicines and any you start or stop using, especially:
NSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.
This list is not complete. Other drugs may interact with mesalamine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Apriso only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 10.01.
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- Drug class: 5-aminosalicylates