Comparing Chlorpheniramine vs Diphenhydramine
| Chlorpheniramine | Diphenhydramine |
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| Chlorpheniramine | Diphenhydramine |
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Prescription and OTC
Prescribed for Urticaria, Allergic Reactions, Allergic Rhinitis, Cold Symptoms, Allergies, Food Allergies. Chlorpheniramine may also be used for purposes not listed in this medication guide. |
Prescription and OTC
Diphenhydramine is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side... View more |
Related suggestions Allergic Rhinitis
Urticaria
Allergies
Popular comparisons
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| More about Chlorpheniramine | More about Diphenhydramine | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Chlorpheniramine has an average rating of 8.2 out of 10 from a total of 53 ratings on Drugs.com. 79% of reviewers reported a positive effect, while 13% reported a negative effect. |
Diphenhydramine has an average rating of 5.5 out of 10 from a total of 543 ratings on Drugs.com. 42% of reviewers reported a positive effect, while 40% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Chlorpheniramine side effects |
View all Diphenhydramine side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Chlorpheniramine prices |
View all Diphenhydramine prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Aller-Chlor, Allergy Relief, Allergy Time, C.P.M., Chlo-Amine, Chlor-Mal, Chlor-Phenit, Chlor-Trimeton, Chlor-Trimeton Allergy SR, Chlorphen, Chlorpheniramine (Allergy), ChlorTan, Ed Chlor Ped Jr., Ed Chlor-Tan, Ed ChlorPed, Ed-Chlortan, Ricobid H, Teldrin HBP Allergy, Topco Allergy, Wal-finate View more | Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Aurodryl Children's Allergy, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep Tablets, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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30 hours |
9.3 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 344 drugs are known to interact with Chlorpheniramine:
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A total of 449 drugs are known to interact with Diphenhydramine:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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July 13, 1949 |
March 04, 1946 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
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| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.