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Benadryl (diphenhydramine) Drug Interactions

A total of 404 drugs are known to interact with Benadryl (diphenhydramine).

  • 12 major drug interactions
  • 390 moderate drug interactions
  • 2 minor drug interactions

Show all medications in the database that may interact with Benadryl (diphenhydramine).

Check for interactions

Type in a drug name to check for interactions with Benadryl (diphenhydramine).

Most frequently checked interactions

View interaction reports for Benadryl (diphenhydramine) and the medicines listed below.

Benadryl (diphenhydramine) alcohol/food interactions

There is 1 alcohol/food interaction with Benadryl (diphenhydramine)

Benadryl (diphenhydramine) disease interactions

There are 8 disease interactions with Benadryl (diphenhydramine) which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.