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Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Hydrocodone CP, Tussionex Pennkinetic, Hydrocodone HD, Triaminic, Coricidin HBP Cold & Flu, Alka-Seltzer Plus Cold, Chlor-Trimeton, Coricidin HBP Cough & Cold, Chlorpheniramine (Allergy), Coricidin D, Show all 810 »Tylenol Cold, Ceron, Tuzistra XR, Advil Allergy Sinus, Sinarest, Aller-Chlor, Chlorphen, Norel AD, Allergy Relief, Rondec, Tanoral, Phenagil CH, Wal-finate, Deconamine, Rynatan, Coricidin HBP Maximum Strength Flu, Hydrocodone GF, Orlenta, Pyrroxate, Dristan Cold Multi Symptom Formula, Protid, Zoden DM Drops, CPM-PSE DM Drops, PCM, Triplex AD, Comhist, Zutripro, Triant-HC, Stahist, Coldcough Syrup, Alka-Seltzer Plus Cold Formula Sparkling Original Effervescent Tablets, Nolamine, Kronofed-A, Chlornade, Gencold, Cophene No 2, Duadacin, ARM Allergy Relief, Alumadrine, Singlet, Bellahist-D LA, Rinade-BID, Tanafed, Cold Medicine Plus, Demazin, Fedahist, Codimal, Pancof, DuraHist, Sudafed PE Sinus & Allergy, Triaminic Cold & Allergy, Cardec, Histadec, Rondex, Ed A-Hist, R-Tanna, Sildec-PE, ChlorDex GP, Phenabid DM, Quartuss DM, Ed A-Hist DM, DCP Drops, Robitussin Cough & Allergy, Quartuss, Reme Tussin DM, Novahistine, Lohist, Codar AR, Endal CD, Naldecon, Zodryl AC, Chlorex A, Allerest Maximum Strength, Coldex, Sinucon, Phenylhistine DH, Carepanto, Triaminic Night Time Cough & Runny Nose, Effective Strength Cough Syrup, QC Cough/Cold, Codehist DH, Phenylhistine DH Expectorant, Triotann, Pancof-PD, Cytuss HC, Sine-Off Sinus/Cold, Gendecon, Vicks Formula 44 Custom Care Cough & Cold PM, Colrex, Congestant, Coughtuss, Highland HC, Onset Forte, Allergy Multi-Symptom, Hydron PCS, Hydrocof-HC, Relasin-HC, Notuss, Coricidin HBP Day & Night Multi-Symptom Cold, Quindal HD, CP-Tannic, Duradal HD, Sinapils, Tylenol Sinus Congestion and Pain Cool Burst Day Night, Novasus, TussiCaps, AH-Chew, Duravent, Duradryl, Denaze, Mintex, Pseudoephedrine Plus, Advil Allergy and Congestion Relief, AlleRx Dose Pack PE (PM Dose), Ed-TLC, Ralix, Theraflu Flu, Cold and Cough Powder, Cyndal HD, VisRx Dose Pack, Dallergy PSE, Allergy AM-PM Dose Pack, Mescolor, Q-V Tussin, Tussin-V, Atuss HD, Histatab, Welltuss HC, Relcof PSE, Hexatussin, Amilon, A-G Tussin, Hyphed, Cordron-HC NR, P-V-Tussin Syrup, Hista-Vent PSE, Rhinaclear, AllePak, Time-Hist QD, Amdry-C, PCM-LA, Cordron-HC, Allergy DN, ScopoHist, Tussend, Coldamine, Pseudo CM TR, Hydrotuss HC, KG-Tussin, Poly-Tussin HD, BP Allergy JR, Allerest PE, Relacon-HC NR, Suphedrine PE Sinus & Allergy, Ricobid NR, AlleRx, Sonahist, Phendal-HD, Echotuss-HC, AccuHist Drops, Phenylhistine, Trigofen Drops, Rhinatate-NF, Virdec, Ny-Tannic, Tusana-D, Neo HC, Relacon-HC, Maxi-Tuss