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Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Hydrocodone CP, Hydrocodone HD, Tussionex Pennkinetic, Triaminic, Alka-Seltzer Plus Cold, Coricidin HBP Cold & Flu, Chlor-Trimeton, Coricidin HBP Cough & Cold, Chlorpheniramine (Allergy), Coricidin D, Show all 810 »Sinarest, Chlorphen, Aller-Chlor, Rondec, Norel AD, Allergy Relief, Coughtuss, Hydrocodone GF, Novasus, Rynatan, Tuzistra XR, Alka-Seltzer Plus Cold Formula Sparkling Original Effervescent Tablets, Phenagil CH, Protid, Coricidin HBP Maximum Strength Flu, Triant-HC, Tylenol Cold, ChlorDex GP, Demazin, Hydron PCS, Stahist, Ed A-Hist, Tanoral, Deconamine, Dicel DM, Orlenta, Ceron, Effective Strength Cough Syrup, Simplet, Amilon, Cold Medicine Plus, Ru-Hist Forte, Sudafed PE Sinus & Allergy, Coldcough Syrup, Aerohist Plus, Duravent, PCM, TussiCaps, Zutripro, Hydrocof-HC, Ralix, Alumadrine, Carbaphen CH, Singlet, NoHist DM, Dihydro-CP, Curaler, Fedahist, Clorfed, Cophene No 2, Brexin LA, Rinade-BID, Klerist-D, Phenylhistine DH Expectorant, Lexuss 210, Codeprex, C-Tanna 12, Notuss-AC, Coldamine, DuraHist, Triplex AD, Triphenicol, Triotann, Triaminic-D Multi-Symptom Cold, Ru-Tuss, Coldcough PD, Codehist DH, Chlorafed, Sinutab Ex-Strength, Duotan, Phenylhistine DH, Sinucon, ARM Allergy Relief, Condrin, Naldecon, Durafed, Pseudoephedrine Plus, Actifed Cold and Allergy, Sildec-PE, Tri-Vent DPC, Welltuss HC, Triaminic Cold & Allergy, Advil Allergy Sinus, Allerest PE, Sinus & Allergy PE, Vicks NyQuil Cold & Flu Nighttime Relief (Alcohol Free), Vicks Formula 44 Custom Care Cough & Cold PM, SudaHist, Coricidin HBP Day & Night Multi-Symptom Cold, Codral Cold and Flu + Cough Day and Night, Ceron-DM, Rondex-DM, Coldtuss-DR, Father John's Medicine Plus, DCP Drops, Theraflu Flu, Cold and Cough Powder, Dex PC, Sine-Off Sinus/Cold, Dristan Cold Multi Symptom Formula, Gendecon, Medicidin-D, Alka-Seltzer Plus Cold & Flu, Cyndal HD, Chlor-Mes, Chlor-Mes D, AH-Chew, Quindal HD, Allergy Multi-Symptom, De-Chlor HC, NoHist LQ, RespiVent DF, Ryneze, Carepanto, Relasin-HC, QC Cough/Cold, AlleRx Dose Pack, Rhinolar, Dallergy PSE, DryMax, DriHist, Xiral SR, AccuHist Drops, RelCof DN PSE, Redur-PCM, Histatab Plus, Phenylhistine, Novahistine Elixir, Ah-chew Ultra, Histatab PH, Re-Drylex Jr, PCM Allergy, Extendryl JR, Ricobid NR, Allergy DN, Pseudo CM TR, Rhinaclear, Novahistine, Relera, Dallergy JR, ScopoHist, Nuhist, Histatab, Nolamine, VisRx Dose Pack, Allergy AM-PM Dose Pack, Lohist, AlleRx, Sonahist, Relcof PSE, BP Allergy JR, Virdec, Ny-Tannic, Rhinatate-NF, Suphedrine PE Sinus & Allergy, Mescolor, Time-Hist QD, AllePak, Amdry-C, PCM-LA, Hista-Vent PSE, Trigofen Drops, CPM-PE-MSC, Cordron-HC NR, Atuss HD, Atuss