Diphenhydramine Alternatives Compared
| Diphenhydramine | Xolair (omalizumab) | Zyrtec (cetirizine) |
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| Diphenhydramine | Xolair (omalizumab) | Zyrtec (cetirizine) |
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Prescription and OTC
Diphenhydramine is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side... View more |
Prescription only
Xolair is an injectable preparation that works by preventing IgE from binding to IgE receptors on mast cells and basophils and may be used to treat allergic asthma, nasal polyps, chronic idiopathic... View more |
Prescription and OTC
Zyrtec is an antihistamine that effectively treats allergic reactions such as hay fever or skin reactions caused by insect bites. Although drowsiness with Zyrtec is uncommon, Zyrtec is more likely... View more |
Related suggestions Urticaria
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| More about Diphenhydramine | More about Xolair (omalizumab) | More about Zyrtec (cetirizine) | ||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||
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Diphenhydramine has an average rating of 5.5 out of 10 from a total of 542 ratings on Drugs.com. 42% of reviewers reported a positive effect, while 40% reported a negative effect. |
Xolair has an average rating of 7.5 out of 10 from a total of 229 ratings on Drugs.com. 67% of reviewers reported a positive effect, while 18% reported a negative effect. |
Zyrtec has an average rating of 5.8 out of 10 from a total of 197 ratings on Drugs.com. 43% of reviewers reported a positive effect, while 36% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||
View all Diphenhydramine side effects |
View all Xolair side effects |
View all Zyrtec side effects |
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| Drug Class | ||||||||||||||||||
| Generic Availability | ||||||||||||||||||
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Lower cost generic |
N/A |
Lower cost generic approved | ||||||||||||||||
| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||
View all Diphenhydramine prices |
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Zyrtec prices |
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| Dosage Forms | ||||||||||||||||||
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| Brand Names | ||||||||||||||||||
| Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Aurodryl Children's Allergy, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more | Other omalizumab brands include: Omlyclo | Other cetirizine brands include: All Day Allergy, All Day Allergy Children's, Aller-Tec, Aller-Tec Children's, Alleroff, Children's Allergy Relief, Equate Allergy Relief, PediaCare Children's 24-Hour Allergy, Quzyttir, Zyrtec Hives View more | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||
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9.3 hours |
624 hours |
10.6 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||
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Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||
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A total of 448 drugs are known to interact with Diphenhydramine:
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A total of 29 drugs are known to interact with Xolair:
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A total of 254 drugs are known to interact with Zyrtec:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||
| First Approval Date | ||||||||||||||||||
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March 04, 1946 |
June 20, 2003 |
N/A |
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| WADA Class View classifications | ||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||
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| Related Treatment Guide | ||||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.