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Hydroxyzine Dosage

Medically reviewed by Drugs.com. Last updated on Mar 25, 2019.

Applies to the following strengths: hydrochloride 25 mg/mL; hydrochloride 50 mg/mL; hydrochloride 10 mg/5 mL; hydrochloride 10 mg; hydrochloride 25 mg; hydrochloride 50 mg; hydrochloride 100 mg; pamoate 25 mg; pamoate 50 mg; pamoate 100 mg; pamoate 25 mg/5 mL; hydrochloride; pamoate

Usual Adult Dose for Anxiety

Oral: 50 to 100 mg orally 4 times a day
Parenteral: 50 to 100 mg IM immediately, then every 4 to 6 hours as needed

Comments:
-Use should be periodically reassessed.
-Treatment for longer than 4 months have not been assessed in clinical studies.

Uses:
Oral:
-As an adjunct in organic disease states in which anxiety is manifested
-Symptomatic relief of anxiety and tension associated with psychoneurosis

Parenteral:
-Adjunctive treatment in alcoholism
-Allay associated anxiety and apprehension attendant to certain types of heart disease
-Alleviating anxiety and tension in acute emotional problems or in the preparation for dental procedures
-As pre-/postoperative and pre-/postpartum adjunctive medication to allay anxiety
-Management of anxiety associated with allergic conditions with strong emotional overlay (e.g., asthma, chronic urticaria, pruritus)
-Management of anxiety associated with organic disturbances
-Treatment of patients who are acutely/chronically alcoholic with anxiety withdrawal symptoms or delirium tremens
-Treatment of patients who are acutely disturbed or hysterical

Usual Adult Dose for Atopic Dermatitis

Oral: 25 mg orally 3 to 4 times a day

Use: Management of pruritus due to histamine-mediated pruritus and allergic conditions (e.g., atopic/contact dermatoses, chronic urticaria)

Usual Adult Dose for Pruritus

Oral: 25 mg orally 3 to 4 times a day

Use: Management of pruritus due to histamine-mediated pruritus and allergic conditions (e.g., atopic/contact dermatoses, chronic urticaria)

Usual Adult Dose for Urticaria

Oral: 25 mg orally 3 to 4 times a day

Use: Management of pruritus due to histamine-mediated pruritus and allergic conditions (e.g., atopic/contact dermatoses, chronic urticaria)

Usual Adult Dose for Sedation

Oral: 50 to 100 mg orally ONCE
Parenteral: 25 to 100 mg IM ONCE

Comment: This drug may potentiate barbiturates and/or meperidine.

Uses:
Oral:
-As a sedative when used as premedication or following general anesthesia
-Pre-anesthetic adjunctive treatment

Parenteral:
-Pre-/postoperative adjunctive medication to permit reduction in narcotic dosage
-Pre-/postpartum adjunctive therapy to permit reduction in narcotic dosage

Usual Adult Dose for Nausea/Vomiting

Parenteral: 25 to 100 mg IM ONCE

Uses:
-Control of nausea and vomiting, excluding nausea and vomiting of pregnancy
-Pre-/postoperative adjunctive medication to control emesis
-Pre-/postpartum adjunctive medication to control emesis

Usual Pediatric Dose for Sedation

Children:
Oral: 0.6 mg/kg orally ONCE
Parenteral: 1.1 mg/kg IM ONCE

Uses:
Oral:
-As a sedative when used as premedication or following general anesthesia
-Pre-anesthetic adjunctive treatment

Parenteral:
-Pre-/postoperative adjunctive medication to permit reduction in narcotic dosage
-Pre-/postpartum adjunctive therapy to permit reduction in narcotic dosage

Usual Pediatric Dose for Anxiety

Children:
-Under 6 years: 50 mg orally per day, given in divided doses
-Over 6 years: 50 to 100 mg orally per day, given in divided doses

Uses:
-Allay associated anxiety and apprehension attendant to certain types of heart disease
-Alleviating anxiety and tension in acute emotional problems or in the preparation for dental procedures
-As pre-/postoperative and pre-/postpartum adjunctive medication to allay anxiety
-Management of anxiety associated with allergic conditions with strong emotional overlay (e.g., asthma, chronic urticaria, pruritus)
-Management of anxiety associated with organic disturbances
-Management of pruritus due to histamine-mediated pruritus and allergic conditions (e.g., atopic/contact dermatoses, chronic urticaria)
-Treatment of patients who are acutely disturbed or hysterical

