Melatonin Interactions
There are 342 drugs known to interact with melatonin, along with 3 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 5 are major, 328 are moderate, and 9 are minor.
- View all 342 medications that may interact with melatonin
- View melatonin alcohol/food interactions (1)
- View melatonin disease interactions (3)
Most frequently checked interactions
View interaction reports for melatonin and the medicines listed below.
- Adderall (amphetamine / dextroamphetamine)
- Ambien (zolpidem)
- Aspirin Low Strength (aspirin)
- Benadryl (diphenhydramine)
- Claritin (loratadine)
- CoQ10 (ubiquinone)
- Cymbalta (duloxetine)
- Eliquis (apixaban)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Flonase (fluticasone nasal)
- Iron Sulfate (ferrous sulfate)
- Lexapro (escitalopram)
- Lyrica (pregabalin)
- Metoprolol Succinate ER (metoprolol)
- MiraLAX (polyethylene glycol 3350)
- Probiotic Formula (bifidobacterium infantis / lactobacillus acidophilus)
- Prozac (fluoxetine)
- Seroquel (quetiapine)
- Singulair (montelukast)
- Synthroid (levothyroxine)
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
- Vyvanse (lisdexamfetamine)
- Xanax (alprazolam)
- Zinc (zinc sulfate)
- Zofran (ondansetron)
- Zoloft (sertraline)
- Zyrtec (cetirizine)
Melatonin alcohol/food interactions
There is 1 alcohol/food interaction with melatonin.
Melatonin disease interactions
There are 3 disease interactions with melatonin which include:
Report options
QR code containing a link to this page
More about melatonin
- melatonin consumer information
- Compare alternatives
- Reviews (239)
- Side effects
- Patient tips
- Support group
- Drug class: minerals and electrolytes
- Breastfeeding
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.