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Buspirone Disease Interactions

There are 5 disease interactions with buspirone:


Anxiolytics/sedatives/hypnotics (Includes buspirone) ↔ depression

Severe Potential Hazard, Moderate plausibility. Applies to: Depression

A variety of abnormal thinking and behavior changes have been reported to occur in association with the use of most anxiolytics, sedatives and hypnotics. Some of these changes include decreased inhibition, aggressiveness, agitation, and hallucinations. These drugs can cause or exacerbate mental depression and cause suicidal behavior and ideation. Therapy with these drugs should be administered cautiously in patients with a history of depression or other psychiatric disorders. Patients should be monitored for any changes in mood or behavior. It may be prudent to refrain from dispensing large quantities of medication to these patients.


  1. "Product Information. Ambien (zolpidem)." sanofi-aventis, Bridgewater, NJ.
  2. "Product Information. Placidyl (ethchlorvynol)." Abbott Pharmaceutical, Abbott Park, IL.
  3. "Product Information. Sonata (zaleplon)" Wyeth-Ayerst Laboratories, Philadelphia, PA.
  4. "Product Information. Equanil (meprobamate)." Wallace Laboratories, Cranbury, NJ.
  5. "Product Information. Aquachloral Supprettes (chloral hydrate)." Medisca, Plattsburg, NY.
View all 5 references

Buspirone (Includes buspirone) ↔ renal/liver disease

Severe Potential Hazard, High plausibility. Applies to: Liver Disease, Renal Dysfunction

Buspirone is primarily metabolized by the liver and subsequently eliminated by the kidney. In one study, steady-state area under the plasma concentration-time curve (AUC) of buspirone increased 13-fold in subjects with hepatic impairment and 4-fold in those with renal impairment compared to healthy subjects. Therapy with buspirone is not recommended in the presence of significantly impaired hepatic or renal function.


  1. Dalhoff K, Poulsen HE, Garred P, et al "Buspirone pharmacokinetics in patients with cirrhosis." Br J Clin Pharmacol 24 (1987): 547-50
  2. Gammans RE, Mayol RF, Labudde JA "Metabolism and disposition of buspirone." Am J Med 80 (1986): 41-51
  3. "Product Information. Buspar (buspirone)." Bristol-Myers Squibb, Princeton, NJ.
  4. Caccia S, Vigano GL, Mingardi G, et al "Clinical pharmacokinetics of oral buspirone in patients with impaired renal function." Clin Pharmacokinet 14 (1988): 171-7
View all 4 references

Anxiolytics/sedatives/hypnotics (Includes buspirone) ↔ glaucoma

Moderate Potential Hazard, Moderate plausibility. Applies to: Glaucoma/Intraocular Hypertension, Urinary Retention

Some hypnotic drugs can have an anticholinergic effect and should be used with caution in patients with glaucoma, and trouble urinating due to retention or enlarged prostate.


Anxiolytics/sedatives/hypnotics (Includes buspirone) ↔ liver disease

Moderate Potential Hazard, Moderate plausibility. Applies to: Liver Disease

In general, anxiolytics, sedatives and hypnotics are extensively metabolized by the liver. Their plasma clearance may be decreased and their half-life prolonged in patients with impaired hepatic function. Therapy with these drugs should be administered cautiously in patients with liver disease (some are not recommended in severe liver impairment), and the dosage should be adjusted accordingly. Laboratory testing is recommended prior and during treatment.


Buspirone (Includes buspirone) ↔ drug dependence

Moderate Potential Hazard, Low plausibility. Applies to: Drug Abuse/Dependence, Alcoholism

In human and animal studies, buspirone has not shown potential for abuse or diversion, and there is no evidence that it causes tolerance or physical and psychological dependence. However, since it is a CNS-active drug, the manufacturers recommend that therapy with buspirone be administered cautiously in addiction-prone individuals, such as those with a history of alcohol or substance abuse. It may be prudent to refrain from dispensing large quantities of medication to these patients.


  1. "Product Information. Buspar (buspirone)." Bristol-Myers Squibb, Princeton, NJ.

Buspirone drug interactions

There are 829 drug interactions with buspirone

Buspirone alcohol/food interactions

There is 1 alcohol/food interaction with buspirone

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.