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User Reviews for Benadryl

Benadryl has an average rating of 7.3 out of 10 from a total of 55 ratings on Drugs.com. 65% of those users who reviewed Benadryl reported a positive effect, while 20% reported a negative effect.

Condition Avg. Rating Reviews Compare
Allergic Reactions  
7.1
17 reviews 188 medications
Nausea/Vomiting  
7.2
16 reviews 159 medications
Allergic Rhinitis  
6.9
12 reviews 895 medications
Cough  
9.7
4 reviews 797 medications
Urticaria  
6.0
3 reviews 189 medications
Cold Symptoms  
9.5
2 reviews 1097 medications
Extrapyramidal Reaction  
9.0
1 reviews 68 medications
Summary of Benadryl reviews 7.3 55 reviews

Reviews may be moderated or edited before publication to correct grammar and spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest in the medication will not be published. As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies.

Reviews for Benadryl

Wil · Taken for less than 1 month March 22, 2021

For Nausea/Vomiting: “I used it originally for food allergies but ended up puking (expected tbh). Not long after I took another to wave off the extra symptoms like nausea. All it did was induce vomiting again.”

5 / 10
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Anonymous · Taken for 6 months to 1 year January 24, 2021

For Nausea/Vomiting: “Take it for my migraines or cluster headaches to help with nausea. Works amazing for me.”

10 / 10
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Nic · Taken for less than 1 month October 19, 2020

For Allergic Reactions: “Received Benadryl via IV in prep for a biologic infusion. My throat starting swelling and my blood pressure skyrocketed. An immunologist tested me, and I showed strongly allergic to Benadryl, so it can happen.”

1 / 10
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Frequently asked questions

Anonymous June 15, 2012

For Nausea/Vomiting: “I have emtophobia, that is, a pervasive fear of vomiting. I do not know if this affects vomiting, but if I feel nauseous, Benadryl works wonders. My stomach settles right down and my anxiety lowers just enough for me to deal with it without the use of benzodiazepines.”

7 / 10
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A biotechnologist. · Taken for less than 1 month December 20, 2015

For Nausea/Vomiting: “I got a severe back injury about 2 years ago. Couldn't function pain was so bad. So my doctor started putting me on codiene, then vicoden, then tramadol, and then so on but they all gave me hours of vomiting, gut wrenching cramps, and sweating. Read about benadryl being used to prevent this side effect. I took 3 25 mg tabs. I know that is one over recommended but I was desperate. 35 mins later I was sitting with my kids and not the trash can for the first time in a while. I can't believe I didn't figure this out sooner especially with a biotech degree.”

10 / 10
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MarD24 June 5, 2016

For Nausea/Vomiting: “I had a couple surgeries on my jaw where I could not open it fully for an extended period of time. I am already semi-allergic to pain meds / anesthesia (excessive vomiting and nausea) so I was terrified to take my pain killers after surgery. The nurse / doctor recommended taking a couple Benadryl tablets (25mg) before the pain meds and it worked wonders! The only side effect is drowsiness.”

10 / 10
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Just me · Taken for less than 1 month May 9, 2020

For Allergic Reactions: “This is an old thread but thought I would share. I was in the hospital in labor. I developed a reaction to the epidural that caused severe itchiness. They gave me something that didn't help and after several hours of itching, a nurse gave me iv benedryl. I immediately couldn't breathe and felt like someone kicked me in the chest. I was warm all over, nauseous and on the edge of passing out. An ekg also showed I had a heart arrhythmia from it. I've taken oral benadryl in the past with no problems. Now it's on my list of allergies and I tell every doc I see. Most terrifying experience.”

1 / 10
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More FAQ

Lori · Taken for less than 1 month June 21, 2018

For Cough: “I have had a cough now for about 6 weeks. I tried all types of antihistamines, even prescribed cough syrup and expectorants. The only thing that finally stopped the cough and even at night time was Benadryl. I wish I had known this weeks ago. I can even sleep at night without the night and morning cough. Thank goodness for Benadryl!”

