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Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Tussionex Pennkinetic, Alka-Seltzer Plus Cold, Chlor-Trimeton, Coricidin HBP Cold & Flu, Allergy Relief, Triplex AD, Coricidin D, Aller-Chlor, Coricidin HBP Cough & Cold, Sudafed PE Sinus & Allergy, Show all 806 »Sinarest, Rondec, Relasin-HC, Wal-finate, Coldcough Syrup, TussiCaps, Singlet, Theraflu Flu, Cold and Cough Powder, Tylenol Cold, Tuzistra XR, Sinucon, Ceron, Triaminic, Alka-Seltzer Plus Cold Formula Sparkling Original Effervescent Tablets, Allpanto-S, Norel AD, Coldex, Ed-Chlortan, Chlo-Amine, Phenagil CH, Sinodec, Zutripro, R-Tanna, Trionate, Hyphed, Triaminic Cold & Allergy, ChlorTan, Phenchlor Tannate Pediatric, Tanoral, Denaze, Effective Strength Cough Syrup, Congestant, Ceron-DM, De-Chlor DM, NoHist DM, Nalex A 12, Ed A-Hist, Coricidin HBP Maximum Strength Flu, Orlenta, Triaminic Multi-Symptom Fever, Ana-Kit, Kolephrin, Histinex HC, Chlorgest HD, Vicks NyQuil Cold & Flu Nighttime Relief (Alcohol Free), Ricobid H, Chlor-Mal, Respa-AR, Carbaphen CH, Ornade Spansules, Cotab AX, Codeprex, Stahist, Carbaphen 12, Condrin, Triac, AllerTan, PediaTan, Rentamine, C.P.M., Ed ChlorPed, Topco Allergy, Chlorphen, Actifed Cold and Allergy, Triant-HC, PCM Allergy, Ralix, Hydrocodone HD, Chemtussin HC, Pancof, Novasus, Vituz, PCM, CPM-PE-MSC, Tussend, Detuss, Notuss, Advil Allergy Sinus, AlleRx DF, Dallergy PE, Dexodryl, RespiVent DF, Coldcough PD, Triaminic-D Multi-Symptom Cold, Cardec DM, Bronkids, Ed A-Hist DM, Rondec-DM, Quartuss, Phenylhistine DH Expectorant, Triaminic Softchews Cough & Runny Nose, Naldecon, Quelidrine, Rynatan, Coldamine, Children's Nyquil, CPM-PSE DM Drops, Amilon, Nolamine, AlleRx, Relera, Lohist, Phenylhistine DH, QC Cough/Cold, Cough Formula M Multi-Symptom, Mintex, Protid, GNP Cold Relief Plus, Trital SR, Time-Hist, Anaplex, Deconamine, Codral Cold and Flu + Cough Day and Night, Codimal, Duralex, Isophen-DF, XL-3 Xtra Cold and Cough, Extendryl Seniors, QV-Allergy, Aerokid, AH-Chew II, Dallergy ER, Neutrahist Drops, Omnihist II LA, Ryna Liquid, AlleRx Dose Pack PE (PM Dose), Rescon Extended Release, Norel SD, Omnihist L.A., Sudogest Cold & Allergy, Duravent DA, Hista-Vent DA, DA Chewable, Extendryl Chews, Genaphed Plus, ScopoHist-PE, Extendryl SR, Prehist D, DA II, Liqui-Allergy, Ex-Histine, WE Allergy, Chlor-Mes D, Sudogest Plus, Drysec, Drize, AH-Chew, Duradryl, Duradryl JR, Durahist PE, Ah-chew Ultra, VisRx Dose Pack, Histatab, Chlor-Trimeton Allergy Decongestant, Histafed LA, Allergy AM-PM Dose Pack, ScopoHist, Rhinaclear, Allergy DN, Pseudo CM TR, Chlorafed, Curaler, Cophene No 2, Pseudochlor, Rescon-Ed, Brexin