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Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Tussionex Pennkinetic, Hydrocodone CP, Coricidin HBP Cold & Flu, Chlor-Trimeton, Alka-Seltzer Plus Cold, Coricidin HBP Cough & Cold, Sinarest, Chlorpheniramine (Allergy), Triaminic, Codral Cold and Flu + Cough Day and Night, Show all 814 »Rondec, PCM, Tuzistra XR, Norel AD, Tylenol Cold, Alka-Seltzer Plus Cold Formula Sparkling Original Effervescent Tablets, Poly-Tussin DM, Allergy Relief, Singlet, Naldecon, Brexin LA, Sudafed PE Sinus & Allergy, Cold & Cough, Simplet, Phenagil, Robitussin Children's Nighttime Cough Long-Acting DM, Novahistine, Theraflu Flu & Cough, Childrens Tylenol Cold Plus Cough, Effective Strength Cough Syrup, Hydrocodone GF, Allerest Maximum Strength, TussiCaps, Cold Medicine Plus, Anaplex, Decongex-3, Phenagil CH, Coricidin HBP Maximum Strength Flu, Robitussin Cough & Allergy, Tanoral, Stahist, Hydrocodone HD, Deconamine, Rinade-BID, Sonahist, Iodal HD, Carbaphen CH, Phenylhistine DH Expectorant, Children's Nyquil, Novasus, Kidkare Cough/Cold, CPM-PSE DM Drops, Tricode AR, Aller-Chlor, Pharbechlor, Rynatan, Allerest PE, C.P.M., Klerist-D, Coldcough Syrup, Wal-finate, Trionate, Sinutab Ex-Strength, Tricof, CapCof, Tuxarin ER, Suclor, Tavist-DA, Histacol LA, Fedahist Timecaps, Demazin, Coricidin D, Rhinatate, Vituz, Hydro-PC II, Coricidin HBP Multi-Symptom Cold (Night), Triaminic Softchews Cough & Runny Nose, Ed A-Hist DM, NeoTuss Plus, Father John's Medicine Plus, Vicks NyQuil Cold & Flu Nighttime Relief (Alcohol Free), Triaminic Multi-Symptom Fever, Sildec-PE DM, Cold Multi-Symptom (Nighttime), NoHist DM, Ceron-DM, Neotuss D, Triant-HC, Hydron PCS, Tylenol Children’s Cold + Flu, XL-3 Xtra Cold and Cough, Vicks Children’s NyQuil Cold & Cough, Cough Formula M Multi-Symptom, Comtrex Cold and Flu Maximum Strength Tablet, Allpanto-S, Relasin-HC, Ed A-Hist, Omnihist L.A., Duravent, Sinus & Allergy PE, Ceron, Cardec, Medicidin-D, Congestant, 999 Cold Remedy Granular, Dexodryl, Advil Allergy Sinus, Advil Allergy and Congestion Relief, ChlorDex GP, Hista-Vent PSE, Mescolor, Relcof PSE, PCM-LA, Dallergy PSE, RelCof DN PSE, AlleRx Dose Pack, Xiral SR, DuraHist, DryMax, Rhinolar, Dallergy Drops, Phenchlor Tannate Pediatric, DriHist, Extendryl JR, Re-Drylex Jr, Nasohist Pediatric, Coldamine, Amdry-C, AccuHist Drops, Chlor-Mes, Lohist, Nuhist, Dallergy JR, Relera, NoHist LQ, AlleRx, Ricobid NR, Suphedrine PE Sinus & Allergy, BP Allergy JR, Virdec, Ny-Tannic, Rhinatate-NF, Trigofen Drops, Phenylhistine, R-Tanna, Pseudo CM TR, Time-Hist QD, AllePak, Rhinaclear, Allergy DN, Rynatan Pediatric, Ed A-Hist LA, ScopoHist, Novahistine Elixir, Allergy AM-PM Dose Pack, Histatab Plus, VisRx Dose Pack, Histatab, Amilon, Nolamine, PCM Allergy, Hycomine