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Cyproheptadine Dosage

Medically reviewed by Drugs.com. Last updated on Oct 12, 2020.

Applies to the following strengths: 4 mg; 2 mg/5 mL

Usual Adult Dose for Allergic Reaction

Initial dose: 4 mg orally 3 times a day
Maintenance dose: 4 to 20 mg orally per day, given in divided doses
Maximum dose: 0.5 mg/kg/day

Comments:
-Doses should be individualized, with doses based on response and patient size.
-Many patients require a daily dose of 12 to 16 mg.
-Some patients need up to 32 mg/day to attain relief.

Uses:
-Adjunctive agent to epinephrine and other standard measures AFTER acute anaphylactic reaction manifestations have been controlled
-Allergic conjunctivitis due to inhalant allergens and foods
-Amelioration of allergic reactions to blood or plasma
-Cold urticaria
-Dermatographism
-Mild, uncomplicated allergic skin manifestations of angioedema and urticaria
-Perennial/seasonal allergic rhinitis
-Vasomotor rhinitis

Usual Adult Dose for Allergic Rhinitis

Initial dose: 4 mg orally 3 times a day
Maintenance dose: 4 to 20 mg orally per day, given in divided doses
Maximum dose: 0.5 mg/kg/day

Comments:
-Doses should be individualized, with doses based on response and patient size.
-Many patients require a daily dose of 12 to 16 mg.
-Some patients need up to 32 mg/day to attain relief.

Uses:
-Adjunctive agent to epinephrine and other standard measures AFTER acute anaphylactic reaction manifestations have been controlled
-Allergic conjunctivitis due to inhalant allergens and foods
-Amelioration of allergic reactions to blood or plasma
-Cold urticaria
-Dermatographism
-Mild, uncomplicated allergic skin manifestations of angioedema and urticaria
-Perennial/seasonal allergic rhinitis
-Vasomotor rhinitis

Usual Adult Dose for Pruritus

Initial dose: 4 mg orally 3 times a day
Maintenance dose: 4 to 20 mg orally per day, given in divided doses
Maximum dose: 0.5 mg/kg/day

Comments:
-Doses should be individualized, with doses based on response and patient size.
-Many patients require a daily dose of 12 to 16 mg.
-Some patients need up to 32 mg/day to attain relief.

Uses:
-Adjunctive agent to epinephrine and other standard measures AFTER acute anaphylactic reaction manifestations have been controlled
-Allergic conjunctivitis due to inhalant allergens and foods
-Amelioration of allergic reactions to blood or plasma
-Cold urticaria
-Dermatographism
-Mild, uncomplicated allergic skin manifestations of angioedema and urticaria
-Perennial/seasonal allergic rhinitis
-Vasomotor rhinitis

Usual Adult Dose for Urticaria

Initial dose: 4 mg orally 3 times a day
Maintenance dose: 4 to 20 mg orally per day, given in divided doses
Maximum dose: 0.5 mg/kg/day

Comments:
-Doses should be individualized, with doses based on response and patient size.
-Many patients require a daily dose of 12 to 16 mg.
-Some patients need up to 32 mg/day to attain relief.

Uses:
-Adjunctive agent to epinephrine and other standard measures AFTER acute anaphylactic reaction manifestations have been controlled
-Allergic conjunctivitis due to inhalant allergens and foods
-Amelioration of allergic reactions to blood or plasma
-Cold urticaria
-Dermatographism
-Mild, uncomplicated allergic skin manifestations of angioedema and urticaria
-Perennial/seasonal allergic rhinitis
-Vasomotor rhinitis

Usual Adult Dose for Allergic Conjunctivitis

Initial dose: 4 mg orally 3 times a day
Maintenance dose: 4 to 20 mg orally per day, given in divided doses
Maximum dose: 0.5 mg/kg/day

Comments:
-Doses should be individualized, with doses based on response and patient size.
-Many patients require a daily dose of 12 to 16 mg.
-Some patients need up to 32 mg/day to attain relief.

Uses:
-Adjunctive agent to epinephrine and other standard measures AFTER acute anaphylactic reaction manifestations have been controlled
-Allergic conjunctivitis due to inhalant allergens and foods
-Amelioration of allergic reactions to blood or plasma
-Cold urticaria
-Dermatographism
-Mild, uncomplicated allergic skin manifestations of angioedema and urticaria
-Perennial/seasonal allergic rhinitis
-Vasomotor rhinitis

Usual Adult Dose for Allergic Urticaria

Initial dose: 4 mg orally 3 times a day
Maintenance dose: 4 to 20 mg orally per day, given in divided doses
Maximum dose: 0.5 mg/kg/day

Comments:
-Doses should be individualized, with doses based on response and patient size.
-Many patients require a daily dose of 12 to 16 mg.
-Some patients need up to 32 mg/day to attain relief.

