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Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Hydrocodone CP, Tussionex Pennkinetic, Hydrocodone HD, Chlor-Trimeton, Alka-Seltzer Plus Cold, Triaminic, Coricidin HBP Cold & Flu, Coricidin D, Aller-Chlor, Coricidin HBP Cough & Cold, Show all 814 »Chlorphen, Allergy Relief, Hydrocodone GF, Ceron, Triant-HC, Chlorpheniramine (Allergy), Triplex AD, Phenylhistine DH Expectorant, Alumadrine, Norel AD, Rondec, Qdall, Rentamine, Advil Allergy Sinus, Sinarest, Tuzistra XR, Ornade Spansules, Vituz, Wal-finate, Cardec DM, Naldecon, Ed A-Hist DM, Histussin HC Liquid, Relasin-HC, Triaminic-D Multi-Symptom Cold, Sudafed PE Sinus & Allergy, Singlet, Tanoral, Stahist, Chlor-Trimeton Sinus, Allpanto-S, PCM, Rescon Extended Release, Chlorafed, Suclor, Hista-Vent PSE, Coldamine, Pseudoephedrine Plus, Histade CR, Ceron Drops, Rondex, Cold Medicine Plus, Kolephrin, Chlor-Trimeton Decongestant, Cardec, Effective Strength Cough Syrup, Norel CS, Genelan NF, Trital DM, Norel DM, C-Phen DM, Zodryl AC, NoHist LQ, R-Tanna, Nolamine, Rhinacon A, Chlortox, Relcof PSE, Chlo-Amine, Codeprex, CapCof, Amilon, Pediacof, Anamine TD, Phenagil CH, Novahistine Elixir, Triotann-S Pediatric, Ru-Hist Forte, Phena-Plus, Phenylhistine DH, Trionate, Phenagil, Lexuss 210, Ed A-Hist, Children's Nyquil, CPM-PSE DM Drops, Isophen-DF, Alka-Seltzer Plus Cold Formula Sparkling Original Effervescent Tablets, Anamine, S-T Forte 2, Dexodryl Suspension, RespiVent DF, Histinex PV, Allergy Multi-Symptom, Protid, XL-3 Cold Medicine, Hydrocof-HC, Coricidin HBP Multi-Symptom Cold (Night), Triaminic Multi-Symptom Fever, Vicks NyQuil Cold & Flu Nighttime Relief (Alcohol Free), Contac Cold + Flu (Night Formula), Zutripro, Tylenol Cold, Colrex, Congestant, 999 Cold Remedy Granular, Histade, ScopoHist-PE, Ralix, AllePak, Rhinaclear, Tussend, Allergy DN, AlleRx Dose Pack, ScopoHist, Allergy AM-PM Dose Pack, VisRx Dose Pack, Histatab, DriHist, Pseudo CM TR, Rhinolar, Notuss-Forte, Hexatussin, Notuss, Detuss, Time-Hist QD, Amdry-C, Welltuss HC, Mescolor, Dallergy PSE, JayCof-HC, Pediatex HC, RelCof DN PSE, Xiral SR, DuraHist, DryMax, PCM-LA, Neo HC, Relacon-HC, Ny-Tannic, Sonahist, Ricobid NR, Suphedrine PE Sinus & Allergy, BP Allergy JR, Allerest PE, Virdec, Rynatan, Relera, Rhinatate-NF, Trigofen Drops, De-Chlor HC, AccuHist Drops, Phenylhistine, Histatab Plus, De-Chlor HD, AlleRx, Dallergy JR, Maxi-Tuss HCX, Relacon-HC NR, Z-Cof HC, DroTuss-CP, Liquicough HC, Poly-Tussin HD, Tussin-V, Tusana-D, Phendal-HD, Novahistine, Echotuss-HC, Rindal HD Plus, Uni-Tricof HC, Hydro-PC II Plus, Atuss MS, Lohist, Nuhist, Hyphed, Extendryl JR, Q-V Tussin, Ah-Chew Ultra Tannate, Dallergy SR, Duradryl Chewable, Aerohist Plus, Duradryl SR, Dallergy PE, CPM-PE-MSC, Triall, Nohist Plus, SymPak PDX, Sinodec, Extendryl SR, Prehist D, Extendryl Chews, DA Chewable, Omnihist L.A., Nohist Plus Jr, DuraTan PE, Hista-Vent DA, Allerx Dose Pack DF, Nohist PE, DriHist SR, Dehistine, Duravent, Ryneze, Dexodryl, aeroHist, Allergy DN PE, RelCof DN PE, NoHist EXT, Allergy DN II, AlleRx DF, RelCof PE, ScopoHist Syrup, AlleRx Dose Pack (PM Dose), Duravent DA, DA II, A-G Tussin, Re-Drylex Jr, AlleRx Dose Pack PE (PM Dose), Redur-PCM, Ah-chew Ultra, Histatab PH, Chlor-Mes, PCM Allergy, Atuss HS, Extendryl Seniors, Atuss HD, Cordron-HC NR, Cordron-HC, Hydron PCS, Hydrotuss HC, P-V-Tussin Syrup, KG-Tussin, QV-Allergy, Dallergy ER, Liqui-Allergy, Ex-Histine, AH-Chew, Duradryl, Duradryl JR, Drize, RelCof CPM, Advil Children's Allergy Sinus, Drysec, WE Allergy, Aerokid, Chlor-Mes D, Norel SD, Durahist PE, Advil Allergy and Congestion Relief, Omnihist II LA, AH-Chew II, Denaze, Hycomine Compound, Sildec-PE Drops, Ed A-Hist LA, Codimal-LA, Deconamine SR, Novafed A, Duratuss DA, Clorfed, Histalet, Fedahist, Tanafed, Chlorafed HS Timecelles, Kronofed-A-Jr, Biohist LA (old formulation), Dura-Tap/PD, Fedahist Timecaps, Orlenta, Chlorphedrin SR, Colfed-A, D-Amine-SR, Deconomed SR, Pseudocot-C, Duralex, Deconamine, Durafed, Suphenamine-SR, Chlornade, Rhinolar-EX 12, Dura-Vent/A, Resaid, Or-Phen-Ade, Demazin, Contac 12 Hour, ARM Allergy Relief, Teldrin, Condrin, Duotan, Ordrine, Decongex-3, Equi-Nade, Gencold, Rhinolar-EX, Triac, Genamin, Allerest 12 Hour, Vanex Forte-R, Rinade-BID, Kronofed-A, Phena-S 12, Sudal-12, Atrohist Pediatric Capsule, Allerest Maximum Strength, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, Dynahist-ER Pediatric, CP-Tannic, Mintex, Re2+30, Pediox Chewable, Hayfebrol Liquid, C-Phed Tannate, De-Congestine, Sudal-12 Chewable, Dicel, Sudal-12 Tannate, SudaHist, AccuHist Drops (old formulation), LoHist-D, Triaminic Softchews Cold and Allergy, Suphedrine Plus, SudoGest Sinus & Allergy, ND Clear, Codimal-LA Half, Chlordrine SR, Time-Hist, Chlorafed Timecelles, Brexin LA, Rescon-Ed, Pseudochlor, Cophene No 2, Anaplex, Klerist-D, Fedahist Gyrocaps, Genaphed Plus, Clorfed II, Curaler, Histafed LA, Chlor-Trimeton Allergy Decongestant, Aller-Chlor Decongestant, Sudogest Plus, Neutrahist Drops, Ryna Liquid, Sudogest Cold & Allergy, MyHist-PD, Poly Hist PD (old formulation), Rynatan Pediatric, Ry-Tann, Actifed Cold and Allergy, Rinate Pediatric, Ed ChlorPed D, Hydro-PC II, Acta-Tabs PE, Sildec-PE, NoHist, Maxichlor PEH, Hista-Vadrin, Triaminic Cold & Allergy, Nalphen, Nalda-Relief Pediatric, Nalgestic Pediatric, Sinucon Pediatric, Nalgest, West-Decon, Nalspan, Uni Decon, Prop-A-Hist, ChlorTan D, P-Tann D, Naldelate, CP Dec Drops, Phenchlor Tannate Pediatric, Nasohist Pediatric, Dallergy Drops, Sinus & Allergy PE, PD-Hist D Drops, PD-Hist D, Tanahist-D, Allan Tannate Pediatric, Chlor-Mes Jr, Cardec Drops, Rondex Drops, Dec-Chlorphen, Dec-Chlorphen Drops, C Phen Drops, C Phen, Tannate Pediatric, Histadec, PediaTan D, CP Dec, Sinucon, Andecon Pediatric Drops, Pyrichlor PE, Triotann, Tri-Tannate Pediatric, Rhinatate Pediatric, Rhinatate, Url-Tannate Pediatric, Tritan, Tanamine, R-Tannamine, URL-Tannate, Histatan, Tri-Tannate, Phena-S, Triotann Pediatric, Chlorex-A 12, Tri-Gestan S, Tri-Hist Pediatric, Tri Tann Pediatric, Nalex A 12, AllerTan, Conal, Tanamine Pediatric, Triple Tannate Pediatric, Histalet Forte, Chlorex A, Vanex Forte, NoHist-A, Nalex-A, Comhist, Linhist-LA, Comhist LA, Q-Hist LA, C-Hist-SR, Nalex-A SR, Coldex, Equitan Pediatric, West-Decon M, Atrohist Pediatric, Rynatan-S Pediatric, R-Tannate Pediatric, Gelhist Pediatric, R-Tannate, Triotann-S, R-Tannamine Pediatric, Tanoral Pediatric, Hydron CP, Cyndal HD, B-Tuss, Rentamine Pediatric, Tussi-12, Tussizone-12 RF, Tannate 12 S, C-Tanna 12, Quad-Tuss, Rynatuss Pediatric, Quadratuss, Rynatuss, Tuss Tan, Tussi-12S, Tuss Tan Pediatric, Tetra Tannate Pediatric, Quad Tuss Pediatric, Quad Tann Pediatric, Quad Tann, Tannic-12, Carbaphen 12, Tannate-12, XiraTuss, Tannic-12 S, Tustan 12S, Exratuss, Alka-Seltzer Plus Cold Formula Cherry Burst Effervescent Tablets, Triaminicin, Sinutab Maximum Strength Caplets, Allergy Sinus Maximum Strength, Actifed Cold & Sinus, Rolatuss, Quelidrine, Alka-Seltzer Plus Flu Formula (old formulation), Alka-Seltzer Plus Cold & Cough Formula Effervescent Tablets, Alka-Seltzer Plus Cold Formula Orange Zest Effervescent Tablets, Atrohist Plus, SymPak II, Deconhist LA, Rolatuss-SR, Protuss Tablet, Ex-Tuss, AccuHist LA, Bellahist-D LA, Histacol LA, Ru-Tuss, Respa-AR, Tanni-Hist 12 RF, Tussi-12 (old formulation), Allerest Headache Strength, Zodryl DAC, Notuss-AC, Endacof-C, Endal CD, T- Koff, Pedituss, Demi-Cof, Dihistine DH, Tricode AR, Decohistine DH, Cotab A, Codehist DH, Novadyne DH, Co-Histine DH, Ryna-C, Codahistine-DH Elixir, Vicks Children’s NyQuil Cold & Cough, Tricodene SF, QC Cough/Cold, Primatuss 4, Cotab AX, TL-Hist CM, Carbaphen CH, C.P.M., DryMax AF, Ricobid H, P-Tann, TanaHist-PD, Ed ChlorPed, Ed-Chlortan, Topco Allergy, Pharbechlor, Teldrin HBP Allergy, Chlor-Mal, Codar AR, Chlor-Trimeton Allergy SR, PediaTan, ChlorTan, Ed Chlor-Tan, Allergy Time, Ed Chlor Ped Jr., Chlor-Phenit, Z-Tuss AC, Tuxarin ER, Sinarest Extra Strength, Comtrex Allergy Sinus Night and Day, Triaminic Softchews Cough & Runny Nose, Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets, XL-3 Xtra Cold and Cough, Cold Multi-Symptom (Nighttime), Multi Symptom Cold (Night Formula), Multi Symptom Cold Relief, Alka-Seltzer Plus Severe Cold & Flu Formula Effervescent Tablets, Alka-Seltzer Plus Flu Formula, Alka-Seltzer Plus Severe Sinus & Cold Hot Drink Mix, Dimetapp Children's Nighttime Flu, Triaminic Multi-Symptom Fever & Cold, Tylenol Cold Head Congestion Day and Night, Comtrex Cold and Flu Maximum Strength, Comtrex Maximum Strength Cold Relief, Contac Severe Cold and Flu Maximum Stength, Theraflu Flu, Cold and Cough Powder, Comtrex Day and Night, Cough Formula M Multi-Symptom, Comtrex Cold and Flu Maximum Strength Tablet, Comtrex Cold and Flu Maximum Strength Liquid, Genacol Maximum Strength, Comtrex Nighttime Cold & Cough, Theraflu Nighttime Severe Cold & Cough Caplets, Contac Cold and Flu Maximum Strength, Tylenol Cold and Flu Severe Day & Night, Cotabflu, Colrex Compound, PediaCare Cough & Runny Nose Plus Acetaminophen, Coricidin HBP Maximum Strength Flu, Mapap Cough & Sinus Formula, Vicks Formula 44 Custom Care Cough & Cold PM, Flu Relief BP, Tylenol Plus Children's Cough & Runny Nose, Coricidin HBP Day & Night Multi-Symptom Cold, Dimetapp Children's Multi-Symptom Cold & Flu (old formulation), Comtrex Cold & Cough Day Night, Tylenol Plus Children's Multi-Symptom Cold, Tylenol Plus Children's Flu, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, PediaCare Multi-Symptom Cold Plus Acetaminophen, Alka-Seltzer Plus Cold & Cough Formula Liquid, PediaCare Flu Plus Acetaminophen, Codral Cold and Flu + Cough Day and Night, Tylenol Cold Multi-Symptom Nighttime, Tylenol Cold Head Congestion Nighttime, Childrens Tylenol Cold Plus Cough, Theraflu Flu & Cough, Comtrex Allergy Sinus Maximum Strength, Duadacin, Tylenol Sinus Congestion and Pain Cool Burst Day Night, Alka-Seltzer Plus Cold & Flu, HEB Allergy, Dryphen, Covangesic, Norel SR, Trital SR, Rhinogesic, Sinulin, Hybrid CF, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Simplet, Tricom, Comtrex Allergy Sinus, Codimal, Allerest Sinus, Tylenol Allergy Sinus, Sinutab Ex-Strength, Sine-Off Sinus/Cold, Tylenol Plus Children's Cold, Co-Apap, Pyrroxate, Theracaps Multi-Symptom Cough & Cold Reliever, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Triaminic Flu, Cough & Fever, Gelpirin-CCF, Medicidin-D, ConRx Allergy Sinus, Allergy Pain Relief, Allergy Sinus PE Pain Relief, PX Allergy Sinus PE, Robitussin Peak Cold Nighttime Nasal Relief, Comtrex Flu Therapy, Relief-PE, Onset Forte, GNP Cold Relief Plus, Super Strength Sinadrin, Gendecon, Dristan Cold Multi Symptom Formula, Tylenol Allergy Multi-Symptom, Tylenol Sinus Congestion & Pain Nighttime, Comtrex Severe Cold & Sinus, Tricodene Sugar Free, Dimetapp Children's Long Acting Cough Plus Cold, Tussive HC, Uni-Cof, Pancof-PD, Despec-PD, Duohist DH, Tusscough DHC, Pancof, Tricof, Hydro-Tussin DHC, Dihydro-CP, Coldcough Syrup, DiHydro-PE, Bronkotuss, Ana-Kit, Allfen A, Z-Tuss 2, SymPak, P Chlor