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Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Tussionex Pennkinetic, Coricidin HBP Cold & Flu, Sinarest, PCM, Allergy Relief, Coricidin HBP Cough & Cold, Coldcough Syrup, Tylenol Cold, Rondec, Chlor-Trimeton, Show all 812 »Norel AD, Hydrocodone CP, Chlorphen, Ed A-Hist, Coricidin D, Sudafed PE Sinus & Allergy, Sudogest Cold & Allergy, Sinus & Allergy PE, Aerohist Plus, Orlenta, SudoGest Sinus & Allergy, Tanafed, Clorfed, Ryneze, Ceron, Rynatan Pediatric, Novahistine, Relacon-HC, Codeprex, TL-Hist CM, Childrens Tylenol Cold Plus Cough, Alka-Seltzer Plus Cold, Ed A-Hist DM, Robitussin Cough & Allergy, Tannic-12 S, Ru-Tuss, Stahist, Vicks 44M Pediatric, Teldrin HBP Allergy, Vicks Children’s NyQuil Cold & Cough, Triaminic, Dryphen, Advil Allergy Sinus, Children's Nyquil, Demazin, Qual-Tussin, AllerTan, Triall, XL-3 Cold Medicine, Wal-finate, Tanoral, AlleRx Dose Pack, Carbaphen CH, Coldamine, ScopoHist, Drysec, Brexin LA, Duralex, Aller-Chlor, Cold Medicine Plus, Sinutab Ex-Strength, Duadacin, Decongex-3, Tylenol Allergy Multi-Symptom, Cyndal HD, Alka-Seltzer Plus Severe Cold & Flu Formula Effervescent Tablets, XL-3 Xtra Cold and Cough, Effective Strength Cough Syrup, Sildec-PE DM, C-Phen DM, NoHist DM, Vicks NyQuil Cold & Flu Nighttime Relief (Alcohol Free), Actifed Cold and Allergy, Donatussin DM Drops, B-Tuss, TussiCaps, Congestant, Cotabflu, Histatab Plus, PCM Allergy, Omnihist II LA, AH-Chew II, Ed A-Hist LA, Rhinolar, Ralix, Trigofen Drops, DriHist, Extendryl JR, Re-Drylex Jr, AccuHist Drops, Novahistine Elixir, Phenylhistine, Denaze, Chlor-Mes, Histatab PH, Aerokid, Dallergy ER, Extendryl Seniors, QV-Allergy, Redur-PCM, AlleRx Dose Pack PE (PM Dose), Rescon Extended Release, Ah-chew Ultra, Ny-Tannic, Rhinatate-NF, Time-Hist QD, Dallergy PSE, Relcof PSE, Mescolor, Hista-Vent PSE, PCM-LA, Amdry-C, AllePak, Nolamine, Rhinaclear, Norel SD, Allergy DN, Histatab, Pseudo CM TR, Allergy AM-PM Dose Pack, VisRx Dose Pack, Amilon, RelCof DN PSE, Rynatan, Sonahist, Virdec, Allerest PE, BP Allergy JR, Suphedrine PE Sinus & Allergy, DryMax, Ricobid NR, AlleRx, Xiral SR, NoHist LQ, Relera, Phenagil, Dallergy JR, Nuhist, Lohist, DuraHist, Durahist PE, Hycomine Compound, Chlor-Mes D, Tussin-V, Notuss, Detuss, Histinex PV, JayCof-HC, Pediatex HC, Tussend, Welltuss HC, Hexatussin, Hyphed, Q-V Tussin, Zutripro, A-G Tussin, KG-Tussin, P-V-Tussin Syrup, Hydrotuss HC, Hydron PCS, Hydrocof-HC, Cordron-HC, Cordron-HC NR, Atuss HD, Notuss-Forte, Maxi-Tuss HCX, Advil Multi-Symptom Cold & Flu, Uni-Tricof HC, Hydrocodone HD, Tussive HC, Hydro-PC II, Hydron CP, De-Chlor HD, De-Chlor HC, Atuss MS, Hydro-PC II Plus, Triant-HC, Rindal HD Plus, Z-Cof HC, Echotuss-HC, Phendal-HD, Relacon-HC NR, Tusana-D, Neo HC, Poly-Tussin HD, Liquicough HC, Relasin-HC, DroTuss-CP, Atuss HS, Advil Allergy and Congestion Relief, WE