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Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Hydrocodone CP, Tussionex Pennkinetic, Hydrocodone HD, Triaminic, Chlor-Trimeton, Alka-Seltzer Plus Cold, Coricidin HBP Cold & Flu, Chlorphen, Chlorpheniramine (Allergy), Norel AD, Show all 813 »Ceron, Allergy Relief, Triant-HC, Coricidin D, Hydrocodone GF, Rondec, Sinarest, Coricidin HBP Cough & Cold, Alumadrine, Tylenol Cold, Phenylhistine DH Expectorant, Triaminic Multi-Symptom Fever, Vituz, TussiCaps, Wal-finate, Stahist, Qdall, Tuzistra XR, Singlet, Rentamine, Naldecon, Ralix, Actifed Cold and Allergy, Suclor, Advil Allergy Sinus, Codeprex, Triplex AD, Zutripro, Ornade Spansules, Tanoral, Ed A-Hist DM, Chlor-Trimeton Sinus, Creomulsion Cough/Cold/Allergy, Quad Tann, Trionate, Cheracol Plus, Triphenicol, Triotann-S Pediatric, Dehistine, PCM, QV-Allergy, Alka-Seltzer Plus Cold Formula Sparkling Original Effervescent Tablets, Dicel, Rescon Extended Release, Ryneze, Histade, Phenagil CH, Relcof PSE, Chlorafed, Genamin, Durafed, Ed ChlorPed, Hista-Vent PSE, Histade CR, Coldamine, Chlorex A, Cold Medicine Plus, Chlortox, Genelan NF, Dexodryl, Allfen A, Rynatan, Ed A-Hist, Novahistine Elixir, R-Tanna, Rondex, Sudafed PE Sinus & Allergy, Hydron PCS, Histinex PV, Allerest PE, Cardec, Effective Strength Cough Syrup, Norel DM, Centergy DM, Ricotuss, Colrex, Congestant, Pediacof, A-G Tussin, NoHist LQ, Histussin HC Liquid, S-T Forte 2, XL-3 Cold Medicine, Coughtuss, Nuhist, Tuxarin ER, Contac Cold + Flu (Night Formula), AH-Chew II, Re-Drylex Jr, Extendryl JR, Ricobid NR, PCM Allergy, Suphedrine PE Sinus & Allergy, BP Allergy JR, Virdec, Ny-Tannic, Histatab PH, Chlor-Mes, AlleRx Dose Pack, Ah-chew Ultra, Redur-PCM, Rhinatate-NF, AlleRx Dose Pack PE (PM Dose), Extendryl Seniors, Dallergy ER, Trigofen Drops, Aerokid, Denaze, DriHist, Sonahist, Pseudo CM TR, Allergy AM-PM Dose Pack, Amdry-C, PCM-LA, Mescolor, Dallergy PSE, RelCof DN PSE, Nolamine, Xiral SR, Amilon, Histatab, VisRx Dose Pack, DuraHist, Rhinolar, DryMax, Time-Hist QD, AllePak, Lohist, Novahistine, Dallergy JR, Phenagil, Relera, Rhinaclear, AlleRx, Allergy DN, ScopoHist, Hycomine Compound, Omnihist II LA, KG-Tussin, JayCof-HC, Pediatex HC, Tussend, Welltuss HC, Hexatussin, Hyphed, Tussin-V, Q-V Tussin, P-V-Tussin Syrup, Notuss, Hydrotuss HC, Hydrocof-HC, Cordron-HC, Cordron-HC NR, Atuss HD, Atuss HS, Advil Allergy and Congestion Relief, Advil Children's Allergy Sinus, RelCof CPM, Detuss, Notuss-Forte, Allergy DN II, Echotuss-HC, B-Tuss, Hydro-PC II, Hydron CP, De-Chlor HD, De-Chlor HC, Atuss MS, Hydro-PC II Plus, Uni-Tricof HC, Rindal HD Plus, Phendal-HD, Relacon-HC, Relacon-HC NR, Tusana-D, Neo HC, Poly-Tussin HD, Liquicough HC, Relasin-HC, DroTuss-CP, Z-Cof HC, Maxi-Tuss HCX, AlleRx DF, NoHist EXT, Durahist PE, DA II, Sinodec, Extendryl SR, Prehist D, Extendryl Chews, DA Chewable, Omnihist L.A., Duravent DA, Hista-Vent DA, Liqui-Allergy, SymPak PDX, AH-Chew, Duradryl, Duradryl JR, Drize, Drysec, Ex-Histine, WE Allergy, Chlor-Mes D, Norel SD, AccuHist Drops, Triall, RespiVent