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Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Tussionex Pennkinetic, Alka-Seltzer Plus Cold, Coricidin HBP Cold & Flu, Chlor-Trimeton, Coricidin HBP Cough & Cold, Theraflu Flu, Cold and Cough Powder, Tuzistra XR, Coricidin D, Phenagil CH, Triaminic, Show all 805 »Rondec, Triplex AD, Sinutab Ex-Strength, Allergy Relief, Wal-finate, Alka-Seltzer Plus Cold Formula Sparkling Original Effervescent Tablets, Relasin-HC, Singlet, TussiCaps, Coldcough Syrup, Deconamine, Vituz, Ed A-Hist, Zutripro, Sinarest, Aller-Chlor, Norel AD, Triall, Cardec, Sinodec, Advil Allergy Sinus, Ceron, Allpanto-S, Hydrocodone HD, Orlenta, Triaminic Softchews Cough & Runny Nose, Chlor-Trimeton Allergy SR, Sinucon, CapCof, B-Tuss, Exo-Tuss, AlleRx Dose Pack, Phenabid DM, Triant-HC, Dallergy PE, Nalex A 12, Chlorphen, Ornade Spansules, Triaminic Cold & Allergy, Rondex, Brexin LA, Duralex, Robitussin Cough & Cold Long-Acting, LoHist-D, Rynatan, R-Tanna, Ana-Kit, Novasus, Lexuss 210, Demazin, Colrex, Tylenol Cold, Cough Formula M Multi-Symptom, Triaminic Multi-Symptom Fever, Hyphed, Coricidin HBP Maximum Strength Flu, Vicks NyQuil Cold & Flu Nighttime Relief (Alcohol Free), AccuHist PDX Drops, M-End DM, Coricidin HBP Multi-Symptom Cold (Night), Triac, Stahist, Dura-Vent/A, Resaid, Kidcare Cough and Cold, Tanoral, CP Dec, Sinapils, AlleRx DF, AlleRx, Lemohist Plus, Congestant, Novahistine, Relera, Amilon, Trionate, Codral Cold and Flu + Cough Day and Night, AllePak, Allergy AM-PM Dose Pack, Coricidin HBP Day & Night Multi-Symptom Cold, Codeprex, ChlorTan, Triaminic-D Multi-Symptom Cold, XL-3 Xtra Cold and Cough, Cotab A, West-Decon M, Carbaphen 12, Rondec-DM, Effective Strength Cough Syrup, Nalphen, Hexatussin, Coldcough PD, Tricode AR, Phenylhistine DH, Codahistine-DH Elixir, CPM-PSE DM Drops, Alka-Seltzer Plus Cold Formula Orange Zest Effervescent Tablets, HyTan, NoHist DM, Trital SR, Ceron-DM, Duadacin, Sudogest Cold & Allergy, Allerest Maximum Strength, Sildec-PE DM, NeoTuss Plus, Ventuss Syrup, Hydrocodone CP, Chemtussin HC, Vanex-HD, Corfen-DM, Novafed A, Pseudochlor, Cardec DM, Time-Hist, Histalet, Isophen-DF, Protid, Tanafed, Ah-chew Ultra, Comtrex Allergy Sinus Maximum Strength, Tylenol Sinus Congestion and Pain Cool Burst Day Night, Kolephrin, Codimal, PCM, Comtrex Cold and Flu Maximum Strength Tablet, DuraHist, Ny-Tannic, Virdec, DryMax, PCM Allergy, BP Allergy JR, RelCof DN PSE, Allerest PE, Re-Drylex Jr, Xiral SR, AccuHist Drops, Extendryl JR, Dallergy PSE, Ed A-Hist LA, Histatab Plus, Notuss-Forte, Novahistine Elixir, Rhinatate-NF, DriHist, Trigofen Drops, Phenylhistine, Rhinolar, Allergy DN, Nolamine, Z-Cof HC, Histatab, Maxi-Tuss HCX, VisRx