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Zyrtec Disease Interactions

There are 2 disease interactions with Zyrtec (cetirizine).

Moderate

Cetirizine (applies to Zyrtec) alcohol

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Acute Alcohol Intoxication

Alcohol should be avoided when using cetirizine, and some other antihistamines. Cetirizine may produce drowsiness that may be increase by the use of alcohol, sedatives and tranquilizers.

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Moderate

Cetirizine (applies to Zyrtec) renal/liver disease

Moderate Potential Hazard, High plausibility. Applicable conditions: Renal Dysfunction

Cetirizine is eliminated primarily by the kidney but also undergoes metabolism in the liver to some extent. Patients with renal and/or liver disease may be at greater risk for adverse effects from cetirizine due to decreased drug clearance. The manufacturer recommends an initial dosage of 5 mg once daily in patients 6 years of age and older with decreased renal function (CrCl <= 30 mL/min, including those on hemodialysis) and/or impaired hepatic function. Cetirizine should preferably not be used in children less than 6 years of age with renal and/or hepatic impairment because of the difficulty in reliably administering doses smaller than 2.5 mg (1/2 teaspoonful) and a lack of pharmacokinetic and safety data in this population.

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Zyrtec drug interactions

There are 258 drug interactions with Zyrtec (cetirizine).

Zyrtec alcohol/food interactions

There is 1 alcohol/food interaction with Zyrtec (cetirizine).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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