HCX, Notuss-Forte, Detuss, JayCof-HC, Histinex PV, Z-Cof HC, DroTuss-CP, Relera, NoHist LQ, Dallergy JR, Nuhist, Liquicough HC, Atuss HS, Pediatex HC, AlleRx DF, Sinodec, Extendryl SR, Prehist D, ScopoHist-PE, SymPak PDX, Ah-Chew Ultra Tannate, Triall, Extendryl Chews, DA Chewable, Liqui-Allergy, Duradryl JR, Drize, DA II, Hista-Vent DA, Omnihist L.A., Duravent DA, CPM-PE-MSC, Dallergy PE, RelCof PE, ScopoHist Syrup, AlleRx Dose Pack (PM Dose), RelCof DN PE, Nohist PE, Dehistine, DriHist SR, Allergy DN PE, DuraTan PE, Aerohist Plus, Duradryl SR, Novahistine Elixir, Duradryl Chewable, Dallergy SR, Nohist Plus, Nohist Plus Jr, Drysec, Ex-Histine, Chlor-Mes, Allergy DN II, RelCof CPM, NoHist EXT, RespiVent DF, Allerx Dose Pack DF, aeroHist, PCM Allergy, Re-Drylex Jr, Advil Children's Allergy Sinus, DryMax, Xiral SR, Rhinolar, AlleRx Dose Pack, Extendryl JR, DriHist, Dexodryl Suspension, Dexodryl, Omnihist II LA, AH-Chew II, Aerokid, Durahist PE, Norel SD, WE Allergy, Chlor-Mes D, Dallergy ER, Extendryl Seniors, Ah-chew Ultra, Histatab PH, Ryneze, Redur-PCM, QV-Allergy, Rescon Extended Release, RelCof DN PSE, Rinate Pediatric, Chlorafed HS Timecelles, Codimal-LA, Kronofed-A-Jr, Dura-Tap/PD, Histalet, Clorfed, Biohist LA (old formulation), Deconamine SR, Novafed A, Duratuss DA, Fedahist Timecaps, Chlorphedrin SR, Suphenamine-SR, Isophen-DF, ND Clear, Chlordrine SR, Duralex, Pseudocot-C, Colfed-A, D-Amine-SR, Deconomed SR, Durafed, Duotan, Resaid, Or-Phen-Ade, Contac 12 Hour, Teldrin, Ornade Spansules, Dura-Vent/A, Poly Hist PD (old formulation), Phena-S 12, MyHist-PD, Rhinolar-EX 12, Condrin, Ordrine, Allerest 12 Hour, Vanex Forte-R, Histade CR, Chlor-Trimeton Decongestant, Genamin, Triac, Decongex-3, Equi-Nade, Rhinolar-EX, Anamine TD, Time-Hist, Suclor, Re2+30, Sudal-12, Pediox Chewable, Histade, Dynahist-ER Pediatric, Suphedrine Plus, Atrohist Pediatric Capsule, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, C-Phed Tannate, De-Congestine, LoHist-D, Triaminic Softchews Cold and Allergy, Qdall, Dynahist ER, AccuHist Drops (old formulation), SudaHist, Sudal-12 Chewable, Dicel, Sudal-12 Tannate, Hayfebrol Liquid, SudoGest Sinus & Allergy, Anamine, Klerist-D, Codimal-LA Half, Fedahist Gyrocaps, Anaplex, Pseudochlor, Chlorafed Timecelles, Brexin LA, Rescon-Ed, Clorfed II, Curaler, Neutrahist Drops, Ryna Liquid, Sudogest Cold & Allergy, Genaphed Plus, Sudogest Plus, Aller-Chlor Decongestant, Chlorafed, Histafed LA, Chlor-Trimeton Allergy Decongestant, Pyrichlor PE, Conal, Acta-Tabs PE, NoHist, Maxichlor PEH, Ry-Tann, Sildec-PE Drops, Ed ChlorPed D, P-Tann D, ChlorTan D, Actifed Cold and Allergy, Rindal HD Plus, Hista-Vadrin, Nalphen, Nalspan, Uni Decon, Prop-A-Hist, Naldelate, West-Decon, Nalgest, Nalda-Relief