Uses:
-Adjunctive agent to epinephrine and other standard measures AFTER acute anaphylactic reaction manifestations have been controlled
-Allergic conjunctivitis due to inhalant allergens and foods
-Amelioration of allergic reactions to blood or plasma
-Cold urticaria
-Dermatographism
-Mild, uncomplicated allergic skin manifestations of angioedema and urticaria
-Perennial/seasonal allergic rhinitis
-Vasomotor rhinitis

Usual Adult Dose for Dermatographism

Initial dose: 4 mg orally 3 times a day
Maintenance dose: 4 to 20 mg orally per day, given in divided doses
Maximum dose: 0.5 mg/kg/day

Comments:
-Doses should be individualized, with doses based on response and patient size.
-Many patients require a daily dose of 12 to 16 mg.
-Some patients need up to 32 mg/day to attain relief.

Uses:
-Adjunctive agent to epinephrine and other standard measures AFTER acute anaphylactic reaction manifestations have been controlled
-Allergic conjunctivitis due to inhalant allergens and foods
-Amelioration of allergic reactions to blood or plasma
-Cold urticaria
-Dermatographism
-Mild, uncomplicated allergic skin manifestations of angioedema and urticaria
-Perennial/seasonal allergic rhinitis
-Vasomotor rhinitis

Usual Pediatric Dose for Allergic Reaction

WEIGHT-BASED OR BODY SURFACE AREA (BSA) DOSING:
Pediatric patients: 0.25 mg/kg orally per day (given in divided doses) OR 8 mg/m2 orally per day (given in divided doses)

FIXED DOSING:
2 to 6 years: 2 mg orally 2 to 3 times a day
-Maximum dose: 12 mg/day

7 to 14 years: 4 mg orally 2 to 3 times a day
-Maximum dose: 16 mg/day

Comments:
-Doses should be individualized, with doses based on response and patient size.
-Many patients require a daily dose of 12 to 16 mg.
-Some patients need up to 32 mg/day to attain relief.

Uses:
-Adjunctive agent to epinephrine and other standard measures AFTER acute anaphylactic reaction manifestations have been controlled
-Allergic conjunctivitis due to inhalant allergens and foods
-Amelioration of allergic reactions to blood or plasma
-Cold urticaria
-Dermatographism
-Mild, uncomplicated allergic skin manifestations of angioedema and urticaria
-Perennial/seasonal allergic rhinitis
-Vasomotor rhinitis

Usual Pediatric Dose for Allergic Rhinitis

WEIGHT-BASED OR BODY SURFACE AREA (BSA) DOSING:
Pediatric patients: 0.25 mg/kg orally per day (given in divided doses) OR 8 mg/m2 orally per day (given in divided doses)

FIXED DOSING:
2 to 6 years: 2 mg orally 2 to 3 times a day
-Maximum dose: 12 mg/day

7 to 14 years: 4 mg orally 2 to 3 times a day
-Maximum dose: 16 mg/day

Comments:
-Doses should be individualized, with doses based on response and patient size.
-Many patients require a daily dose of 12 to 16 mg.
-Some patients need up to 32 mg/day to attain relief.

Uses:
-Adjunctive agent to epinephrine and other standard measures AFTER acute anaphylactic reaction manifestations have been controlled
-Allergic conjunctivitis due to inhalant allergens and foods
-Amelioration of allergic reactions to blood or plasma
-Cold urticaria
-Dermatographism
-Mild, uncomplicated allergic skin manifestations of angioedema and urticaria
-Perennial/seasonal allergic rhinitis
-Vasomotor rhinitis

Usual Pediatric Dose for Pruritus

WEIGHT-BASED OR BODY SURFACE AREA (BSA) DOSING:
Pediatric patients: 0.25 mg/kg orally per day (given in divided doses) OR 8 mg/m2 orally per day (given in divided doses)

FIXED DOSING:
2 to 6 years: 2 mg orally 2 to 3 times a day
-Maximum dose: 12 mg/day

7 to 14 years: 4 mg orally 2 to 3 times a day
-Maximum dose: 16 mg/day

Comments:
-Doses should be individualized, with doses based on response and patient size.
-Many patients require a daily dose of 12 to 16 mg.
-Some patients need up to 32 mg/day to attain relief.

Uses:
-Adjunctive agent to epinephrine and other standard measures AFTER acute anaphylactic reaction manifestations have been controlled
-Allergic conjunctivitis due to inhalant allergens and foods
-Amelioration of allergic reactions to blood or plasma
-Cold urticaria
-Dermatographism
-Mild, uncomplicated allergic skin manifestations of angioedema and urticaria
-Perennial/seasonal allergic rhinitis
-Vasomotor rhinitis

Usual Pediatric Dose for Urticaria

WEIGHT-BASED OR BODY SURFACE AREA (BSA) DOSING:
Pediatric patients: 0.25 mg/kg orally per day (given in divided doses) OR 8 mg/m2 orally per day (given in divided doses)

FIXED DOSING:
2 to 6 years: 2 mg orally 2 to 3 times a day
-Maximum dose: 12 mg/day

7 to 14 years: 4 mg orally 2 to 3 times a day
-Maximum dose: 16 mg/day

Comments:
-Doses should be individualized, with doses based on response and patient size.
-Many patients require a daily dose of 12 to 16 mg.
-Some patients need up to 32 mg/day to attain relief.

