Benadryl (diphenhydramine) Drug Interactions

A total of 383 drugs are known to interact with Benadryl (diphenhydramine).

Check for interactions

Type in a drug name to check for interactions with Benadryl (diphenhydramine).

View interaction reports for Benadryl (diphenhydramine) and the medicines listed below.

There is 1 alcohol/food interaction with Benadryl (diphenhydramine)

There are 8 disease interactions with Benadryl (diphenhydramine) which include:

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major	Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate	Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor	Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown	No interaction information available.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.