Comparing Buspirone vs Hydroxyzine

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
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Buspirone

Hydroxyzine

Buspirone may be used for the treatment of anxiety and is less likely to cause sedation than other anti-anxiety drugs. Prescribed for Anxiety, Panic Disorder. May also be prescribed off label for... View more

Hydroxyzine may be used to relieve anxiety or itching; however, it causes sedation so can affect a person's ability to drive or operate machinery. It should not be used during pregnancy or while... View more

Prescription only

Ratings & Reviews

View all 1138 reviews

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Drug Class

Miscellaneous anxiolytics, sedatives and hypnotics

Side Effects

Commonly reported side effects include: dizziness.

See the full buspirone side effects document.

See the full hydroxyzine side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	100 each
Dosage	10 mg
Per Unit^*	$0.46
Cost^*	$45.78

View all buspirone prices

Quantity	6 tablet
Dosage	hydrochloride 25 mg
Per Unit^*	$1.85
Cost^*	$11.08

View all hydroxyzine prices

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Generic Availability

Yes (this medicine)

Dosage Form(s) Available

Oral tablet

Intramuscular solution
Oral capsule
Oral syrup
Oral tablet

Brand Names

BuSpar

N/A

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

11.3 hours

7 hours

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category B No proven risk in humans

See the full Pregnancy Warnings document.

Category N Not classified

See the full Pregnancy Warnings document.

Drug Interactions

A total of 442 drugs are known to interact with buspirone:

88 major drug interactions (322 brand and generic names)
352 moderate drug interactions (1302 brand and generic names)
2 minor drug interactions (5 brand and generic names)

A total of 540 drugs are known to interact with hydroxyzine:

84 major drug interactions (342 brand and generic names)
451 moderate drug interactions (1835 brand and generic names)
5 minor drug interactions (25 brand and generic names)

Alcohol/Food/Lifestyle Interactions

You should avoid the use of alcohol while being treated with busPIRone. Alcohol can increase the... View more

Alcohol can increase the nervous system side effects of hydrOXYzine such as dizziness, drowsiness... View more

Disease Interactions

First Approval Date

September 29, 1986

April 12, 1956

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

Consumer Resources

Advanced Reading

Professional Resources

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer