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Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Hydrocodone CP, Tussionex Pennkinetic, Chlor-Trimeton, Hydrocodone HD, Coricidin HBP Cold & Flu, Coricidin D, Triaminic, Alka-Seltzer Plus Cold, Norel AD, Chlorphen, Show all 813 »Hydrocodone GF, Chlorpheniramine (Allergy), Alumadrine, Wal-finate, Tylenol Cold, Coricidin HBP Cough & Cold, Aller-Chlor, Allergy Relief, TussiCaps, Rescon Extended Release, Sudafed PE Sinus & Allergy, Ceron, Relasin-HC, Tuzistra XR, Ed A-Hist DM, Zutripro, Sinarest, Phenagil, Tanoral, PCM, Effective Strength Cough Syrup, Triaminic Multi-Symptom Fever, Ed A-Hist, Sinutab Ex-Strength, GNP Cold Relief Plus, RespiVent DF, NoHist, Rondec, Cold Medicine Plus, Norel DM, NoHist DM, Qdall, Novasus, Simplet, Ornade Spansules, Balamine DM, Contac Cold + Flu (Night Formula), Singlet, Rondec-DM, Coricidin HBP Day & Night Multi-Symptom Cold, Stahist, Amilon, Relera, Advil Allergy Sinus, Tricode AR, Codar AR, Triplex AD, Alka-Seltzer Plus Cold & Flu, Chlor-Mal, HistadecDM, Carbaphen CH, Naldelate, Naldecon, Duralex, Kronofed-A, Codimal-LA Half, Creomulsion Cough/Cold/Allergy, Cardec DM, Deconamine, C-Phen DM, Chlor-Trimeton Allergy Decongestant, Dicel, Nalex-A, Zoden DM Drops, Trital DM, Rynatan, Decohistine DH, Novafed A, Rondex, Children's Nyquil, Exratuss, M-End DM, Sildec-PE Drops, Chlor-Trimeton Allergy SR, Nalex A 12, Sinucon, Phenylhistine DH Expectorant, Entre-S, Neutrahist PDX Drops, Rentamine, Dihydro-CP, URL-Tannate, Tritan, Triotann-S, Demazin, Condrin, Equi-Nade, Sonahist, Alka-Seltzer Plus Cold Formula Sparkling Original Effervescent Tablets, Alka-Seltzer Plus Cold Formula Cherry Burst Effervescent Tablets, AccuHist LA, Tylenol Sinus Congestion & Pain Nighttime, Theraflu Flu, Cold and Cough Powder, ScopoHist-PE, Durahist PE, Omnihist II LA, Denaze, Allpanto-S, Genacol Maximum Strength, Cough Formula M Multi-Symptom, Tusana-D, Triant-HC, Hydro-PC II, Dallergy PE, Triall, Vicks NyQuil Cold & Flu Nighttime Relief (Alcohol Free), Coricidin HBP Maximum Strength Flu, Robitussin Peak Cold Nighttime Nasal Relief, Codral Cold and Flu + Cough Day and Night, Sinulin, Tylenol Allergy Multi-Symptom, Lemohist Plus, Norel SR, XL-3 Xtra Cold and Cough, Dristan Cold Multi Symptom Formula, Hybrid CF, Coughtuss, Highland HC, Quindal HD, Advil Allergy and Congestion Relief, Alka-Seltzer Plus Cold & Cough Formula Liquid, P-V-Tussin Syrup, KG-Tussin, VisRx Dose Pack, A-G Tussin, Allergy AM-PM Dose Pack, Q-V Tussin, ScopoHist, Histatab, Hydrocof-HC, Hydrotuss HC, Amdry-C, Dallergy PSE, Relcof PSE, Mescolor, Hista-Vent PSE, PCM-LA, Cordron-HC, Time-Hist QD, Hydron PCS, AllePak, Rhinaclear, Allergy DN, Pseudo CM TR, Coldamine, Nolamine, Tussin-V, ScopoHist