Compound, Histatab PH, AlleRx DF, Hydrotuss HC, Hydrocof-HC, Cordron-HC, Cordron-HC NR, Atuss HD, Atuss HS, Advil Multi-Symptom Cold & Flu, Advil Children's Allergy Sinus, RelCof CPM, Allergy DN II, KG-Tussin, NoHist EXT, RespiVent DF, aeroHist, Allerx Dose Pack DF, Dexodryl Suspension, Ryneze, Dehistine, DriHist SR, Nohist PE, P-V-Tussin Syrup, A-G Tussin, RelCof PE, Zutripro, Relacon-HC NR, Tusana-D, Neo HC, Poly-Tussin HD, Liquicough HC, DroTuss-CP, Z-Cof HC, Maxi-Tuss HCX, Relacon-HC, Notuss-Forte, Q-V Tussin, Notuss, Detuss, Histinex PV, JayCof-HC, Pediatex HC, Tussend, Welltuss HC, Hexatussin, Hyphed, Tussin-V, RelCof DN PE, ScopoHist Syrup, Ah-chew Ultra, Omnihist II LA, Duradryl, Duradryl JR, Drize, Drysec, Ex-Histine, WE Allergy, Chlor-Mes D, Norel SD, Durahist PE, AH-Chew II, Liqui-Allergy, Ralix, Denaze, Aerokid, Dallergy ER, Extendryl Seniors, QV-Allergy, Rescon Extended Release, AlleRx Dose Pack PE (PM Dose), Redur-PCM, AH-Chew, DA II, AlleRx Dose Pack (PM Dose), CPM-PE-MSC, Allergy DN PE, DuraTan PE, Nohist Plus, Nohist Plus Jr, Dallergy SR, Duradryl Chewable, Aerohist Plus, Duradryl SR, Dallergy PE, Ah-Chew Ultra Tannate, Hista-Vent DA, Triall, SymPak PDX, ScopoHist-PE, Sinodec, Extendryl SR, Prehist D, Extendryl Chews, DA Chewable, Duravent DA, Ceron Drops, PD-Hist D Drops, Ed ChlorPed D, PD-Hist D, Kronofed-A-Jr, Novafed A, Duratuss DA, Clorfed, Histalet, Fedahist, Tanafed, Chlorafed HS Timecelles, Codimal-LA, Dura-Tap/PD, Biohist LA (old formulation), Orlenta, Chlorphedrin SR, Colfed-A, D-Amine-SR, Deconomed SR, Pseudocot-C, Duralex, Suphenamine-SR, Isophen-DF, Deconamine SR, Durafed, ND Clear, Condrin, Dura-Vent/A, Ornade Spansules, Resaid, Or-Phen-Ade, Contac 12 Hour, ARM Allergy Relief, Teldrin, Chlornade, Ordrine, Duotan, Equi-Nade, Gencold, Rhinolar-EX, Triac, Genamin, Allerest 12 Hour, Vanex Forte-R, Histade CR, Chlor-Trimeton Decongestant, Kronofed-A, Chlordrine SR, Triplex AD, C-Phed Tannate, Chlor-Trimeton Allergy Decongestant SR, Dynahist-ER Pediatric, CP-Tannic, Histade, Mintex, Re2+30, Sudal-12, Pediox Chewable, De-Congestine, Suphedrine Plus, Sudal-12 Chewable, Dicel, Sudal-12 Tannate, SudaHist, AccuHist Drops (old formulation), LoHist-D, Triaminic Softchews Cold and Allergy, Pseudoephedrine Plus, Qdall, Atrohist Pediatric Capsule, Hayfebrol Liquid, Anamine TD, Clorfed II, Time-Hist, Chlorafed Timecelles, Rescon-Ed, Pseudochlor, Cophene No 2, Anamine, Codimal-LA Half, Fedahist Gyrocaps, Curaler, SudoGest Sinus & Allergy, Chlorafed, Histafed LA, Chlor-Trimeton Allergy Decongestant, Aller-Chlor Decongestant, Sudogest Plus, Neutrahist Drops, Ryna Liquid, Sudogest Cold & Allergy, Genaphed Plus, Rhinolar-EX 12, MyHist-PD, Tanahist-D, Nalgest, NoHist, Maxichlor PEH, Ry-Tann, Hista-Vadrin, Nalphen, Nalda-Relief Pediatric, Nalgestic