Allergies, Cough/Cold Medications and Alcohol Interactions
Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on Dec 16, 2019.
Allergy, cough, cold and flu medications are commonly bought without a prescription and are used to treat symptoms such as:
- hives, swelling and itching
- runny nose
- nasal congestion
- itchy and watery eyes
Interactions with alcohol and over-the-counter (OTC) medications like antihistamines are especially worrisome, as OTCs are often accessed without advice from your doctor or pharmacist. Allergy medication or cold medicine, when mixed with alcohol (also called ethanol), can commonly lead to worsened side effects, such as drowsiness, sedation, difficulty concentrating, and dizziness. Driving or other activities can become hazardous.
Many allergy medicines are available as both brand and generic products commonly found in pharmacies, grocery stores, other retail shops, or bought online. Some antihistamines or other cough and cold drugs may require a prescription from your doctor.
You should avoid or limit the use of sedating allergy medicine and alcohol; check the package labeling for any specific wording. Ask your pharmacist or doctor for specific recommendations. Avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you.
Also, if you take an antihistamine at a higher dose than recommended or consume excessive amounts of alcohol, the side effects of this interaction can be worse for people with the following medical conditions:
- enlarged prostate
- overactive thyroid
- heart disease
- liver problems
Learn More: Alcohol (Ethanol) Drug Interactions
Antihistamines work by blocking histamine release from the body when an allergen is encountered. Antihistamines can be classified as first generation (sedating) antihistamines and second generation (non-sedating) antihistamines. Antihistamines are most commonly used for allergic reactions, hay fever, cold and flu symptoms, or hives, but can also be used as a medication to help with sleep or for motion sickness.
- First generation antihistamines are more likely to cause drowsiness as they work in the brain and spinal cord to block the histamine-1 (H-1) receptor, as well as other receptors in the body. These drugs causes significant drowsiness for most people.
- Second generation antihistamines cause less or little drowsiness because they primarily work on the H-1 receptors outside the brain. However, cetirizine (Zyrtec) may cause significant drowsiness in up to 15% of people and especially with higher doses.
Antihistamines may be bought as a single agent or in combination with decongestants like pseudoephedrine or phenylephrine; combined with fever, headache and pain relievers like acetaminophen or ibuprofen; added to cough suppressants like dextromethorphan; or with expectorants like guaifenesin. For example, Theraflu Nighttime Severe Cough and Cold contains a fixed-dose mixture of acetaminophen, diphenhydramine, and phenylephrine.
Always check the label on the over-the-counter or prescription medications to review for interactions with alcohol.
- Commonly used sedating antihistamines and brand name examples include:
- Commonly used non-sedating antihistamines and brand name examples include:
- You should avoid the use of dextromethorphan cough syrup and alcohol as the combination can have additive effects on central nervous system depression.
- Do not drive, operate machinery or engage in hazardous activities while using dextromethorphan.
- You may find that some products combine these cough suppressants with antihistamines or decongestants.
- Narcotic-based cough suppressants should not be combined with alcohol due to additive drowsiness and possible respiratory depression (slowed or stopped breathing).
Sustained-release formulations of hydrocodone, such as Tussionex Pennkinetic, also should not be consumed with alcohol.
- Alcohol combined with some sustained-release formulations of hydrocodone may cause a rapid release of the drug, resulting in high blood levels of hydrocodone that may be potentially lethal.
- You should not combine ANY narcotic, including codeine and hydrocodone, with alcohol due to additive CNS and respiratory depression that could be fatal.
Some OTC cough, cold and flu medicines like Vick’s Nyquil contain alcohol which may lead to drowsiness. Mixing alcohol with Nyquil, or other medications that contain alcohol, should be avoided.
The cough suppressant benzonatate (Tessalon Perles) does not contain a narcotic agent and does not list alcohol as a possible drug interaction. However, sedation, headache, dizziness, mental confusion, and visual hallucinations are listed as possible side effects to the drug, and could have an additive effect with alcohol.
Guaifenesin (brands include Mucinex, Robitussin, Triaminic Chest Congestion) is an expectorant that thins mucus to help relieve chest congestion. Alcohol does not interact with guaifenesin by itself, but guaifenesin may be found in combination products that contain narcotics, sedating cough suppressants, or other sedating ingredients.
Promethazine VC with Codeine is a combination medicine used for the temporary relief of coughs, sneezing, runny nose or nasal congestion associated with allergy or the common cold in adults. Promethazine is considered a phenothiazine with antihistamine (H-1) properties.
- However, the combination of promethazine and alcohol can lead to uncontrollable movements, agitation, seizures, dizziness, fainting, coma, very deep sleep, irregular heartbeats, and high or low body temperature.
