Benadryl (diphenhydramine) Drug Interactions
A total of 801 drugs (4781 brand and generic names) are known to interact with Benadryl (diphenhydramine).
- 33 major drug interactions (160 brand and generic names)
- 765 moderate drug interactions (4611 brand and generic names)
- 3 minor drug interactions (10 brand and generic names)
Check for interactions with Benadryl (diphenhydramine)
Common medications checked in combination with Benadryl (diphenhydramine)
- albuterol
- aspirin
- clonazepam
- Cymbalta (duloxetine)
- gabapentin
- ibuprofen
- levothyroxine
- lisinopril
- melatonin
- metformin
- omeprazole
- prednisone
- Singulair (montelukast)
- tramadol
- trazodone
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Zyrtec (cetirizine)
Benadryl (diphenhydramine) alcohol/food Interactions
There is 1 alcohol/food interaction with Benadryl (diphenhydramine)
Benadryl (diphenhydramine) disease Interactions
There are 8 disease interactions with Benadryl (diphenhydramine) which include:
- Anticholinergic Effects
- Depression
- Asthma/Copd
- Cardiovascular
- Renal/Liver Disease
- Glaucoma
- Liver Disease
- Resp Depression
See also...
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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