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Medications for Pruritus

Other names: Itching; Itchy Skin

What is Pruritus:  1. Itching, an unpleasant cutaneous sensation that provokes the desire to rub or scratch the skin to obtain relief.

2. Any of various conditions marked by itching, the specific site or type being indicated by a modifying term.

Medications to treat Pruritus

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
hydroxyzine N N X 27 reviews
7.0

Generic name: hydroxyzine systemic

Brand name:  Vistaril

Drug class: miscellaneous anxiolytics, sedatives and hypnotics, antihistamines

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Benadryl B N X Add review
9.0

Generic name: diphenhydramine systemic

Drug class: miscellaneous anxiolytics, sedatives and hypnotics, antihistamines, anticholinergic antiemetics, anticholinergic antiparkinson agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Vistaril N N X Add review
8.0

Generic name: hydroxyzine systemic

Drug class: miscellaneous anxiolytics, sedatives and hypnotics, antihistamines

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Zofran Off Label B N Add review Rate

Generic name: ondansetron systemic

Drug class: 5HT3 receptor antagonists

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
diphenhydramine B N X Add review
9.0

Generic name: diphenhydramine systemic

Brand names:  Benadryl, Benadryl Allergy, Banophen, Q-Dryl, Benadryl Children's Allergy, Dicopanol, Diphedryl, Diphenhist, Allermax, Complete Allergy Relief, Dytuss, Quenalin, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Twilite, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief

Drug class: miscellaneous anxiolytics, sedatives and hypnotics, antihistamines, anticholinergic antiemetics, anticholinergic antiparkinson agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
AmLactin B N Add review Rate

Generic name: ammonium lactate topical

Drug class: topical emollients

For consumers: dosage, side effects

 
Benadryl Allergy B N X Add review Rate

Generic name: diphenhydramine systemic

Drug class: miscellaneous anxiolytics, sedatives and hypnotics, antihistamines, anticholinergic antiemetics, anticholinergic antiparkinson agents

For consumers: dosage, interactions, side effects

 
hydrocortisone C N 4 reviews
8.0

Generic name: hydrocortisone topical

Brand names:  Anucort-HC, Cortizone-10, Proctosol-HC, Proctozone HC, Westcort, Ala-Cort, Locoid, Cortaid, Hytone, Ala-Scalp, Ala-Scalp HP, Anumed-HC, Anusol-HC, Anusol-HC Suppositories, Aquanil HC, Beta HC, Bioelements Immediate Comfort, Caldecort, Cetacort, Corticaine, Cortizone-5, Cortizone-10 Anal Itch Cream, Cotacort, Dermarest Plus Anti-Itch, Dermasorb HC, Dermtex HC, Gly-Cort, Gynecort Maximum Strength, Instacort, Itch-X Lotion, Keratol HC, Lacticare-HC, Locoid Lipocream, NuCort, Nutracort, Pandel, Pediaderm HC, Preparation H Anti-Itch Cream Hydrocortisone 1%, Procto-Kit 1%, Procto-Kit 2.5%, Procto-Med HC, Procto-Pak 1%, ProctoCare-HC, Proctocort, Proctocream-HC, Proctosert HC, Proctozone-H, Recort Plus, Rectacort-HC, Rectasol-HC, Sarnol-HC, Scalacort, Scalp-Cort, Texacort, Tucks Hydrocortisone Anti-Itch Ointment, U-Cort

Drug class: topical steroids

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
gabapentin Off Label C N X 3 reviews
8.0

Generic name: gabapentin systemic

Drug class: gamma-aminobutyric acid analogs

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
ondansetron Off Label B N Add review Rate

Generic name: ondansetron systemic

Brand names:  Zofran, Zofran ODT

Drug class: 5HT3 receptor antagonists

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
ammonium lactate B N Add review
9.0

Generic name: ammonium lactate topical

Brand names:  AmLactin, Lac-Hydrin, Geri-Hydrolac, Kerasal AL, Laclotion

Drug class: topical emollients

For consumers: dosage, side effects

For professionals: Prescribing Information

 
Anucort-HC C N Add review Rate

Generic name: hydrocortisone topical

Drug class: topical steroids

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Banophen B N X Add review Rate

Generic name: diphenhydramine systemic

Drug class: miscellaneous anxiolytics, sedatives and hypnotics, antihistamines, anticholinergic antiemetics, anticholinergic antiparkinson agents

For consumers: dosage, interactions, side effects

 
Cortizone-10 C N 1 review
10

Generic name: hydrocortisone topical

Drug class: topical steroids

For consumers: dosage, interactions, side effects

 
cyproheptadine B N X Add review
9.0

Generic name: cyproheptadine systemic

Drug class: antihistamines

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Zofran ODT Off Label B N Add review Rate

Generic name: ondansetron systemic

Drug class: 5HT3 receptor antagonists

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off Label: Yes

 
Lac-Hydrin B N Add review Rate

Generic name: ammonium lactate topical

Drug class: topical emollients

For consumers: dosage, side effects

For professionals: Prescribing Information

 
lidocaine B N Add review Rate

Generic name: lidocaine topical

Brand names:  Xylocaine Jelly, Xylocaine Topical, AneCream, Bactine, Senatec, CidalEaze, DermacinRx Lidotral´╗┐, DermacinRx Lido V Pak, Eha Lotion, LidaMantle, Lidocream, Lidopin, LidoRx, LidoRxKit, Lidotrans 5 Pak, Lidovex, Lidozol, Medi-Quik Spray, Regenecare HA Spray

Drug class: topical anesthetics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

 
Xylocaine Jelly B N Add review Rate

Generic name: lidocaine topical

Drug class: topical anesthetics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Proctosol-HC C N Add review Rate

Generic name: hydrocortisone topical

Drug class: topical steroids

For consumers: dosage, interactions, side effects

 
calamine N N 2 reviews
9.0

Generic name: calamine topical

Brand name:  Calamine Plain

Drug class: miscellaneous topical agents

For consumers: side effects

 
Proctozone HC C N Add review Rate

Generic name: hydrocortisone topical

Drug class: topical steroids

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Westcort C N Add review Rate

Generic name: hydrocortisone topical

Drug class: topical steroids

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Ala-Cort C N Add review Rate

Generic name: hydrocortisone topical

Drug class: topical steroids

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
doxepin B N X 1 review
9.0

Generic name: doxepin topical

Brand names:  Zonalon, Prudoxin

Drug class: topical antihistamines

For consumers: interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
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Topics under Pruritus

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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