EpiPen Costs and Alternatives: What Are Your Best Options?
Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on Aug 7, 2020.
Concerns about pharmaceutical drug pricing -- some might even call it price gouging -- have been rampant in the United States.
For example, take the EpiPen (epinephrine), an injectable medication required by people who have severe, life-threatening allergies (anaphylaxis). Bee stings, medications, peanut butter, shellfish, and latex are just a few of the allergens (or allergy triggers) that can lead to anaphylaxis (pronounced "ana-fi-LAX-is"). Keeping this medication on hand is the only option as the allergic reaction can be quickly fatal.
What Is An EpiPen Used For?
- Epinephrine is the man-made version of adrenaline, a natural hormone substance the body releases in response to stress, and it is classified as a catecholamine.
- Without the immediate administration of epinephrine, those who are having a severe allergic reaction can go into anaphylactic shock, which can be fatal.
EpiPen, also known by its generic name as epinephrine, is a prescription-only brand name medication made by Mylan. EpiPen was initially approved in 1989, but its active ingredient, epinephrine was first synthesized in 1906.
It’s always best, when possible, to avoid the allergy trigger that causes your severe allergic reaction. However, if exposure does occurs, an auto-injectable epinephrine like EpiPen is used to help prevent anaphylaxis and should be given quickly.
Several epinephrine products come in an auto-injector pen that can be used by the patient, parent, teacher, school nurse, or any bystander. The injection is given in the thigh, and can even be given through clothing.
What is Anaphylaxis?
Anaphylaxis is an allergic medical emergency and results in:
- Hives and swelling
- Breathing difficulty or swallowing problems due to throat swelling
- Drop in blood pressure (hypotension), fainting
- Chest tightness
- Nausea, vomiting, stomach cramps
- Pale or red skin color
How Much Does an EpiPen Cost?
One brand name EpiPen or EpiPen Jr. package (which contains 2 auto-injectors) will cost roughly $650 to $700 if you are paying cash, although pharmacy coupons or manufacturers discounts may lower the price. It may be worthwhile to check with your insurance company before you get your prescription to find out which epinephrine product is covered.
- See Table 1 below for available EpiPen brands, authorized generics and generic products on the U.S. market.
Mylan has released an authorized generic version of the EpiPen, which is the same drug and device without the EpiPen brand name. Using online coupons, consumers can get the authorized generic epinephrine auto-injector two pack from $150 to over $400 at some pharmacies; again it’s worth checking around if you are a cash customer. Some patients may be eligible for EpiPen or authorized generic discounts or co-pay coupon cards through Mylan and the EpiPen website. Also, if you are paying cash, look for an online coupon.
Is There a Generic for EpiPen?
Yes, cheaper options are now available after much controversy about the high price of this life-saving drug. In fact, the first generic version of EpiPen and EpiPen Jr (epinephrine) auto-injector, from Teva Pharmaceuticals, was approved in August 2018. The generic epinephrine auto-injector comes in 0.3 mg and 0.15 mg strengths to be used for patients who weigh more than 33 pounds (15 kilograms). It's the same drug and the same device you'd find with the Epipen, and it's used exactly the same way.
There are other more affordable alternatives to the EpiPen brand name product, including the authorized generic from Mylan for EpiPen and EpiPen Jr. Mylan now offers the authorized generic for Epipen for roughly $150 to $400 for a two-pack, depending upon the pharmacy and if you use an online coupon.
Another option is a product known as Adrenaclick, which is an epinephrine auto-injector that is similar to EpiPen. Adrenaclick is expensive, running close to $500 per two-pack. However, Adrenaclick also has an authorized generic epinephrine auto-injector and it can be obtained from CVS Pharmacy for $109.99 for a two-pack. Other pharmacies also offer the authorized generic for Adrenaclick, but double check the cash price, as it may be more expensive.
What is An Authorized Generic?
The only difference between an authorized generic and its brand name alternative is the name on the label.
- For example, the authorized generic for EpiPen is the same drug (therapeutically equivalent) and the same device; however, the packaging states “epinephrine” on the label instead of “EpiPen”.
