Diphenhydramine Alternatives Compared
| Diphenhydramine | Trazodone | Ambien |
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| Diphenhydramine | Trazodone | Ambien zolpidem |
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Diphenhydramine is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and to relieve some symptoms of Parkinson's disease. Sedation is a common... View more |
Trazodone is mostly used for its sleep-inducing effects (an off-label indication) rather than as an antidepressant. Only generic forms are available which makes it a lot cheaper than some other... View more |
Ambien induces sleep; however, Ambien CR, in particular, may impair physical and mental capabilities the next day. Ambien has also been associated with complex or dangerous sleep-related behaviors... View more |
Choose a suggestion below Insomnia
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| More about Diphenhydramine | More about Trazodone | More about Ambien (zolpidem) | ||||||||||||||||||||||||
| Generic Status | ||||||||||||||||||||||||||
| Availability | ||||||||||||||||||||||||||
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Prescription and OTC |
Prescription only |
Prescription only |
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| Ratings & Reviews | ||||||||||||||||||||||||||
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Diphenhydramine has an average rating of 5.6 out of 10 from a total of 454 ratings on Drugs.com. 45% of reviewers reported a positive effect, while 40% reported a negative effect. |
Trazodone has an average rating of 6.4 out of 10 from a total of 1321 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 30% reported a negative effect. |
Ambien has an average rating of 7.0 out of 10 from a total of 540 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 21% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
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See the full diphenhydramine side effects document. |
Commonly reported side effects include: blurred vision, dizziness, drowsiness, headache, nausea, vomiting, xerostomia. See the full trazodone side effects document. |
Common side effects include: dizziness. See the full Ambien side effects document. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all diphenhydramine prices |
View all trazodone prices |
View all Ambien prices and generic prices |
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| Dosage Form(s) Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more | Desyrel, Desyrel Dividose | Other zolpidem brands include: Ambien CR, Edluar, Zolpimist | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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9.3 hours |
7.5 hours |
2.6 hours |
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| CSA Schedule** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Some potential for abuse
Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category B
No proven risk in humans
See the full Pregnancy Warnings document. |
Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 412 drugs are known to interact with diphenhydramine:
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A total of 605 drugs are known to interact with trazodone:
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A total of 430 drugs are known to interact with Ambien:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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| First Approval Date | ||||||||||||||||||||||||||
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March 04, 1946 |
December 24, 1981 |
December 16, 1992 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
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| Related Treatment Guide | ||||||||||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.