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Hydroxyzine Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Hydroxyzine Xanax Clonazepam
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Hydroxyzine Xanax (alprazolam) Clonazepam
Prescription only

Hydroxyzine may be used to relieve anxiety or itching; however, it causes sedation so can affect a person's ability to drive or operate machinery. It should not be used during pregnancy or while... View more

Prescription only

Xanax may be used for the treatment of anxiety or panic disorder; however, it is addictive, and withdrawal symptoms can be severe. Can interact with several drugs including those that cause... View more

Prescription only

Clonazepam may reduce seizure frequency in specific seizure disorders and can be used short-term for panic disorder, to relieve anxiety, or to sedate. When used long-term it can cause dependence and... View more

More about Hydroxyzine More about Xanax (alprazolam) More about Clonazepam
Generic Status

Lower-cost generic is available

Lower-cost generic is available

Lower-cost generic is available
Ratings & Reviews

Hydroxyzine has an average rating of 5.7 out of 10 from a total of 1346 ratings on Drugs.com. 45% of reviewers reported a positive effect, while 37% reported a negative effect.

Xanax has an average rating of 8.7 out of 10 from a total of 913 ratings on Drugs.com. 83% of reviewers reported a positive effect, while 8% reported a negative effect.

Clonazepam has an average rating of 8.2 out of 10 from a total of 2063 ratings on Drugs.com. 78% of reviewers reported a positive effect, while 12% reported a negative effect.

View all 1346 reviews

View all 913 reviews

View all 2063 reviews

Drug Class
Side Effects

See also: hydroxyzine side effects in more detail.

Common side effects include:

  • ataxia
  • cognitive dysfunction
  • constipation
  • difficulty in micturition
  • drowsiness
  • dysarthria
  • fatigue
  • memory impairment
  • skin rash
  • weight gain
  • weight loss
  • anxiety
  • blurred vision
  • diarrhea
  • insomnia
  • decreased libido
  • increased appetite
  • decreased appetite
  • show all 18

See also: Xanax side effects in more detail.

Commonly reported side effects include:

  • drowsiness

See also: clonazepam side effects in more detail.
Pricing and Coupons * Prices are without insurance
Quantity 4 tablet
Dosage hydrochloride 25 mg
Per Unit* $2.64
Cost* $10.56

View all hydroxyzine prices

Quantity 100 tablet
Dosage 0.25 mg
Per Unit* $5.56
Cost* $555.84

View all Xanax prices and generic prices

Quantity 10 tablet
Dosage 0.5 mg
Per Unit* $1.18
Cost* $11.75

View all clonazepam prices

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Dosage Form(s) Available
  • Intramuscular solution
  • Oral capsule
  • Oral syrup
  • Oral tablet
  • Oral tablet
  • Oral tablet
  • Oral tablet, disintegrating
Brand Names
Vistaril Other alprazolam brands include: Alprazolam Intensol, Xanax XR Klonopin
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

7 hours

20 hours

40 hours
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
4
Some potential for abuse

Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
4
Some potential for abuse

Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
Pregnancy Category
N
Category N Not classified

See the full pregnancy warnings document.
D
Category D Positive evidence of risk

See the full pregnancy warnings document.
D
Category D Positive evidence of risk

See the full pregnancy warnings document.
Drug Interactions

A total of 571 drugs are known to interact with hydroxyzine:

  • 89 major drug interactions (359 brand and generic names)
  • 478 moderate drug interactions (1941 brand and generic names)
  • 4 minor drug interactions (16 brand and generic names)

A total of 539 drugs are known to interact with Xanax:

  • 54 major drug interactions (212 brand and generic names)
  • 446 moderate drug interactions (1640 brand and generic names)
  • 39 minor drug interactions (329 brand and generic names)

A total of 513 drugs are known to interact with clonazepam:

  • 29 major drug interactions (153 brand and generic names)
  • 452 moderate drug interactions (1660 brand and generic names)
  • 32 minor drug interactions (208 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Alcohol can increase the nervous system side effects of hydrOXYzine such as dizziness, drowsiness... View more
  • Grapefruit and grapefruit juice may interact with ALPRAZolam and lead to potentially dangerous side... View more
  • Using clonazePAM together with alcohol can increase nervous system side effects such as dizziness... View more
Disease Interactions
First Approval Date

April 12, 1956

N/A

June 04, 1975
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources
Professional Resources
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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