Dose Pack, Notuss, DroTuss-CP, NoHist LQ, Dallergy JR, Nuhist, Lohist, ScopoHist, Relacon-HC, PCM-LA, Amdry-C, Hista-Vent PSE, Suphedrine PE Sinus & Allergy, Mescolor, Time-Hist QD, Rhinaclear, Sonahist, Ricobid NR, Coldamine, Pseudo CM TR, Relcof PSE, Q-V Tussin, Cordron-HC NR, Cordron-HC, Hydrocof-HC, Duradryl Chewable, Atuss HD, Atuss HS, RelCof CPM, Advil Children's Allergy Sinus, Advil Allergy and Congestion Relief, Aerohist Plus, Duradryl SR, ScopoHist-PE, Extendryl SR, Prehist D, Hydrotuss HC, SymPak PDX, CPM-PE-MSC, Hydron PCS, Ah-Chew Ultra Tannate, Allergy DN II, Dallergy SR, RelCof DN PE, RelCof PE, ScopoHist Syrup, Nohist PE, DriHist SR, Dexodryl, Duravent, Dehistine, AlleRx Dose Pack (PM Dose), Allergy DN PE, RespiVent DF, NoHist EXT, Nohist Plus Jr, aeroHist, Allerx Dose Pack DF, DuraTan PE, Nohist Plus, Dexodryl Suspension, Rynatan Pediatric, P-V-Tussin Syrup, Ryneze, Extendryl Seniors, QV-Allergy, Tussin-V, Dallergy ER, Aerokid, AH-Chew II, Ralix, Denaze, Welltuss HC, Tussend, Redur-PCM, Histatab PH, Chlor-Mes, AlleRx Dose Pack PE (PM Dose), Rescon Extended Release, Pediatex HC, JayCof-HC, Histinex PV, Omnihist II LA, Durahist PE, Duravent DA, Hista-Vent DA, DA II, A-G Tussin, Omnihist L.A., KG-Tussin, Extendryl Chews, DA Chewable, Liqui-Allergy, AH-Chew, WE Allergy, Chlor-Mes D, Norel SD, Ex-Histine, Drysec, Duradryl, Duradryl JR, Drize, Detuss, Nalda-Relief Pediatric, Fedahist, Chlorafed HS Timecelles, Codimal-LA, Kronofed-A-Jr, Clorfed, Duratuss DA, Duotan, Durafed, Biohist LA (old formulation), Deconamine SR, Dura-Tap/PD, Fedahist Timecaps, Rinade-BID, Suphenamine-SR, Kronofed-A, ND Clear, Pseudocot-C, Deconomed SR, Chlorphedrin SR, Colfed-A, D-Amine-SR, Chlor-Trimeton Decongestant, Histade CR, Rhinolar-EX 12, Or-Phen-Ade, Contac 12 Hour, ARM Allergy Relief, MyHist-PD, Phena-S 12, Conal, Pyrichlor PE, Poly Hist PD (old formulation), Teldrin, Chlornade, Rhinolar-EX, Genamin, Allerest 12 Hour, Vanex Forte-R, Gencold, Equi-Nade, Condrin, Ordrine, Decongex-3, Chlordrine SR, Anamine TD, Suclor, Re2+30, Sudal-12, Pediox Chewable, Mintex, Histade, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, Dynahist-ER Pediatric, CP-Tannic, C-Phed Tannate, De-Congestine, Triaminic Softchews Cold and Allergy, Pseudoephedrine Plus, Qdall, Dynahist ER, AccuHist Drops (old formulation), SudaHist, Sudal-12 Chewable, Dicel, Sudal-12 Tannate, Atrohist Pediatric Capsule, Suphedrine Plus, Klerist-D, Codimal-LA Half, Fedahist Gyrocaps, Clorfed II, Anamine, Anaplex, Chlorafed Timecelles, Rescon-Ed, Cophene No 2, Curaler, Chlorafed, Ryna Liquid, Genaphed Plus, SudoGest Sinus & Allergy, Hayfebrol Liquid, Neutrahist Drops, Sudogest Plus, Histafed LA, Chlor-Trimeton Allergy