Allergy, DA Chewable, Dallergy PE, CPM-PE-MSC, Ah-Chew Ultra Tannate, SymPak PDX, ScopoHist-PE, Sinodec, Extendryl SR, Prehist D, Extendryl Chews, Omnihist L.A., Duradryl Chewable, Duravent DA, Hista-Vent DA, DA II, Liqui-Allergy, AH-Chew, Duradryl, Duradryl JR, Drize, Ex-Histine, Duradryl SR, Dallergy SR, Advil Children's Allergy Sinus, Duravent, RelCof CPM, AlleRx DF, Allergy DN II, NoHist EXT, RespiVent DF, aeroHist, Allerx Dose Pack DF, Dexodryl Suspension, Dexodryl, Dehistine, Nohist Plus Jr, DriHist SR, Nohist PE, RelCof DN PE, RelCof PE, ScopoHist Syrup, AlleRx Dose Pack (PM Dose), Allergy DN PE, DuraTan PE, Nohist Plus, R-Tanna, CP Dec, Phenchlor Tannate Pediatric, Dura-Tap/PD, Deconamine, Deconamine SR, Novafed A, Duratuss DA, Histalet, Fedahist, Chlorafed HS Timecelles, Codimal-LA, Kronofed-A-Jr, Fedahist Timecaps, Durafed, Chlorphedrin SR, Colfed-A, D-Amine-SR, Deconomed SR, Pseudocot-C, Rinade-BID, Suphenamine-SR, Isophen-DF, Kronofed-A, Biohist LA (old formulation), Duotan, Chlordrine SR, Chlornade, Triplex AD, Rhinolar-EX 12, Dura-Vent/A, Ornade Spansules, Resaid, Or-Phen-Ade, Contac 12 Hour, ARM Allergy Relief, Teldrin, Condrin, Chlor-Trimeton Decongestant, Ordrine, Equi-Nade, Gencold, Rhinolar-EX, Triac, Genamin, Allerest 12 Hour, Vanex Forte-R, Histade CR, ND Clear, Anamine TD, Phena-S 12, C-Phed Tannate, Tavist-DA, Dynahist-ER Pediatric, CP-Tannic, Histade, Mintex, Suclor, Re2+30, Sudal-12, Pediox Chewable, De-Congestine, Allerest Maximum Strength, Sudal-12 Chewable, Dicel, Sudal-12 Tannate, SudaHist, AccuHist Drops (old formulation), LoHist-D, Triaminic Softchews Cold and Allergy, Pseudoephedrine Plus, Qdall, Chlor-Trimeton Allergy Decongestant SR, Atrohist Pediatric Capsule, Time-Hist, Clorfed II, Chlorafed Timecelles, Rescon-Ed, Pseudochlor, Cophene No 2, Anaplex, Anamine, Klerist-D, Codimal-LA Half, Fedahist Gyrocaps, Curaler, Suphedrine Plus, Chlorafed, Histafed LA, Chlor-Trimeton Allergy Decongestant, Aller-Chlor Decongestant, Sudogest Plus, Neutrahist Drops, Ryna Liquid, Genaphed Plus, Hayfebrol Liquid, MyHist-PD, Poly Hist PD (old formulation), Nasohist Pediatric, Nalda-Relief Pediatric, Cardec, Sildec-PE Drops, Acta-Tabs PE, Sildec-PE, NoHist, Maxichlor PEH, Ry-Tann, Hista-Vadrin, Nalphen, Nalgestic Pediatric, Rinate Pediatric, Sinucon Pediatric, Nalgest, West-Decon, Nalspan, Uni Decon, Prop-A-Hist, Sinucon, Naldelate, Andecon Pediatric Drops, Ed ChlorPed D, ChlorTan D, Histalet Forte, Rondex Drops, Dallergy Drops, PD-Hist D Drops, Ceron Drops, PD-Hist D, Tanahist-D, Allan Tannate Pediatric, CP Dec Drops, Chlor-Mes Jr, Rondex, Dec-Chlorphen, Triaminic Cold & Allergy, Dec-Chlorphen Drops, C Phen Drops, C Phen, Tannate Pediatric, Histadec, PediaTan D, Duradal HD, Cardec Drops, P-Tann D, Naldecon, Vanex Forte, Pyrichlor PE, Ru-Hist Forte, Tri-Tannate Pediatric, Rhinatate Pediatric, Rhinatate, Url-Tannate