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Benadryl and Allergic Reaction: What Users Say

Allergic reaction: mentioned by 3 users (3.8%)

Based on user experiences from 79 Benadryl reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

drowsiness 15.2%
nausea 8.9%
itching 6.3%
heart palpitations 5.1%
shortness of breath 5.1%
swelling 5.1%
allergic reaction 3.8%
anxiety 3.8%
dry mouth 3.8%
increased heart rate 3.8%

Reviews for Benadryl

Showing 3 reviews tagged with "allergic reaction". Clear filters to view all 79 reviews.
Commonly mentioned side effects
  • Anonymous
  • October 23, 2010

For Allergic Reactions "I like this medicine, but unfortunately developed an allergy to it, yes contrary to anyone's belief I am allergic to Benadryl. My legs started to get really, really hot and felt like I just had to stretch them and run them under freezing cold water, then I woke up with hives all over."

6 / 10
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  • Son...
  • Taken for less than 1 month
  • October 15, 2016

For Allergic Reactions "My adult-sized teenage son was given Benadryl IV, 50 mg, along with Compazine IV as a 'headache cocktail' in an emergency room in September of 2016. While there is no way to know for certain if Compazine or Benadryl caused the severe reaction he experienced, he has tolerated oral Benadryl just fine in the past. However, it seems important to share our experience based on the severity of his reaction that day and that multiple reports of similar exist. I do not recommend the 'headache cocktail' of Benadryl and Compazine together and hope the number of similar reports is looked into."

6 / 10
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28 Report
  • Abb...
  • Taken for less than 1 month
  • June 29, 2020

For Urticaria "I was admitted to the hospital with a bad case of hives. I was put on an IV. They injected Benadryl into my IV to help with the hives. Within seconds, I couldn't breathe. The nurses had just injected it and were leaving to do some other errands. I couldn't breathe, and I couldn't speak, and I knew I was gonna die. I managed to pull myself up in the bed, sitting up, and started pounding on the side of the bed rails to get attention. That's when one of the nurses turned around and saw that I could not breathe. Within seconds, I had doctors and nurses around my bed. I now have to list Benadryl as an allergy. I probably should carry a medical bracelet just in case. That was a horrifying day."

1 / 10
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14 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.