Pediatric, Sinucon Pediatric, West-Decon, Acta-Tabs PE, Nalspan, Uni Decon, Prop-A-Hist, Sinucon, Naldelate, Andecon Pediatric Drops, Histalet Forte, Vanex Forte, NoHist-A, Sildec-PE, Sildec-PE Drops, Rhinacon A, C Phen, Allan Tannate Pediatric, CP Dec Drops, Chlor-Mes Jr, Rondex, Rondex Drops, Dec-Chlorphen, Dec-Chlorphen Drops, C Phen Drops, Tannate Pediatric, Echotuss-HC, Histadec, PediaTan D, CP Dec, Cardec Drops, P-Tann D, Triaminic Cold & Allergy, ChlorTan D, Actifed Cold and Allergy, Rinate Pediatric, Nalex-A, Comhist, Phena-S 12, Triotann Pediatric, Tritan, Tanamine, R-Tannamine, URL-Tannate, Triotann, Ru-Hist Forte, Histatan, Phena-S, Chlorex-A 12, Rhinatate Pediatric, Tri-Gestan S, Tri-Hist Pediatric, Phena-Plus, Tri Tann Pediatric, Nalex A 12, AllerTan, Conal, Pyrichlor PE, Poly Hist PD (old formulation), Url-Tannate Pediatric, Tri-Tannate Pediatric, Linhist-LA, Rynatan-S Pediatric, Comhist LA, Q-Hist LA, Chlortox, C-Hist-SR, Nalex-A SR, Chlorex A, Coldex, West-Decon M, Atrohist Pediatric, R-Tannate Pediatric, Tanamine Pediatric, Gelhist Pediatric, R-Tannate, Triotann-S, R-Tannamine Pediatric, Triotann-S Pediatric, Tanoral Pediatric, Equitan Pediatric, Triple Tannate Pediatric, Tri-Tannate, Phendal-HD, Hyphen-HD, Rindal HD Plus, Tetra Tannate Pediatric, Quad-Tuss, Rynatuss Pediatric, Quadratuss, Rynatuss, Rentamine Pediatric, Rentamine, Tuss Tan, Tuss Tan Pediatric, Quad Tuss Pediatric, Tannate 12 S, Quad Tann Pediatric, Quad Tann, Tannic-12, Carbaphen 12, Tannate-12, XiraTuss, Tanni-Hist 12 RF, Exratuss, Tussi-12 (old formulation), C-Tanna 12, Tussizone-12 RF, Ricobid H, Rolatuss-SR, Rolatuss, Quelidrine, Alka-Seltzer Plus Flu Formula (old formulation), Alka-Seltzer Plus Cold & Cough Formula Effervescent Tablets, Alka-Seltzer Plus Cold Formula Orange Zest Effervescent Tablets, Alka-Seltzer Plus Cold Formula Cherry Burst Effervescent Tablets, Atrohist Plus, Deconhist LA, Protuss Tablet, Tussi-12, Ex-Tuss, AccuHist LA, Bellahist-D LA, Ru-Tuss, Respa-AR, SymPak II, Tustan 12S, Tussi-12S, Tannic-12 S, DryMax AF, P-Tann, Allergy Sinus Maximum Strength, Phenylhistine DH, Endacof-C, Endal CD, T- Koff, Pediacof, Pedituss, Demi-Cof, Dihistine DH, Zodryl DAC, Decohistine DH, Codeprex, Codehist DH, Novadyne DH, Co-Histine DH, Ryna-C, Codahistine-DH Elixir, Tricodene SF, QC Cough/Cold, Primatuss 4, Tricodene Sugar Free, Notuss-AC, Lexuss 210, TanaHist-PD, PediaTan, Ed ChlorPed, Ed-Chlortan, Topco Allergy, Teldrin HBP Allergy, Chlor-Mal, Chlo-Amine, Chlorphen, Chlor-Trimeton Allergy SR, ChlorTan, Cotab AX, Ed Chlor-Tan, Allergy Time, Ed Chlor Ped Jr., Chlor-Phenit, Z-Tuss AC, Zodryl AC, Codar AR, TL-Hist CM, Cotab A, Actifed Cold & Sinus, Sinutab Maximum Strength Caplets, Robitussin Children's Cough & Cold Long-Acting, Contac Severe Cold and Flu Maximum Stength, Alka-Seltzer Plus Severe Cold & Flu Formula Effervescent Tablets, Alka-Seltzer Plus Flu Formula, Alka-Seltzer Plus Severe Sinus & Cold Hot Drink Mix, Dimetapp Children's Nighttime Flu, Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets, Triaminic Multi-Symptom Fever & Cold, Comtrex Cold and Flu Maximum Strength, Comtrex Maximum Strength Cold Relief, Theraflu Flu, Cold and Cough Powder, Multi Symptom Cold Relief, Comtrex Day and Night, Comtrex Cold and Flu Maximum Strength Liquid, Genacol Maximum Strength, Contac Cold and Flu Maximum Strength, Co-Apap, Theracaps Multi-Symptom Cough & Cold Reliever, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Triaminic Flu, Cough & Fever, Gelpirin-CCF, Alka-Seltzer Plus Maximum Strength Cold & Cough Liquid Gels, Multi Symptom Cold (Night Formula), ConRx Allergy Sinus, Coricidin HBP Day & Night Multi-Symptom Cold, Cotabflu, Colrex Compound, Colrex, Tylenol Children’s Cold + Cough + Runny Nose, PediaCare Cough & Runny Nose Plus Acetaminophen, Mapap Cough & Sinus Formula, Vicks Formula 44 Custom Care Cough & Cold PM, Flu Relief BP, Tylenol Cold and Flu Severe Day & Night, Comtrex Nighttime Cold & Cough, Dimetapp Children's Multi-Symptom Cold & Flu (old formulation), PediaCare Multi-Symptom Cold Plus Acetaminophen, Alka-Seltzer Plus Cold & Cough Formula Liquid, PediaCare Flu Plus Acetaminophen, Tylenol Cold Multi-Symptom Nighttime, Tylenol Cold Head Congestion Nighttime, Comtrex Cold & Cough Day Night, Theraflu Nighttime Severe Cold & Cough Caplets, Tylenol Cold Head Congestion Day and Night, Contac Cold + Flu (Night Formula), Allergy Pain Relief, Triaminicin, Comtrex Nighttime Flu Therapy, Norel SR, Trital SR, Rhinogesic, Alumadrine, Duadacin, Sinulin, Chlor-Trimeton Sinus, Comtrex Sinus and Nasal, Tricom, Dryphen, Comtrex Allergy Sinus, Codimal, Kolephrin, Allerest Sinus, Tylenol Allergy Sinus, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Covangesic, HEB Allergy, Allergy Sinus PE Pain Relief, Dristan Cold Multi Symptom Formula, PX Allergy Sinus PE, Allergy Multi-Symptom, Pyrroxate, Robitussin Peak Cold Nighttime Nasal Relief, Relief-PE, Onset Forte, GNP Cold Relief Plus, Super Strength Sinadrin, Gendecon, Tylenol Allergy Multi-Symptom, Alka-Seltzer Plus Cold & Flu, Tylenol Sinus Congestion & Pain Nighttime, Comtrex Severe Cold & Sinus, Comtrex Flu Therapy, Tylenol Plus Children's Cold, Protid, XL-3 Cold Medicine, Hybrid CF, Sine-Off Sinus/Cold, Tylenol Sinus Congestion and Pain Cool Burst Day Night, Dimetapp Children's Long Acting Cough Plus Cold, Robitussin Cough & Cold Long-Acting, Uni-Tricof HC, P Chlor GG, Hydro-Tussin DHC, Dihydro-CP, Uni-Cof, Bronkotuss, Ana-Kit, Allfen A, Z-Tuss 2, SymPak, Donatussin Pediatric, Tusscough DHC, Qual-Tussin Pediatric, Lemohist Plus, S-T Forte 