- An authorized generic is made by the same manufacturer under their existing New Drug Application (NDA) already approved by the FDA. The same manufacturing plant is also used.
- Manufacturers are allowed to sell an authorized generic of their brand name product, and may sell it at a lower price, although it may not be as affordable as true generic.
Why is EpiPen So Expensive?
In August 2016 two U.S. senators questioned why there had been such a massive EpiPen price increase by Mylan, the manufacturer of EpiPen. Concerns existed that the drug was not priced fairly for patients with a life-threatening allergy without other options. Over the last decade, the EpiPen cost had soared from roughly $100 to over $600 per two-injector package.
Members of Congress also raised the point that the EpiPen, which is used by many children on the government assistance program Medicaid, was unfairly overpriced and that taxpayers were “picking up the tab” for the drug.
Before the availability of cheaper generics for EpiPen, Mylan controlled 90% of the market and faced little competition for EpiPen. According to The New York Times, Mylan also blocked competition by requiring schools that obtained discounted EpiPens to sign a contract that forbid them from buying injectors from other companies.
Mylan defended itself saying that EpiPen improvements had led to price increases, that insurance often covers the devices, and that the company provides discounts to those who qualify. However, in response to an outcry, in December 2016 Mylan launched the first authorized generic for EpiPen at a 50% discount to the brand name product. However, since the launch of Mylan’s authorized generic for EpiPen, even more affordable generic epinephrine auto-injectors have become available.
EpiPen Patient Assistance & Coupons
EpiPen Coupons and Savings Cards
For patients who quality, financial assistance from Mylan may be available for the EpiPen 2-Pak and EpiPen Jr. 2-Pak. The EpiPen Savings Card, found on Mylan's website, can be used to reduce the amount of out-of-pocket expenses for the patient. The Savings Card is not considered health insurance. Present the Savings Card, valid prescription, and insurance card to your pharmacy.
The following are the requirement to be eligible to use the EpiPen Savings Card:
- 18 years of age or older, resident of the U.S.
- Only valid for patients with commercial insurance
- Not valid for patients without insurance
- Not valid for patients who are covered by any state or federally funded healthcare program
- Not valid if patient is Medicare eligible and enrolled in an employer-sponsored health plan or prescription benefit program for retirees
- Not valid if the patient’s insurance plan is paying the entire cost of this prescription
- This program may not be valid in some states.
This offer that can provide you up to $300 savings for each EpiPen 2-Pak carton per prescription refill (a maximum of 6 2-pack cartons per year). Mylan also is offering a savings card for the authorized generic for eligible patients with commercial health insurance. The card provides up to $25 off the out-of-pocket cost on the authorized generic.
EpiPen Patient Assistance
Mylan also offers an EpiPen patient assistance program for those who are eligible. To enroll, patients must complete the patient assistance program form with their physician.
Patients can obtain additional information on the program by emailing customer service at Mylan or calling Mylan Customer Relations at 1-800-395-3376 to speak with a representative.
What is Auvi-Q?
Auvi-Q is a brand name epinephrine auto-injector with unique features such as voice instructions that help guide a user with step-by-step instructions through the epinephrine delivery process, a smaller size, and an automatic retractable needle system. This serves as a safety feature and retracts the needle back into the device within seconds.
Auvi-Q was recalled from the market in 2015 due to a concern that the device was delivering incorrect doses. However, after addressing these concerns, the manufacturer Kaleo re-introduced Auvi-Q to the U.S. market in 2017. The cash price for Auvi-Q is significant -- roughly $5,000 for two injectors -- but Kaleo has posted a $0 out-of-pocket costs for commercially insured patients on the Auvi-Q website (through the direct delivery service or pick up at Walgreens). Other discounts may be available as well.
According to the Auvi-Q Affordability Program:
- Millions of Americans with commercial insurance, including those with high-deductible plans, will be able to obtain Auvi-Q for as little as $0 out-of-pocket.
- Auvi-Q may be available free of charge to patients with a household income of less than $100,000 who do not have government or commercial insurance.
