Benadryl (diphenhydramine) Drug Interactions
A total of 821 drugs (4853 brand and generic names) are known to interact with Benadryl (diphenhydramine).
- 33 major drug interactions (160 brand and generic names)
- 784 moderate drug interactions (4681 brand and generic names)
- 4 minor drug interactions (12 brand and generic names)
Check for interactions with Benadryl (diphenhydramine)
Common medications checked in combination with Benadryl (diphenhydramine)
- Advil (ibuprofen)
- albuterol
- Aleve (naproxen)
- Allegra (fexofenadine)
- aspirin
- Claritin (loratadine)
- clonazepam
- Cymbalta (duloxetine)
- gabapentin
- hydrocodone
- ibuprofen
- levothyroxine
- lisinopril
- melatonin
- metformin
- Motrin (ibuprofen)
- Mucinex (guaifenesin)
- Mucinex DM (dextromethorphan / guaifenesin)
- omeprazole
- prednisone
- Singulair (montelukast)
- tramadol
- trazodone
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin D3 (cholecalciferol)
- wine
- Xanax (alprazolam)
- Zoloft (sertraline)
- Zyrtec (cetirizine)
Benadryl (diphenhydramine) alcohol/food Interactions
There is 1 alcohol/food interaction with Benadryl (diphenhydramine)
Benadryl (diphenhydramine) disease Interactions
There are 8 disease interactions with Benadryl (diphenhydramine) which include:
- Anticholinergic Effects
- Asthma/Copd
- Depression
- Cardiovascular
- Renal/Liver Disease
- Glaucoma
- Liver Disease
- Resp Depression
More about Benadryl (diphenhydramine)
- Benadryl Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Patient Tips
- Drug Images
- Compare Alternatives
- Support Group
- Pricing & Coupons
- En Español
- 46 Reviews
- Drug class: anticholinergic antiemetics
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No information available. |
Do not stop taking any medications without consulting your healthcare provider.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