LA, Anamine, Klerist-D, Clorfed II, Fedahist Gyrocaps, Codimal-LA Half, AllePak, Time-Hist QD, DriHist, AlleRx Dose Pack, Rhinolar, Aller-Chlor Decongestant, Extendryl JR, Re-Drylex Jr, SudoGest Sinus & Allergy, Histatab PH, Chlor-Mes, DryMax, DuraHist, Hista-Vent PSE, PCM-LA, Amdry-C, Mescolor, Relcof PSE, Xiral SR, RelCof DN PSE, Dallergy PSE, Redur-PCM, Hayfebrol Liquid, Hydron PCS, Hydrocof-HC, Cordron-HC, Hydrotuss HC, P-V-Tussin Syrup, Q-V Tussin, A-G Tussin, KG-Tussin, Cordron-HC NR, Atuss HD, Sudal-12 Tannate, Dicel, RelCof CPM, SudaHist, Advil Children's Allergy Sinus, Atuss HS, Advil Allergy and Congestion Relief, AccuHist Drops (old formulation), Tussin-V, Hexatussin, Z-Cof HC, Maxi-Tuss HCX, Relacon-HC, DroTuss-CP, Liquicough HC, Tusana-D, Neo HC, Poly-Tussin HD, Dynahist ER, Qdall, JayCof-HC, Pediatex HC, Welltuss HC, Histinex PV, Notuss-Forte, Pseudoephedrine Plus, Triaminic Softchews Cold and Allergy, LoHist-D, Allergy DN II, NoHist EXT, Suphedrine Plus, AlleRx Dose Pack (PM Dose), Allergy DN PE, Atrohist Pediatric Capsule, Allerest Maximum Strength, RelCof PE, ScopoHist Syrup, Chlor-Trimeton Allergy Decongestant SR, DuraTan PE, Nohist Plus, Duradryl SR, Ah-Chew Ultra Tannate, Triall, Aerohist Plus, Nuhist, Nohist Plus Jr, Dallergy SR, Duradryl Chewable, RelCof DN PE, Tavist-DA, De-Congestine, C-Phed Tannate, Pediox Chewable, Sudal-12 Chewable, Ryneze, aeroHist, Allerx Dose Pack DF, Dexodryl Suspension, Sudal-12, Duravent, Histade, CP-Tannic, Dynahist-ER Pediatric, Suclor, Re2+30, Dehistine, DriHist SR, Nohist PE, SymPak PDX, Suphedrine PE Sinus & Allergy, Biohist LA (old formulation), Durafed, Duotan, Deconamine SR, Novafed A, R-Tannate Pediatric, Gelhist Pediatric, Duratuss DA, Chlor-Trimeton Decongestant, Histade CR, Equitan Pediatric, Triple Tannate Pediatric, Vanex Forte-R, Tanoral Pediatric, Triotann-S Pediatric, R-Tannate, Triotann-S, R-Tannamine Pediatric, Rynatan-S Pediatric, Atrohist Pediatric, Q-Hist LA, Chlortox, C-Hist-SR, Comhist LA, Linhist-LA, Nalex-A, Rhinacon A, Comhist, Nalex-A SR, Kronofed-A-Jr, Fedahist, Histalet, Clorfed, Tanafed, West-Decon M, Codimal-LA, Chlorafed HS Timecelles, Chlorex A, Tri-Tannate, Tanamine Pediatric, Phena-S 12, MyHist-PD, Equi-Nade, Poly Hist PD (old formulation), Pyrichlor PE, Rhinolar-EX, Gencold, Conal, Decongex-3, Ordrine, ARM Allergy Relief, Or-Phen-Ade, Demazin, Resaid, Dura-Vent/A, Chlornade, Rhinolar-EX 12, Teldrin, Tri Tann Pediatric, Phena-Plus, Tanamine, R-Tannamine, URL-Tannate, Tritan, Url-Tannate Pediatric, Tri-Tannate Pediatric, Rhinatate Pediatric, Rhinatate, Triotann, Allerest 12 Hour, Tri-Gestan S, Tri-Hist Pediatric, Genamin, Chlorex-A 12, Triotann Pediatric, Ru-Hist