10 / 10
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Anonymous · Taken for 10 years or more June 11, 2018

For Allergic Rhinitis: “Benadryl really helps take the sinus pressure away and I found out recently it even worked best for my migraine. Out of Tylenol and Motrin Benadryl was the only one to knock it out. It does cause me dry mouth and drowsiness. It also helps to calm me when I feel a panic attack or anxiety coming on. I rather take benadryl then psych meds or all kinds of prescription meds anyday . I hope it stays working wonders for me because claratin and flonase did nothing for me and I don't want to have to try anything else.”

10 / 10
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Amensus · Taken for 10 years or more April 28, 2016

For Allergic Reactions: “I take one before bed which keeps me breathing easily during the night despite my allergies. It also helps me get to sleep and stay asleep. The active ingredient, dyphenhydramine HCL, you will find is the main ingredient in quite a few over the counter sleep medications so that should tell us something. And Benadryl or a generic drugstore brand are cheaper and just as effective. Have been taking this for over 20 years and have no side effects”

9 / 10
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Anonymous January 7, 2012

For Cough: “Variant asthma, chronic, have been on many antihistamines and other costly asthma medicines over the years. I began taking Benadryl in late November 2011. Taking 25 mg after awakening in the morning followed an hour or so later with 25 mg with another 25mg early afternoon (when symptoms occur) and 25 mg prior to bedtime in conjunction with Symbicort twice/day. I have a much improved quality of life and am beginning to have some control over the chronic cough. ”

9 / 10
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Anonymous October 23, 2010

For Allergic Reactions: “I like this medicine, but unfortunately developed an allergy to it, yes contrary to ANYONE'S belief I AM allergic to Benadryl. My legs started to get really, really hot and felt like I just had to stretch them and run them under freezing cold water, then I woke up with hives all over.”

6 / 10
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use caution when taking October 28, 2014

For Allergic Reactions: “I was given Benadryl at the hospital for an allergic reaction. It instantly shot my heart rate up to 217 bpm and instantly my mouth got dry I couldn't swallow my chest felt hot like an elephant was sitting on it and I got really cold. It put me into shock my body wouldn't stop shaking, I could breath. It was so scary I thought I was dead thanks to the doctors quick response he saved me but it almost killed me. ”

8 / 10
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DE19702 October 16, 2009

For Insomnia: “After having scripts for lots of different benzodiazepines and sleeping pills, I still rely on this a couple times a month. The ONLY problem is after a couple of days it loses it's effectiveness. It is perfect for sleep and not feeling drugged.”

9 / 10
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Son, age 16 · Taken for less than 1 month October 15, 2016

For Allergic Reactions: “My adult size teenage son was given Benadryl IV, 50mg, *along with Compazine IV as a "headache cocktail" in an emergency room in September of 2016. While there is no way to know for certain if Compazine or Benadryl caused the severe reaction he experienced, he has tolerated oral Benadryl just fine in the past. However, it seems important to share our experience based on the severity of his reaction that day and that multiple reports of similar exist. I do not recommend the "headache cocktail" of Benadryl and Compazine together and hope the number of similar reports are looked into.”

6 / 10
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robertocsada · Taken for less than 1 month January 12, 2015

For Extrapyramidal Reaction: “Diphenhydramine definitely calms down my muscles and helps with any antipsychotic induced akathesia at night. Great for sleep as well and helps me stay in bed in the mornings, but I'm able to get up early if I need to.”

9 / 10
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Simon Charles · Taken for less than 1 month September 14, 2017

For Nausea/Vomiting: “ER gave me 25mg diphenhydramine IV for nausea. The only effect was delirium and a brief medication nap. I felt woozy and poisoned for at least two hours afterwards. It may work for others, but it certainly didn't help me.”

3 / 10
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Anonymous October 20, 2009

For Allergic Reactions: “A little known and rare side effect of this drug is a condition that would probably be called idiopathic thrombocytopenic purpura (ITP). This describes a serious depletion of platelets in the blood. The blood will not clot properly and an injury can be life threatening due to uncontrolled bleeding. It's rare but if it happens and the cause is not figured out by your physician(s) this is a big problem.”

1 / 10
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diphenman May 3, 2010

For Insomnia: “Works excellent if you haven't built a tolerance to it. After a few days of use you may find the medicine is less effective than it was when you first used it. Benadryl knocks me out quite quick when I use it, the only problem I have with it is that I tend to oversleep or wake up groggy the morning after, which is generally relieved with some sort of caffeinated beverage.”

