Benadryl (diphenhydramine) Drug Interactions

A total of 819 drugs (4846 brand and generic names) are known to interact with Benadryl (diphenhydramine).

Check for interactions with Benadryl (diphenhydramine)

Type in a drug name and select a drug from the list.

There is 1 alcohol/food interaction with Benadryl (diphenhydramine)

There are 8 disease interactions with Benadryl (diphenhydramine) which include:

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major	Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate	Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor	Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown	No information available.

Do not stop taking any medications without consulting your healthcare provider.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.