HS, Advil Allergy and Congestion Relief, Cordron-HC, Hydrotuss HC, Q-V Tussin, A-G Tussin, KG-Tussin, P-V-Tussin Syrup, Advil Children's Allergy Sinus, RelCof CPM, Dexodryl Suspension, Dexodryl, Dehistine, DriHist SR, Allerx Dose Pack DF, aeroHist, AlleRx DF, Allergy DN II, NoHist EXT, Tussin-V, Hyphed, Neo HC, Poly-Tussin HD, Liquicough HC, DroTuss-CP, Tusana-D, Relacon-HC NR, Rindal HD Plus, Echotuss-HC, Phendal-HD, Z-Cof HC, Maxi-Tuss HCX, JayCof-HC, Pediatex HC, Tussend, Hexatussin, Histinex PV, Detuss, Relacon-HC, Notuss-Forte, Notuss, Nohist PE, RelCof DN PE, Duradryl JR, Drize, Drysec, Ex-Histine, Duradryl, Liqui-Allergy, Duravent DA, Hista-Vent DA, DA II, WE Allergy, Norel SD, Dallergy ER, Extendryl Seniors, QV-Allergy, Rescon Extended Release, Aerokid, Denaze, Durahist PE, Omnihist II LA, AH-Chew II, Omnihist L.A., DA Chewable, Nohist Plus, Nohist Plus Jr, Dallergy SR, Duradryl Chewable, DuraTan PE, Allergy DN PE, RelCof PE, ScopoHist Syrup, AlleRx Dose Pack (PM Dose), Duradryl SR, Dallergy PE, Sinodec, Extendryl SR, Prehist D, Extendryl Chews, ScopoHist-PE, SymPak PDX, Ed A-Hist LA, Ah-Chew Ultra Tannate, Triall, AlleRx Dose Pack PE (PM Dose), Ed ChlorPed D, Tanafed, Chlorafed HS Timecelles, Codimal-LA, Kronofed-A-Jr, Histalet, Duratuss DA, Chlor-Trimeton Decongestant, Biohist LA (old formulation), Deconamine SR, Novafed A, Dura-Tap/PD, Fedahist Timecaps, Duralex, Suphenamine-SR, Isophen-DF, Kronofed-A, Pseudocot-C, Deconomed SR, Chlorphedrin SR, Colfed-A, D-Amine-SR, Histade CR, Vanex Forte-R, Dura-Vent/A, Ornade Spansules, Resaid, Or-Phen-Ade, Rhinolar-EX 12, MyHist-PD, Conal, Pyrichlor PE, Poly Hist PD (old formulation), Phena-S 12, Contac 12 Hour, Teldrin, Rhinolar-EX, Triac, Genamin, Allerest 12 Hour, Gencold, Equi-Nade, Chlornade, Ordrine, Decongex-3, ND Clear, Chlordrine SR, Mintex, Suclor, Re2+30, Sudal-12, Histade, CP-Tannic, Allerest Maximum Strength, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, Dynahist-ER Pediatric, Pediox Chewable, C-Phed Tannate, LoHist-D, Triaminic Softchews Cold and Allergy, Qdall, Dynahist ER, AccuHist Drops (old formulation), Sudal-12 Tannate, De-Congestine, Sudal-12 Chewable, Dicel, Atrohist Pediatric Capsule, Suphedrine Plus, Anaplex, Anamine, Codimal-LA Half, Fedahist Gyrocaps, Pseudochlor, Rescon-Ed, Anamine TD, Time-Hist, Chlorafed Timecelles, Clorfed II, Histafed LA, Sudogest Cold & Allergy, Genaphed Plus, SudoGest Sinus & Allergy, Hayfebrol Liquid, Ryna Liquid, Neutrahist Drops, Chlor-Trimeton Allergy Decongestant, Aller-Chlor Decongestant, Sudogest Plus, AllerTan, Nalex A 12, Acta-Tabs PE, NoHist, Maxichlor PEH, Ry-Tann, Sildec-PE Drops, Cardec, P-Tann D, ChlorTan D, Rinate Pediatric, Uni-Tricof HC, Hista-Vadrin, Nalphen, Nalspan, Uni