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Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Tussionex Pennkinetic, Hydrocodone CP, Chlor-Trimeton, Alka-Seltzer Plus Cold, Chlorpheniramine (Allergy), Coricidin HBP Cold & Flu, Allergy Relief, Chlorphen, Hydrocodone HD, Coricidin D, Show all 813 »Sinarest, Deconamine, Triaminic, Tuzistra XR, Rondec, Notuss, Ed A-Hist, Advil Allergy Sinus, Coricidin HBP Cough & Cold, Phenagil, Allergy Multi-Symptom, Children's Nyquil, Demazin, Alumadrine, Ceron, Norel AD, PCM, CapCof, TussiCaps, Ed A-Hist DM, Triaminic Multi-Symptom Fever, Hydrocodone GF, Sinutab Ex-Strength, ChlorTan, Tylenol Cold, Drysec, Vicks NyQuil Cold & Flu Nighttime Relief (Alcohol Free), Sildec-PE Drops, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Tylenol Sinus Congestion & Pain Nighttime, Rondec-DM, Deconamine SR, Sildec-PE DM, Broncopectol, Naldecon, Tanoral, Actifed Cold and Allergy, Kidcare Cough and Cold, Amilon, Allergy DN PE, CPM-PE-MSC, Novasus, Creomulsion Cough/Cold/Allergy, Stahist, Codeprex, Clorfed, Esocor P, Entre-S, Rhinolar-EX, Xiral SR, Mescolor, Coldamine, Coldcough PD, Fedahist, Dynahist ER, Actifed Cold & Sinus, Singlet, M-End DM, Allerest Maximum Strength, Dicel, Duadacin, Rescon-DM, Chlor-Trimeton Allergy Decongestant, Neotuss D, Rindal-HD, Quartuss, Cough Formula M Multi-Symptom, Lohist, Suphedrine PE Sinus & Allergy, Tannate Pediatric, Sinapils, Congestant, Coricidin HBP Maximum Strength Flu, Theraflu Flu & Cough, Coricidin HBP Multi-Symptom Cold (Night), Robitussin Children's Cough & Cold Long-Acting, C-Phen DM, Cold Multi-Symptom (Nighttime), Sine-Off Sinus/Cold, Zutripro, JayCof-HC, Comtrex Cold and Flu Maximum Strength Tablet, Cardec, Phenylhistine DH Expectorant, Relacon-HC, Protid, Relief-PE, Robitussin Peak Cold Nighttime Nasal Relief, Triant-HC, Echotuss-HC, Hydrocof-HC, Allergy DN II, Ryneze, Redur-PCM, Histatab PH, Ah-chew Ultra, Virdec, Extendryl JR, Ny-Tannic, Rynatan, Rhinatate-NF, Extendryl Seniors, AccuHist Drops, Trigofen Drops, PCM Allergy, Phenylhistine, Re-Drylex Jr, Novahistine Elixir, Chlor-Mes, Rescon Extended Release, AlleRx Dose Pack PE (PM Dose), Histatab Plus, DriHist, QV-Allergy, Ricobid NR, AlleRx Dose Pack, AlleRx, Aerokid, Nolamine, Histatab, VisRx Dose Pack, Allergy AM-PM Dose Pack, ScopoHist, Pseudo CM TR, Allergy DN, Nuhist, Novahistine, Dallergy JR, Relera, NoHist LQ, Sonahist, Rhinolar, Rhinaclear, AllePak, Time-Hist QD, Amdry-C, PCM-LA, Hista-Vent PSE, Relcof PSE, Dallergy PSE, RelCof DN PSE, DuraHist, DryMax, BP Allergy JR, Allerest PE, Dallergy ER, Hycomine Compound, Denaze, Cordron-HC, Hyphed, Tussin-V, Q-V Tussin, A-G Tussin, KG-Tussin, P-V-Tussin Syrup, Hydrotuss HC, Hydron PCS, Cordron-HC NR, Welltuss HC, Atuss HD, Atuss HS, Advil Allergy and Congestion Relief, Advil Children's Allergy Sinus, RelCof CPM, AlleRx DF, NoHist EXT, RespiVent DF, Hexatussin, Tussend, Allerx Dose Pack DF, Neo HC, De-Chlor HC, Atuss MS, Hydro-PC II Plus, Uni-Tricof HC, Rindal HD Plus, Phendal-HD, Relacon-HC NR, Tusana-D, Poly-Tussin HD, Pediatex HC, Liquicough HC, Relasin-HC, DroTuss-CP, Z-Cof HC, Maxi-Tuss HCX, Notuss-Forte, Detuss, Histinex PV, aeroHist, Dexodryl Suspension, Ralix, Duradryl, Extendryl Chews, DA Chewable, Omnihist L.A., Duravent DA, Hista-Vent DA, DA II, Liqui-Allergy, AH-Chew, Duradryl JR, Extendryl SR, Drize, Ex-Histine, WE Allergy, Chlor-Mes D, Norel SD, Durahist PE, Omnihist II LA, AH-Chew II, Prehist D, Sinodec, Dexodryl, DuraTan PE, Duravent, Dehistine, DriHist SR, Nohist PE, RelCof DN PE, RelCof PE, ScopoHist Syrup, AlleRx Dose Pack (PM Dose), Nohist Plus, ScopoHist-PE, Nohist Plus Jr, Dallergy SR, Duradryl Chewable, Aerohist Plus, Duradryl SR, Dallergy PE, Ah-Chew Ultra Tannate, Triall, Ed A-Hist LA, SymPak PDX, Cardec Drops, Rynatan Pediatric, Fedahist Timecaps, Biohist LA (old formulation), Novafed A, Duratuss DA, Histalet, Tanafed, Chlorafed HS Timecelles, Codimal-LA, Kronofed-A-Jr, Dura-Tap/PD, Orlenta, Duotan, Chlorphedrin SR, Colfed-A, D-Amine-SR, Deconomed SR, Pseudocot-C, Duralex, Rinade-BID, Suphenamine-SR, Isophen-DF, Durafed, Chlor-Trimeton Decongestant, ND Clear, Teldrin, MyHist-PD, Triplex AD, Rhinolar-EX 12, Dura-Vent/A, Ornade Spansules, Resaid, Or-Phen-Ade, Contac 12 Hour, ARM Allergy Relief, Chlornade, Histade CR, Condrin, Ordrine, Decongex-3, Equi-Nade, Gencold, Triac, Genamin, Allerest 12 Hour, Vanex Forte-R, Kronofed-A, Chlordrine SR, Poly Hist PD (old formulation), Sudal-12, Atrohist Pediatric Capsule, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, Dynahist-ER Pediatric, CP-Tannic, Histade, Mintex, Suclor, Re2+30, Pediox Chewable, Hayfebrol Liquid, C-Phed Tannate, De-Congestine, Sudal-12 Chewable, Sudal-12 Tannate, SudaHist, AccuHist Drops (old formulation), LoHist-D, Triaminic Softchews Cold and Allergy, Pseudoephedrine Plus, Suphedrine Plus, SudoGest Sinus & Allergy, Anamine TD, Codimal-LA Half, Time-Hist, Chlorafed Timecelles, Brexin LA, Rescon-Ed, Pseudochlor, Cophene No 2, Anaplex, Anamine, Klerist-D, Fedahist Gyrocaps, Genaphed Plus, Clorfed II, Curaler, Chlorafed, Histafed LA, Aller-Chlor Decongestant, Sudogest Plus, Neutrahist Drops, Ryna Liquid, Sudogest Cold & Allergy, Phena-S 12, Pyrichlor PE, R-Tanna, Nalphen, ChlorTan D, Rinate Pediatric, Ed ChlorPed D, Acta-Tabs PE, Sildec-PE, NoHist, Maxichlor PEH, Ry-Tann, Hista-Vadrin, Nalda-Relief Pediatric, P-Tann D, Nalgestic Pediatric, Sinucon Pediatric, Nalgest, West-Decon, Nalspan, Uni Decon, Prop-A-Hist, Sinucon, Naldelate, Triaminic Cold & Allergy, Hydron CP, Histalet Forte, CP Dec Drops, Phenchlor Tannate Pediatric, Nasohist Pediatric, Dallergy Drops, Sinus & Allergy PE, PD-Hist D Drops, Ceron Drops, PD-Hist D, Tanahist-D, Allan Tannate Pediatric, Chlor-Mes Jr, CP Dec, Rondex, Rondex Drops, Dec-Chlorphen, Dec-Chlorphen Drops, C Phen Drops, C Phen, Histadec, PediaTan D, Sudafed PE Sinus & Allergy, Andecon Pediatric Drops, Vanex Forte, Conal, Ru-Hist Forte, Tri-Tannate Pediatric, Rhinatate Pediatric, Rhinatate, Url-Tannate Pediatric, Tritan, Tanamine, R-Tannamine, URL-Tannate, Triotann, Histatan, Tri-Tannate, Phena-S, Triotann Pediatric, Chlorex-A 12, Tri-Gestan S, Tri-Hist Pediatric, Phena-Plus, Tri Tann Pediatric, Nalex A 12, AllerTan, Tanamine Pediatric, Triple Tannate Pediatric, NoHist-A, Chlorex A, Nalex-A, Rhinacon A, Comhist, Linhist-LA, Comhist LA, Q-Hist LA, Chlortox, C-Hist-SR, Nalex-A SR, Coldex, Equitan Pediatric, West-Decon M, Atrohist Pediatric, Rynatan-S Pediatric, R-Tannate Pediatric, Gelhist Pediatric, R-Tannate, Triotann-S, R-Tannamine Pediatric, Triotann-S Pediatric, Tanoral Pediatric, De-Chlor HD, Cyndal HD, Hydro-PC II, Tuss Tan Pediatric, C-Tanna 12, Quad-Tuss, Rynatuss Pediatric, Quadratuss, Rynatuss, Rentamine Pediatric, Rentamine, Tuss Tan, Tetra Tannate Pediatric, Tannate 12 S, Quad Tuss Pediatric, Quad Tann Pediatric, Quad Tann, Tannic-12, Carbaphen 12, Tannate-12, XiraTuss, Tanni-Hist 12 RF, Exratuss, Trionate, Tussizone-12 RF, Phenagil CH, Protuss Tablet, Alka-Seltzer Plus Flu Formula (old formulation), Alka-Seltzer Plus Cold & Cough Formula Effervescent Tablets, Alka-Seltzer Plus Cold Formula Sparkling Original Effervescent Tablets, Alka-Seltzer Plus Cold Formula Orange Zest Effervescent Tablets, Alka-Seltzer Plus Cold Formula Cherry Burst Effervescent Tablets, Atrohist Plus, Deconhist LA, Rolatuss-SR, Ex-Tuss, Tussi-12, AccuHist LA, Bellahist-D LA, Histacol LA, Ru-Tuss, Respa-AR, SymPak II, Tustan 12S, Tussi-12S, Tannic-12 S, Tussi-12 (old formulation), Carbaphen CH, Rolatuss, Pedituss, Cotab A, Cotab AX, Lexuss 210, Notuss-AC, Endacof-C, Endal CD, T- Koff, Pediacof, Demi-Cof, Codar AR, Dihistine DH, Tricode AR, Zodryl DAC, Phenylhistine DH, Decohistine DH, Codehist DH, Novadyne DH, Co-Histine DH, Ryna-C, TL-Hist CM, Tuxarin ER, DryMax AF, C.P.M., Ricobid H, Aller-Chlor, P-Tann, TanaHist-PD, Ed ChlorPed, Ed-Chlortan, Topco Allergy, Pharbechlor, Teldrin HBP Allergy, Chlor-Mal, Zodryl AC, Chlo-Amine, Chlor-Trimeton Allergy SR, PediaTan, Wal-finate, Ed Chlor-Tan, Allergy Time, Ed Chlor Ped Jr., Chlor-Phenit, Z-Tuss AC, Quelidrine, Cold Medicine Plus, Vicks Children’s NyQuil Cold & Cough, Triaminic Multi-Symptom Fever & Cold, XL-3 Xtra Cold and Cough, Multi Symptom Cold (Night Formula), Multi Symptom Cold Relief, Alka-Seltzer Plus Severe Cold & Flu Formula