Skip to Content

Diphenhydramine Pregnancy and Breastfeeding Warnings

Diphenhydramine is also known as: 40 Winks, Banophen, Benadryl, Benadryl Allergy, Benadryl Children's Allergy, Buckley's Bedtime, Dicopanol, Diphedryl, Diphen, Diphenadryl, Diphendryl, Diphenhist, Diphenydramine Quick Melt, Diphenylin, Hydramine, Hyrexin, Nervine, Nytol, Q-Dryl, Sleep, Sleepwell 2-nite, Sominex, Somnicaps, Unisom SleepGels, ZzzQuil

Diphenhydramine Pregnancy Warnings

Animal models have failed to reveal evidence of impaired fertility or fetal harm at doses up to 5 times the human dose. There are no controlled data in human pregnancy. AU TGA pregnancy category A: Drugs which have been taken by a large number of pregnant women and women of childbearing age without any proven increase in the frequency of malformations or other direct or indirect harmful effects on the fetus having been observed. US FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.

Use is recommended only if clearly needed and the benefit outweighs the risk. AU TGA pregnancy category: A US FDA pregnancy category: B Comment: -Exposure during the third trimester may result in adverse reactions in premature infants and neonates.

See references

Diphenhydramine Breastfeeding Warnings

Use is not recommended. -According to some authorities: Use is contraindicated. Excreted into human milk: Yes Comments: -The effects in the nursing infant are unknown. -This drug may affect milk production, especially at high doses given early in the postpartum period and/or when used concomitantly with a sympathomimetic drug.

See references

References for pregnancy information

  1. Cerner Multum, Inc. "Australian Product Information." O 0
  2. "Product Information. Benadryl Childrens Allergy Fastmelt (diphenhydrAMINE)." Pfizer U.S. Pharmaceuticals Group, New York, NY.
  3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  4. "Product Information. Benadryl (diphenhydramine)." Parke-Davis, Morris Plains, NJ.

References for breastfeeding information

  1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  2. Cerner Multum, Inc. "Australian Product Information." O 0
  3. "Product Information. Benadryl (diphenhydramine)." Parke-Davis, Morris Plains, NJ.
  4. "Product Information. Benadryl Childrens Allergy Fastmelt (diphenhydrAMINE)." Pfizer U.S. Pharmaceuticals Group, New York, NY.
  5. United States National Library of Medicine "Toxnet. Toxicology Data Network. Available from: URL: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT." ([cited 2013 -]):

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

Hide