Decongestant, Aller-Chlor Decongestant, AllerTan, Tri Tann Pediatric, NoHist, Maxichlor PEH, Ry-Tann, Hista-Vadrin, Sildec-PE, Acta-Tabs PE, Actifed Cold and Allergy, Rinate Pediatric, Ed ChlorPed D, Sildec-PE Drops, Liquicough HC, Nalgestic Pediatric, Prop-A-Hist, Naldelate, Andecon Pediatric Drops, Naldecon, Uni Decon, Nalspan, Sinucon Pediatric, Nalgest, West-Decon, ChlorTan D, P-Tann D, PD-Hist D, Tanahist-D, Allan Tannate Pediatric, CP Dec Drops, Ceron Drops, PD-Hist D Drops, Nasohist Pediatric, Dallergy Drops, Sinus & Allergy PE, Chlor-Mes Jr, Rondex Drops, Histadec, PediaTan D, Sudafed PE Sinus & Allergy, Cardec Drops, Tannate Pediatric, C Phen, Dec-Chlorphen, Dec-Chlorphen Drops, C Phen Drops, Histalet Forte, Vanex Forte, Rhinatate, Url-Tannate Pediatric, Tritan, Tanamine, Rhinatate Pediatric, Tri-Tannate Pediatric, Triple Tannate Pediatric, Tri-Tannate, Tanamine Pediatric, R-Tannamine, URL-Tannate, Chlorex-A 12, Tri-Gestan S, Tri-Hist Pediatric, Phena-Plus, Triotann Pediatric, Phena-S, Triotann, Ru-Hist Forte, Histatan, Equitan Pediatric, Tanoral Pediatric, Comhist LA, Q-Hist LA, Chlortox, C-Hist-SR, Linhist-LA, Comhist, NoHist-A, Nalex-A, Rhinacon A, Nalex-A SR, Chlorex A, R-Tannate, Triotann-S, R-Tannamine Pediatric, Triotann-S Pediatric, Gelhist Pediatric, R-Tannate Pediatric, Coldex, Atrohist Pediatric, Rynatan-S Pediatric, Phenchlor Tannate Pediatric, Cyndal HD, Quad Tuss Pediatric, Quad Tann Pediatric, Quad Tann, Tannic-12, Tetra Tannate Pediatric, Tuss Tan Pediatric, Rynatuss, Rentamine Pediatric, Rentamine, Tuss Tan, Tannate-12, XiraTuss, Ricobid H, P-Tann, TanaHist-PD, Ed ChlorPed, DryMax AF, Carbaphen CH, Tanni-Hist 12 RF, Exratuss, Tussi-12 (old formulation), Quadratuss, Rynatuss Pediatric, Ex-Tuss, AccuHist LA, Bellahist-D LA, Histacol LA, Protuss Tablet, Rolatuss-SR, Alka-Seltzer Plus Cold Formula Cherry Burst Effervescent Tablets, Atrohist Plus, Deconhist LA, Ru-Tuss, Respa-AR, Tussizone-12 RF, Tannate 12 S, C-Tanna 12, Quad-Tuss, Tussi-12, Tannic-12 S, SymPak II, Tustan 12S, Tussi-12S, Ed-Chlortan, Topco Allergy, Novadyne DH, Co-Histine DH, Ryna-C, Vicks Children’s NyQuil Cold & Cough, Phenylhistine DH Expectorant, Codehist DH, Demi-Cof, Dihistine DH, Zodryl DAC, Decohistine DH, Tricodene SF, QC Cough/Cold, Cold & Cough, Vicks Pediatric Formula 44m Cough & Cold Relief, Triaminic Night Time Cough & Runny Nose, Scot-Tussin DM, Carepanto, Robitussin Children's Cough & Cold Long-Acting, Primatuss 4, Tricodene Sugar Free, Dimetapp Children's Long Acting Cough Plus Cold, Pedituss, Pediacof, PediaTan, Chlorpheniramine (Allergy), Ed Chlor-Tan, Allergy Time, Chlo-Amine, Chlor-Mal, Pharbechlor, Teldrin HBP Allergy, C.P.M., Chlor-Phenit, Z-Tuss AC, Notuss-AC, Endacof-C, Endal