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Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Hydrocodone CP, Tussionex Pennkinetic, Chlor-Trimeton, Hydrocodone HD, Triaminic, Alka-Seltzer Plus Cold, Coricidin HBP Cold & Flu, Chlorpheniramine (Allergy), Allergy Relief, Naldecon, Show all 812 »Ceron, Tuzistra XR, Advil Allergy Sinus, Norel AD, Rondec, Hydrocodone GF, Coricidin D, Orlenta, Relasin-HC, Wal-finate, PCM, C-Phen DM, Tylenol Cold, Coughtuss, Deconamine, Sinarest, Coricidin HBP Cough & Cold, Protid, Triplex AD, Deconamine SR, Triall, Novahistine, Demazin, Sinus & Allergy PE, Stahist, Triac, Sudafed PE Sinus & Allergy, Nolamine, Pseudoephedrine Plus, Sinutab Ex-Strength, Duadacin, Allerest Maximum Strength, Teldrin, Coldcough Syrup, Notuss, Triant-HC, AlleRx Dose Pack PE (PM Dose), CP-Tannic, Denaze, Drize, Singlet, Alumadrine, Dehistine, Nohist PE, Norel SR, Tanafed, Anaplex, Triotann, Carepanto, Triaminic Night Time Cough & Runny Nose, Effective Strength Cough Syrup, Lohist, Endal CD, Codehist DH, Scot-Tussin DM, Phenagil, Genelan NF, Trital DM, Cardec, Histadec, Sonahist, Rynatan, CapCof, Pseudo CM TR, Equitan Pediatric, Aller-Chlor, Mintex, CPM-PSE DM Drops, Ordrine, Chlornade, Chlor-Mal, Chlorphen, Comhist, Mescolor, Linhist-LA, Chlorex A, Coldex, Coldcough PD, Alka-Seltzer Plus Cold Formula Sparkling Original Effervescent Tablets, Suclor, Histinex HC, Theraflu Flu, Cold and Cough Powder, Advil Allergy and Congestion Relief, Onset Forte, Allergy Multi-Symptom, Zutripro, Tussend, Colrex, Allpanto-S, Coricidin HBP Maximum Strength Flu, Quindal HD, Highland HC, H-C Tussive, Dristan Cold Multi Symptom Formula, Pyrroxate, Ryneze, Congestant, Tylenol Allergy Multi-Symptom, aeroHist, Sinapils, Pancof, Novasus, Duravent, PCM-LA, Allergy AM-PM Dose Pack, ScopoHist, Z-Cof HC, Hista-Vent PSE, Coldamine, Maxi-Tuss HCX, Relcof PSE, Relacon-HC, Allergy DN, Rhinaclear, Time-Hist QD, AllePak, Amdry-C, DryMax, Pediatex HC, JayCof-HC, Histinex PV, Welltuss HC, DriHist, Re-Drylex Jr, Extendryl JR, AlleRx Dose Pack, Rhinolar, Xiral SR, RelCof DN PSE, DuraHist, VisRx Dose Pack, Detuss, Notuss-Forte, Dallergy PSE, Rindal HD Plus, Ricobid NR, Suphedrine PE Sinus & Allergy, BP Allergy JR, AlleRx, NoHist LQ, Dallergy JR, Relera, Allerest PE, Hydro-PC II, AccuHist Drops, Phenylhistine, Ed A-Hist, Trigofen Drops, Rhinatate-NF, Virdec, Ny-Tannic, Nuhist, Hydron CP, Neo HC, Tusana-D, Relacon-HC NR, Poly-Tussin HD, Liquicough HC, DroTuss-CP, Amilon, Phendal-HD, Echotuss-HC, De-Chlor HC, De-Chlor HD, Atuss MS, Hydro-PC II Plus, PCM Allergy, Uni-Tricof HC, Histatab, P-V-Tussin Syrup, Duradryl Chewable, Aerohist Plus, Duradryl SR, Dallergy SR, Nohist Plus Jr, Atuss HD, Cordron-HC NR, Novahistine Elixir, Dallergy