- Medicaid patients may be able to obtain Auvi-Q for $0 out-of-pocket through the Kaleo Cares Patient Assistance Program.
- Each carton comes with 2 auto-injectors and 1 trainer device.
- Your out-of-pocket costs may vary.
Two lower doses of Auvi-Q (0.1 mg and 0.15 mg) are also approved to deliver a dose of epinephrine appropriate for infants and small children weighing 16.5 to 33 lb (7.5 to 15 kilograms) and 33 to 66 lb (15 to 30 kg), respectively.
What is Symjepi?
In June, 2017 the FDA cleared Symjepi (epinephrine), a new, single-dose, prefilled syringe of epinephrine also used for the emergency treatment of anaphylaxis. The product provides two, single dose syringes of epinephrine (not an auto-injector).
The manufacturer reports that Symjepi is lower cost, a smaller size and has a more user-friendly design than EpiPen.
- Unlike most auto-injectors, Symjepi's needle is not spring-loaded; instead, the needed is first inserted in the thigh, then the top plunger is depressed until it clicks to release the medicine.
- The more simple design may help to keep prices within reason.
- The cost for Symjepi is roughly $240-$280 for 2 syringes using an online discount coupon.
How Long Do EpiPens Last?
EpiPens can remain unused for long periods of time, so many patients wonder how long an EpiPen can last before it expires. Expiration dates for the auto-injectors come up quickly, usually in one year, meaning regular - and affordable - replacement for this life-saving medication is a must. Patients usually need multiple EpiPen packs to keep at home, work, or school in case of exposure to the allergen.
Always check your epinephrine injector at the counter when you pick it up from the pharmacy and make sure it has at least one year before expiring. If not, speak to your pharmacist about getting a different injector with a longer expiration.
Most schools in the U.S. now either require or allow the school to have access to epinephrine for those who do not have their own supply. Keep a supply of epinephrine at home, work AND at school, and remember to refill your prescription before your epinephrine auto-injector has expired.
Is EpiPen Available Without a Prescription? (OTC)
In the U.S., you cannot buy EpiPen unless you have a prescription from your doctor. Some schools do stock the product for emergency use, but use in that setting would still be under the direction of a health care provider.
Other countries, such as Canada, have epinephrine auto-injectors available without a prescription at the pharmacy.
How Much Does an EpiPen Cost in Canada?
If you happen to be in Canada, buying an EpiPen from an established pharmacy will cost you around $100 to $150, and it is available without a prescription. Canada, like the U.S., does have strict laws overseeing the safety of prescription medications. However, bringing an epinephrine auto-injector over the border from Canada into the U.S. may be questioned and your medication may be confiscated by customs officials at the border.
Consumers should be wary of online purchases of EpiPen over the Internet, even those that claim to be Canadian pharmacies. The product might be contaminated or a fraud containing no medication at all. It’s not worth it to purchase a life-saving drug when you can’t be sure of it’s authenticity or safety.
|Product||Strengths Available||Price Estimate (2-pack)||Ways to Save|
|EpiPen; EpiPen Jr. (epinephrine auto-injector)||0.15 mg; 0.3 mg||About $650-$700 cash price (two auto-injectors).||Possibly save $300 on EpiPen or EpiPen Jr from Mylan.|
|Authorized generic for EpiPen and EpiPen Jr. (epinephrine auto-injector) from Mylan||0.15 mg; 0.3 mg||About $125 to $400; possibly higher priced at some pharmacies; call ahead.||Coupon may be needed.|
|epinephrine (generic for EpiPen, EpiPen Jr.) from Teva Pharma||0.15 mg; 0.3 mg||$95 to upwards of $300 for a 2-pack using cost-saving coupons. Prices vary among pharmacies.||Expected to be low cost but coupon may still be beneficial.|
|Adrenaclick||0.15 mg; 0.3 mg||Roughly $450 to $500; price varies among pharmacies.||Drugs.com Discount Card|
|Authorized generic for Adrenaclick (epinephrine auto-injector) from Impax||0.15 mg; 0.3 mg||$109.99 cash price at US-based CVS Pharmacy; may be higher at other pharmacies; call ahead.||No coupon needed; save from Impax Pharmaceuticals.|
|Auvi-Q||0.1 mg, 0.15 mg, and 0.3 mg||$0 copay for insured patients and for families with income of less than $100,000/year without insurance. One prescription includes two auto-injectors. Has voice instructions.||AUVI-Q AffordAbility Patient Assistance|
|Symjepi||0.3 mg||Cash price is $240-$280 for 2 syringes; one prescription includes two syringes.||See manufacturer’s website for patient assistance.|
Note: Prices may vary depending on the pharmacy you visit or manufacturer price adjustments. Look for online discount coupons or discount cards if paying cash out-of-pocket. Generic epinephrine is covered by most insurers, including Medicare and commercial insurance plans.