Forte, Histatan, Phena-S, NoHist-A, Dura-Tap/PD, CP Dec Drops, Chlor-Mes Jr, Rondex, Allan Tannate Pediatric, Tanahist-D, PD-Hist D Drops, Ceron Drops, PD-Hist D, Rondex Drops, Dec-Chlorphen, Dec-Chlorphen Drops, C Phen Drops, C Phen, Kronofed-A, ND Clear, Chlorafed Timecelles, Anamine TD, Chlordrine SR, Sinus & Allergy PE, Dallergy Drops, BP Allergy JR, Allerest PE, Virdec, Contac 12 Hour, Ricobid NR, Dallergy JR, NoHist LQ, Sonahist, Ny-Tannic, Rhinatate-NF, Ed A-Hist LA, Rynatan Pediatric, Nasohist Pediatric, Histatab Plus, Novahistine Elixir, Trigofen Drops, AccuHist Drops, Phenylhistine, Tannate Pediatric, Histadec, Nalgestic Pediatric, Sinucon Pediatric, Nalgest, Nalda-Relief Pediatric, Nalphen, Relacon-HC NR, D-Amine-SR, Colfed-A, West-Decon, Nalspan, Andecon Pediatric Drops, Histalet Forte, Vanex Forte, Naldelate, Fedahist Timecaps, Uni Decon, Prop-A-Hist, Chlorphedrin SR, Deconomed SR, Pseudocot-C, ChlorTan D, Rinate Pediatric, Ed ChlorPed D, P-Tann D, Cardec Drops, PediaTan D, CP Dec, Suphenamine-SR, Cardec, Sildec-PE Drops, Ry-Tann, Hista-Vadrin, Rinade-BID, Maxichlor PEH, NoHist, Acta-Tabs PE, Sildec-PE, Novahistine, Tuss-PD, Rentamine Pediatric, Tuss Tan, Tuss Tan Pediatric, Tetra Tannate Pediatric, Rynatuss, Quadratuss, Tannate 12 S, C-Tanna 12, Quad-Tuss, Rynatuss Pediatric, Quad Tuss Pediatric, Quad Tann Pediatric, Exratuss, Tussi-12 (old formulation), DryMax AF, P-Tann, Tanni-Hist 12 RF, XiraTuss, Quad Tann, Tannic-12, Tannate-12, Tussizone-12 RF, Tussi-12, Alka-Seltzer Plus Cold Formula Orange Zest Effervescent Tablets, Alka-Seltzer Plus Cold Formula Cherry Burst Effervescent Tablets, Atrohist Plus, Deconhist LA, Alka-Seltzer Plus Cold & Cough Formula Effervescent Tablets, Alka-Seltzer Plus Flu Formula (old formulation), Allergy Sinus Maximum Strength, Cold Medicine Plus, Actifed Cold & Sinus, Rolatuss, Rolatuss-SR, Protuss Tablet, SymPak II, Tustan 12S, Tussi-12S, Tannic-12 S, Ru-Tuss, Histacol LA, Ex-Tuss, AccuHist LA, Bellahist-D LA, TanaHist-PD, Pharbechlor, Co-Histine DH, Ryna-C, Codahistine-DH Elixir, Vicks Children’s NyQuil Cold & Cough, Novadyne DH, Codehist DH, Dihistine DH, Tricode AR, Zodryl DAC, Decohistine DH, Tricodene SF, Primatuss 4, Cold & Cough, Vicks Pediatric Formula 44m Cough & Cold Relief, Triaminic Night Time Cough & Runny Nose, Scot-Tussin DM, Carepanto, Robitussin Cough & Cold Long-Acting, Tricodene Sugar Free, Dimetapp Children's Long Acting Cough Plus Cold, Robitussin Children's Cough & Cold Long-Acting, Demi-Cof, Pedituss, Ed Chlor Ped Jr., Chlor-Phenit, Z-Tuss AC, Zodryl AC, Allergy Time, Ed Chlor-Tan, Teldrin HBP Allergy, Chlor-Trimeton Allergy SR, Chlorpheniramine (Allergy), Tuxarin ER, Codar AR, CapCof, Endal