PE, CPM-PE-MSC, Extendryl SR, Prehist D, Extendryl Chews, Sinodec, ScopoHist-PE, Ah-Chew Ultra Tannate, SymPak PDX, Nohist Plus, DuraTan PE, NoHist EXT, Allergy DN II, AlleRx DF, RespiVent DF, Allerx Dose Pack DF, Dexodryl, Dexodryl Suspension, RelCof CPM, Advil Children's Allergy Sinus, ScopoHist Syrup, AlleRx Dose Pack (PM Dose), Allergy DN PE, RelCof PE, RelCof DN PE, Atuss HS, DriHist SR, DA Chewable, Omnihist L.A., Hydron PCS, Hydrotuss HC, Rescon Extended Release, Hydrocof-HC, QV-Allergy, Dallergy ER, Extendryl Seniors, Redur-PCM, KG-Tussin, Hexatussin, Ah-chew Ultra, Histatab PH, Hyphed, Tussin-V, A-G Tussin, Q-V Tussin, Aerokid, Ralix, Liqui-Allergy, AH-Chew, Duradryl, DA II, Hista-Vent DA, Duravent DA, Cordron-HC, Duradryl JR, Drysec, Durahist PE, Omnihist II LA, AH-Chew II, Norel SD, Chlor-Mes D, Ex-Histine, WE Allergy, Chlor-Mes, ChlorTan D, Chlorafed HS Timecelles, Codimal-LA, Kronofed-A-Jr, Dura-Tap/PD, Fedahist, Histalet, Biohist LA (old formulation), Novafed A, Duratuss DA, Clorfed, Fedahist Timecaps, Chlorphedrin SR, Rinade-BID, Suphenamine-SR, Isophen-DF, Kronofed-A, Duralex, Pseudocot-C, Colfed-A, D-Amine-SR, Deconomed SR, Durafed, Duotan, Ornade Spansules, Resaid, Or-Phen-Ade, Contac 12 Hour, Dura-Vent/A, Rhinolar-EX 12, Pyrichlor PE, Poly Hist PD (old formulation), Phena-S 12, MyHist-PD, ARM Allergy Relief, Condrin, Allerest 12 Hour, Vanex Forte-R, Histade CR, Chlor-Trimeton Decongestant, Genamin, Rhinolar-EX, Decongex-3, Equi-Nade, Gencold, ND Clear, Chlordrine SR, Histade, Re2+30, Sudal-12, Pediox Chewable, Dynahist-ER Pediatric, Tavist-DA, Hayfebrol Liquid, Suphedrine Plus, Atrohist Pediatric Capsule, Chlor-Trimeton Allergy Decongestant SR, C-Phed Tannate, De-Congestine, LoHist-D, Triaminic Softchews Cold and Allergy, Qdall, Dynahist ER, AccuHist Drops (old formulation), SudaHist, Sudal-12 Chewable, Dicel, Sudal-12 Tannate, SudoGest Sinus & Allergy, Genaphed Plus, Cophene No 2, Anamine, Klerist-D, Codimal-LA Half, Pseudochlor, Rescon-Ed, Anamine TD, Time-Hist, Chlorafed Timecelles, Brexin LA, Fedahist Gyrocaps, Clorfed II, Sudogest Plus, Neutrahist Drops, Ryna Liquid, Sudogest Cold & Allergy, Aller-Chlor Decongestant, Chlor-Trimeton Allergy Decongestant, Curaler, Chlorafed, Histafed LA, Conal, AllerTan, Sildec-PE Drops, Acta-Tabs PE, Sildec-PE, NoHist, Ed ChlorPed D, Rinate Pediatric, P-Tann D, Triaminic Cold & Allergy, B-Tuss, Actifed Cold and Allergy, Maxichlor PEH, Ry-Tann, Nalgest, West-Decon, Nalspan, Uni Decon, Sinucon Pediatric, Nalgestic Pediatric, Hista-Vadrin, Nalphen, Nalda-Relief Pediatric, Cardec Drops, CP Dec, PD-Hist D Drops, Ceron Drops, PD-Hist D, Tanahist-D, Dallergy Drops, Nasohist Pediatric, Ed A-Hist LA, Rynatan Pediatric, R-Tanna, Phenchlor Tannate Pediatric, Allan