Pediatric, Tritan, Tanamine, R-Tannamine, URL-Tannate, Triotann, Histatan, Tri-Tannate, Phena-S, Triotann Pediatric, Chlorex-A 12, Tri-Gestan S, Tri-Hist Pediatric, Phena-Plus, Tri Tann Pediatric, Nalex A 12, Conal, Tanamine Pediatric, Triple Tannate Pediatric, NoHist-A, Chlorex A, Nalex-A, Rhinacon A, Comhist, Linhist-LA, Comhist LA, Q-Hist LA, Chlortox, C-Hist-SR, Nalex-A SR, Coldex, Equitan Pediatric, West-Decon M, Atrohist Pediatric, Rynatan-S Pediatric, R-Tannate Pediatric, Gelhist Pediatric, R-Tannate, Triotann-S, R-Tannamine Pediatric, Triotann-S Pediatric, Tanoral Pediatric, Liquitussin HC Syrup, Endotuss-HD, Chlorphen HD, Rentamine Pediatric, Tussizone-12 RF, Tannate 12 S, Trionate, C-Tanna 12, Quad-Tuss, Rynatuss Pediatric, Quadratuss, Rynatuss, Rentamine, Tussi-12S, Tuss Tan, Tuss Tan Pediatric, Tetra Tannate Pediatric, Quad Tuss Pediatric, Quad Tann Pediatric, Quad Tann, Tannic-12, Carbaphen 12, Tannate-12, Tussi-12, Tustan 12S, Tanni-Hist 12 RF, Alka-Seltzer Plus Cold Formula Orange Zest Effervescent Tablets, Triaminicin, Sinutab Maximum Strength Caplets, Allergy Sinus Maximum Strength, Actifed Cold & Sinus, Rolatuss, Quelidrine, Alka-Seltzer Plus Flu Formula (old formulation), Alka-Seltzer Plus Cold & Cough Formula Effervescent Tablets, Alka-Seltzer Plus Cold Formula Sparkling Original Effervescent Tablets, Alka-Seltzer Plus Cold Formula Cherry Burst Effervescent Tablets, SymPak II, Atrohist Plus, Deconhist LA, Rolatuss-SR, Protuss Tablet, Ex-Tuss, AccuHist LA, Bellahist-D LA, Histacol LA, Respa-AR, XiraTuss, Exratuss, Allerest Headache Strength, Pediacof, Cotab A, Cotab AX, Tuzistra XR, Lexuss 210, Notuss-AC, Endacof-C, CapCof, Endal CD, T- Koff, Pedituss, Tuxarin ER, Demi-Cof, Dihistine DH, Tricode AR, Zodryl DAC, Phenylhistine DH, Decohistine DH, Codehist DH, Phenylhistine DH Expectorant, Novadyne DH, Codar AR, Zodryl AC, Tussi-12 (old formulation), C.P.M., Phenagil CH, DryMax AF, Ricobid H, P-Tann, TanaHist-PD, Ed ChlorPed, Ed-Chlortan, Topco Allergy, Pharbechlor, Chlor-Mal, Z-Tuss AC, Chlo-Amine, Chlor-Trimeton Allergy SR, PediaTan, Chlorpheniramine (Allergy), ChlorTan, Ed Chlor-Tan, Allergy Time, Ed Chlor Ped Jr., Chlor-Phenit, Sinarest Extra Strength, Comtrex Allergy Sinus Night and Day, Ryna-C, Comtrex Cold and Flu Maximum Strength, Alka-Seltzer Plus Maximum Strength Cold & Cough, Cold Multi-Symptom (Nighttime), Multi Symptom Cold (Night Formula), Multi Symptom Cold Relief, Alka-Seltzer Plus Maximum Strength Cold & Cough Liquid Gels, Alka-Seltzer Plus Severe Sinus & Cold Hot Drink Mix, Dimetapp Children's Nighttime Flu, Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets, Triaminic Multi-Symptom Fever & Cold, Comtrex Maximum Strength Cold Relief, Tylenol Cold Head Congestion Day and Night, Contac Severe Cold and Flu Maximum Stength, Theraflu Flu, Cold and Cough Powder, Comtrex Day and Night, Cough Formula M Multi-Symptom, Comtrex