CD, T- Koff, Pediacof, Endacof-C, Notuss-AC, TL-Hist CM, Cotab A, Lexuss 210, Sinutab Maximum Strength Caplets, Triaminicin, Alka-Seltzer Plus Severe Sinus & Cold Hot Drink Mix, Dimetapp Children's Nighttime Flu, Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets, Triaminic Multi-Symptom Fever & Cold, Alka-Seltzer Plus Flu Formula, Alka-Seltzer Plus Severe Cold & Flu Formula Effervescent Tablets, Comtrex Nighttime Cold & Cough, Cold Multi-Symptom (Nighttime), Multi Symptom Cold (Night Formula), Multi Symptom Cold Relief, Comtrex Cold and Flu Maximum Strength, Comtrex Maximum Strength Cold Relief, Childrens Tylenol Cold Plus Cough, Contac Cold and Flu Maximum Strength, Theraflu Flu & Cough, Co-Apap, Genacol Maximum Strength, Comtrex Cold and Flu Maximum Strength Liquid, Contac Severe Cold and Flu Maximum Stength, Comtrex Day and Night, Comtrex Cold and Flu Maximum Strength Tablet, Tylenol Cold Head Congestion Day and Night, Theraflu Nighttime Severe Cold & Cough Caplets, Vicks Formula 44 Custom Care Cough & Cold PM, Flu Relief BP, Coricidin HBP Multi-Symptom Cold (Night), Tylenol Plus Children's Cough & Runny Nose, Mapap Cough & Sinus Formula, PediaCare Cough & Runny Nose Plus Acetaminophen, Sinapils, Cotabflu, Colrex Compound, Colrex, Coricidin HBP Day & Night Multi-Symptom Cold, Dimetapp Children's Multi-Symptom Cold & Flu (old formulation), PediaCare Flu Plus Acetaminophen, Tylenol Cold Multi-Symptom Nighttime, Tylenol Cold Head Congestion Nighttime, Comtrex Cold & Cough Day Night, Alka-Seltzer Plus Cold & Cough Formula Liquid, PediaCare Multi-Symptom Cold Plus Acetaminophen, Tylenol Plus Children's Multi-Symptom Cold, Tylenol Plus Children's Flu, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Triaminic Flu, Cough & Fever, Duadacin, Sinulin, Chlor-Trimeton Sinus, Comtrex Sinus and Nasal, Alumadrine, Rhinogesic, HEB Allergy, Dryphen, Covangesic, Norel SR, Comtrex Nighttime Flu Therapy, Simplet, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Sinutab Ex-Strength, Tylenol Allergy Sinus, Tricom, Comtrex Allergy Sinus, Allerest Sinus, Alka-Seltzer Plus Cold & Flu, Tylenol Sinus Congestion and Pain Cool Burst Day Night, Allergy Multi-Symptom, Pyrroxate, Robitussin Peak Cold Nighttime Nasal Relief, Relief-PE, Allergy Sinus PE Pain Relief, Allergy Pain Relief, Gelpirin-CCF, Contac Cold + Flu (Night Formula), ConRx Allergy Sinus, Onset Forte, Gendecon, Tylenol Plus Children's Cold, XL-3 Cold Medicine, Hybrid CF, Sine-Off Sinus/Cold, Comtrex Flu Therapy, Comtrex Severe Cold & Sinus, Dristan Cold Multi Symptom Formula, Tylenol Allergy Multi-Symptom, Tylenol Sinus Congestion & Pain Nighttime, St. Joseph HBP Cough & Cold, Robitussin Children's Nighttime Cough