Uses:
-Adjunctive agent to epinephrine and other standard measures AFTER acute anaphylactic reaction manifestations have been controlled
-Allergic conjunctivitis due to inhalant allergens and foods
-Amelioration of allergic reactions to blood or plasma
-Cold urticaria
-Dermatographism
-Mild, uncomplicated allergic skin manifestations of angioedema and urticaria
-Perennial/seasonal allergic rhinitis
-Vasomotor rhinitis

Usual Pediatric Dose for Allergic Conjunctivitis

WEIGHT-BASED OR BODY SURFACE AREA (BSA) DOSING:
Pediatric patients: 0.25 mg/kg orally per day (given in divided doses) OR 8 mg/m2 orally per day (given in divided doses)

FIXED DOSING:
2 to 6 years: 2 mg orally 2 to 3 times a day
-Maximum dose: 12 mg/day

7 to 14 years: 4 mg orally 2 to 3 times a day
-Maximum dose: 16 mg/day

Comments:
-Doses should be individualized, with doses based on response and patient size.
-Many patients require a daily dose of 12 to 16 mg.
-Some patients need up to 32 mg/day to attain relief.

Uses:
-Adjunctive agent to epinephrine and other standard measures AFTER acute anaphylactic reaction manifestations have been controlled
-Allergic conjunctivitis due to inhalant allergens and foods
-Amelioration of allergic reactions to blood or plasma
-Cold urticaria
-Dermatographism
-Mild, uncomplicated allergic skin manifestations of angioedema and urticaria
-Perennial/seasonal allergic rhinitis
-Vasomotor rhinitis

Usual Pediatric Dose for Allergic Urticaria

WEIGHT-BASED OR BODY SURFACE AREA (BSA) DOSING:
Pediatric patients: 0.25 mg/kg orally per day (given in divided doses) OR 8 mg/m2 orally per day (given in divided doses)

FIXED DOSING:
2 to 6 years: 2 mg orally 2 to 3 times a day
-Maximum dose: 12 mg/day

7 to 14 years: 4 mg orally 2 to 3 times a day
-Maximum dose: 16 mg/day

Comments:
-Doses should be individualized, with doses based on response and patient size.
-Many patients require a daily dose of 12 to 16 mg.
-Some patients need up to 32 mg/day to attain relief.

Uses:
-Adjunctive agent to epinephrine and other standard measures AFTER acute anaphylactic reaction manifestations have been controlled
-Allergic conjunctivitis due to inhalant allergens and foods
-Amelioration of allergic reactions to blood or plasma
-Cold urticaria
-Dermatographism
-Mild, uncomplicated allergic skin manifestations of angioedema and urticaria
-Perennial/seasonal allergic rhinitis
-Vasomotor rhinitis

Usual Pediatric Dose for Dermatographism

WEIGHT-BASED OR BODY SURFACE AREA (BSA) DOSING:
Pediatric patients: 0.25 mg/kg orally per day (given in divided doses) OR 8 mg/m2 orally per day (given in divided doses)

FIXED DOSING:
2 to 6 years: 2 mg orally 2 to 3 times a day
-Maximum dose: 12 mg/day

7 to 14 years: 4 mg orally 2 to 3 times a day
-Maximum dose: 16 mg/day

Comments:
-Doses should be individualized, with doses based on response and patient size.
-Many patients require a daily dose of 12 to 16 mg.
-Some patients need up to 32 mg/day to attain relief.

Uses:
-Adjunctive agent to epinephrine and other standard measures AFTER acute anaphylactic reaction manifestations have been controlled
-Allergic conjunctivitis due to inhalant allergens and foods
-Amelioration of allergic reactions to blood or plasma
-Cold urticaria
-Dermatographism
-Mild, uncomplicated allergic skin manifestations of angioedema and urticaria
-Perennial/seasonal allergic rhinitis
-Vasomotor rhinitis

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:
-Hypersensitivity to the active component or to any of the ingredients
-MAO inhibitor treatment
-Newborn or premature infants
-Older, debilitated patients
-Patients who are nursing
-Patients with bladder neck obstruction
-Pyloroduodenal obstruction
-Stenosing peptic ulcer
-Symptomatic prostatic hypertrophy

Safety and efficacy have not been established in patients younger than 2 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Oral solution/syrup formulations may be used in adults who cannot swallow tablets.

Storage requirements:
-Oral solution/syrup: Protect from light.

Patient advice:
-Inform patients that this drug may cause drowsiness and somnolence, and they should avoid driving or operating machinery if these side effects occur.
-Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.