GG, Donatussin Pediatric, Qual-Tussin Pediatric, Lemohist Plus, Coldcough PD, Novahistine DH, Novasus, Atuss DS, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Kidcare Cough and Cold, Rescon-DM, Tanafed-DM, C-Phed DM, M-End DM, Atuss-12 DM, Dicel DM, Entre-S, Pedia Relief Cough-Cold, Maxichlor PSE DM, Kidkare Cough/Cold, Neutrahist PDX Drops, AccuHist PDX Drops, Esocor P, Mesehist DM, Allres DS, Duotan DM, T-Tanna DM, HyTan, TussiCaps, Rhinosyn-DM, Uni Tuss HC, Tuss-HC, Ventuss Syrup, Maxi-Tuss SA, Maxi-Tuss HC, Histinex HC, Coughtuss, KG-Dal HD Plus, Highland HC, H-C Tussive, Enplus-HD, Cytuss HC, Tuss-DS, Efasin-HD Plus, Quindal HD Plus, Quindal HD, Hi-Tuss HC, Chlorphen HD, Duradal HD, Liquitussin HC Syrup, Comtussin HC, Endal-HD Plus, Endagen-HD, Nasatuss, Chemdal HD, Iodal HD, Rindal-HD, Ed-TLC, Efasin-HD, Guiaphen HD, Mintuss MS, Vanex-HD, Chemdal HD Plus, Iotussin HC, Exo-Tuss, Chlorgest HD, Ed-Tuss HC, Sinapils, Hyphen-HD, Tuss-PD, KG-Dal HD, Endotuss-HD, Ditussin-HC, Chemtussin HC, Vicks 44M Pediatric, Threamine DM, Robitussin Children's Cough & Cold Long-Acting, Tussplex DM, HistadecDM, CP Dec DM, Neo DM Drops, Nasohist-DM Pediatric, Cardec DM Drops, Balamine DM, Reme Tussin DM, NoHist DM, Robitussin Cough & Allergy, Dec-Chlorphen DM, C-Phen DM Drops, Sildec-PE DM Drops, Sildec-PE DM, DCP Drops, EndaCof Drops, PE-Hist DM, Maxichlor PEH DM, ED DM, Poly-Tussin DM, Dec-Chlorphen DM Drops, Rondex-DM Drops, Tri-Dex PE, Broncopectol, Robitussin Cough & Cold Long-Acting, Carepanto, Cold & Cough, Vicks Pediatric Formula 44m Cough & Cold Relief, Triaminic Night Time Cough & Runny Nose, Scot-Tussin DM, St. Joseph HBP Cough & Cold, Robitussin Children's Nighttime Cough Long-Acting DM, SymPak DM, ChlorDex GP, Rondex-DM, Qual-Tussin, Quartuss, Zotex-DM, Neotuss D, Extendryl DM, Rondec-DM, Donatussin DM, Ceron-DM Drops, Ceron-DM, Ricotuss, Z-Dex 12 D, Kophane, Atuss DR, Centergy DM, Atuss DM, Father John's Medicine Plus, NeoTuss Plus, De-Chlor DM, De-Chlor DR, Coldtuss-DR, Tri-Vent DPC, Corfen-DM, Tussar DM, Uni-Tuss DM, Mintuss DR, P Chlor DM, Dex PC, Tricodene Forte, Tricodene NN, Cheracol Plus, Therahist, Triphenicol, Liquituss R-DM, Maxiphen ADT, Trigofen DM Drops, Nasohist-DM, Virdec DM, Zoden DM Drops, Phenabid DM, Re DCP, Sonahist-DM, RE DCP Drops, Nohist-DMX, Bronkids, Donatussin DM Drops, DM-PE-Chlor, Cerose DM, CP Dec-DM Drops, PD-Cof Drops, PD-Cof, Zotex-12D, Quartuss DM, Statuss DM, NoHist-PDX, Relahist-DM, Albatussin SR, Dynahist ER

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as spseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Effects on Lactation and Breastmilk

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

64

Last Revision Date

20170110

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