Syrup, Hyphed, Z-Cof HC, Rhinatate-NF, Trigofen Drops, Notuss, Notuss-Forte, Relacon-HC, Maxi-Tuss HCX, DroTuss-CP, Virdec, Liquicough HC, Poly-Tussin HD, AccuHist Drops, Phenylhistine, Novahistine Elixir, Histatab Plus, Ed A-Hist LA, Ny-Tannic, Allerest PE, Hexatussin, Detuss, Welltuss HC, Tussend, Pediatex HC, JayCof-HC, Xiral SR, Histinex PV, Lohist, BP Allergy JR, Nuhist, Novahistine, Dallergy JR, NoHist LQ, AlleRx, Ricobid NR, Suphedrine PE Sinus & Allergy, RelCof DN PSE, Extendryl JR, DuraHist, Sinodec, Duradryl JR, Duradryl, AH-Chew, Liqui-Allergy, DA II, Hista-Vent DA, Duravent DA, Omnihist L.A., DA Chewable, R-Tanna, Duravent, Extendryl Chews, Prehist D, Extendryl SR, SymPak PDX, Drysec, DuraTan PE, RelCof DN PE, AlleRx Dose Pack (PM Dose), Nohist PE, DriHist SR, Dehistine, Allergy DN PE, Nohist Plus, Ah-Chew Ultra Tannate, Nohist Plus Jr, Dallergy SR, Duradryl Chewable, Aerohist Plus, Duradryl SR, CPM-PE-MSC, Drize, Ex-Histine, Cordron-HC NR, RelCof CPM, Histatab PH, Chlor-Mes, PCM Allergy, Re-Drylex Jr, RelCof PE, AlleRx DF, Advil Children's Allergy Sinus, Allergy DN II, Atuss HS, DriHist, AlleRx Dose Pack, Rhinolar, DryMax, Atuss HD, Ah-chew Ultra, NoHist EXT, WE Allergy, Extendryl Seniors, Chlor-Mes D, Norel SD, AH-Chew II, Ralix, Aerokid, Dallergy ER, QV-Allergy, aeroHist, AlleRx Dose Pack PE (PM Dose), Ryneze, Dexodryl, Redur-PCM, Dexodryl Suspension, Allerx Dose Pack DF, Rynatan Pediatric, Hycomine Compound, Phenchlor Tannate Pediatric, Orlenta, Histalet, Fedahist, Tanafed, Chlorafed HS Timecelles, Codimal-LA, Kronofed-A-Jr, Dura-Tap/PD, Fedahist Timecaps, Chlorphedrin SR, Duratuss DA, Colfed-A, D-Amine-SR, Deconomed SR, Pseudocot-C, Rinade-BID, Suphenamine-SR, Isophen-DF, ND Clear, Clorfed, Deconamine SR, Anamine TD, Decongex-3, Dura-Vent/A, Resaid, Or-Phen-Ade, Contac 12 Hour, ARM Allergy Relief, Teldrin, Chlornade, Ordrine, Gencold, Biohist LA (old formulation), Rhinolar-EX, Triac, Genamin, Allerest 12 Hour, Vanex Forte-R, Histade CR, Chlor-Trimeton Decongestant, Duotan, Durafed, Chlordrine SR, Time-Hist, MyHist-PD, Sudal-12, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, Dynahist-ER Pediatric, CP-Tannic, Histade, Mintex, Suclor, Re2+30, Pediox Chewable, Atrohist Pediatric Capsule, C-Phed Tannate, De-Congestine, Sudal-12 Chewable, Sudal-12 Tannate, SudaHist, AccuHist Drops (old formulation), LoHist-D, Triaminic Softchews Cold and Allergy, Pseudoephedrine Plus, Allerest Maximum Strength, Suphedrine Plus, Chlorafed Timecelles, Clorfed II, Brexin LA, Rescon-Ed, Pseudochlor, Cophene No 2, Anaplex, Anamine, Klerist-D, Fedahist Gyrocaps, Curaler, Hayfebrol Liquid, Chlorafed, Histafed LA, Aller-Chlor Decongestant, Sudogest Plus, Neutrahist Drops, Ryna Liquid, Sudogest Cold & Allergy, Genaphed Plus, SudoGest Sinus & Allergy, Rhinolar-EX 12, Phena-S 12, Nasohist Pediatric, Relacon-HC NR, Rinate Pediatric, Ed ChlorPed D, Cardec, Acta-Tabs PE, Sildec-PE, Maxichlor PEH, Ry-Tann, Hista-Vadrin, Nalphen, ChlorTan D, Nalda-Relief Pediatric, Nalgestic Pediatric, Sinucon Pediatric, Nalgest, West-Decon, Nalspan, Uni Decon, Prop-A-Hist, Actifed Cold and Allergy, Triaminic Cold & Allergy, Histalet Forte, Chlor-Mes Jr, Dallergy Drops, Sinus & Allergy PE, PD-Hist D Drops, Ceron Drops, PD-Hist D, Tanahist-D, Allan Tannate Pediatric, CP Dec Drops, Rondex Drops, P-Tann D, Dec-Chlorphen, Dec-Chlorphen Drops, C Phen Drops, C Phen, Tannate Pediatric, Histadec, PediaTan D, CP Dec, Cardec Drops, Andecon Pediatric Drops, Vanex Forte, Poly Hist PD (old formulation), Histatan, Tri-Tannate Pediatric, Rhinatate Pediatric, Rhinatate, Url-Tannate Pediatric, Tanamine, R-Tannamine, Triotann, Ru-Hist Forte, Phena-S, Tri-Tannate, Triotann Pediatric, Chlorex-A 12, Tri-Gestan S, Tri-Hist Pediatric, Phena-Plus, Tri Tann Pediatric, AllerTan, Conal, Pyrichlor PE, Tanamine Pediatric, Triple Tannate Pediatric, NoHist-A, Chlorex A, Rhinacon A, Comhist, Linhist-LA, Comhist LA, Q-Hist LA, Chlortox, C-Hist-SR, Nalex-A SR, Coldex, Equitan Pediatric, West-Decon M, Atrohist Pediatric, Rynatan-S Pediatric, R-Tannate Pediatric, Gelhist Pediatric, R-Tannate, R-Tannamine Pediatric, Triotann-S Pediatric, Tanoral Pediatric, Neo HC, Nasatuss, Phendal-HD, Carbaphen 12, Rentamine Pediatric, Tuss Tan, Tuss Tan Pediatric, Tetra Tannate Pediatric, Quad Tuss Pediatric, Quad Tann Pediatric, Quad Tann, Tannic-12, Tannate-12, Quadratuss, XiraTuss, Tanni-Hist 12 RF, Tussi-12 (old formulation), Phenagil CH, DryMax AF, Ricobid H, P-Tann, TanaHist-PD, Rynatuss, Rynatuss Pediatric, Ed-Chlortan, Ru-Tuss, Alka-Seltzer Plus Cold Formula Orange Zest Effervescent Tablets, Atrohist Plus, Deconhist LA, Rolatuss-SR, Protuss Tablet, Ex-Tuss, Bellahist-D LA, Histacol LA, Respa-AR, Quad-Tuss, SymPak II, Tustan 12S, Tussi-12S, Tannic-12 S, Tussi-12, Tussizone-12 RF, Tannate 12 S, Trionate, C-Tanna 12, Ed ChlorPed, Topco Allergy, Alka-Seltzer Plus Flu Formula (old formulation), Ryna-C, Pedituss, Demi-Cof, Dihistine DH, Zodryl DAC, Phenylhistine DH, Codehist DH, Novadyne DH, Co-Histine DH, Codahistine-DH Elixir, T- Koff, Vicks Children’s NyQuil Cold & Cough, Tricodene SF, QC Cough/Cold, Primatuss 4, Tricodene Sugar Free, Triaminic Softchews Cough & Runny Nose, Dimetapp Children's Long Acting Cough Plus Cold, Robitussin Children's Cough & Cold Long-Acting, Robitussin Cough & Cold Long-Acting, Pediacof, Endal CD, Pharbechlor, Chlor-Phenit, Teldrin HBP Allergy, C.P.M., Chlo-Amine, PediaTan, ChlorTan, Ed Chlor-Tan, Allergy Time, Ed Chlor Ped Jr., Z-Tuss AC, CapCof, Zodryl