Pediatric, Nalgestic Pediatric, Sinucon Pediatric, Cardec Drops, CP Dec, Sinus & Allergy PE, PD-Hist D Drops, Ceron Drops, PD-Hist D, Dallergy Drops, Nasohist Pediatric, Ed A-Hist LA, Rynatan Pediatric, Phenchlor Tannate Pediatric, Tanahist-D, Allan Tannate Pediatric, C Phen Drops, C Phen, Tannate Pediatric, PediaTan D, Dec-Chlorphen Drops, Dec-Chlorphen, CP Dec Drops, Chlor-Mes Jr, Rondex Drops, Andecon Pediatric Drops, Histalet Forte, Tritan, Tanamine, R-Tannamine, URL-Tannate, Url-Tannate Pediatric, Rhinatate, Tri-Tannate, Tanamine Pediatric, Tri-Tannate Pediatric, Rhinatate Pediatric, Ru-Hist Forte, Histatan, Phena-Plus, Tri Tann Pediatric, Nalex A 12, AllerTan, Tri-Hist Pediatric, Tri-Gestan S, Phena-S, Triotann Pediatric, Chlorex-A 12, Triple Tannate Pediatric, Equitan Pediatric, Comhist LA, Q-Hist LA, Chlortox, C-Hist-SR, Linhist-LA, Rhinacon A, Vanex Forte, NoHist-A, Nalex-A, Nalex-A SR, West-Decon M, Triotann-S, R-Tannamine Pediatric, Triotann-S Pediatric, Tanoral Pediatric, R-Tannate, Gelhist Pediatric, Atrohist Pediatric, Rynatan-S Pediatric, R-Tannate Pediatric, Histatab Plus, Chemdal HD Plus, Rentamine Pediatric, Rentamine, Tuss Tan, Tuss Tan Pediatric, Rynatuss, Quadratuss, Trionate, C-Tanna 12, Quad-Tuss, Rynatuss Pediatric, Tetra Tannate Pediatric, Quad Tuss Pediatric, XiraTuss, Tanni-Hist 12 RF, Exratuss, Tussi-12 (old formulation), Tannate-12, Carbaphen 12, Quad Tann Pediatric, Quad Tann, Tannic-12, Tannate 12 S, Tussizone-12 RF, Alka-Seltzer Plus Cold Formula Cherry Burst Effervescent Tablets, Atrohist Plus, Deconhist LA, Rolatuss-SR, Alka-Seltzer Plus Cold Formula Orange Zest Effervescent Tablets, Alka-Seltzer Plus Cold & Cough Formula Effervescent Tablets, Actifed Cold & Sinus, Rolatuss, Quelidrine, Alka-Seltzer Plus Flu Formula (old formulation), Protuss Tablet, Ex-Tuss, Tustan 12S, Tussi-12S, Tannic-12 S, Tussi-12, SymPak II, Respa-AR, AccuHist LA, Histacol LA, Ru-Tuss, Carbaphen CH, DryMax AF, Pediacof, Pedituss, Demi-Cof, Dihistine DH, T- Koff, CapCof, Lexuss 210, Codeprex, Notuss-AC, Endacof-C, Tricode AR, Zodryl DAC, Vicks Children’s NyQuil Cold & Cough, Tricodene SF, Primatuss 4, Tricodene Sugar Free, Codahistine-DH Elixir, Ryna-C, Decohistine DH, Novadyne DH, Co-Histine DH, Cotab AX, Cotab A, Pharbechlor, Teldrin HBP Allergy, C.P.M., Chlor-Mal, Topco Allergy, Ed-Chlortan, Ricobid H, P-Tann, TanaHist-PD, Ed ChlorPed, Chlo-Amine, Chlor-Trimeton Allergy SR, Chlor-Phenit, Z-Tuss AC, Tuxarin ER, TL-Hist CM, Ed Chlor Ped Jr., Allergy Time, PediaTan, ChlorTan, Ed Chlor-Tan, Allergy Sinus Maximum Strength, Sinutab Maximum Strength Caplets, Alka-Seltzer Plus Severe Sinus & Cold Hot Drink Mix, Dimetapp Children's Nighttime Flu, Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets, Triaminic