7 / 10
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Big bishop · Taken for 6 months to 1 year October 31, 2017

For Allergic Rhinitis: “I have allergic rhinitis. Was prescribed Zyrtec, Allegra and Flonase and I couldn't get relief. A pharmacist suggested Benadryl and its the only med that works. Took a generic brand and all hell broke loose. Went back to the original and I'm feeling much better.”

9 / 10
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marlene1020 · Taken for 10 years or more June 14, 2018

For Allergic Reactions: “I've used this and given it to my children for over 20 years. My teenage son would take 1 before going to bed so he could sleep without allergic reactions. I've used it for unknown allergies like bee stings and sunless tanner. Works great and so does the topical cream. No adverse affects with us.”

10 / 10
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Abby55 · Taken for less than 1 month June 29, 2020

For Urticaria: “I was admitted to the hospital with a bad case of hives . I was put on an IV. They injected Benadryl into my IV to help with the hives . Within seconds I couldn't breathe . The nurses had just injected in and we're leaving to do some other errands . I couldn't breathe and I couldn't speak and I knew I was gonna die . I managed to pull myself up in the bed sitting up and started pounding on the side of the bed rails to get attention . That's one of the nurses turned around and saw that I could not breathe. Within seconds I have doctors and nurses around my bed . I now have to list Benadryl as an allergy. I probably should carry a magic bracelet to just in case . That was a horrifying day.”

1 / 10
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Connert2 April 26, 2017

For Allergic Reactions: “I have no rest every time I take benadryl. I feel I have a really bad reaction as I feel restless, my body feels like itchy, nauseous and it makes me feel angry feeling restless it really hurts my stomach am I allergic to it? or it a bad reaction”

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Jen234 · Taken for 6 months to 1 year May 12, 2012

For Allergic Reactions: “I use this medicine for weather allergies and allergies to medications when I need it. It does help greatly but does not last long and my burning sensation comes back into my body and the hives start to show. However a lot of people say that this medicine makes them feel sedated. I have the complete opposite I take 1 before bed and I will not sleep.”

8 / 10
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Julia372 July 21, 2017

For Allergic Rhinitis: “I have a lot of allergies. About a year ago I began taking benadryl at night to help me sleep. It also helped a lot with the allergies. I only take it at night because of the drowsiness. Recently my stomach was upset for a month and I noticed they've begun putting calcium in it! This is so upsetting! Calcium stimulates stomach acid and people with allergies are sensitive to acid. This has been documented in the allergy journal. I would have thought a pharma company would know better than this! I wish the two corp. drugstores in my area had a better selection of drowsy antihistamines. They mostly have only benadryl. CVS has chlorphen, but it has lactose in it. :( For now I'm making do with a Walgreens combo that includes chlorphen.”

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Nurse-student July 11, 2016

For Urticaria: “I would get so worked up with hives before an exam with my gynecologist, that I would have to cancel. One day I took a Benadryl (they usually come in 25 mg or 50 mg tablets, or in packs of two 25 mg tablets)- just 25 mg before my appointment, and it really took the edge off. I had no hives and was much more relaxed. I buy the generic brand at the Dollar Store. This is used in our house for insomnia, allergic reactions, stuffy noses, and what I had previously mentioned. It is not habit-forming, and at such low doses, it's easy to control. Just make sure you stay hydrated! One word of caution to parents with young kids or teens- there have been many cases of suicide attempts and to trip out on.”

10 / 10
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Madam2 January 25, 2016

For Allergic Reactions: “Allergy reaction to nuts. Started feeling swelling around mouth, throat.... very scary, feel like I am stopping to breath. This instant relieve. Give it 10-15 minutes till kicks in. WORKS WONDERS. BUT.... you might need a good snooze after a good dose...”

10 / 10
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Anonymous September 5, 2011

For Allergic Rhinitis: “I absolutely love Benadryl. It's works fast when I need it and relieves the symptoms enough to make me feel comfortable. It does make me sleepy so I take it at night. I do take it during the day occasionally when I know I don't have to drive anywhere.”

9 / 10
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This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.