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Buspirone Side Effects

In Summary

Commonly reported side effects of buspirone include: dizziness. Other side effects include: headache and nervousness. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to buspirone: oral tablet

Along with its needed effects, buspirone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking buspirone:

Rare
  • Chest pain
  • confusion
  • fast or pounding heartbeat
  • fever
  • incoordination
  • mental depression
  • muscle weakness
  • numbness, tingling, pain, or weakness in the hands or feet
  • skin rash or hives
  • sore throat
  • stiffness of the arms or legs
  • uncontrolled movements of the body

Get emergency help immediately if any of the following symptoms of overdose occur while taking buspirone:

Symptoms of overdose
  • Dizziness or lightheadedness especially when getting up from a sitting or lying position suddenly
  • drowsiness (severe)
  • loss of consciousness
  • nausea or vomiting
  • stomach upset
  • very small pupils of the eyes

Some side effects of buspirone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Restlessness, nervousness, or unusual excitement
Less common or rare
  • Blurred vision
  • clamminess or sweating
  • decreased concentration
  • diarrhea
  • drowsiness
  • dryness of the mouth
  • muscle pain, spasms, cramps, or stiffness
  • ringing in the ears
  • trouble with sleeping, nightmares, or vivid dreams
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to buspirone: compounding powder, oral tablet

Nervous system

Very common (10% or more): Dizziness (12%), drowsiness (10%)
Common (1% to 10%): Lightheadedness, decreased concentration, numbness, paresthesia, incoordination, headache, tremor, syncope, seizures
Rare (less than 0.1%): Cerebrovascular accident
Very rare (less than 0.01%): Serotonin syndrome, amnesia, cogwheel rigidity, dystonia/dystonic reactions, dyskinesias (acute and tardive), ataxias, parkinsonism, akathisia, restless leg syndrome
Postmarketing reports: Vertigo, extrapyramidal symptoms, transient difficulty with recall[Ref]

Cardiovascular

Common (1% to 10%): Tachycardia/palpitations, chest pain
Uncommon (0.1% to 1%): Hypotension, hypertension
Rare (less than 0.1%): Congestive heart failure, myocardial infarction, cardiomyopathy, bradycardia[Ref]

Dermatologic

Common (1% to 10%): Rash, sweating/clamminess
Uncommon (0.1% to 1%): Pruritus, flushing, easy bruising, hair loss, dry skin, facial edema, blisters
Rare (less than 0.1%): Acne, thinning of nails, ecchymosis, urticaria[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, dry mouth, abdominal/gastric distress, diarrhea, constipation, vomiting
Uncommon (0.1% to 1%): Flatulence, anorexia, increased appetite, salivation, irritable colon, rectal bleeding
Rare (less than 0.1%): Burning of the tongue[Ref]

Musculoskeletal

Common (1% to 10%): Musculoskeletal aches/pains
Uncommon (0.1% to 1%): Muscle cramps, muscle spasms, rigid/stiff muscles, arthralgias
Rare (less than 0.1%): Muscle weakness[Ref]

Ocular

Common (1% to 10%): Blurred vision
Uncommon (0.1% to 1%): Eye redness and itching, conjunctivitis, eye pain, eye pressure, photophobia
Very rare (less than 0.01%): Visual changes (including tunnel vision)[Ref]

Other

Common (1% to 10%): Fatigue, weakness, tinnitus, sore throat
Uncommon (0.1% to 1%): Altered taste, altered smell, inner ear abnormality, edema, fever, roaring sensation in the head, malaise
Rare (less than 0.1%): Alcohol abuse, loss of voice, hiccoughs[Ref]

Psychiatric

Common (1% to 10%): Insomnia, nervousness, excitement, anger/hostility, confusion, depression, dream disturbances, attention disturbance, sleep disorder
Uncommon (0.1% to 1%): Depersonalization, dysphoria, noise intolerance, euphoria, akathisia, fearfulness, loss of interest, dissociative reaction, hallucinations, involuntary movements, slowed reaction time, suicidal ideation, decreased or increased libido
Rare (less than 0.1%): Claustrophobia, cold intolerance, stupor, slurred speech, psychosis, delayed ejaculation, impotence
Very rare (less than 0.01%): Depersonalization
Postmarketing reports: Emotional lability, restlessness[Ref]

Respiratory

Common (1% to 10%): Nasal congestion, pharyngolaryngeal pain
Uncommon (0.1% to 1%): Hyperventilation, shortness of breath, chest congestion
Rare (less than 0.1%): Epistaxis[Ref]

Genitourinary

Uncommon (0.1% to 1%): Urinary frequency, urinary hesitancy, menstrual irregularity and spotting, dysuria
Rare (less than 0.1%): Amenorrhea, pelvic inflammatory disease, enuresis, nocturia
Very rare (less than 0.01%): Urinary retention[Ref]

Hepatic

Uncommon (0.1% to 1%): Increases in hepatic aminotransferases (SGOT, SGPT)[Ref]

Metabolic

Uncommon (0.1% to 1%): Weight gain, weight loss[Ref]

Endocrine

Rare (less than 0.1%): Galactorrhea, thyroid abnormality[Ref]

Hematologic

Rare (less than 0.1%): Eisonophilia, leukopenia, thrombocytopenia, bleeding disturbance[Ref]

Hypersensitivity

Postmarketing reports: Allergic reactions, angioedema[Ref]

References

1. "Product Information. Buspar (buspirone)." Bristol-Myers Squibb, Princeton, NJ.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Some side effects of buspirone may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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