- This product also contains codeine and you should not combine with alcohol due to the risk for respiratory depression (slowed or stopped breathing) and sedation.
- Do not drive, operating machinery, or performing other hazardous activities while using this medication.
Visit the Drugs.com Interaction Checker to review drug interactions with all of your medications.
Common Allergy, Cough, and Cold Medicines
|Generic Name||Common Brand Names|
|chlorpheniramine and hydrocodone||Tussionex Pennkinetic|
|clemastine||Tavist (brand discontinued)|
|codeine and guaifenesin||Cheratussin AC, Robitussin AC|
|codeine, phenylephrine, and promethazine||Promethazine VC with Codeine|
|dextromethorphan||Benylin DM, DayQuil, Delsym, Robitussin, Nyquil|
|dextromethorphan and guaifenesin||Robitussin DM|
|diphenhydramine||Benadryl, Pediacare Children’s Allergy, ZzzQuil|
|homatropine and hydrocodone||Hycodan|
|triprolidine||Histex PD Drops, Vanaclear|
*Note: This is not a complete list; always check with your pharmacist for possible drug-alcohol interactions. Review the OTC Drug Facts label or prescription warnings on every package. If you have any questions, ask your pharmacist or doctor for help. Tell your healthcare providers about all the other medications you use, including prescription, over-the-counter (OTC) drugs, vitamins, dietary supplements and herbal products.
Types of Drug Interactions With Alcohol
- Acne Medicines and Alcohol Interactions
- ADHD Medications and Alcohol
- Antibiotic Medications and Alcohol
- Antidepressant Medications and Alcohol Interactions
- Antipsychotic Medications and Alcohol
- Anxiety Medications and Alcohol
- Bipolar Medications and Alcohol
- Birth Control Medications and Alcohol
- Blood Thinners and Alcohol: A Dangerous Mix?
- Caffeine, Energy Drinks and Alcohol
- Can You Mix Weight Loss Drugs and Alcohol?
- Cholesterol Medications and Alcohol
- Diabetes Medications and Alcohol
- Enlarged Prostate (BPH) Medications and Alcohol Interactions
- Erectile Dysfunction Medications and Alcohol
- Heart Medications and Alcohol
- Herbal Supplements and Alcohol
- Illicit Drugs and Alcohol Interactions
- Motion Sickness Drugs and Alcohol Interactions
- Muscle Relaxants and Alcohol Interactions
- Pain / Fever Drugs and Alcohol Interactions
- Seizure Medications and Alcohol Interactions
- Sleep (Insomnia) Medications and Alcohol
- Stomach / Heartburn Medications and Alcohol
- Pawel P, Tomasz R, Renata, D et al. Second generation H1 - antihistamines interaction with food and alcohol-A systematic review. Biomedicine & Pharmacotherapy 2017: 93;27-39. Accessed Dec. 16, 2019 at https://doi.org/10.1016/j.biopha.2017.06.008
- Alcohol Facts & Statistics. National Institute on Alcohol and Abuse and Alcoholism (NIAAA). National Institutes of Health (NIH). Accessed Dec. 16, 2019 at https://www.niaaa.nih.gov/publications/brochures-and-fact-sheets/alcohol-facts-and-statistics
- Harmful Interactions. Mixing Alcohol With Medicines. National Institute on Alcohol Abuse and Alcoholism (NIAAA) https://www.niaaa.nih.gov/publications/brochures-and-fact-sheets/harmful-interactions-mixing-alcohol-with-medicines
- Zimatkin S, Anichtchik O. Alcohol-histamine interactions. Alcohol and Alcoholism 1999:34;141–147 Accessed Dec. 16, 2019 at https://doi.org/10.1093/alcalc/34.2.141 https://www.ncbi.nlm.nih.gov/pubmed/10344773
- Okay to drink alcohol when on antihistamines? Go Ask Alice. Columbia University. Accessed Dec. 16, 2019 at https://goaskalice.columbia.edu/answered-questions/okay-drink-alcohol-when-antihistamines-0
- Drug Interaction Checker. In Drugs.com online. Accessed Dec. 16, 2019 at https://www.drugs.com/drug_interactions.html.
- Hansten P, Horn J. The Top 100 Drug Interactions, A Guide to Patient Management. 2017 Edition. H&H Publications, LLP. Freeland, WA. Accessed Dec. 16, 2019.
- Weathermon R, Crabb DW. Alcohol and medication interactions. Alcohol Res. Health. 1999;23(1):40-54. Accessed Nov. 11, 2019.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.