Decon, Prop-A-Hist, Naldelate, West-Decon, Nalgest, Nalda-Relief Pediatric, Nalgestic Pediatric, Sinucon Pediatric, Cardec Drops, CP Dec, Ceron Drops, PD-Hist D, Tanahist-D, Allan Tannate Pediatric, PD-Hist D Drops, Dallergy Drops, R-Tanna, Phenchlor Tannate Pediatric, Nasohist Pediatric, CP Dec Drops, Chlor-Mes Jr, C Phen, Tannate Pediatric, Histadec, PediaTan D, C Phen Drops, Dec-Chlorphen Drops, Rondex, Rondex Drops, Dec-Chlorphen, Andecon Pediatric Drops, Histalet Forte, Rhinatate Pediatric, Rhinatate, Url-Tannate Pediatric, Tritan, Tri-Tannate Pediatric, Tanamine Pediatric, Tanoral Pediatric, Equitan Pediatric, Triple Tannate Pediatric, Tri-Tannate, Tanamine, R-Tannamine, Tri-Gestan S, Tri-Hist Pediatric, Phena-Plus, Tri Tann Pediatric, Chlorex-A 12, Triotann Pediatric, URL-Tannate, Histatan, Phena-S, Triotann-S Pediatric, R-Tannamine Pediatric, Linhist-LA, Comhist LA, Q-Hist LA, Chlortox, Comhist, Rhinacon A, Vanex Forte, NoHist-A, Nalex-A, C-Hist-SR, Nalex-A SR, R-Tannate Pediatric, Gelhist Pediatric, R-Tannate, Triotann-S, Rynatan-S Pediatric, Atrohist Pediatric, Chlorex A, Coldex, West-Decon M, Rynatan Pediatric, Iotussin HC, Rynatuss, Rentamine Pediatric, Rentamine, Tuss Tan, Quadratuss, Rynatuss Pediatric, Tussizone-12 RF, Tannate 12 S, Trionate, Quad-Tuss, Tuss Tan Pediatric, Tetra Tannate Pediatric, XiraTuss, Tanni-Hist 12 RF, Exratuss, Tussi-12 (old formulation), Tannate-12, Carbaphen 12, Quad Tuss Pediatric, Quad Tann Pediatric, Quad Tann, Tannic-12, Tussi-12, Tannic-12 S, Alka-Seltzer Plus Cold & Cough Formula Effervescent Tablets, Alka-Seltzer Plus Cold Formula Orange Zest Effervescent Tablets, Alka-Seltzer Plus Cold Formula Cherry Burst Effervescent Tablets, Atrohist Plus, Alka-Seltzer Plus Flu Formula (old formulation), Quelidrine, Sinutab Maximum Strength Caplets, Allergy Sinus Maximum Strength, Actifed Cold & Sinus, Rolatuss, Deconhist LA, Rolatuss-SR, Respa-AR, SymPak II, Tustan 12S, Tussi-12S, Histacol LA, Bellahist-D LA, Protuss Tablet, Ex-Tuss, AccuHist LA, DryMax AF, Ricobid H, Pediacof, Pedituss, Demi-Cof, Dihistine DH, T- Koff, Endal CD, Cotab A, Cotab AX, Endacof-C, CapCof, Tricode AR, Zodryl DAC, Vicks Children’s NyQuil Cold & Cough, Tricodene SF, Primatuss 4, Tricodene Sugar Free, Codahistine-DH Elixir, Ryna-C, Decohistine DH, Novadyne DH, Co-Histine DH, TL-Hist CM, Codar AR, Teldrin HBP Allergy, C.P.M., Chlor-Mal, Chlo-Amine, Pharbechlor, Topco Allergy, P-Tann, TanaHist-PD, Ed ChlorPed, Ed-Chlortan, Chlor-Trimeton Allergy SR, PediaTan, Chlor-Phenit, Z-Tuss AC, Zodryl AC, Tuxarin ER, Ed Chlor Ped Jr., Allergy Time, Wal-finate, ChlorTan, Ed Chlor-Tan, Triaminicin, Sinarest Extra Strength, Alka-Seltzer Plus Flu Formula, Alka-Seltzer Plus Severe Sinus & Cold Hot Drink Mix, Dimetapp