Cold and Flu Maximum Strength Tablet, Comtrex Cold and Flu Maximum Strength Liquid, Genacol Maximum Strength, Contac Cold and Flu Maximum Strength, Theraflu Flu & Cough, Comtrex Nighttime Cold & Cough, Theraflu Nighttime Severe Cold & Cough Caplets, Co-Apap, Flu Relief BP, 999 Cold Remedy Granular, Colrex Compound, Colrex, Triaminic Multi-Symptom Fever, Tylenol Children’s Cold + Cough + Runny Nose, PediaCare Cough & Runny Nose Plus Acetaminophen, Coricidin HBP Maximum Strength Flu, Mapap Cough & Sinus Formula, Vicks Formula 44 Custom Care Cough & Cold PM, Coricidin HBP Multi-Symptom Cold (Night), Comtrex Cold & Cough Day Night, Coricidin HBP Day & Night Multi-Symptom Cold, Tylenol Cold and Flu Severe Day & Night, Dimetapp Children's Multi-Symptom Cold & Flu (old formulation), Tylenol Children’s Cold + Flu, PediaCare Multi-Symptom Cold Plus Acetaminophen, PediaCare Flu Plus Acetaminophen, Codral Cold and Flu + Cough Day and Night, Tylenol Cold Multi-Symptom Nighttime, Tylenol Cold Head Congestion Nighttime, Allpanto-S, Theracaps Multi-Symptom Cough & Cold Reliever, Comtrex Allergy Sinus Maximum Strength, Chlor-Trimeton Sinus, Sine-Off Sinus/Cold, Tylenol Sinus Congestion and Pain Cool Burst Day Night, HEB Allergy, Covangesic, Norel SR, Trital SR, Rhinogesic, Alumadrine, Sinulin, Comtrex Sinus and Nasal, Protid, Comtrex Nighttime Flu Therapy, Singlet, Simplet, Tricom, Comtrex Allergy Sinus, Codimal, Kolephrin, Allerest Sinus, Tylenol Allergy Sinus, Hybrid CF, Tylenol Plus Children's Cold, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Allergy Multi-Symptom, Triaminic Flu, Cough & Fever, Gelpirin-CCF, Contac Cold + Flu (Night Formula), Medicidin-D, BC Sinus Pain & Congestion, ConRx Allergy Sinus, Allergy Pain Relief, Allergy Sinus PE Pain Relief, PX Allergy Sinus PE, Pyrroxate, Comtrex Flu Therapy, Robitussin Peak Cold Nighttime Nasal Relief, Relief-PE, Onset Forte, GNP Cold Relief Plus, Super Strength Sinadrin, Gendecon, Dristan Cold Multi Symptom Formula, Tylenol Sinus Congestion & Pain Nighttime, Comtrex Severe Cold & Sinus, Co-Histine DH, Codahistine-DH Elixir, Hi-Tuss HC, Pancof, Pedia Relief Cough-Cold, Novahistine DH, DiHydro-PE, Coldcough PD, Pancof-PD, Despec-PD, Duohist DH, Tusscough DHC, Tricof, Duotan DM, Hydro-Tussin DHC, Dihydro-CP, Uni-Cof, Bronkotuss, Ana-Kit, Allfen A, Z-Tuss 2, SymPak, P Chlor GG, T-Tanna DM, Allres DS, Qual-Tussin Pediatric, Atuss-12 DM, Threamine DM, Rhinosyn-DM, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Kidcare Cough and Cold, Rescon-DM, Tanafed-DM, C-Phed DM, M-End DM, Dicel DM, Triaminic-D Multi-Symptom Cold, Atuss DS, Entre-S, Maxichlor PSE DM, Kidkare Cough/Cold, Neutrahist PDX Drops, AccuHist PDX Drops, CPM-PSE DM Drops, Esocor P, Mesehist DM, Donatussin Pediatric, Lemohist Plus, Triphenicol, Coughtuss, Exo-Tuss, Endal-HD Plus, Enplus-HD, Comtussin HC, Tuss-HC, Ventuss Syrup, Maxi-Tuss