CD, T- Koff, Cotab AX, TL-Hist CM, Zodryl AC, Tuxarin ER, Codar AR, Alka-Seltzer Plus Cold & Cough Formula Effervescent Tablets, Alka-Seltzer Plus Flu Formula (old formulation), Triaminic Multi-Symptom Fever & Cold, Comtrex Cold and Flu Maximum Strength, Comtrex Maximum Strength Cold Relief, Contac Severe Cold and Flu Maximum Stength, Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets, Dimetapp Children's Nighttime Flu, Multi Symptom Cold Relief, Alka-Seltzer Plus Severe Cold & Flu Formula Effervescent Tablets, Alka-Seltzer Plus Flu Formula, Alka-Seltzer Plus Severe Sinus & Cold Hot Drink Mix, Comtrex Day and Night, Comtrex Cold and Flu Maximum Strength Liquid, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Triaminic Flu, Cough & Fever, Gelpirin-CCF, Contac Cold + Flu (Night Formula), Co-Apap, Theraflu Flu & Cough, Genacol Maximum Strength, Childrens Tylenol Cold Plus Cough, Contac Cold and Flu Maximum Strength, Multi Symptom Cold (Night Formula), Cold Multi-Symptom (Nighttime), Flu Relief BP, Tylenol Plus Children's Cough & Runny Nose, Dimetapp Children's Multi-Symptom Cold & Flu (old formulation), Tylenol Plus Children's Multi-Symptom Cold, Vicks Formula 44 Custom Care Cough & Cold PM, Mapap Cough & Sinus Formula, Cotabflu, Colrex Compound, PediaCare Cough & Runny Nose Plus Acetaminophen, Tylenol Plus Children's Flu, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, Comtrex Cold & Cough Day Night, Theraflu Nighttime Severe Cold & Cough Caplets, Tylenol Cold Head Congestion Day and Night, Comtrex Nighttime Cold & Cough, Tylenol Cold Head Congestion Nighttime, Tylenol Cold Multi-Symptom Nighttime, PediaCare Multi-Symptom Cold Plus Acetaminophen, Alka-Seltzer Plus Cold & Cough Formula Liquid, PediaCare Flu Plus Acetaminophen, ConRx Allergy Sinus, Allergy Pain Relief, Simplet, Tricom, Comtrex Allergy Sinus, Allerest Sinus, Comtrex Nighttime Flu Therapy, Comtrex Sinus and Nasal, Rhinogesic, Alumadrine, Sinulin, Chlor-Trimeton Sinus, Tylenol Allergy Sinus, Comtrex Allergy Sinus Night and Day, Cold Medicine Plus, Actifed Cold & Sinus, Rolatuss, Quelidrine, Allergy Sinus Maximum Strength, Sinutab Maximum Strength Caplets, Allerest Headache Strength, Sinarest Extra Strength, Triaminicin, Norel SR, Covangesic, Onset Forte, GNP Cold Relief Plus, Gendecon, Dristan Cold Multi Symptom Formula, Relief-PE, Robitussin Peak Cold Nighttime Nasal Relief, Allergy Sinus PE Pain Relief, Allergy Multi-Symptom, Pyrroxate, Tylenol Allergy Multi-Symptom, Tylenol Sinus Congestion & Pain Nighttime, Sine-Off Sinus/Cold, Alka-Seltzer Plus Cold & Flu, HEB Allergy, Dryphen, Hybrid CF, XL-3 Cold Medicine, Comtrex Severe Cold & Sinus, Comtrex Flu Therapy, Tylenol Plus Children's Cold, St. Joseph