Children's Nighttime Flu, Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets, Alka-Seltzer Plus Severe Cold & Flu Formula Effervescent Tablets, Multi Symptom Cold Relief, Comtrex Nighttime Cold & Cough, XL-3 Xtra Cold and Cough, Cold Multi-Symptom (Nighttime), Multi Symptom Cold (Night Formula), Triaminic Multi-Symptom Fever & Cold, Comtrex Cold and Flu Maximum Strength, Comtrex Cold and Flu Maximum Strength Liquid, Genacol Maximum Strength, Childrens Tylenol Cold Plus Cough, Contac Cold and Flu Maximum Strength, Comtrex Cold and Flu Maximum Strength Tablet, Cough Formula M Multi-Symptom, Comtrex Maximum Strength Cold Relief, Contac Severe Cold and Flu Maximum Stength, Comtrex Day and Night, Tylenol Cold Head Congestion Day and Night, Theraflu Nighttime Severe Cold & Cough Caplets, PediaCare Cough & Runny Nose Plus Acetaminophen, Mapap Cough & Sinus Formula, Flu Relief BP, Coricidin HBP Multi-Symptom Cold (Night), Triaminic Multi-Symptom Fever, Colrex, Sinapils, Congestant, Cotabflu, Colrex Compound, Tylenol Plus Children's Cough & Runny Nose, Dimetapp Children's Multi-Symptom Cold & Flu (old formulation), PediaCare Flu Plus Acetaminophen, Tylenol Cold Multi-Symptom Nighttime, Tylenol Cold Head Congestion Nighttime, Comtrex Cold & Cough Day Night, Alka-Seltzer Plus Cold & Cough Formula Liquid, PediaCare Multi-Symptom Cold Plus Acetaminophen, Tylenol Plus Children's Multi-Symptom Cold, Tylenol Plus Children's Flu, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, Theraflu Flu & Cough, Allpanto-S, Rhinogesic, Duadacin, Sinulin, Chlor-Trimeton Sinus, Trital SR, Norel SR, Tylenol Sinus Congestion and Pain Cool Burst Day Night, HEB Allergy, Dryphen, Covangesic, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Tylenol Allergy Sinus, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Allerest Sinus, Kolephrin, Tricom, Comtrex Allergy Sinus, Codimal, Hybrid CF, XL-3 Cold Medicine, ConRx Allergy Sinus, Allergy Pain Relief, Allergy Sinus PE Pain Relief, PX Allergy Sinus PE, Contac Cold + Flu (Night Formula), Gelpirin-CCF, Co-Apap, Theracaps Multi-Symptom Cough & Cold Reliever, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Triaminic Flu, Cough & Fever, Pyrroxate, Robitussin Peak Cold Nighttime Nasal Relief, Tylenol Sinus Congestion & Pain Nighttime, Comtrex Severe Cold & Sinus, Comtrex Flu Therapy, Tylenol Plus Children's Cold, Tylenol Allergy Multi-Symptom, Super Strength Sinadrin, Relief-PE, Onset Forte, GNP Cold Relief Plus, Triaminic Softchews Cough & Runny Nose, Dimetapp Children's Long Acting Cough Plus Cold, Uni-Cof, Bronkotuss, Ana-Kit, Allfen A, Hydro-Tussin DHC, Tricof, Despec-PD, Duohist DH, Tusscough DHC, Pancof, Z-Tuss 2, SymPak, HyTan, Vituz, Endagen-HD, Chemdal HD, S-T Forte 2, Lemohist