Doxepin Topical Side Effects
Medically reviewed by Drugs.com. Last updated on Aug 30, 2024.
Applies to doxepin topical: topical cream.
Precautions
If your skin problem does not improve after 8 days or if it becomes worse, check with your doctor.
This medicine will add to the effects of alcohol (alcoholic beverages or other alcohol-containing preparations [e.g., elixirs, cough syrups, tonics]) and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine.
Topical doxepin may cause some people to become drowsy. Make sure you know how to react to this medicine before you drive, use machines, or do other jobs that require you to be alert. If too much drowsiness occurs, it may be necessary to use less medicine, use it less often, or stop using it completely. However, check with your doctor first before lessening your dose or stopping use of this medicine.
This medicine may cause dryness of the mouth. For temporary relief, use sugarless gum or candy, or melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.
Serious side effects of doxepin topical
Along with its needed effects, doxepin topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur while taking doxepin topical:
More common side effects
Rare side effects
- fever
Symptoms of overdose
- abdominal pain and swelling
- blurring of vision
- convulsions (seizures)
- decreased awareness or responsiveness
- difficulty in breathing
- difficulty in passing urine
- dizziness, fainting, or lightheadedness
- drowsiness
- enlarged pupils
- excessive dryness of mouth
- extremely high fever or body temperature
- extremely low body temperature
- fast heartbeat
- increased or excessive unconscious or jerking movements
- incurable constipation
- irregular heartbeat
- unconsciousness
- vomiting
- weak pulse
Other side effects of doxepin topical
Some side effects of doxepin topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common side effects
- burning and/or stinging at the site of application
- changes in taste
- dizziness
- drowsiness
- dryness and tightness of skin
- dryness of mouth and/or lips
- emotional changes
- headache
- thirst
- unusual tiredness or weakness
Less common side effects
- anxiety
- irritation, tingling, scaling, and cracking of skin
- nausea
For healthcare professionals
Applies to doxepin topical: topical cream.
General adverse events
The most frequently reported adverse effects were drowsiness and burning/stinging at application site.[Ref]
Nervous system
- Very common (10% or more): Drowsiness (up to 22%)
- Common (1% to 10%): Dizziness, taste perversion
- Uncommon (0.1% to 1%): Headache
- Frequency not reported: Lightheadedness, taste bitter, taste metallic[Ref]
Gastrointestinal
- Common (1% to 10%): Dry mouth
- Uncommon (0.1% to 1%): Numbness of tongue, nausea
- Frequency not reported: Dry lips, dry throat, thirst, indigestion, vomiting, diarrhea, constipation[Ref]
Dermatologic
- Common (1% to 10%): Pruritus, eczema exacerbated
- Frequency not reported: Localized rash, pruritus exacerbated
- Postmarketing reports: Allergic contact dermatitis[Ref]
Local
- Very common (10% or more): Burning/stinging (23%)
- Common (1% to 10%): Other application site reaction
- Frequency not reported: Irritation, tingling[Ref]
Genitourinary
- Frequency not reported: Urinary retention[Ref]
Hypersensitivity
- Frequency not reported: Type IV hypersensitivity reaction[Ref]
Ocular
- Frequency not reported: Blurred vision, dry eyes[Ref]
Other
- Common (1% to 10%): Fatigue/tiredness, edema
- Uncommon (0.1% to 1%): Fever
- Frequency not reported: Vertigo[Ref]
Psychiatric
- Common (1% to 10%): Mental emotional changes
- Uncommon (0.1% to 1%): Nervousness/anxiety[Ref]
See also:
Benadryl
Benadryl is an antihistamine and is used to treat sneezing, runny nose, itching and other ...
Atarax
Atarax (hydroxyzine) is used to treat anxiety disorders and allergic skin conditions. Inludes ...
Dupixent
Dupixent is used to treat eczema, eosinophilic or oral-corticosteroid-dependent asthma, chronic ...
Vistaril
Vistaril (hydroxyzine) is used as a sedative to treat anxiety and tension and to treat allergic ...
Lidoderm
Lidoderm is a lidocaine patch used to relieve nerve pain after shingles by numbing the skin and ...
Cyproheptadine
Cyproheptadine systemic is used for allergic reactions, allergic rhinitis, allergies, anorexia ...
Hydrocortisone topical
Hydrocortisone cream is used to treat eczema, dermatitis, psoriasis, hemorrhoids, insect bites or ...
Lidocaine topical
Lidocaine topical is used for anal itching, anesthesia, burns, external, gastrointestinal surgery ...
Diphenhydramine
Diphenhydramine is an antihistamine used to treat sneezing, runny nose, itching, hives and other ...
Triamcinolone
Triamcinolone is used to treat allergies, skin conditions, ulcerative colitis, and arthritis. Learn ...
References
1. (2001) "Product Information. Zonalon (doxepin topical)." Bioglan Pharmaceutical Inc
2. MHRA. Medicines and Health Regulatory Agency (2013) MHRA Drug Safety Update. http://www.mhra.gov.uk/Safetyinformation/DrugSafetyUpdate
More about doxepin topical
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (4)
- Dosage information
- During pregnancy
- Drug class: topical antihistamines
- Breastfeeding
- En español
Patient resources
Other brands
Professional resources
Other brands
Related treatment guides
Further information
Doxepin topical side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.