HBP Cough & Cold, Robitussin Children's Nighttime Cough Long-Acting DM, P Chlor GG, Donatussin Pediatric, Qual-Tussin Pediatric, Hydrocodone GF, SymPak, Z-Tuss 2, Dihydro-CP, Uni-Cof, Bronkotuss, Allfen A, S-T Forte 2, Endagen-HD, Guiaphen HD, Mintuss MS, Chemdal HD Plus, Nasatuss, Efasin-HD, Ed-TLC, Chemdal HD, Iodal HD, Rindal-HD, Hydro-Tussin DHC, Tricof, Maxichlor PSE DM, Kidkare Cough/Cold, Neutrahist PDX Drops, Esocor P, Entre-S, Atuss DS, C-Phed DM, Atuss-12 DM, Dicel DM, Mesehist DM, Allres DS, Despec-PD, Duohist DH, Tusscough DHC, Pancof, Pancof-PD, DiHydro-PE, Duotan DM, T-Tanna DM, Novahistine DH, Iotussin HC, Chlorgest HD, Liquitussin HC Syrup, Tussive HC, Hydro-PC II, Hydron CP, Duradal HD, Chlorphen HD, Efasin-HD Plus, Quindal HD Plus, Quindal HD, Hi-Tuss HC, De-Chlor HD, De-Chlor HC, Phendal-HD, Relacon-HC NR, Tusana-D, Neo HC, Echotuss-HC, Rindal HD Plus, Atuss MS, Hydro-PC II Plus, Uni-Tricof HC, Tuss-DS, Cytuss HC, Endotuss-HD, Ditussin-HC, Endal-HD Plus, Enplus-HD, KG-Dal HD, Tuss-PD, Ed-Tuss HC, Hycomine Compound, Hyphen-HD, Comtussin HC, Tuss-HC, Highland HC, Uni Tuss HC, H-C Tussive, Histussin HC Liquid, KG-Dal HD Plus, Coughtuss, Maxi-Tuss SA, Maxi-Tuss HC, Histinex HC, Tanafed-DM, Rescon-DM, DCP Drops, EndaCof Drops, PE-Hist DM, Maxichlor PEH DM, Sildec-PE DM Drops, C-Phen DM Drops, Tussplex DM, Norel CS, C-Phen DM, Robitussin Cough & Allergy, ED DM, Poly-Tussin DM, Zoden DM Drops, Re DCP, Sonahist-DM, RE DCP Drops, Virdec DM, Trigofen DM Drops, Ricotuss, Tri-Dex PE, Z-Dex 12 D, Reme Tussin DM, Balamine DM, Genelan NF, Zotex-DM, Neotuss D, Extendryl DM, Quartuss, Qual-Tussin, SymPak DM, Broncopectol, ChlorDex GP, Donatussin DM, Ceron-DM Drops, CP Dec DM, Neo DM Drops, Nasohist-DM Pediatric, Cardec DM Drops, HistadecDM, Dec-Chlorphen DM Drops, Rondex-DM, Rondex-DM Drops, Dec-Chlorphen DM, Nohist-DMX, Bronkids, Ed A-Hist DM, P Chlor DM, Dex PC, Tricodene Forte, Trital DM, Mintuss DR, Coldtuss-DR, Tri-Vent DPC, Atuss DR, Uni-Tuss DM, Tricodene NN, Cheracol Plus, Vicks 44M Pediatric, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Children's Nyquil, Rhinosyn-DM, Threamine DM, Therahist, Triphenicol, Kophane, De-Chlor DR, De-Chlor DM, PD-Cof, Zotex-12D, Quartuss DM, Statuss DM, PD-Cof Drops, CP Dec-DM Drops, Donatussin DM Drops, Nasohist-DM, DM-PE-Chlor, NoHist-PDX, Relahist-DM, Centergy DM, Atuss DM, Father John's Medicine Plus, Norel DM, Liquituss R-DM, Tussar DM, Albatussin SR, Cerose DM, Maxiphen ADT, Poly-Tussin HD

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Effects on Lactation and Breastmilk

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

64

Last Revision Date

20150310

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