Multi-Symptom Fever & Cold, Alka-Seltzer Plus Flu Formula, Alka-Seltzer Plus Severe Cold & Flu Formula Effervescent Tablets, XL-3 Xtra Cold and Cough, Cold Multi-Symptom (Nighttime), Multi Symptom Cold (Night Formula), Multi Symptom Cold Relief, Comtrex Cold and Flu Maximum Strength, Comtrex Maximum Strength Cold Relief, Genacol Maximum Strength, Childrens Tylenol Cold Plus Cough, Contac Cold and Flu Maximum Strength, Theraflu Flu & Cough, Comtrex Cold and Flu Maximum Strength Liquid, Comtrex Cold and Flu Maximum Strength Tablet, Contac Severe Cold and Flu Maximum Stength, Comtrex Day and Night, Cough Formula M Multi-Symptom, Comtrex Nighttime Cold & Cough, Tylenol Cold Head Congestion Day and Night, Flu Relief BP, Coricidin HBP Multi-Symptom Cold (Night), Tylenol Plus Children's Cough & Runny Nose, Dimetapp Children's Multi-Symptom Cold & Flu (old formulation), Mapap Cough & Sinus Formula, PediaCare Cough & Runny Nose Plus Acetaminophen, Cotabflu, Colrex Compound, Vicks NyQuil Cold & Flu Nighttime Relief (Alcohol Free), Triaminic Multi-Symptom Fever, Tylenol Plus Children's Multi-Symptom Cold, Tylenol Plus Children's Flu, Tylenol Cold Multi-Symptom Nighttime, Tylenol Cold Head Congestion Nighttime, Comtrex Cold & Cough Day Night, Theraflu Nighttime Severe Cold & Cough Caplets, Codral Cold and Flu + Cough Day and Night, PediaCare Flu Plus Acetaminophen, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, PediaCare Multi-Symptom Cold Plus Acetaminophen, Alka-Seltzer Plus Cold & Cough Formula Liquid, Allpanto-S, Co-Apap, Chlor-Trimeton Sinus, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Simplet, Sinulin, Rhinogesic, Dryphen, Covangesic, Norel SR, Trital SR, Tricom, Comtrex Allergy Sinus, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Triaminicin, Comtrex Allergy Sinus Maximum Strength, Sinutab Ex-Strength, Kolephrin, Allerest Sinus, Tylenol Allergy Sinus, HEB Allergy, Alka-Seltzer Plus Cold & Flu, ConRx Allergy Sinus, Allergy Pain Relief, Allergy Sinus PE Pain Relief, PX Allergy Sinus PE, Medicidin-D, Contac Cold + Flu (Night Formula), Theracaps Multi-Symptom Cough & Cold Reliever, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Triaminic Flu, Cough & Fever, Gelpirin-CCF, Robitussin Peak Cold Nighttime Nasal Relief, Relief-PE, Comtrex Flu Therapy, Tylenol Plus Children's Cold, XL-3 Cold Medicine, Hybrid CF, Comtrex Severe Cold & Sinus, Tylenol Sinus Congestion & Pain Nighttime, GNP Cold Relief Plus, Super Strength Sinadrin, Tylenol Allergy Multi-Symptom, Triaminic Softchews Cough & Runny Nose, Dimetapp Children's Long Acting Cough Plus Cold, Hydro-Tussin DHC, Dihydro-CP, Uni-Cof, Bronkotuss, Tricof, Tusscough DHC, DiHydro-PE, Coldcough PD, Despec-PD, Duohist DH, Ana-Kit, Allfen A, Lemohist