Comparing Alprazolam vs Hydroxyzine

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
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Alprazolam

Hydroxyzine

Alprazolam effectively relieves anxiety; however, it is addictive and withdrawal symptoms can be severe. Prescribed for Anxiety, Panic Disorder. May also be prescribed off label for Borderline... View more

Hydroxyzine may be used to relieve anxiety or itching; however, it causes sedation so can affect a person's ability to drive or operate machinery. It should not be used during pregnancy or while... View more

Prescription only

Ratings & Reviews

View all 1319 reviews

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Drug Class

Benzodiazepines

Side Effects

Commonly reported side effects include: ataxia, cognitive dysfunction, constipation, depression, difficulty in micturition, drowsiness, dysarthria, fatigue, headache, memory impairment, menstrual disease, nervousness, sedated state, skin rash, tremor, weight gain, weight loss, anxiety, blurred vision, diarrhea, insomnia, decreased libido, increased appetite, irritability, and decreased appetite.

See the full alprazolam side effects document.

See the full hydroxyzine side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	6 tablet
Dosage	0.25 mg
Per Unit^*	$1.78
Cost^*	$10.70

View all alprazolam prices

Quantity	6 tablet
Dosage	hydrochloride 25 mg
Per Unit^*	$1.85
Cost^*	$11.08

View all hydroxyzine prices

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Generic Availability

Yes (this medicine)

Dosage Form(s) Available

Oral concentrate
Oral tablet
Oral tablet, disintegrating
Oral tablet, extended release

Intramuscular solution
Oral capsule
Oral syrup
Oral tablet

Brand Names

Alprazolam Intensol, Xanax, Xanax XR

N/A

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

20 hours

7 hours

CSA Schedule**

View glossary of terms.

Some potential for abuse

Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category D Positive evidence of risk

See the full Pregnancy Warnings document.

Category N Not classified

See the full Pregnancy Warnings document.

Drug Interactions

A total of 497 drugs are known to interact with alprazolam:

51 major drug interactions (204 brand and generic names)
406 moderate drug interactions (1490 brand and generic names)
40 minor drug interactions (331 brand and generic names)

A total of 540 drugs are known to interact with hydroxyzine:

84 major drug interactions (342 brand and generic names)
451 moderate drug interactions (1835 brand and generic names)
5 minor drug interactions (25 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Grapefruit and grapefruit juice may interact with ALPRAZolam and lead to potentially dangerous side... View more

Alcohol can increase the nervous system side effects of hydrOXYzine such as dizziness, drowsiness... View more

Disease Interactions

First Approval Date

October 16, 1981

April 12, 1956

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

Consumer Resources

Professional Resources

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer