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Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Tussionex Pennkinetic, Alka-Seltzer Plus Cold, Chlor-Trimeton, Coricidin HBP Cold & Flu, Coricidin HBP Cough & Cold, Tuzistra XR, Triplex AD, Coricidin D, Allergy Relief, Singlet, Show all 805 »Theraflu Flu, Cold and Cough Powder, Phenagil CH, Rondec, Wal-finate, Relasin-HC, Triaminic, Tylenol Cold, Allpanto-S, TussiCaps, Sinarest, Coldcough Syrup, Deconamine, Sinodec, Chlo-Amine, Ana-Kit, Ed-Chlortan, Coldex, Coricidin HBP Maximum Strength Flu, Sinucon, Sudafed PE Sinus & Allergy, Rynatan, Ceron, Nalex A 12, Cough Formula M Multi-Symptom, Hyphed, Zutripro, Alka-Seltzer Plus Cold Formula Sparkling Original Effervescent Tablets, Dallergy PE, Triant-HC, Norel AD, Chlorgest HD, Denaze, Triaminic Multi-Symptom Fever, Ceron-DM, ChlorTan, Ed A-Hist, Brexin LA, Ricobid H, Vicks NyQuil Cold & Flu Nighttime Relief (Alcohol Free), Demazin, LoHist-D, Advil Allergy Sinus, Congestant, Triaminic Cold & Allergy, Orlenta, Chlor-Mal, Vituz, M-End DM, AccuHist PDX Drops, Coldcough PD, Ornade Spansules, Condrin, Triac, Alka-Seltzer Plus Cold Formula Orange Zest Effervescent Tablets, Dura-Vent/A, Respa-AR, Triaminic-D Multi-Symptom Cold, Carbaphen 12, Rentamine, Trionate, CPM-PSE DM Drops, PediaTan, Novahistine, Relera, AlleRx, Naldecon, Amilon, Effective Strength Cough Syrup, Triaminic Softchews Cough & Runny Nose, Rondex, Quartuss, Phenabid DM, Corfen-DM, Sildec-PE DM, Rondec-DM, Actifed Cold and Allergy, Cardec, QC Cough/Cold, Phenylhistine DH, Chlorphen, Chlor-Trimeton Allergy SR, C.P.M., Topco Allergy, Aller-Chlor, Ed ChlorPed, AllerTan, Tanoral, Allergy AM-PM Dose Pack, West-Decon M, Codeprex, Lexuss 210, Cotab A, Cotab AX, Children's Nyquil, Stahist, Detuss, Chemtussin HC, Trital SR, Mintex, Time-Hist, Duralex, Isophen-DF, Novasus, Lemohist Plus, GNP Cold Relief Plus, Protid, Ah-chew Ultra, PCM, HyTan, Triall, Codimal, Tanafed, AlleRx DF, Comtrex Allergy Sinus Maximum Strength, Dexodryl, Hydrocodone CP, Ventuss Syrup, XL-3 Xtra Cold and Cough, Kolephrin, Sinutab Ex-Strength, Codral Cold and Flu + Cough Day and Night, Nolamine, P-V-Tussin Syrup, Hydron PCS, VisRx Dose Pack, Cordron-HC, ScopoHist, Hydrocof-HC, Hydrotuss HC, Coldamine, Histatab, Rhinaclear, Relcof PSE, Mescolor, Hista-Vent PSE, Dallergy PSE, RelCof DN PSE, DuraHist, Xiral SR, PCM-LA, Atuss HS, AllePak, Allergy DN, Time-Hist QD, Amdry-C, Atuss HD, Cordron-HC NR, Pseudo CM TR, JayCof-HC, Allerest PE, Virdec, Ny-Tannic, BP Allergy JR, Suphedrine PE Sinus & Allergy, DroTuss-CP, Liquicough HC, Ricobid NR, Rhinatate-NF, Trigofen Drops, Ed A-Hist LA, Rynatan Pediatric, R-Tanna, Histatab Plus, Novahistine Elixir, AccuHist Drops, Phenylhistine, Z-Cof HC, Maxi-Tuss HCX, Tussend, Pediatex HC, DryMax, Welltuss HC, Hexatussin, A-G Tussin, Q-V Tussin, Tussin-V, Histinex PV, Notuss, NoHist LQ, Sonahist, Relacon-HC, Dallergy JR, Nuhist, Notuss-Forte, Lohist, KG-Tussin, AlleRx Dose Pack, Drysec, Ex-Histine, WE Allergy, Drize, Duradryl JR, AH-Chew, Duradryl, Chlor-Mes D, Norel SD, Aerokid, Dallergy ER, Ralix, AH-Chew II, Durahist PE, Omnihist II LA, Phenchlor Tannate Pediatric, Liqui-Allergy, SymPak PDX, ScopoHist-PE, Extendryl SR, Ah-Chew Ultra Tannate, CPM-PE-MSC, Aerohist Plus, Duradryl SR, Prehist D, Extendryl Chews, Hista-Vent DA, DA II, Dallergy SR, Duravent DA, DA Chewable, Omnihist L.A., Extendryl Seniors, QV-Allergy, Extendryl JR, DriHist, Duradryl Chewable, Re-Drylex Jr, PCM Allergy, Ryneze, Dexodryl Suspension, Allerx Dose Pack DF, aeroHist, Advil Children's Allergy Sinus, Rhinolar, RelCof CPM, Allergy DN II, RespiVent DF, NoHist EXT, Duravent, Dehistine, Histatab PH, Nohist Plus, DuraTan PE, Redur-PCM, Nohist Plus Jr, Rescon Extended Release, AlleRx Dose Pack PE (PM Dose), Allergy DN PE, Chlor-Mes, Nohist PE, DriHist SR, RelCof DN PE, RelCof PE, AlleRx Dose Pack (PM Dose), ScopoHist Syrup, Advil Allergy and Congestion Relief, Sinucon Pediatric, Codimal-LA, Kronofed-A-Jr, Dura-Tap/PD, Fedahist Timecaps, Chlorafed HS Timecelles, Fedahist, Novafed A, Duratuss DA, Clorfed, Histalet, Chlorphedrin SR, Colfed-A, Kronofed-A, ND Clear, Chlordrine SR, Anamine TD, Suphenamine-SR, Rinade-BID, D-Amine-SR, Deconomed SR, Pseudocot-C, Deconamine SR, Biohist LA (old formulation), ARM Allergy Relief, Teldrin, Chlornade, Ordrine, Contac 12 Hour, Or-Phen-Ade, MyHist-PD, Rhinolar-EX 12, Resaid, Decongex-3, Equi-Nade, Histade CR, Chlor-Trimeton Decongestant, Duotan, Durafed, Vanex Forte-R, Allerest 12 Hour, Gencold, Rhinolar-EX, Genamin, Chlorafed Timecelles, Rescon-Ed, Suclor, Re2+30, Sudal-12, Pediox Chewable, Histade, CP-Tannic, Allerest Maximum Strength, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, Dynahist-ER Pediatric, C-Phed Tannate, De-Congestine, Triaminic Softchews Cold and Allergy, Pseudoephedrine Plus, Qdall, Dynahist ER, AccuHist Drops (old formulation), SudaHist, Sudal-12 Chewable, Dicel, Sudal-12 Tannate, Atrohist Pediatric Capsule, Suphedrine Plus, Codimal-LA Half, Fedahist Gyrocaps, Clorfed II, Curaler, Klerist-D, Anamine, Pseudochlor, Cophene No 2, Anaplex, Chlorafed, Histafed LA, Sudogest Cold & Allergy, Genaphed Plus, SudoGest Sinus & Allergy, Hayfebrol Liquid, Ryna Liquid, Neutrahist Drops, Chlor-Trimeton Allergy Decongestant, Aller-Chlor Decongestant, Sudogest Plus, Phena-S 12, Poly Hist PD (old formulation), Ry-Tann, Hista-Vadrin, Nalphen, Nalda-Relief Pediatric, Maxichlor PEH, NoHist, Ed ChlorPed D, Sildec-PE Drops, Acta-Tabs PE, Sildec-PE, Nalgestic Pediatric, Poly-Tussin HD, Naldelate, Andecon Pediatric Drops, Histalet Forte, Vanex Forte, Prop-A-Hist, Uni Decon, Nalgest, West-Decon, Nalspan, Rinate Pediatric, ChlorTan D, Tanahist-D, Allan Tannate Pediatric, CP Dec Drops, Chlor-Mes Jr, PD-Hist D, Ceron Drops, Dallergy Drops, Sinus & Allergy PE, PD-Hist D Drops, Rondex Drops, Dec-Chlorphen, PediaTan D, CP Dec, Cardec Drops, P-Tann D, Histadec, Tannate Pediatric, Dec-Chlorphen Drops, C Phen Drops, C Phen, NoHist-A, Nalex-A, Tanamine, R-Tannamine, URL-Tannate, Triotann, Tritan, Url-Tannate Pediatric, Tri-Tannate Pediatric, Rhinatate Pediatric, Rhinatate, Ru-Hist Forte, Histatan, Phena-Plus, Tri Tann Pediatric, Conal, Pyrichlor PE, Tri-Hist Pediatric, Tri-Gestan S, Phena-S, Triotann Pediatric, Chlorex-A 12, Tanamine Pediatric, Tri-Tannate, Chlortox, C-Hist-SR, Nalex-A SR, Chlorex A, Q-Hist LA, Comhist LA, Rhinacon A, Comhist, Linhist-LA, Atrohist Pediatric, Rynatan-S Pediatric, Triotann-S Pediatric, Tanoral Pediatric, Equitan Pediatric, Triple Tannate Pediatric, R-Tannamine Pediatric, Triotann-S, R-Tannate Pediatric, Gelhist Pediatric, R-Tannate, Nasohist Pediatric, KG-Dal HD, Tuss Tan, Tuss Tan Pediatric, Tetra Tannate Pediatric, Quad Tuss Pediatric, Rentamine Pediatric, Rynatuss, C-Tanna 12, Quad-Tuss, Rynatuss Pediatric, Quadratuss, Quad Tann Pediatric, Quad Tann, Tussi-12 (old formulation), Carbaphen CH, DryMax AF, P-Tann, Exratuss, Tanni-Hist 12 RF, Tannic-12, Tannate-12, XiraTuss, Tannate 12 S, Tussizone-12 RF, Alka-Seltzer Plus Cold Formula Cherry Burst Effervescent Tablets, Atrohist Plus, Deconhist LA, Rolatuss-SR, Alka-Seltzer Plus Cold & Cough Formula Effervescent Tablets, Alka-Seltzer Plus Flu Formula (old formulation), Cold Medicine Plus, Actifed Cold & Sinus, Rolatuss, Quelidrine, Protuss Tablet, Ex-Tuss, Tustan 12S, Tussi-12S, Tannic-12 S, Tussi-12, SymPak II, Ru-Tuss, AccuHist LA, Bellahist-D LA, Histacol LA, TanaHist-PD, Pharbechlor, Vicks Children’s NyQuil Cold & Cough, Tricodene SF, Primatuss 4, Tricodene Sugar Free, Codahistine-DH Elixir, Ryna-C, Codehist DH, Phenylhistine DH Expectorant, Novadyne DH, Co-Histine DH, Dimetapp Children's Long Acting Cough Plus Cold, Robitussin Children's Cough & Cold Long-Acting, Scot-Tussin DM, St. Joseph HBP Cough & Cold, Robitussin Children's Nighttime Cough Long-Acting DM, SymPak DM, Triaminic Night Time Cough & Runny Nose, Vicks Pediatric Formula 44m Cough & Cold Relief, Robitussin Cough & Cold Long-Acting, Carepanto, Cold & Cough, Decohistine DH, Zodryl DAC, Z-Tuss AC, Zodryl AC, Tuxarin ER, Codar AR, Chlor-Phenit, Allergy Time, Teldrin HBP Allergy, Chlorpheniramine (Allergy), Ed Chlor-Tan, TL-Hist CM, Notuss-AC, Pedituss, Demi-Cof, Dihistine DH, Tricode AR, Pediacof, T- Koff, Endacof-C, CapCof, Endal CD, Allergy Sinus Maximum Strength, Sinutab Maximum Strength Caplets, Alka-Seltzer Plus Flu Formula, Alka-Seltzer Plus Severe Sinus & Cold Hot Drink Mix, Dimetapp Children's Nighttime Flu, Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets, Alka-Seltzer Plus Severe Cold & Flu Formula Effervescent Tablets, Multi Symptom Cold Relief, Tylenol Cold Head Congestion Day and Night, Comtrex Nighttime Cold & Cough, Cold Multi-Symptom (Nighttime), Multi Symptom Cold (Night Formula), Triaminic Multi-Symptom Fever & Cold, Comtrex Cold and Flu Maximum Strength, Genacol Maximum Strength, Childrens Tylenol Cold Plus Cough, Contac Cold and Flu Maximum Strength, Theraflu Flu & Cough, Comtrex Cold and Flu Maximum Strength Liquid, Comtrex Cold and Flu Maximum Strength Tablet, Comtrex Maximum Strength Cold Relief, Contac Severe Cold and Flu Maximum Stength, Comtrex Day and Night, Theraflu Nighttime Severe Cold & Cough Caplets, Comtrex Cold & Cough Day Night, Mapap Cough & Sinus Formula, Vicks Formula 44 Custom Care Cough & Cold PM, Flu Relief BP, Coricidin HBP Multi-Symptom Cold (Night), PediaCare Cough & Runny Nose Plus Acetaminophen, Colrex, Sinapils, Cotabflu, Colrex Compound, Tylenol Plus Children's Cough & Runny Nose, Coricidin HBP Day & Night Multi-Symptom Cold, Alka-Seltzer Plus Cold & Cough Formula Liquid, PediaCare Flu Plus Acetaminophen, Tylenol Cold Multi-Symptom Nighttime, Tylenol Cold Head Congestion Nighttime, PediaCare Multi-Symptom Cold Plus Acetaminophen, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, Dimetapp Children's Multi-Symptom Cold & Flu (old formulation), Tylenol Plus Children's Multi-Symptom Cold, Tylenol Plus Children's Flu, Co-Apap, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Alumadrine, Duadacin, Sinulin, Chlor-Trimeton Sinus, Rhinogesic, Norel SR, Alka-Seltzer Plus Cold & Flu, HEB Allergy, Dryphen, Covangesic, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Triaminicin, Tylenol Allergy Sinus, Allerest Sinus, Simplet, Tricom, Comtrex Allergy Sinus, Tylenol Sinus Congestion and Pain Cool Burst Day Night, Sine-Off Sinus/Cold, Allergy Sinus PE Pain Relief, Allergy Multi-Symptom, Pyrroxate, Robitussin Peak Cold Nighttime Nasal Relief, Allergy Pain Relief, ConRx Allergy Sinus, Triaminic Flu, Cough & Fever, Gelpirin-CCF, Contac Cold + Flu (Night Formula), Relief-PE, Onset Forte, Comtrex Flu Therapy, Tylenol Plus Children's Cold, XL-3 Cold Medicine, Hybrid CF, Comtrex Severe Cold & Sinus, Tylenol Sinus Congestion & Pain Nighttime, Gendecon, Dristan Cold Multi Symptom Formula, Tylenol Allergy Multi-Symptom, Broncopectol, ChlorDex GP, Qual-Tussin Pediatric, Hydrocodone GF, S-T Forte 2, Endagen-HD, Donatussin Pediatric, P Chlor GG, Bronkotuss, Allfen A, Z-Tuss 2, SymPak, Chemdal HD, Iodal HD, Vanex-HD, Chemdal HD Plus, Nasatuss, Iotussin HC, Mintuss MS, Guiaphen HD, Rindal-HD, Ed-TLC, Efasin-HD, Uni-Cof, Dihydro-CP, Neutrahist PDX Drops, Esocor P, Mesehist DM, Allres DS, Kidkare Cough/Cold, Maxichlor PSE DM, Atuss-12 DM, Dicel DM, Atuss DS, Entre-S, Duotan DM, T-Tanna DM, Tusscough DHC, Pancof, Tricof, Hydro-Tussin DHC, Duohist DH, Despec-PD, Novahistine DH, DiHydro-PE, Pancof-PD, Ed-Tuss HC, Cyndal HD, Hydrocodone HD, Tussive HC, B-Tuss, Hydro-PC II, Liquitussin HC Syrup, Duradal HD, Quindal HD Plus, Quindal HD, Hi-Tuss HC, Chlorphen HD, Hydron CP, De-Chlor HD, Echotuss-HC, Phendal-HD, Relacon-HC NR, Tusana-D, Rindal HD Plus, Uni-Tricof HC, De-Chlor HC, Atuss MS, Hydro-PC II Plus, Efasin-HD Plus, Tuss-DS, Exo-Tuss, Endal-HD Plus, Enplus-HD, Comtussin HC, Ditussin-HC, Endotuss-HD, Hyphen-HD, Tuss-PD, Hycomine Compound, Tuss-HC, Maxi-Tuss SA, Uni Tuss HC, H-C Tussive, Histussin HC Liquid, Cytuss HC, Highland HC, KG-Dal HD Plus, Maxi-Tuss HC, Histinex HC, Coughtuss, C-Phed DM, Tanafed-DM, PE-Hist DM, Maxichlor PEH DM, ED DM, Poly-Tussin DM, EndaCof Drops, DCP Drops, C-Phen DM, Robitussin Cough & Allergy, C-Phen DM Drops, Sildec-PE DM Drops, Ricotuss, Tri-Dex PE, Sonahist-DM, RE DCP Drops, Nohist-DMX, Bronkids, Re DCP, Zoden DM Drops, Z-Dex 12 D, Trigofen DM Drops, Virdec DM, Cardec DM, Norel CS, Donatussin DM, Ceron-DM Drops, Rondex-DM, Rondex-DM Drops, Extendryl DM, Neotuss D, Qual-Tussin, Genelan NF, Zotex-DM, Dec-Chlorphen DM, Dec-Chlorphen DM Drops, Balamine DM, Reme Tussin DM, NoHist DM, Tussplex DM, Cardec DM Drops, Nasohist-DM Pediatric, HistadecDM, CP Dec DM, Neo DM Drops, Donatussin DM Drops, Nasohist-DM, P Chlor DM, Dex PC, Tricodene Forte, Tricodene NN, Ed A-Hist DM, Trital DM, Tri-Vent DPC, Atuss DR, Uni-Tuss DM, Mintuss DR, Cheracol Plus, Therahist, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Kidcare Cough and Cold, Rescon-DM, Vicks 44M Pediatric, Rhinosyn-DM, Triphenicol, Kophane, Threamine DM, Coldtuss-DR, De-Chlor DR, Quartuss DM, Statuss DM, NoHist-PDX, Relahist-DM, Zotex-12D, PD-Cof, DM-PE-Chlor, CP Dec-DM Drops, PD-Cof Drops, Albatussin SR, Cerose DM, Father John's Medicine Plus, Norel DM, NeoTuss Plus, De-Chlor DM, Atuss DM, Centergy DM, Maxiphen ADT, Tussar DM, Liquituss R-DM, Neo HC

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Effects on Lactation and Breastmilk

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

64

Last Revision Date

20150310

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