Benadryl (diphenhydramine) Drug Interactions
A total of 404 drugs are known to interact with Benadryl (diphenhydramine).
- 12 major drug interactions
- 390 moderate drug interactions
- 2 minor drug interactions
Check for interactions
Most frequently checked interactions
View interaction reports for Benadryl (diphenhydramine) and the medicines listed below.
- albuterol
- aspirin
- clonazepam
- gabapentin
- ibuprofen
- levothyroxine
- lisinopril
- melatonin
- metformin
- omeprazole
- prednisone
- Singulair (montelukast)
- tramadol
- trazodone
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Zyrtec (cetirizine)
Benadryl (diphenhydramine) alcohol/food interactions
There is 1 alcohol/food interaction with Benadryl (diphenhydramine)
Benadryl (diphenhydramine) disease interactions
There are 8 disease interactions with Benadryl (diphenhydramine) which include:
- depression
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
More about Benadryl (diphenhydramine)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Patient Tips
- Drug Images
- Compare Alternatives
- Support Group
- Pricing & Coupons
- En Español
- 54 Reviews
- Drug class: anticholinergic antiemetics
- FDA Alerts (2)
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
