Benadryl Interactions
There are 449 drugs known to interact with Benadryl (diphenhydramine), along with 8 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 15 are major, 431 are moderate, and 3 are minor.
- View all 449 medications that may interact with Benadryl
- View Benadryl alcohol/food interactions (1)
- View Benadryl disease interactions (8)
Most frequently checked interactions
View interaction reports for Benadryl (diphenhydramine) and the medicines listed below.
- albuterol
- albuterol
- aspirin
- aspirin
- gabapentin
- gabapentin
- ibuprofen
- ibuprofen
- levothyroxine
- levothyroxine
- lisinopril
- lisinopril
- melatonin
- melatonin
- metformin
- metformin
- omeprazole
- omeprazole
- prednisone
- prednisone
- trazodone
- trazodone
- Tylenol (acetaminophen)
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin B12 (cyanocobalamin)
- Vitamin D3 (cholecalciferol)
- Vitamin D3 (cholecalciferol)
- Zyrtec (cetirizine)
- Zyrtec (cetirizine)
Benadryl alcohol/food interactions
There is 1 alcohol/food interaction with Benadryl (diphenhydramine).
Benadryl disease interactions
There are 8 disease interactions with Benadryl (diphenhydramine) which include:
- depression
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
Report options
More about Benadryl (diphenhydramine)
- Benadryl consumer information
- Compare alternatives
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- Reviews (80)
- Drug images
- Latest FDA alerts (3)
- Side effects
- Dosage information
- Patient tips
- During pregnancy
- Support group
- Drug class: anticholinergic antiemetics
- Breastfeeding
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
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Xolair
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Montelukast
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Lorazepam
Lorazepam is in a group of drugs called benzodiazepines and is used to treat anxiety disorders ...
Cetirizine
Cetirizine treats cold or allergy symptoms such as sneezing, itching, watery eyes, or runny nose ...
Fluticasone nasal
Fluticasone nasal is used for allergic rhinitis, allergies, chronic rhinosinusitis with nasal ...
Ondansetron
Ondansetron is used to prevent nausea and vomiting caused by surgery, chemotherapy, or radiation by ...
Hydroxyzine
Hydroxyzine is an antihistamine used to treat itching, hives, and anxiety. It also acts as a ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