2, HyTan, Endagen-HD, Chemdal HD, Rindal-HD, Ed-TLC, Efasin-HD, Pancof, Duohist DH, Mintuss MS, Esocor P, M-End DM, Atuss-12 DM, Dicel DM, Atuss DS, Entre-S, Maxichlor PSE DM, Neutrahist PDX Drops, AccuHist PDX Drops, Mesehist DM, Despec-PD, Triaminic-D Multi-Symptom Cold, Allres DS, Duotan DM, T-Tanna DM, Pedia Relief Cough-Cold, Novahistine DH, DiHydro-PE, Coldcough PD, Pancof-PD, Guiaphen HD, Vanex-HD, Tanafed-DM, Hi-Tuss HC, Uni Tuss HC, H-C Tussive, Histussin HC Liquid, Cytuss HC, Tuss-DS, Efasin-HD Plus, Quindal HD Plus, Quindal HD, Chlorphen HD, KG-Dal HD Plus, Duradal HD, Liquitussin HC Syrup, Tussive HC, B-Tuss, Hydron CP, De-Chlor HD, De-Chlor HC, Atuss MS, Hydro-PC II Plus, Highland HC, Coughtuss, Chemdal HD Plus, Endotuss-HD, Nasatuss, Iotussin HC, Chlorgest HD, Ed-Tuss HC, Cyndal HD, Sinapils, Tuss-PD, KG-Dal HD, Ditussin-HC, Histinex HC, Chemtussin HC, Exo-Tuss, Endal-HD Plus, Enplus-HD, Comtussin HC, Tuss-HC, Ventuss Syrup, Maxi-Tuss SA, Maxi-Tuss HC, C-Phed DM, Rescon-DM, Carepanto, DCP Drops, Balamine DM, Reme Tussin DM, Tussplex DM, Norel CS, Cardec DM, C-Phen DM, C-Phen DM Drops, Sildec-PE DM Drops, EndaCof Drops, Nasohist-DM Pediatric, PE-Hist DM, Maxichlor PEH DM, ED DM, Ricotuss, Tri-Dex PE, Z-Dex 12 D, Trigofen DM Drops, Virdec DM, Zoden DM Drops, Cardec DM Drops, Neo DM Drops, Re DCP, Genelan NF, Vicks Pediatric Formula 44m Cough & Cold Relief, Triaminic Night Time Cough & Runny Nose, Scot-Tussin DM, St. Joseph HBP Cough & Cold, SymPak DM, Broncopectol, Qual-Tussin, Quartuss, Zotex-DM, CP Dec DM, Extendryl DM, Rondec-DM, Donatussin DM, Ceron-DM Drops, Rondex-DM, Rondex-DM Drops, Dec-Chlorphen DM, Dec-Chlorphen DM Drops, HistadecDM, Phenabid DM, Sonahist-DM, Kidcare Cough and Cold, Tricodene Forte, Tri-Vent DPC, Atuss DR, Corfen-DM, Uni-Tuss DM, Mintuss DR, Trital DM, P Chlor DM, Dex PC, Tricodene NN, De-Chlor DR, Cheracol Plus, Therahist, Triphenicol, Kophane, Threamine DM, Rhinosyn-DM, Vicks 44M Pediatric, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Coldtuss-DR, De-Chlor DM, RE DCP Drops, Quartuss DM, Nohist-DMX, Bronkids, Donatussin DM Drops, Nasohist-DM, DM-PE-Chlor, CP Dec-DM Drops, PD-Cof Drops, PD-Cof, Zotex-12D, Statuss DM, Norel DM, NoHist-PDX, Relahist-DM, Albatussin SR, Cerose DM, Maxiphen ADT, Tussar DM, Liquituss R-DM, Centergy DM, Atuss DM, Dynahist ER

Medically reviewed by Drugs.com. Last updated on Aug 30, 2018.

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as spseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Effects on Lactation and Breastmilk

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Breast Feeding

Lactation

Antihistamines

Administrative Information

LactMed Record Number

64

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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