Comparing Diphenhydramine vs Melatonin
| Diphenhydramine Remove Diphenhydramine from your drug comparison | Melatonin Remove Melatonin from your drug comparison |
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| Diphenhydramine Remove Diphenhydramine from your drug comparison | Melatonin Remove Melatonin from your drug comparison | ||||||||
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Diphenhydramine is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and to relieve some symptoms of Parkinson's disease. Sedation is a common... View more |
Supplemental melatonin is very effective at reducing symptoms of jet lag, particularly that brought about by eastward travel across five or more time zones. Effectiveness for other indications is not... View more |
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Prescription and OTC |
Prescription and OTC |
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Ratings & ReviewsRecent helpful reviews |
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6.0
For Insomnia: I take this to help me sleep every now and then, however the last 2 times I've been having weird and slightly creepy visual and auditory hallucinations, it's almost like I'm having an incredibly realistic dream while I'm completely conscious and full functionable! But other than that it knocks me right out |
6.1
For Insomnia: Melatonin helps me get off to sleep no problem at around 11pm. But always seem to wake again about 2am. My doctor gave me Circadin 2mg to help me get off Zopiclone 3.75 mg as Zopiclone side effects are bad. But up to now still taking reduced dose of Zopiclone as need it to get back to sleep. Going to have to bite the bullet this week which will probably mean very little sleep after 2am. Which to me is horrible thought. Any advice welcome For Insomnia: I have Delayed Sleep Phase Disorder. When it works, it works great. When it doesn't, it's difficult. I have noticed that if I do not fall asleep within 30 minutes of taking melatonin, I end up tossing and turning for most of the night. The worst part is I feel as though I have to constantly stretch my legs. |
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Drug Class |
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Side Effects |
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See the full diphenhydramine side effects document. |
See the full melatonin side effects document. |
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Pricing and Coupons* Prices are without insurance |
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View all diphenhydramine prices |
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
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Generic Availability |
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Yes (this medicine) |
N/A |
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Dosage Form(s) Available |
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N/A | ||||||||
Brand Names |
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| Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more | Bio-Melatonin, Melatonin Time Release, SGard | ||||||||
Half LifeThe half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. |
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9.3 hours |
N/A |
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CSA Schedule**View glossary of terms. |
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category |
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Category B
No proven risk in humans
See the full Pregnancy Warnings document. |
Category N
Not classified
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FDA Alerts |
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N/A |
N/A |
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Drug Interactions |
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A total of 402 drugs are known to interact with diphenhydramine:
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A total of 61 drugs are known to interact with melatonin:
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Alcohol/Food/Lifestyle Interactions |
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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Disease Interactions |
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First Approval Date |
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March 04, 1946 |
N/A |
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WADA ClassView World Anti-Doping Agency classifications. |
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N/A |
N/A |
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More Information |
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Consumer Resources |
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N/A |
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Professional Resources |
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Related Treatment Guide |
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
For Insomnia: Works quite well on insomnia but careful when combining with other meds that also work on your sympathetic/parasympathetic nervous system. I took it with lexapro and got significant problems with too low heart rate, respiratory issues and hypnic jerks.