Effervescent Tablets, Alka-Seltzer Plus Flu Formula, Alka-Seltzer Plus Severe Sinus & Cold Hot Drink Mix, Dimetapp Children's Nighttime Flu, Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets, Comtrex Cold and Flu Maximum Strength, Tylenol Cold Head Congestion Day and Night, Comtrex Maximum Strength Cold Relief, Contac Severe Cold and Flu Maximum Stength, Theraflu Flu, Cold and Cough Powder, Comtrex Day and Night, Comtrex Cold and Flu Maximum Strength Liquid, Genacol Maximum Strength, Childrens Tylenol Cold Plus Cough, Contac Cold and Flu Maximum Strength, Allpanto-S, Comtrex Nighttime Cold & Cough, Theraflu Nighttime Severe Cold & Cough Caplets, Theracaps Multi-Symptom Cough & Cold Reliever, Coricidin HBP Day & Night Multi-Symptom Cold, 999 Cold Remedy Granular, Cotabflu, Colrex Compound, Colrex, Tylenol Children’s Cold + Cough + Runny Nose, PediaCare Cough & Runny Nose Plus Acetaminophen, Mapap Cough & Sinus Formula, Vicks Formula 44 Custom Care Cough & Cold PM, Flu Relief BP, Tylenol Cold and Flu Severe Day & Night, Comtrex Cold & Cough Day Night, Dimetapp Children's Multi-Symptom Cold & Flu (old formulation), Tylenol Children’s Cold + Flu, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, PediaCare Multi-Symptom Cold Plus Acetaminophen, Alka-Seltzer Plus Cold & Cough Formula Liquid, PediaCare Flu Plus Acetaminophen, Codral Cold and Flu + Cough Day and Night, Tylenol Cold Multi-Symptom Nighttime, Tylenol Cold Head Congestion Nighttime, Co-Apap, Triaminic Flu, Cough & Fever, Allergy Sinus Maximum Strength, Comtrex Allergy Sinus, Trital SR, Rhinogesic, Sinulin, Chlor-Trimeton Sinus, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Simplet, Tricom, Codimal, Covangesic, Kolephrin, Allerest Sinus, Tylenol Allergy Sinus, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Triaminicin, Sinutab Maximum Strength Caplets, Norel SR, Dryphen, Gelpirin-CCF, Super Strength Sinadrin, Contac Cold + Flu (Night Formula), Medicidin-D, ConRx Allergy Sinus, Allergy Pain Relief, Allergy Sinus PE Pain Relief, PX Allergy Sinus PE, Pyrroxate, Onset Forte, GNP Cold Relief Plus, Gendecon, HEB Allergy, Dristan Cold Multi Symptom Formula, Tylenol Allergy Multi-Symptom, Comtrex Severe Cold & Sinus, Comtrex Flu Therapy, Tylenol Plus Children's Cold, XL-3 Cold Medicine, Hybrid CF, Tylenol Sinus Congestion and Pain Cool Burst Day Night, Alka-Seltzer Plus Cold & Flu, Codahistine-DH Elixir, Tricodene SF, B-Tuss, Uni-Cof, Pancof-PD, Despec-PD, Duohist DH, Tusscough DHC, Pancof, Tricof, Hydro-Tussin DHC, Dihydro-CP, Coldcough Syrup, Novahistine DH, Bronkotuss, Ana-Kit, Allfen A, Z-Tuss 2, SymPak, P Chlor GG, Donatussin Pediatric, Qual-Tussin Pediatric, Lemohist Plus, DiHydro-PE, Pedia Relief Cough-Cold, HyTan, Dicel DM, Triphenicol, Kophane, Threamine