Tannate Pediatric, CP Dec Drops, C Phen Drops, C Phen, Tannate Pediatric, PediaTan D, Dec-Chlorphen Drops, Dec-Chlorphen, Chlor-Mes Jr, Rondex, Rondex Drops, Prop-A-Hist, Sinucon, Tritan, Tanamine, R-Tannamine, Tanoral, Url-Tannate Pediatric, Rhinatate, Tri-Tannate, Tanamine Pediatric, Tri-Tannate Pediatric, Rhinatate Pediatric, URL-Tannate, Ru-Hist Forte, Tri-Hist Pediatric, Phena-Plus, Tri Tann Pediatric, Nalex A 12, Tri-Gestan S, Chlorex-A 12, Histatan, Phena-S, Triotann Pediatric, Triple Tannate Pediatric, Tanoral Pediatric, Rhinacon A, Comhist LA, Q-Hist LA, Chlortox, Nalex-A, NoHist-A, Naldelate, Andecon Pediatric Drops, Histalet Forte, Vanex Forte, C-Hist-SR, Nalex-A SR, R-Tannate, Triotann-S, R-Tannamine Pediatric, Triotann-S Pediatric, Gelhist Pediatric, R-Tannate Pediatric, West-Decon M, Atrohist Pediatric, Rynatan-S Pediatric, Histatab Plus, Nasatuss, Rynatuss Pediatric, Quadratuss, Rynatuss, Rentamine Pediatric, Quad-Tuss, C-Tanna 12, Tussi-12, Tussizone-12 RF, Tannate 12 S, Trionate, Rentamine, Tuss Tan, Carbaphen 12, Tannate-12, XiraTuss, Tanni-Hist 12 RF, Tannic-12, Quad Tann, Tuss Tan Pediatric, Tetra Tannate Pediatric, Quad Tuss Pediatric, Quad Tann Pediatric, Tannic-12 S, Tussi-12S, Alka-Seltzer Plus Cold & Cough Formula Effervescent Tablets, Alka-Seltzer Plus Cold Formula Orange Zest Effervescent Tablets, Alka-Seltzer Plus Cold Formula Cherry Burst Effervescent Tablets, Atrohist Plus, Alka-Seltzer Plus Flu Formula (old formulation), Quelidrine, Allergy Sinus Maximum Strength, Cold Medicine Plus, Actifed Cold & Sinus, Rolatuss, Deconhist LA, Rolatuss-SR, Ru-Tuss, Respa-AR, SymPak II, Tustan 12S, Histacol LA, Bellahist-D LA, Protuss Tablet, Ex-Tuss, AccuHist LA, Exratuss, Tussi-12 (old formulation), Notuss-AC, Endacof-C, T- Koff, Pediacof, Codeprex, Lexuss 210, Codar AR, TL-Hist CM, Cotab A, Cotab AX, Pedituss, Demi-Cof, Novadyne DH, Co-Histine DH, Ryna-C, Codahistine-DH Elixir, Phenylhistine DH Expectorant, Decohistine DH, Dihistine DH, Tricode AR, Zodryl DAC, Phenylhistine DH, Tuxarin ER, Zodryl AC, Ed ChlorPed, Ed-Chlortan, Topco Allergy, Pharbechlor, TanaHist-PD, P-Tann, Phenagil CH, Carbaphen CH, DryMax AF, Ricobid H, Teldrin HBP Allergy, C.P.M., Allergy Time, Ed Chlor Ped Jr., Chlor-Phenit, Z-Tuss AC, Ed Chlor-Tan, ChlorTan, Chlo-Amine, Chlor-Trimeton Allergy SR, PediaTan, Sinutab Maximum Strength Caplets, Triaminicin, Multi Symptom Cold Relief, Alka-Seltzer Plus Severe Cold & Flu Formula Effervescent Tablets, Alka-Seltzer Plus Flu Formula, Alka-Seltzer Plus Severe Sinus & Cold Hot Drink Mix, Multi Symptom Cold (Night Formula), Cold Multi-Symptom (Nighttime), Theraflu Nighttime Severe Cold & Cough Caplets, Tylenol Cold Head Congestion Day and Night, Comtrex Nighttime Cold & Cough, XL-3 Xtra Cold and Cough, Dimetapp Children's Nighttime Flu, Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets, Comtrex Cold and Flu Maximum Strength Tablet, Comtrex Cold and Flu Maximum Strength Liquid, Genacol Maximum Strength, Childrens Tylenol Cold Plus Cough, Cough Formula M Multi-Symptom, Comtrex Day and Night, Triaminic Multi-Symptom Fever & Cold, Comtrex Cold and Flu Maximum Strength, Comtrex Maximum Strength Cold Relief, Contac Severe Cold and Flu Maximum Stength, Comtrex Cold & Cough Day Night, Tylenol Cold Head Congestion Nighttime, Mapap Cough & Sinus Formula, Vicks Formula 44 Custom Care Cough & Cold PM, Flu Relief BP, Coricidin HBP Multi-Symptom Cold (Night), PediaCare Cough & Runny Nose Plus Acetaminophen, Triaminic Multi-Symptom Fever, 999 Cold Remedy Granular, Cotabflu, Colrex Compound, Vicks NyQuil Cold & Flu Nighttime Relief (Alcohol Free), Tylenol Plus Children's Cough & Runny Nose, Coricidin HBP Day & Night Multi-Symptom Cold, Alka-Seltzer Plus Cold & Cough Formula Liquid, PediaCare Flu Plus Acetaminophen, Codral Cold and Flu + Cough Day and Night, Tylenol Cold Multi-Symptom Nighttime, PediaCare Multi-Symptom Cold Plus Acetaminophen, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, Dimetapp Children's Multi-Symptom Cold & Flu (old formulation), Tylenol Plus Children's Multi-Symptom Cold, Tylenol Plus Children's Flu, Contac Cold and Flu Maximum Strength, Theraflu Flu & Cough, Rhinogesic, Sinulin, Chlor-Trimeton Sinus, Comtrex Sinus and Nasal, Trital SR, Covangesic, Tylenol Sinus Congestion and Pain Cool Burst Day Night, Alka-Seltzer Plus Cold & Flu, HEB Allergy, Dryphen, Comtrex Nighttime Flu Therapy, Simplet, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Tylenol Allergy Sinus, Allerest Sinus, Tricom, Comtrex Allergy Sinus, Codimal, Kolephrin, Sine-Off Sinus/Cold, Hybrid CF, Medicidin-D, ConRx Allergy Sinus, Allergy Pain Relief, Allergy Sinus PE Pain Relief, Contac Cold + Flu (Night Formula), Gelpirin-CCF, Co-Apap, Theracaps Multi-Symptom Cough & Cold Reliever, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Triaminic Flu, Cough & Fever, PX Allergy Sinus PE, Robitussin Peak Cold Nighttime Nasal Relief, Comtrex Severe Cold & Sinus, Comtrex Flu Therapy, Tylenol Plus Children's Cold, XL-3 Cold Medicine, Tylenol Sinus Congestion & Pain Nighttime, Gendecon, Relief-PE, GNP Cold Relief Plus, Super Strength Sinadrin, Vicks Children’s NyQuil Cold & Cough, Tricodene SF, Novahistine DH, DiHydro-PE, Pancof-PD, Despec-PD, T-Tanna DM, Duotan DM, Esocor P, Mesehist DM, Triaminic-D Multi-Symptom Cold, Allres DS, Duohist DH, Tusscough DHC, Allfen A, Z-Tuss 2, SymPak, P Chlor GG, Ana-Kit, Bronkotuss, Tricof, Hydro-Tussin DHC, Dihydro-CP, Uni-Cof, AccuHist PDX Drops, Neutrahist