SA, Maxi-Tuss HC, Histinex HC, KG-Dal HD Plus, Ditussin-HC, Highland HC, Uni Tuss HC, H-C Tussive, Histussin HC Liquid, Cytuss HC, Tuss-DS, Efasin-HD Plus, Quindal HD Plus, Quindal HD, Chemtussin HC, Sinapils, Hydrocodone GF, Efasin-HD, S-T Forte 2, HyTan, Novasus, Vituz, Endagen-HD, Chemdal HD, Iodal HD, Rindal-HD, Ed-TLC, Guiaphen HD, KG-Dal HD, Mintuss MS, Vanex-HD, Chemdal HD Plus, Nasatuss, Iotussin HC, Chlorgest HD, Ed-Tuss HC, Hyphen-HD, Tuss-PD, Kophane, Therahist, QC Cough/Cold, Reme Tussin DM, Rondex-DM Drops, Dec-Chlorphen DM, Dec-Chlorphen DM Drops, HistadecDM, CP Dec DM, Neo DM Drops, Nasohist-DM Pediatric, Cardec DM Drops, Balamine DM, Tussplex DM, Ceron-DM, Norel CS, Cardec DM, C-Phen DM Drops, Sildec-PE DM Drops, DCP Drops, EndaCof Drops, PE-Hist DM, Maxichlor PEH DM, ED DM, Rondex-DM, Ceron-DM Drops, Ricotuss, St. Joseph HBP Cough & Cold, Primatuss 4, Tricodene Sugar Free, Triaminic Softchews Cough & Runny Nose, Dimetapp Children's Long Acting Cough Plus Cold, Robitussin Children's Cough & Cold Long-Acting, Robitussin Cough & Cold Long-Acting, Carepanto, Triaminic Night Time Cough & Runny Nose, Scot-Tussin DM, Robitussin Children's Nighttime Cough Long-Acting DM, Donatussin DM, SymPak DM, Broncopectol, ChlorDex GP, Quartuss, Genelan NF, Zotex-DM, Neotuss D, Extendryl DM, Rondec-DM, Poly-Tussin DM, Tri-Dex PE, Cheracol Plus, Coldtuss-DR, Tussar DM, Liquituss R-DM, Centergy DM, Atuss DM, Father John's Medicine Plus, Norel DM, NeoTuss Plus, De-Chlor DM, De-Chlor DR, Tri-Vent DPC, Cerose DM, Atuss DR, Corfen-DM, Uni-Tuss DM, Mintuss DR, Trital DM, P Chlor DM, Dex PC, Tricodene Forte, Tricodene NN, Maxiphen ADT, Albatussin SR, Z-Dex 12 D, Nasohist-DM, Trigofen DM Drops, Virdec DM, Zoden DM Drops, Phenabid DM, Re DCP, Sonahist-DM, RE DCP Drops, Nohist-DMX, Bronkids, DM-PE-Chlor, Relahist-DM, CP Dec-DM Drops, PD-Cof Drops, PD-Cof, Zotex-12D, Quartuss DM, Statuss DM, Gencontuss, Giltuss Allergy Plus, NoHist-PDX, Dynahist ER

Medically reviewed by Drugs.com. Last updated on Feb 28, 2021.

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Effects on Lactation and Breastmilk

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2,3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1.
Ito S, Blajchman A, Stephenson M, et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393–9. [PubMed: 8498418]
2.
Messinis IE, Souvatzoglou A, Fais N, et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143–6. [PubMed: 3928731]
3.
Pontiroli AE, De Castro e Silva E, Mazzoleni F, et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: Sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924–8. [PubMed: 7228996]

Substance Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Breast Feeding

Lactation

Antihistamines

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Further information

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