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Benadryl Extra Strength Itch Stopping Gel Side Effects

Generic name: diphenhydramine topical

Medically reviewed by Last updated on Aug 18, 2022.

Note: This document contains side effect information about diphenhydramine topical. Some dosage forms listed on this page may not apply to the brand name Benadryl Extra Strength Itch Stopping Gel .

Applies to diphenhydramine topical: external cream, external gel, external solution.

Serious side effects

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Very bad skin irritation.

Other side effects

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Skin irritation.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

For Healthcare Professionals

Applies to diphenhydramine topical: topical cream, topical gel, topical spray, topical stick.


No side effects have been reported with the use of diphenhydramine topical (the active ingredient contained in Benadryl Extra Strength Itch Stopping Gel ) [Ref]

More about Benadryl Extra Strength Itch Stopping Gel (diphenhydramine topical)

Patient resources

Other brands

Itch Relief

Professional resources

Other formulations

Related treatment guides


1. "Product Information. Benadryl Itch Stopping (diphenhydramine-zinc acetate topical)." Pfizer U.S. Pharmaceuticals Group (2004):

2. "Product Information. Benadryl Itch Stop Gel Maximum Strength (diphenhydramine topical)." Pfizer U.S. Pharmaceuticals Group (2005):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.