Plus, P Chlor GG, Donatussin Pediatric, Qual-Tussin Pediatric, Pancof-PD, DiHydro-PE, M-End DM, Atuss-12 DM, Atuss DS, Entre-S, C-Phed DM, Tanafed-DM, Creomulsion Pediatric, Kidcare Cough and Cold, Children's Nyquil, Rescon-DM, Maxichlor PSE DM, Kidkare Cough/Cold, Allres DS, Duotan DM, T-Tanna DM, Novahistine DH, Mesehist DM, Esocor P, Neutrahist PDX Drops, AccuHist PDX Drops, CPM-PSE DM Drops, Iodal HD, Rindal-HD, Histussin HC Liquid, Cytuss HC, Tuss-DS, Efasin-HD Plus, H-C Tussive, Uni Tuss HC, Maxi-Tuss HC, Histinex HC, KG-Dal HD Plus, Highland HC, Quindal HD Plus, Hi-Tuss HC, Hydro-PC II, Hydron CP, De-Chlor HD, Atuss MS, B-Tuss, Tussive HC, Chlorphen HD, Duradal HD, Liquitussin HC Syrup, Maxi-Tuss SA, Ventuss Syrup, Nasatuss, Hycomine Compound, Chlorgest HD, Ed-Tuss HC, Chemdal HD Plus, Vanex-HD, Ed-TLC, Efasin-HD, Guiaphen HD, Mintuss MS, Hyphen-HD, Tuss-PD, Endal-HD Plus, Enplus-HD, Comtussin HC, Tuss-HC, Exo-Tuss, Chemtussin HC, KG-Dal HD, Endotuss-HD, Ditussin-HC, Creomulsion Cough/Cold/Allergy, Vicks 44M Pediatric, Tussplex DM, Norel CS, Cardec DM, C-Phen DM, Reme Tussin DM, Balamine DM, CP Dec DM, Neo DM Drops, Nasohist-DM Pediatric, Cardec DM Drops, Robitussin Cough & Allergy, C-Phen DM Drops, ED DM, Poly-Tussin DM, Ricotuss, Tri-Dex PE, Maxichlor PEH DM, PE-Hist DM, Sildec-PE DM Drops, Sildec-PE DM, EndaCof Drops, HistadecDM, Dec-Chlorphen DM Drops, St. Joseph HBP Cough & Cold, Robitussin Children's Nighttime Cough Long-Acting DM, SymPak DM, Broncopectol, Scot-Tussin DM, Triaminic Night Time Cough & Runny Nose, Robitussin Children's Cough & Cold Long-Acting, Robitussin Cough & Cold Long-Acting, Cold & Cough, Vicks Pediatric Formula 44m Cough & Cold Relief, Qual-Tussin, Quartuss, Donatussin DM, Ceron-DM Drops, Rondex-DM Drops, Dec-Chlorphen DM, Rondec-DM, Extendryl DM, Genelan NF, Zotex-DM, Neotuss D, Z-Dex 12 D, Trigofen DM Drops, De-Chlor DR, Atuss DR, Corfen-DM, Uni-Tuss DM, De-Chlor DM, NeoTuss Plus, Liquituss R-DM, Centergy DM, Atuss DM, Norel DM, Mintuss DR, Trital DM, Therahist, Kophane, Threamine DM, Rhinosyn-DM, Cheracol Plus, Tricodene NN, Ed A-Hist DM, P Chlor DM, Tricodene Forte, Tussar DM, Maxiphen ADT, Nohist-DMX, Bronkids, Donatussin DM Drops, Nasohist-DM, RE DCP Drops, Sonahist-DM, Virdec DM, Zoden DM Drops, Phenabid DM, Re DCP, DM-PE-Chlor, CP Dec-DM Drops, NoHist-PDX, Relahist-DM, Albatussin SR, Cerose DM, Statuss DM, Quartuss DM, PD-Cof Drops, PD-Cof, Zotex-12D, Hydro-PC II Plus

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as spseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Effects on Lactation and Breastmilk

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

64

Last Revision Date

20170110

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