Generic name: diphenhydramine [ DYE-fen-HYE-dra-meen ]
Brand names: Allermax, Benadryl, Compoz Nighttime Sleep Aid, Diphedryl, Dytuss, ... show all 17 brands Nytol QuickCaps, Scot-Tussin Allergy Relief Formula, Siladryl Allergy, Simply Sleep, Sleepinal, Sominex, Twilite, Unisom Sleep Gels, Valu-Dryl, Vanamine PD, Z-Sleep, ZzzQuil
Drug classes: Anticholinergic antiemetics, Anticholinergic antiparkinson agents, Antihistamines, Miscellaneous anxiolytics, sedatives and hypnotics
What is Dytuss?
Dytuss is an antihistamine that is used to treat sneezing, runny nose, watery eyes, hives, skin rash, itching, and other cold or allergy symptoms.
Dytuss is also used to treat motion sickness, to induce sleep, and to treat certain symptoms of Parkinson's disease. This medicine sleep aid medicine is not for use in children younger than 12 years old.
There are many brands and forms of diphenhydramine available. Not all brands are listed on this leaflet.
Dytuss may also be used for purposes not listed in this medication guide.
Use Dytuss exactly as directed. Taking too much Dytuss can lead to serious heart problems, seizures, coma, or death.
Do not use this medicine to make a child sleepy. Dytuss sleep aid medicine is not for use in children younger than 12 years old.
Before taking this medicine
You should not use Dytuss if you are allergic to it.
Ask a doctor or pharmacist if this medicine is safe to use if you have ever had:
an enlarged prostate or urination problems;
asthma, chronic obstructive pulmonary disease (COPD), or other breathing disorder;
a thyroid disorder.
Ask a doctor before using this medicine if you are pregnant or breastfeeding. Dytuss may slow breast milk production.
How should I take Dytuss?
Use exactly as directed on the label, or as prescribed by your doctor. Dytuss is only for short-term use until your symptoms clear up.
Taking too much Dytuss can lead to serious heart problems, seizures, coma, or death.
Always follow directions on the medicine label about giving Dytuss to a child. Do not use the medicine only to make a child sleepy. Death can occur from the misuse of antihistamines in very young children.
For motion sickness, take Dytuss 30 minutes before you will be in a situation that causes you motion sickness (such as a long car ride, airplane or boat travel, amusement park rides, etc). Continue taking this medicine with meals and at bedtime for the rest of the time you will be in a motion-sickness situation.
As a sleep aid, take Dytuss within 30 minutes before bedtime.
You must chew the chewable tablet before you swallow it.
Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).
Remove an orally disintegrating tablet from the package only when you are ready to take the medicine. Place the tablet in your mouth and allow it to dissolve, without chewing. Swallow several times as the tablet dissolves.
Call your doctor if the condition you are treating with Dytuss does not improve, or if you have a fever with a headache, cough, or skin rash.
Do not use Dytuss for longer than 2 weeks to treat sleep problems, or longer than 7 days to treat cold or allergy symptoms.
Dytuss can affect the results of allergy skin tests. Tell any doctor who treats you that you are using Dytuss.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Since Dytuss is used when needed, you may not be on a dosing schedule. Skip any missed dose if it's almost time for your next dose. Do not use two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of diphenhydramine can be fatal.
Overdose symptoms may include vomiting, confusion, severe drowsiness, ringing in your ears, no urination, very dry eyes and mouth, dilated pupils, fast heartbeats, tremor, agitation, hallucinations, or seizure.
What should I avoid while taking Dytuss?
Avoid driving or hazardous activity until you know how Dytuss will affect you. Your reactions could be impaired.
Drinking alcohol can increase certain side effects of diphenhydramine.
Ask a doctor or pharmacist before using any other medicine that may contain Dytuss. This includes medicines for sleep, cold/allergy symptoms, or anti-itch medicine used on the skin. Using too much this medicine may lead to a fatal overdose.
Dytuss side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Dytuss may cause serious side effects. Stop using Dytuss and call your doctor at once if you have:
severe drowsiness; or
painful or difficult urination.
Side effects such as dry mouth, constipation, and confusion may be more likely in older adults.
Common side effects of Dytuss may include:
dry eyes, blurred vision;
dry mouth, nose, or throat;
feeling restless or excited (especially in children); or
day-time drowsiness or "hangover" feeling after night-time use.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Dytuss?
Ask a doctor or pharmacist before using Dytuss with any other medicines, especially drugs that can cause drowsiness (such as opioid medication, sleep medicine, a muscle relaxer, or medicine for anxiety or seizures). Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.
The maximum oral dose of diphenhydramine for adults is generally reported as 100mg for a single dose or no more than 300mg in 24 hours, but this can vary depending on what condition diphenhydramine is being used for, the salt of diphenhydramine used (there are two salts available in the US diphenhydramine citrate and diphenhydramine chloride), the age of the person, how much diphenhydramine they have tolerated before, and if they are on any interacting medications. Taking too much diphenhydramine can be fatal. Continue reading
Increased blood pressure is not a typical side effect of diphenhydramine, a first-generation antihistamine that lowers the effects of histamines in your body. However, in rare cases, the drug may cause hypotension, or decreased blood pressure. This side effect is most likely to occur in people who are over the age of 60. Continue reading
Diphenhydramine can be used as a short-term sleep aid to help ease occasional sleep problems, such as when you have a cold or cough and it is preventing you from falling asleep. Older adults, children under age 16 and pregnant women should avoid taking diphenhydramine, as the risks to these groups may outweigh the benefits. Continue reading
The difference between diphenhydramine hydrochloride and diphenhydramine citrate is that the salt used to bind the diphenhydramine, is different. For diphenhydramine hydrochloride the salt is hydrochloride and for diphenhydramine citrate the salt is citrate. This salt can change how quickly and effectively the diphenhydramine dissolves and is absorbed but once it is in the body it has no effect. Essentially 25 mg of diphenhydramine hydrochloride is equivalent to 38 mg of diphenhydramine citrate. Continue reading
More about Dytuss (diphenhydramine)
- Check interactions
- Latest FDA alerts (2)
- Side effects
- Dosage information
- During pregnancy
- Drug class: anticholinergic antiemetics
- En español
Benadryl, Banophen, ZzzQuil, Benadryl Allergy, ... +17 more
Related treatment guides
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2023 Cerner Multum, Inc. Version: 7.01.