Plus, S-T Forte 2, HyTan, Vituz, Qual-Tussin Pediatric, Donatussin Pediatric, Z-Tuss 2, SymPak, P Chlor GG, Novahistine DH, T-Tanna DM, C-Phed DM, M-End DM, Atuss-12 DM, Dicel DM, Tanafed-DM, Rescon-DM, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Kidcare Cough and Cold, Children's Nyquil, Atuss DS, Entre-S, Mesehist DM, Triaminic-D Multi-Symptom Cold, Allres DS, Duotan DM, Esocor P, AccuHist PDX Drops, Maxichlor PSE DM, Kidkare Cough/Cold, Neutrahist PDX Drops, Endagen-HD, Chemdal HD, Histussin HC Liquid, Tuss-DS, Efasin-HD Plus, Quindal HD Plus, H-C Tussive, Uni Tuss HC, Maxi-Tuss SA, Maxi-Tuss HC, Histinex HC, KG-Dal HD Plus, Hi-Tuss HC, Chlorphen HD, De-Chlor HD, De-Chlor HC, Atuss MS, Hydro-PC II Plus, Hydron CP, Hydro-PC II, Liquitussin HC Syrup, Tussive HC, B-Tuss, Ventuss Syrup, Tuss-HC, Hycomine Compound, Nasatuss, Iotussin HC, Chlorgest HD, Vanex-HD, Mintuss MS, Iodal HD, Rindal-HD, Efasin-HD, Guiaphen HD, Ed-Tuss HC, Hyphen-HD, Exo-Tuss, Endal-HD Plus, Enplus-HD, Comtussin HC, Chemtussin HC, Ditussin-HC, Tuss-PD, KG-Dal HD, Endotuss-HD, Vicks 44M Pediatric, Rhinosyn-DM, Tussplex DM, Norel CS, Cardec DM, C-Phen DM, NoHist DM, Balamine DM, CP Dec DM, Neo DM Drops, Nasohist-DM Pediatric, Cardec DM Drops, C-Phen DM Drops, Sildec-PE DM Drops, Poly-Tussin DM, Ricotuss, Tri-Dex PE, Z-Dex 12 D, ED DM, Maxichlor PEH DM, Sildec-PE DM, EndaCof Drops, PE-Hist DM, HistadecDM, Dec-Chlorphen DM Drops, Robitussin Children's Nighttime Cough Long-Acting DM, SymPak DM, Broncopectol, Qual-Tussin, St. Joseph HBP Cough & Cold, Scot-Tussin DM, Robitussin Children's Cough & Cold Long-Acting, Robitussin Cough & Cold Long-Acting, Cold & Cough, Vicks Pediatric Formula 44m Cough & Cold Relief, Genelan NF, Zotex-DM, Ceron-DM, Rondex-DM, Rondex-DM Drops, Dec-Chlorphen DM, Ceron-DM Drops, Donatussin DM, Neotuss D, Extendryl DM, Rondec-DM, Trigofen DM Drops, Virdec DM, Tri-Vent DPC, Atuss DR, Corfen-DM, Uni-Tuss DM, Coldtuss-DR, De-Chlor DR, Father John's Medicine Plus, Norel DM, NeoTuss Plus, De-Chlor DM, Mintuss DR, Trital DM, Therahist, Triphenicol, Kophane, Threamine DM, Cheracol Plus, Tricodene NN, P Chlor DM, Dex PC, Tricodene Forte, Atuss DM, Centergy DM, Donatussin DM Drops, Nasohist-DM, DM-PE-Chlor, CP Dec-DM Drops, Bronkids, Nohist-DMX, Re DCP, Sonahist-DM, RE DCP Drops, PD-Cof Drops, PD-Cof, Cerose DM, Maxiphen ADT, Tussar DM, Liquituss R-DM, Albatussin SR, Relahist-DM, Zotex-12D, Statuss DM, NoHist-PDX, Uni-Tricof HC

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as spseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Effects on Lactation and Breastmilk

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

64

Last Revision Date

20170110

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