Usual Pediatric Dose for Atopic Dermatitis

Children:
-Under 6 years: 50 mg orally per day, given in divided doses
-Over 6 years: 50 to 100 mg orally per day, given in divided doses

Uses:
-Allay associated anxiety and apprehension attendant to certain types of heart disease
-Alleviating anxiety and tension in acute emotional problems or in the preparation for dental procedures
-As pre-/postoperative and pre-/postpartum adjunctive medication to allay anxiety
-Management of anxiety associated with allergic conditions with strong emotional overlay (e.g., asthma, chronic urticaria, pruritus)
-Management of anxiety associated with organic disturbances
-Management of pruritus due to histamine-mediated pruritus and allergic conditions (e.g., atopic/contact dermatoses, chronic urticaria)
-Treatment of patients who are acutely disturbed or hysterical

Usual Pediatric Dose for Pruritus

Children:
-Under 6 years: 50 mg orally per day, given in divided doses
-Over 6 years: 50 to 100 mg orally per day, given in divided doses

Uses:
-Allay associated anxiety and apprehension attendant to certain types of heart disease
-Alleviating anxiety and tension in acute emotional problems or in the preparation for dental procedures
-As pre-/postoperative and pre-/postpartum adjunctive medication to allay anxiety
-Management of anxiety associated with allergic conditions with strong emotional overlay (e.g., asthma, chronic urticaria, pruritus)
-Management of anxiety associated with organic disturbances
-Management of pruritus due to histamine-mediated pruritus and allergic conditions (e.g., atopic/contact dermatoses, chronic urticaria)
-Treatment of patients who are acutely disturbed or hysterical

Usual Pediatric Dose for Urticaria

Children:
-Under 6 years: 50 mg orally per day, given in divided doses
-Over 6 years: 50 to 100 mg orally per day, given in divided doses

Uses:
-Allay associated anxiety and apprehension attendant to certain types of heart disease
-Alleviating anxiety and tension in acute emotional problems or in the preparation for dental procedures
-As pre-/postoperative and pre-/postpartum adjunctive medication to allay anxiety
-Management of anxiety associated with allergic conditions with strong emotional overlay (e.g., asthma, chronic urticaria, pruritus)
-Management of anxiety associated with organic disturbances
-Management of pruritus due to histamine-mediated pruritus and allergic conditions (e.g., atopic/contact dermatoses, chronic urticaria)
-Treatment of patients who are acutely disturbed or hysterical

Usual Pediatric Dose for Nausea/Vomiting

Children:
Parenteral: 1.1 mg/kg IM ONCE

Uses:
-Control of nausea and vomiting, excluding nausea and vomiting of pregnancy
-Pre-/postoperative adjunctive medication to control emesis

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:
-Hypersensitivity to the active component or to any of the ingredients
-In early pregnancy
-Patients with a prolonged QT interval
-Parenteral formulations: Intraarterial, IV, or subcutaneous administration

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration Advice:
-Tablets should be taken with enough water.
-This drug may be taken without regard to food.
-Use at the lowest effective dose and for the shortest possible duration.
-Adjust dosage according to the patient's response to therapy.
-If initiating treatment by the IM route, administer subsequent doses orally whenever practical.

Storage Requirements:
The manufacturer product information should be consulted.

IV compatibility:
-Incompatible: Aminophylline, benzylpenicillin salts, chloramphenicol sodium succinate, dimenhydrinate, doxorubicin hydrochloride (in a liposomal formulation), thioridazine, and some soluble barbiturates

General:
-This drug has demonstrated primary skeletal muscle relaxation and antispasmodic properties experimentally.
-This drug is not chemically related to benzodiazepines, phenothiazines, reserpine, or meprobamate.

Patient Advice:
-Inform patients that this drug may cause drowsiness, and they should avoid driving or operating machinery if these side effects occur.
-Patients should be instructed to avoid drinking alcohol while taking this drug.
-Patients should be advised to avoid changing the dose without consulting with their healthcare provider.
-Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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