Melatonin Drug Interactions
Currently displaying a list of 345 drugs known to interact with melatonin.
- 5 major drug interactions
- 331 moderate drug interactions
- 9 minor drug interactions
Medications known to interact with melatonin
Note: Showing generic names only.
A
- abametapir topical
- acetylcarbromal
- acrivastine
- alfentanil
- allopurinol
- alprazolam
- amiodarone
- amisulpride
- amitriptyline
- amlodipine
- amobarbital
- amoxapine
- anagrelide
- apalutamide
- apomorphine
- aripiprazole
- armodafinil
- asenapine
- atazanavir
- azatadine
- azelastine nasal
B
- baclofen
- benztropine
- bepridil
- biperiden
- brexanolone
- brexpiprazole
- brivaracetam
- bromocriptine
- brompheniramine
- buprenorphine
- bupropion
- buspirone
- butabarbital
- butalbital
- butorphanol
C
- caffeine
- cannabidiol
- cannabis
- capmatinib
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- cenobamate
- cetirizine
- chlophedianol
- chloral hydrate
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chlorotrianisene
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorzoxazone
- cimetidine
- ciprofloxacin
- citalopram
- clemastine
- clevidipine
- clobazam
- clomipramine
- clonazepam
- clonidine
- clorazepate
- clozapine
- codeine
- conjugated estrogens
- conjugated estrogens topical
- cyclizine
- cyclobenzaprine
- cyproheptadine
D
- dantrolene
- daridorexant
- darifenacin
- deferasirox
- dehydroepiandrosterone
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexbrompheniramine
- dexchlorpheniramine
- dexmedetomidine
- dextromethorphan
- dezocine
- diazepam
- diethylstilbestrol
- difelikefalin
- diltiazem
- dimenhydrinate
- diphenhydramine
- divalproex sodium
- doxepin
- doxepin topical
- doxylamine
- dronabinol
- droperidol
- duloxetine
E
- echinacea
- efavirenz
- enasidenib
- enoxacin
- entacapone
- epcoritamab
- escitalopram
- esketamine
- eslicarbazepine
- estazolam
- esterified estrogens
- estradiol
- estrone
- estropipate
- eszopiclone
- ethanol
- ethchlorvynol
- ethinyl estradiol
- ethosuximide
- ethotoin
- ezogabine
F
- felbamate
- felodipine
- fenfluramine
- fentanyl
- fexinidazole
- flavoxate
- flibanserin
- fluconazole
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- fosphenytoin
- fospropofol
G
H
I
- ifosfamide
- iloperidone
- imatinib
- imipramine
- interferon alfa-2a
- interferon alfa-2b
- isocarboxazid
- isoniazid
- isradipine
K
L
- lamotrigine
- lasmiditan
- lemborexant
- leniolisib
- levamlodipine
- levetiracetam
- levocetirizine
- levodopa
- levomethadyl acetate
- levorphanol
- lidocaine
- lithium
- lofexidine
- lorazepam
- loxapine
- lumateperone
- lurasidone
M
- maprotiline
- meclizine
- meperidine
- mephenytoin
- mephobarbital
- meprobamate
- mesoridazine
- metaxalone
- methadone
- methdilazine
- methocarbamol
- methohexital
- methotrimeprazine
- methoxsalen
- methsuximide
- methyldopa
- metoclopramide
- metyrosine
- mexiletine
- mibefradil
- midazolam
- mirtazapine
- mitotane
- modafinil
- molindone
- momelotinib
- morphine
- morphine liposomal
- moxifloxacin
N
- nabilone
- nalbuphine
- nalidixic acid
- nefazodone
- nicardipine
- niclosamide
- nicotine
- nifedipine
- nimodipine
- niraparib
- nisoldipine
- norfloxacin
- nortriptyline
O
- obeticholic acid
- ofloxacin
- olanzapine
- olaparib
- oliceridine
- omeprazole
- opicapone
- opium
- orphenadrine
- osilodrostat
- osimertinib
- oxazepam
- oxcarbazepine
- oxycodone
- oxymorphone
P
- pacritinib
- paliperidone
- paraldehyde
- paramethadione
- paroxetine
- peginterferon alfa-2a
- peginterferon alfa-2b
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perphenazine
- phenacemide
- phenelzine
- phenindamine
- phenobarbital
- phensuximide
- phenytoin
- pimozide
- pramipexole
- pregabalin
- primaquine
- primidone
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propafenone
- propiomazine
- propofol
- propoxyphene
- propranolol
- protriptyline
- pyrilamine
Q
R
- ramelteon
- rasagiline
- remifentanil
- remimazolam
- ribociclib
- rifampin
- risperidone
- ritlecitinib
- ritonavir
- rofecoxib
- ropinirole
- ropivacaine
- rotigotine
- rucaparib
- rufinamide
S
- safinamide
- scopolamine
- secobarbital
- selegiline
- sertraline
- sibutramine
- sodium oxybate
- st. john's wort
- stiripentol
- sufentanil
- suvorexant
T
- tapentadol
- tasimelteon
- temazepam
- teriflunomide
- tetrabenazine
- thalidomide
- thiabendazole
- thiethylperazine
- thiopental
- thioridazine
- thiothixene
- tiagabine
- ticlopidine
- tirzepatide
- tizanidine
- tolcapone
- tolterodine
- topiramate
- tramadol
- tranylcypromine
- trazodone
- triazolam
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
V
- valbenazine
- valerian
- valproic acid
- varenicline
- vemurafenib
- venlafaxine
- verapamil
- vigabatrin
- viloxazine
W
Z
Melatonin alcohol/food interactions
There is 1 alcohol/food interaction with melatonin.
Melatonin disease interactions
There are 3 disease interactions with melatonin which include:
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More about melatonin
- melatonin consumer information
- Check interactions
- Compare alternatives
- Reviews (240)
- Side effects
- Patient tips
- Support group
- Drug class: minerals and electrolytes
- Breastfeeding
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.