- Slideshow: Understanding Anaphylaxis: Don't Let It Shock You
- Drugs.com Epinephrine Prices, Coupons, and Patient Assistance Program
- Learn More About Anaphylaxis and Treatments
- FDA Approves First Generic Version of EpiPen. Drugs.com. August 16, 2018. Accessed August 7, 2020. https://www.drugs.com/news/fda-approves-first-epipen-76449.html
- FDA Approves Kaléo’s Auvi-Q (Epinephrine Injection, USP) 0.1 mg Auto-Injector for Life-Threatening Allergic Reactions in Infants and Small Children. Drugs.com. Accessed August 7, 2020. https://www.drugs.com/history/auvi-q.html
- Sneader W. The discovery and synthesis of epinephrine. Drug News Perspect. 2001;14(8):491-494. doi:10.1358/dnp.2001.14.8.858417 Accessed August 7, 2020.
- Mylan.com. Mylan's Authorized Generic to EpiPen. (epinephrine injection, USP) Auto-injector. Accessed August 7, 2020 at https://www.mylan.com/-/media/mylancom/files/news/2-mylan-epinephrine-auto-injectors-ag-to-epipen-auto-injector.pdf
- Mukherjee S. Mylan’s CEO Tells Congress the EpiPen Price Hike Was ‘Fair’. Fortune.com. Sept. 21, 2016 Accessed August 19, 2018.
- Editorial. The EpiPen Outrage Continues. Sept. 21, 2016. New York Times. Accessed August 7, 2020 at https://www.nytimes.com/2016/09/22/opinion/the-epipen-outrage-continues.html
- Adrenaclick 2-Pack. Drugs.com. Accessed August 7, 2020. https://www.drugs.com/cons/adrenaclick.html
- Epinephrine injection, USP auto-injector. Amedra Pharmaceuticals. Horsham, PA. Accessed August 7, 2020. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020800s035lbl.pdf
- CVS Cuts Price of Generic Competitor to EpiPen. Drugs.com.
- Kaléo Announces U.S. Availability and Pricing to Patients of Auvi-Q (Epinephrine Injection, USP) Auto-Injector, For Life-Threatening Allergic Reactions. Jan 19, 2017. Accessed August 7, 2020 at https://kaleo.com/kaleo-announces-u-s-availability-and-pricing-to-patients-of-auvi-q-epinephrine-injection-usp-auto-injector-for-life-threatening-allergic-reactions/
- Carr T. Don't Order EpiPens From Canada. Consumer Reports.org. Accessed August 7, 2020 at https://www.consumerreports.org/drugs/dont-order-epipens-from-canada/
- Americans turn to Canada for cheaper EpiPens. The Star.com Accessed August 7, 2020 at https://www.thestar.com/news/canada/2016/08/25/americans-turn-to-canada-for-cheaper-epipens.html
- FDA Approves Symjepi. Drugs.com. June 15, 2017. Accessed August 7, 2020 at https://www.drugs.com/history/symjepi.html
- Auvi-Q (epinephrine) Product Labeling. Kaleo Pharmaceuticals. Richmond, VA. Accessed August 20, 2018 at https://www.auvi-q.com/
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.