Long-Acting DM, Donatussin Pediatric, Qual-Tussin Pediatric, Lemohist Plus, Hydrocodone GF, P Chlor GG, SymPak, Uni-Cof, Bronkotuss, Allfen A, Z-Tuss 2, S-T Forte 2, HyTan, Efasin-HD, Guiaphen HD, Mintuss MS, Vanex-HD, Ed-TLC, Rindal-HD, Endagen-HD, Chemdal HD, Iodal HD, Dihydro-CP, Hydro-Tussin DHC, Kidkare Cough/Cold, Neutrahist PDX Drops, AccuHist PDX Drops, Esocor P, Maxichlor PSE DM, Entre-S, M-End DM, Atuss-12 DM, Dicel DM, Atuss DS, Mesehist DM, Allres DS, Despec-PD, Duohist DH, Tusscough DHC, Tricof, Pancof-PD, DiHydro-PE, Duotan DM, T-Tanna DM, Novahistine DH, Chemdal HD Plus, Nasatuss, Chlorphen HD, Duradal HD, Liquitussin HC Syrup, Hydrocodone CP, Hi-Tuss HC, Quindal HD, Cytuss HC, Tuss-DS, Efasin-HD Plus, Quindal HD Plus, Tussive HC, B-Tuss, Hydro-PC II Plus, Uni-Tricof HC, Rindal HD Plus, Echotuss-HC, Atuss MS, De-Chlor HC, Hydro-PC II, Hydron CP, De-Chlor HD, Histussin HC Liquid, H-C Tussive, KG-Dal HD, Endotuss-HD, Ditussin-HC, Exo-Tuss, Hycomine Compound, Hyphen-HD, Iotussin HC, Ed-Tuss HC, Cyndal HD, Endal-HD Plus, Enplus-HD, Coughtuss, KG-Dal HD Plus, Highland HC, Uni Tuss HC, Maxi-Tuss HC, Maxi-Tuss SA, Comtussin HC, Tuss-HC, Ventuss Syrup, C-Phed DM, Tanafed-DM, EndaCof Drops, PE-Hist DM, Maxichlor PEH DM, ED DM, DCP Drops, Sildec-PE DM, C-Phen DM, Robitussin Cough & Allergy, C-Phen DM Drops, Sildec-PE DM Drops, Poly-Tussin DM, Ricotuss, Phenabid DM, Re DCP, Sonahist-DM, RE DCP Drops, Zoden DM Drops, Virdec DM, Tri-Dex PE, Z-Dex 12 D, Trigofen DM Drops, Norel CS, Tussplex DM, Neotuss D, Extendryl DM, Donatussin DM, Ceron-DM Drops, Zotex-DM, Genelan NF, SymPak DM, Broncopectol, ChlorDex GP, Qual-Tussin, Rondex-DM, Rondex-DM Drops, Nasohist-DM Pediatric, Cardec DM Drops, Balamine DM, Reme Tussin DM, Neo DM Drops, CP Dec DM, Dec-Chlorphen DM, Dec-Chlorphen DM Drops, HistadecDM, Nohist-DMX, Donatussin DM Drops, P Chlor DM, Dex PC, Tricodene Forte, Tricodene NN, Trital DM, Mintuss DR, Tri-Vent DPC, Atuss DR, Corfen-DM, Uni-Tuss DM, Cheracol Plus, Therahist, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Kidcare Cough and Cold, Rescon-DM, Vicks 44M Pediatric, Rhinosyn-DM, Triphenicol, Kophane, Threamine DM, Coldtuss-DR, De-Chlor DR, Zotex-12D, Quartuss DM, Statuss DM, NoHist-PDX, PD-Cof, PD-Cof Drops, Nasohist-DM, DM-PE-Chlor, CP Dec-DM Drops, Relahist-DM, Albatussin SR, Atuss DM, Father John's Medicine Plus, Norel DM, NeoTuss Plus, Centergy DM, Liquituss R-DM, Cerose DM, Maxiphen ADT, Tussar DM, Phendal-HD

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Effects on Lactation and Breastmilk

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

64

Last Revision Date

20150310

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