AC, Tuxarin ER, TL-Hist CM, Cotab A, Cotab AX, Lexuss 210, Codeprex, Notuss-AC, Endacof-C, Alka-Seltzer Plus Cold & Cough Formula Effervescent Tablets, Quelidrine, Cold & Cough, Triaminic Multi-Symptom Fever & Cold, Cold Multi-Symptom (Nighttime), Multi Symptom Cold (Night Formula), Multi Symptom Cold Relief, Alka-Seltzer Plus Severe Cold & Flu Formula Effervescent Tablets, Alka-Seltzer Plus Flu Formula, Alka-Seltzer Plus Severe Sinus & Cold Hot Drink Mix, Dimetapp Children's Nighttime Flu, Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets, Comtrex Cold and Flu Maximum Strength, Tylenol Cold Head Congestion Day and Night, Comtrex Maximum Strength Cold Relief, Contac Severe Cold and Flu Maximum Stength, Comtrex Day and Night, Comtrex Cold and Flu Maximum Strength Tablet, Comtrex Cold and Flu Maximum Strength Liquid, Childrens Tylenol Cold Plus Cough, Contac Cold and Flu Maximum Strength, Theraflu Flu & Cough, Comtrex Nighttime Cold & Cough, Theraflu Nighttime Severe Cold & Cough Caplets, Theracaps Multi-Symptom Cough & Cold Reliever, Vicks Formula 44 Custom Care Cough & Cold PM, Congestant, 999 Cold Remedy Granular, Cotabflu, Colrex Compound, Colrex, Tylenol Children’s Cold + Cough + Runny Nose, PediaCare Cough & Runny Nose Plus Acetaminophen, Mapap Cough & Sinus Formula, Flu Relief BP, Comtrex Cold & Cough Day Night, Coricidin HBP Multi-Symptom Cold (Night), Tylenol Cold and Flu Severe Day & Night, Dimetapp Children's Multi-Symptom Cold & Flu (old formulation), Tylenol Children’s Cold + Flu, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, PediaCare Multi-Symptom Cold Plus Acetaminophen, PediaCare Flu Plus Acetaminophen, Tylenol Cold Multi-Symptom Nighttime, Tylenol Cold Head Congestion Nighttime, Co-Apap, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Rolatuss, Kolephrin, Rhinogesic, Duadacin, Chlor-Trimeton Sinus, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Tricom, Comtrex Allergy Sinus, Codimal, Allerest Sinus, Covangesic, Tylenol Allergy Sinus, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Triaminicin, Sinutab Maximum Strength Caplets, Allergy Sinus Maximum Strength, Actifed Cold & Sinus, Trital SR, Dryphen, Triaminic Flu, Cough & Fever, Relief-PE, Gelpirin-CCF, Medicidin-D, ConRx Allergy Sinus, Allergy Pain Relief, Allergy Sinus PE Pain Relief, PX Allergy Sinus PE, Allergy Multi-Symptom, Pyrroxate, Onset Forte, HEB Allergy, Super Strength Sinadrin, Gendecon, Comtrex Severe Cold & Sinus, Comtrex Flu Therapy, Tylenol Plus Children's Cold, Protid, XL-3 Cold Medicine, Sine-Off Sinus/Cold, Tylenol Sinus Congestion and Pain Cool Burst Day Night, Carepanto, Vicks Pediatric Formula 44m Cough & Cold Relief, Echotuss-HC, Donatussin Pediatric, Uni-Cof, Coldcough Syrup, Bronkotuss, Ana-Kit, Allfen