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Generic Name: levocetirizine (LEE voe se TIR a zeen)
Brand Names: Xyzal

What is Xyzal?

Xyzal (levocetirizine) is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Xyzal is used to treat symptoms of year-round (perennial) allergies in adults and children who are at least 6 months old. It is also used to treat symptoms of seasonal allergies in adults and children who are at least 2 years old.

Xyzal is also used to treat itching and swelling caused by chronic urticaria (hives) in adults and children who are at least 6 months old.

Important information

Do not take Xyzal if you have end-stage kidney disease or if you are on dialysis. Any child younger than 12 years old with kidney disease should not take this medicine.

Before taking Xyzal, tell your doctor if you have liver disease, kidney disease, or gallbladder problems.

It is very important not to give a child more than the prescribed dose of Xyzal. A child's body absorbs twice as much of the same dose size of levocetirizine as an adult's body.

Call your doctor if your symptoms do not improve, if they get worse, or if you also have a fever.

Before taking this medicine

You should not use Xyzal if you are allergic to levocetirizine or cetirizine (Zyrtec).

To make sure Xyzal is safe for you, tell your doctor if you have:

  • kidney disease;

  • liver disease;

  • urination problems (caused by conditions such as enlarged prostate or spinal cord lesion); or

  • gallbladder problems.

It is not known whether Xyzal will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Levocetirizine can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

Xyzal is not approved for use by anyone younger than 6 months old.

How should I take Xyzal?

Take Xyzal exactly as prescribed by your doctor. Follow the directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

It is very important not to give a child more than the prescribed dose of Xyzal. A child's body absorbs twice as much of the same dose size of levocetirizine as an adult's body.

Taking more of this medication will not make it more effective, and may cause severe drowsiness.

Xyzal is usually taken in the evening. You may take this medication with or without food.

Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Call your doctor if your symptoms do not improve, if they get worse, or if you also have a fever.

Store Xyzal at room temperature away from moisture and heat.

Xyzal dosing information

Usual Adult Dose for Allergic Rhinitis:

Seasonal and perennial allergic rhinitis and chronic idiopathic urticaria;
5 mg orally once daily in the evening

Usual Adult Dose for Urticaria:

Seasonal and perennial allergic rhinitis and chronic idiopathic urticaria;
5 mg orally once daily in the evening

Usual Pediatric Dose for Allergic Rhinitis:

Seasonal allergic rhinitis:
12 years or older: 5 mg orally once daily in the evening
6 to 11 years old: 2.5 mg orally once daily in the evening
2 to 5 years old: 1.25 mg orally once daily in the evening

Perennial allergic rhinitis and chronic idiopathic urticaria:
12 years or older: 5 mg orally once daily in the evening
6 to 11 years old: 2.5 mg orally once daily in the evening
6 months to 5 years old: 1.25 mg orally once daily in the evening

Usual Pediatric Dose for Urticaria:

Seasonal allergic rhinitis:
12 years or older: 5 mg orally once daily in the evening
6 to 11 years old: 2.5 mg orally once daily in the evening
2 to 5 years old: 1.25 mg orally once daily in the evening

Perennial allergic rhinitis and chronic idiopathic urticaria:
12 years or older: 5 mg orally once daily in the evening
6 to 11 years old: 2.5 mg orally once daily in the evening
6 months to 5 years old: 1.25 mg orally once daily in the evening

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Xyzal?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Drinking alcohol can increase certain side effects of Xyzal.

Xyzal side effects

Get emergency medical help if you have signs of an allergic reaction to Xyzal: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using Xyzal and call your doctor at once if you have:

  • painful or difficult urination;

  • little or no urinating;

  • pain or fullness in your ear, hearing problems;

  • a light-headed feeling, like you might pass out;

  • fever; or

  • worsening allergy or urticaria symptoms.

Common Xyzal side effects may include:

  • drowsiness, weakness;

  • feeling tired;

  • fever;

  • stuffy nose, sinus pain, sore throat, cough;

  • vomiting, diarrhea, constipation;

  • dry mouth; or

  • weight gain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Xyzal?

Taking this medicine with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking Xyzal with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • ritonavir (Norvir, Kaletra); or

  • theophylline (Aquaphyllin, Asmalix, Elixophyllin, Theolair, Theosol).

This list is not complete. Other drugs may interact with levocetirizine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

  • Your pharmacist can provide more information about Xyzal.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Xyzal only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2016 Cerner Multum, Inc. Version: 3.01. Revision Date: 2016-07-20, 3:22:20 PM.

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