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User Reviews for Diphenhydramine

Also known as: 40 Winks, Aler-Dryl, Aler-Tab, Alka-Seltzer Plus Allergy, Aller-G-Time, Allergia-C, Allermax, Altaryl, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl, Benadryl Allergy, ...show all 97 brand names

The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.

Learn more about Diphenhydramine.

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Condition DownUp Reviews Compare Avg. Ratings DownUp
Motion Sickness 1 reviews 114 medications
   
8.8
Allergic Reactions 28 reviews 187 medications
   
8.0
Nausea/Vomiting 16 reviews 160 medications
   
7.4
Cold Symptoms 4 reviews 1080 medications
   
7.1
Insomnia 89 reviews 106 medications
   
6.7
Allergic Rhinitis 15 reviews 887 medications
   
6.6
Urticaria 7 reviews 189 medications
   
6.6
Cough 3 reviews 796 medications
   
5.7
Extrapyramidal Reaction 1 reviews 68 medications
   
5.5
Summary of Diphenhydramine reviews 164 reviews 6.9

Reviews for Diphenhydramine

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For Insomnia: "I suffer with chronic insomnia and I tried several OTC sleep aids and finally came across NYTOL EXTRA STRENGTH CAPLETS. I break it in half and take 1/2 nightly and am asleep within the hour. I will still sometimes get up at night to pee but am able to fall right back asleep. I awake feeling refreshed and not drowsy or anything like the other sleep aids left me. I was concerned about taking them nightly and spoke to my doc who said he would rather I take the NYTOL as opposed to a sleeping pill prescription. He said NYTOL was just Benedryl and wouldn't hurt me. I have been taking NYTOL nightly for almost 2 years now and am so glad to have found it!"

   
10

Sunseekersam59 September 24, 2017

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Benadryl (diphenhydramine) for Nausea/Vomiting: "ER gave me 25mg diphenhydramine IV for nausea. The only effect was delirium and a brief medication nap. I felt woozy and poisoned for at least two hours afterwards. It may work for others, but it certainly didn't help me."

   
3.0

Simon Charles (taken for less than 1 month) September 14, 2017

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Nytol (diphenhydramine) for Insomnia: "I took these every night for a week after struggling with insomnia, hate the groggy feeling sleeping tablets give you the next day so thought I'd give these ago. Worked perfectly with no side effects. Went away for the weekend and forgot to take them with me. First night, didn't sleep at all, second night finally drifted off sometime after 7.30am and was woke at 9.45, last night got about an hour to 2 hours. Was absolutely done in, got home and that night took a nytol and slept like a baby. My fear is can I survive without these tablets now. Hopefully they keep working so I don't need too."

   
10

Singy (taken for less than 1 month) September 6, 2017

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ZzzQuil (diphenhydramine) for Insomnia: "I have used ZzzQuil off and on for a year or so to help me fall asleep. I have noticed that on the nights that I take it (1/2 dose) the next day I experience head shaking tremors that I have to consciously control, especially when I drive. I will no longer take this medication as I am concerned about the side-effect."

lashoani (taken for 6 months to 1 year) September 5, 2017

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Benadryl (diphenhydramine) for Nausea/Vomiting: "I take Methotrexate weekly 25mg and have found that taking Benadryl at dose and 12 and 24hrs after my weekly dose help reduce the nausea"

   
8.0

Anonymous September 2, 2017

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Benadryl Allergy (diphenhydramine) for Allergic Rhinitis: "Take it at night if visiting people who own cats or dogs. Only problem is drowsiness if taken when your not going to sleep."

Anonymous August 3, 2017

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Sominex (diphenhydramine) for Insomnia: "Certainly helps me to sleep. But first time I slept for about 12 hours which meant that I slept badly the following night. I now take 3/4 of the tablet for a solid 8 hours. I suggest trying 1/2 or 3/4 your first time The first half hour or so on waking leaves me groggy, then I'm fine. Also seems to help me sleep really well the following night. I use only occasionally."

   
9.0

Motoguzzibob (taken for 2 to 5 years) August 3, 2017

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For Insomnia: "I take this to help me sleep every now and then, however the last 2 times I've been having weird and slightly creepy visual and auditory hallucinations, it's almost like I'm having an incredibly realistic dream while I'm completely conscious and full functionable! But other than that it knocks me right out"

   
7.0

Bethanyb123 (taken for less than 1 month) August 1, 2017

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Unisom SleepGels (diphenhydramine) for Insomnia: "I have extreme insomnia and I've taken everything that's is suppose to help you sleep since I was 14yrs old. Please see a professional for your insomnia because OTC sleep aids don't work most of time n you can do damage to ur internal organs by taking more n more. Lunesta BEST EVER!"

   
2.0

AMHNLM July 22, 2017

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Benadryl (diphenhydramine) for Allergic Rhinitis: "I have a lot of allergies. About a year ago I began taking benadryl at night to help me sleep. It also helped a lot with the allergies. I only take it at night because of the drowsiness. Recently my stomach was upset for a month and I noticed they've begun putting calcium in it! This is so upsetting! Calcium stimulates stomach acid and people with allergies are sensitive to acid. This has been documented in the allergy journal. I would have thought a pharma company would know better than this! I wish the two corp. drugstores in my area had a better selection of drowsy antihistamines. They mostly have only benadryl. CVS has chlorphen, but it has lactose in it. :( For now I'm making do with a Walgreens combo that includes chlorphen."

Julia372 July 21, 2017

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For Insomnia: "It is not a true sleep drug like prescription z drugs or benzodiazapines. It can cause tiredness and thus help initiate sleep, but it's not very powerful in this regard. The effect is decent in those who have not used it much. Tolerance builds quickly. If you have not used it, it may work well, but after a few nights it will likely lose most effect."