A, Z-Tuss 2, SymPak, P Chlor GG, Qual-Tussin Pediatric, Tricof, S-T Forte 2, HyTan, Vituz, Endagen-HD, Chemdal HD, Iodal HD, Rindal-HD, Ed-TLC, Hydro-Tussin DHC, Pancof, Guiaphen HD, Triaminic-D Multi-Symptom Cold, Dicel DM, Atuss DS, Maxichlor PSE DM, Kidkare Cough/Cold, AccuHist PDX Drops, CPM-PSE DM Drops, Esocor P, Mesehist DM, Allres DS, Tusscough DHC, Duotan DM, T-Tanna DM, Pedia Relief Cough-Cold, Novahistine DH, DiHydro-PE, Coldcough PD, Pancof-PD, Despec-PD, Duohist DH, Efasin-HD, Mintuss MS, C-Phed DM, Duradal HD, H-C Tussive, Histussin HC Liquid, Cytuss HC, Tuss-DS, Efasin-HD Plus, Quindal HD Plus, Hi-Tuss HC, Chlorphen HD, Liquitussin HC Syrup, KG-Dal HD Plus, Tussive HC, B-Tuss, Hydron CP, De-Chlor HD, De-Chlor HC, Atuss MS, Hydro-PC II Plus, Uni-Tricof HC, Rindal HD Plus, Uni Tuss HC, Histinex HC, Vanex-HD, KG-Dal HD, Chemdal HD Plus, Sinapils, Iotussin HC, Chlorgest HD, Ed-Tuss HC, Cyndal HD, Hyphen-HD, Tuss-PD, Endotuss-HD, Maxi-Tuss HC, Ditussin-HC, Chemtussin HC, Exo-Tuss, Endal-HD Plus, Enplus-HD, Comtussin HC, Tuss-HC, Ventuss Syrup, Maxi-Tuss SA, Atuss-12 DM, Tanafed-DM, Triaminic Night Time Cough & Runny Nose, EndaCof Drops, Reme Tussin DM, Tussplex DM, Norel CS, Robitussin Cough & Allergy, C-Phen DM Drops, Sildec-PE DM Drops, Sildec-PE DM, DCP Drops, PE-Hist DM, Nasohist-DM Pediatric, Maxichlor PEH DM, ED DM, Poly-Tussin DM, Ricotuss, Tri-Dex PE, Z-Dex 12 D, Trigofen DM Drops, Virdec DM, Phenabid DM, Cardec DM Drops, Neo DM Drops, Sonahist-DM, Genelan NF, Scot-Tussin DM, St. Joseph HBP Cough & Cold, Robitussin Children's Nighttime Cough Long-Acting DM, SymPak DM, Broncopectol, ChlorDex GP, Qual-Tussin, Quartuss, Zotex-DM, CP Dec DM, Neotuss D, Extendryl DM, Donatussin DM, Ceron-DM Drops, Ceron-DM, Rondex-DM, Rondex-DM Drops, Dec-Chlorphen DM, Dec-Chlorphen DM Drops, Re DCP, RE DCP Drops, Rescon-DM, Tricodene Forte, Coldtuss-DR, Tri-Vent DPC, Atuss DR, Corfen-DM, Uni-Tuss DM, Mintuss DR, P Chlor DM, Dex PC, Tricodene NN, De-Chlor DM, Cheracol Plus, Therahist, Triphenicol, Kophane, Threamine DM, Rhinosyn-DM, Vicks 44M Pediatric, Creomulsion Pediatric, Kidcare Cough and Cold, De-Chlor DR, NeoTuss Plus, Nohist-DMX, Quartuss DM, Bronkids, Donatussin DM Drops, Nasohist-DM, DM-PE-Chlor, CP Dec-DM Drops, PD-Cof Drops, PD-Cof, Zotex-12D, Statuss DM, Father John's Medicine Plus, NoHist-PDX, Relahist-DM, Albatussin SR, Cerose DM, Maxiphen ADT, Tussar DM, Liquituss R-DM, Centergy DM, Atuss DM, Dynahist ER

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as spseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Effects on Lactation and Breastmilk

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

64

Last Revision Date

20170110

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