DM, Rhinosyn-DM, Vicks 44M Pediatric, Creomulsion Pediatric, Tanafed-DM, C-Phed DM, Atuss-12 DM, Atuss DS, T-Tanna DM, Maxichlor PSE DM, Kidkare Cough/Cold, Neutrahist PDX Drops, AccuHist PDX Drops, CPM-PSE DM Drops, Mesehist DM, Triaminic-D Multi-Symptom Cold, Allres DS, Duotan DM, S-T Forte 2, Vituz, Cheracol Plus, Histussin HC Liquid, Maxi-Tuss SA, Maxi-Tuss HC, Histinex HC, Coughtuss, KG-Dal HD Plus, Highland HC, Uni Tuss HC, H-C Tussive, Cytuss HC, Tuss-HC, Tuss-DS, Efasin-HD Plus, Quindal HD Plus, Quindal HD, Hi-Tuss HC, Chlorphen HD, Duradal HD, Liquitussin HC Syrup, Tussive HC, Ventuss Syrup, Comtussin HC, Endagen-HD, Iotussin HC, Chemdal HD, Iodal HD, Ed-TLC, Efasin-HD, Guiaphen HD, Mintuss MS, Vanex-HD, Chemdal HD Plus, Nasatuss, Chlorgest HD, Enplus-HD, Ed-Tuss HC, Hyphen-HD, Tuss-PD, KG-Dal HD, Endotuss-HD, Ditussin-HC, Chemtussin HC, Exo-Tuss, Endal-HD Plus, Therahist, Tricodene NN, QC Cough/Cold, Reme Tussin DM, Dec-Chlorphen DM, Dec-Chlorphen DM Drops, HistadecDM, CP Dec DM, Neo DM Drops, Nasohist-DM Pediatric, Cardec DM Drops, Balamine DM, NoHist DM, Rondex-DM, Tussplex DM, Norel CS, Cardec DM, Robitussin Cough & Allergy, C-Phen DM Drops, Sildec-PE DM Drops, DCP Drops, EndaCof Drops, PE-Hist DM, Rondex-DM Drops, Ceron-DM, ED DM, Triaminic Night Time Cough & Runny Nose, Effective Strength Cough Syrup, Primatuss 4, Tricodene Sugar Free, Triaminic Softchews Cough & Runny Nose, Dimetapp Children's Long Acting Cough Plus Cold, Robitussin Cough & Cold Long-Acting, Carepanto, Cold & Cough, Vicks Pediatric Formula 44m Cough & Cold Relief, Scot-Tussin DM, Ceron-DM Drops, St. Joseph HBP Cough & Cold, Robitussin Children's Nighttime Cough Long-Acting DM, SymPak DM, ChlorDex GP, Qual-Tussin, Genelan NF, Zotex-DM, Extendryl DM, Donatussin DM, Maxichlor PEH DM, Poly-Tussin DM, Tricodene Forte, De-Chlor DM, Maxiphen ADT, Tussar DM, Liquituss R-DM, Centergy DM, Atuss DM, Father John's Medicine Plus, Norel DM, NeoTuss Plus, De-Chlor DR, Albatussin SR, Coldtuss-DR, Tri-Vent DPC, Atuss DR, Corfen-DM, Uni-Tuss DM, Mintuss DR, Trital DM, P Chlor DM, Dex PC, Cerose DM, Relahist-DM, Ricotuss, Nohist-DMX, Tri-Dex PE, Z-Dex 12 D, Trigofen DM Drops, Virdec DM, Zoden DM Drops, Phenabid DM, Re DCP, Sonahist-DM, RE DCP Drops, Bronkids, NoHist-PDX, Donatussin DM Drops, Nasohist-DM, DM-PE-Chlor, CP Dec-DM Drops, PD-Cof Drops, PD-Cof, Zotex-12D, Quartuss DM, Statuss DM, Qdall

Medically reviewed on January 10, 2017.

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as spseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Effects on Lactation and Breastmilk

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

64

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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