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Zyrtec (cetirizine) Disease Interactions

There are 2 disease interactions with Zyrtec (cetirizine):


Cetirizine (applies to Zyrtec) alcohol

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Acute Alcohol Intoxication

Alcohol should be avoided when using cetirizine, and some other antihistamines. Cetirizine may produce drowsiness that may be increase by the use of alcohol, sedatives and tranquilizers.


Cetirizine (applies to Zyrtec) renal/liver disease

Moderate Potential Hazard, High plausibility. Applicable conditions: Renal Dysfunction

Cetirizine is eliminated primarily by the kidney but also undergoes metabolism in the liver to some extent. Patients with renal and/or liver disease may be at greater risk for adverse effects from cetirizine due to decreased drug clearance. The manufacturer recommends an initial dosage of 5 mg once daily in patients 6 years of age and older with decreased renal function (CrCl <= 30 mL/min, including those on hemodialysis) and/or impaired hepatic function. Cetirizine should preferably not be used in children less than 6 years of age with renal and/or hepatic impairment because of the difficulty in reliably administering doses smaller than 2.5 mg (1/2 teaspoonful) and a lack of pharmacokinetic and safety data in this population.


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  6. Matzke GR, Yeh J, Awni WM, Halstenson CE, Chung M "Pharmacokinetics of cetirizine in the elderly and patients with renal insufficiency." Ann Allergy 59 (1987): 25-30
  7. "Product Information. Zyrtec (cetirizine)." Pfizer US Pharmaceuticals, New York, NY.
  8. Barnes CL, McKenzie CA, Webster KD, Poinsett-Holmes K "Cetirizine: a new, nonsedating antihistamine." Ann Pharmacother 27 (1993): 464-70
View all 8 references

Zyrtec (cetirizine) drug interactions

There are 244 drug interactions with Zyrtec (cetirizine)

Zyrtec (cetirizine) alcohol/food interactions

There is 1 alcohol/food interaction with Zyrtec (cetirizine)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.