PDX Drops, Vicks 44M Pediatric, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Kidcare Cough and Cold, Rhinosyn-DM, Threamine DM, Cheracol Plus, Therahist, Triphenicol, Kophane, Children's Nyquil, Rescon-DM, Atuss DS, Entre-S, Maxichlor PSE DM, Kidkare Cough/Cold, Dicel DM, Atuss-12 DM, Tanafed-DM, C-Phed DM, M-End DM, Donatussin Pediatric, Qual-Tussin Pediatric, Comtussin HC, Tuss-HC, Ventuss Syrup, Maxi-Tuss SA, Enplus-HD, Endal-HD Plus, Endotuss-HD, Ditussin-HC, Chemtussin HC, Exo-Tuss, Maxi-Tuss HC, KG-Dal HD Plus, Hi-Tuss HC, Chlorphen HD, Duradal HD, Liquitussin HC Syrup, Quindal HD Plus, Efasin-HD Plus, Uni Tuss HC, Histussin HC Liquid, Cytuss HC, Tuss-DS, KG-Dal HD, Tuss-PD, Chemdal HD, Iodal HD, Rindal-HD, Ed-TLC, Endagen-HD, Vituz, Lemohist Plus, S-T Forte 2, HyTan, TussiCaps, Efasin-HD, Guiaphen HD, Chlorgest HD, Ed-Tuss HC, Cyndal HD, Hyphen-HD, Iotussin HC, Hycomine Compound, Mintuss MS, Vanex-HD, Chemdal HD Plus, Tricodene NN, Tricodene Forte, Neo DM Drops, Nasohist-DM Pediatric, Cardec DM Drops, Balamine DM, CP Dec DM, HistadecDM, Rondex-DM, Rondex-DM Drops, Dec-Chlorphen DM, Dec-Chlorphen DM Drops, Reme Tussin DM, NoHist DM, Sildec-PE DM, DCP Drops, EndaCof Drops, PE-Hist DM, Sildec-PE DM Drops, C-Phen DM Drops, Tussplex DM, Norel CS, Cardec DM, Robitussin Cough & Allergy, Ceron-DM, Ceron-DM Drops, Robitussin Cough & Cold Long-Acting, Cold & Cough, Vicks Pediatric Formula 44m Cough & Cold Relief, St. Joseph HBP Cough & Cold, Robitussin Children's Cough & Cold Long-Acting, Dimetapp Children's Long Acting Cough Plus Cold, QC Cough/Cold, Primatuss 4, Tricodene Sugar Free, Triaminic Softchews Cough & Runny Nose, Robitussin Children's Nighttime Cough Long-Acting DM, SymPak DM, Neotuss D, Extendryl DM, Rondec-DM, Donatussin DM, Zotex-DM, Quartuss, Broncopectol, ChlorDex GP, Qual-Tussin, Maxichlor PEH DM, ED DM, Centergy DM, Atuss DM, Father John's Medicine Plus, Norel DM, Liquituss R-DM, Tussar DM, Relahist-DM, Albatussin SR, Cerose DM, Maxiphen ADT, NeoTuss Plus, De-Chlor DM, Mintuss DR, Ed A-Hist DM, P Chlor DM, Dex PC, Uni-Tuss DM, Corfen-DM, De-Chlor DR, Coldtuss-DR, Tri-Vent DPC, Atuss DR, NoHist-PDX, Statuss DM, Zoden DM Drops, Phenabid DM, Re DCP, Sonahist-DM, Virdec DM, Trigofen DM Drops, Poly-Tussin DM, Ricotuss, Tri-Dex PE, Z-Dex 12 D, RE DCP Drops, Nohist-DMX, PD-Cof Drops, PD-Cof, Zotex-12D, Quartuss DM, CP Dec-DM Drops, DM-PE-Chlor, Bronkids, Donatussin DM Drops, Nasohist-DM, Tussive HC

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as spseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Effects on Lactation and Breastmilk

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

64

Last Revision Date

20170110

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