   
4.0

Steve Packard (taken for 1 to 6 months) July 19, 2017

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Nytol (diphenhydramine) for Insomnia: "Did not seem to work Felt tired the next day"

   
3.0

Ford C Max July 7, 2017

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Unisom SleepGels (diphenhydramine) for Insomnia: "Garbage .. Don't waste your $$$.. Took as directed at 11pm and still tossing and turning at 1:22am.. Buyer beware .. A total waste ."

STILL SLEEPLESS (taken for less than 1 month) June 28, 2017

1 users found this comment helpful.

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Unisom SleepGels (diphenhydramine) for Insomnia: "At first I thought I found the perfect drug, I slept finally! But the side effects for are pretty much there. (Dizzy, blurred vision, strange emotions, anxiety) and after every use they are getting stronger."

Quir June 21, 2017

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Sominex (diphenhydramine) for Insomnia: "I have been using sominex for a long time, I asked GP about it and he would rather I take it than prescribing me sleeping tabs, it works well for me, I take it at least an hour before bed, fall asleep easily and can still wake up for the bathroom and go straight back to sleep, feel fine on waking with no after effects, a great over the counter product."

   
9.0

Anonymous (taken for 2 to 5 years) June 13, 2017

6 users found this comment helpful.

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ZzzQuil (diphenhydramine) for Insomnia: "I usually work a 10 hr shift in the afternoon but my boss has changed my Saturday shift to 5am-1pm. We live on a farm and have 3 outside dogs that like to bark at night. The first morning shift I only got 2 hrs sleep because of our dogs. I purchased Zzquill to get some help falling asleep the night before my morning shifts. I took the recommended dose (2pills) at 8pm. I went to bed at 8:30. I didn't feel any effect from the medication until almost 10:30!! And then I woke up again at 12:30am! I do not recommend Zzquill if you want to fall asleep quickly and stay asleep."

   
4.0

LAG768 May 27, 2017

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ZzzQuil (diphenhydramine) for Insomnia: "Gave me rapid heart beats !!!!!!!!!"

   
1.0

Anonymous (taken for less than 1 month) May 26, 2017

1 users found this comment helpful.

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Benadryl (diphenhydramine) for Allergic Reactions: "I have no rest every time I take benadryl. I feel I have a really bad reaction as I feel restless, my body feels like itchy, nauseous and it makes me feel angry feeling restless it really hurts my stomach am I allergic to it? or it a bad reaction"

Connert2 April 26, 2017

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Sominex (diphenhydramine) for Insomnia: "I believe this is the strongest non prescription sleeping aid that you can take. This works really well for me on the few occasions that I need it, within about 10 minutes of taking it, I fall asleep and stay so for longer than I normally would without it. You can even try 1/2 or 1/4 tablet if you don't want to take a whole one. . Definitely recommend this!"

   
9.0

Agg67 March 19, 2017

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Unisom SleepGels (diphenhydramine) for Insomnia: "There are no side effects. It works well."

   
10

Kimgu March 15, 2017

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For Insomnia: "I have occasional sleeping problems such linked to stress, such as not being able to fall asleep for around 2 to 5 hours or waking up in the middle of night and not being able to fall asleep afterwards. Someone recommended me to try Nustasium (diphenhydramine). It kicked in after 30 minutes to 1 hour I took it and it helped me sleep without waking up till morning for as many as 8-9 hours. However I felt dizzy and sleepy in the mornings. And in cases when I slept more than 8 hours like at the weekend I felt very weak and dizzy the whole day. Might be good for occasional use when I know I need long hours of sleep as with it I don't wake up early, but certainly not for continuous use, at least for me."

   
8.0

Perchuhi Jan Jan (taken for less than 1 month) February 26, 2017

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For Nausea/Vomiting: "I took diphenhydramine by mouth for spring allergies. It made me drowsy and helped my allergies, but also made me dizzy and nauseated, which it is supposed to prevent. I do know that it is probably one of the best antihistamines on the market."

   
1.0

Mitch1951 (taken for less than 1 month) February 22, 2017

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For Nausea/Vomiting: "If you got a migraine cocktail in ER, then the med that gave you the anxiety, was most likely the compazine, it makes you feel very anxious that's why they give the benadryl with it to counteract the side effect of anxiety. (migraine cocktail consists of benadryl, compazine and depakote or Solumedrol). I had to take more benadryl to get rid of the severe anxiety"

   
9.0

sylviasylvia2 (taken for 1 to 6 months) February 21, 2017

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For Insomnia: "I have sleep apnea but can't stand a mask on me, and without drugs I wake up constantly by stopping to breath. I take 75 mg of diph. an hour before I want to go to sleep, have a couple puffs of indica (night time pot,) ( it's legal here) and it works like a charm, I stay asleep for 5 or 6 hrs which is a long time for me, little groggy when I wake up but it goes away after a couple puffs of sativa (day time pot) I've been a toker for 49 yrs, it's good for a lot of uses. I am 66 My doctor says he agrees that pot is easier on the body and mind than prescription drugs for anxiety, insomnia, depression, pain,and loss of appetite. They make edibles, gum, etc for those that hate smoke."

   
8.0

All nighter (taken for 2 to 5 years) January 26, 2017

6 users found this comment helpful.

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Benadryl Allergy (diphenhydramine) for Allergic Reactions: "Takes 4 hours to work and by then you need another dose. Since they took the other ingredient out, Benadryl and Wal-Dryl no longer work for me. Back to experimenting. No side affects, but not effective either."

   
1.0

Schnozola (taken for less than 1 month) January 7, 2017

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