Benadryl (diphenhydramine) Drug Interactions
A total of 811 drugs (4826 brand and generic names) are known to interact with Benadryl (diphenhydramine).
- 33 major drug interactions (160 brand and generic names)
- 774 moderate drug interactions (4654 brand and generic names)
- 4 minor drug interactions (12 brand and generic names)
Common medications checked in combination with Benadryl (diphenhydramine)
- Advil (ibuprofen)
- albuterol
- Aleve (naproxen)
- Allegra (fexofenadine)
- aspirin
- Claritin (loratadine)
- clonazepam
- Cymbalta (duloxetine)
- gabapentin
- hydrocodone
- ibuprofen
- levothyroxine
- lisinopril
- melatonin
- metformin
- Motrin (ibuprofen)
- Mucinex (guaifenesin)
- Mucinex DM (dextromethorphan / guaifenesin)
- omeprazole
- prednisone
- Singulair (montelukast)
- tramadol
- trazodone
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin D3 (cholecalciferol)
- wine
- Xanax (alprazolam)
- Zoloft (sertraline)
- Zyrtec (cetirizine)
Check for interactions with Benadryl (diphenhydramine)
Benadryl (diphenhydramine) alcohol/food Interactions
There is 1 alcohol/food interaction with Benadryl (diphenhydramine)
Benadryl (diphenhydramine) disease Interactions
There are 8 disease interactions with Benadryl (diphenhydramine) which include:
- Anticholinergic Effects
- Depression
- Asthma/Copd
- Cardiovascular
- Renal/Liver Disease
- Glaucoma
- Liver Disease
- Resp Depression
See Also
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No information available. |
Do not stop taking any medications without consulting your healthcare provider.
Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2018 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.