DF, AlleRx Dose Pack (PM Dose), aeroHist, Allerx Dose Pack DF, Dexodryl Suspension, Duravent, DriHist SR, Nohist PE, RelCof DN PE, RelCof PE, ScopoHist Syrup, Allergy DN PE, Ah-Chew Ultra Tannate, DuraTan PE, Nohist Plus, Nohist Plus Jr, Dallergy SR, Duradryl Chewable, Aerohist Plus, Duradryl SR, Dallergy PE, CPM-PE-MSC, ScopoHist-PE, CP Dec, Phenylhistine, Dura-Tap/PD, Novafed A, Duratuss DA, Clorfed, Histalet, Fedahist, Tanafed, Chlorafed HS Timecelles, Codimal-LA, Kronofed-A-Jr, Fedahist Timecaps, Deconamine, Orlenta, Chlorphedrin SR, Colfed-A, D-Amine-SR, Deconomed SR, Pseudocot-C, Duralex, Rinade-BID, Suphenamine-SR, Deconamine SR, Biohist LA (old formulation), Kronofed-A, Chlornade, MyHist-PD, Rhinolar-EX 12, Dura-Vent/A, Resaid, Or-Phen-Ade, Demazin, Contac 12 Hour, ARM Allergy Relief, Teldrin, Condrin, Duotan, Ordrine, Decongex-3, Equi-Nade, Gencold, Rhinolar-EX, Triac, Allerest 12 Hour, Vanex Forte-R, Chlor-Trimeton Decongestant, Isophen-DF, ND Clear, Poly Hist PD (old formulation), Sudal-12, Suphedrine Plus, Atrohist Pediatric Capsule, Allerest Maximum Strength, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, Dynahist-ER Pediatric, CP-Tannic, Mintex, Re2+30, Pediox Chewable, SudoGest Sinus & Allergy, C-Phed Tannate, De-Congestine, Sudal-12 Chewable, Sudal-12 Tannate, SudaHist, AccuHist Drops (old formulation), LoHist-D, Triaminic Softchews Cold and Allergy, Pseudoephedrine Plus, Hayfebrol Liquid, Genaphed Plus, Chlordrine SR, Klerist-D, Anamine TD, Time-Hist, Chlorafed Timecelles, Brexin LA, Rescon-Ed, Pseudochlor, Cophene No 2, Anaplex, Anamine, Codimal-LA Half, Sudogest Cold & Allergy, Fedahist Gyrocaps, Clorfed II, Curaler, Histafed LA, Chlor-Trimeton Allergy Decongestant, Aller-Chlor Decongestant, Sudogest Plus, Neutrahist Drops, Ryna Liquid, Phena-S 12, Pyrichlor PE, Histatab Plus, Ry-Tann, Triaminic Cold & Allergy, ChlorTan D, Rinate Pediatric, Ed ChlorPed D, Sildec-PE Drops, Acta-Tabs PE, Sildec-PE, NoHist, Maxichlor PEH, Hista-Vadrin, Cardec Drops, Nalphen, Nalda-Relief Pediatric, Nalgestic Pediatric, Sinucon Pediatric, Nalgest, West-Decon, Nalspan, Uni Decon, Prop-A-Hist, P-Tann D, Liquitussin HC Syrup, Naldelate, Tanahist-D, Ed A-Hist LA, Rynatan Pediatric, Phenchlor Tannate Pediatric, Nasohist Pediatric, Dallergy Drops, Sinus & Allergy PE, PD-Hist D Drops, Ceron Drops, PD-Hist D, Allan Tannate Pediatric, PediaTan D, CP Dec Drops, Chlor-Mes Jr, Rondex Drops, Dec-Chlorphen, Dec-Chlorphen Drops, C Phen Drops, C Phen, Tannate Pediatric, Histadec, Sinucon, Andecon Pediatric Drops, Conal, Ru-Hist Forte, Tri-Tannate Pediatric, Rhinatate Pediatric, Rhinatate, Url-Tannate Pediatric, Tritan, Tanamine, R-Tannamine, URL-Tannate, Triotann, Histatan, Tri-Tannate, Phena-S, Triotann Pediatric, Chlorex-A 12, Tri-Gestan S, Tri-Hist Pediatric, Phena-Plus, Tri Tann Pediatric, Nalex A 12, AllerTan, Tanamine Pediatric, Triple Tannate Pediatric, Histalet Forte, Nalex-A SR, Vanex Forte, NoHist-A, Nalex-A, Rhinacon A, Comhist, Linhist-LA, Comhist LA, Q-Hist LA, C-Hist-SR, Coldex, Equitan Pediatric, West-Decon M, Atrohist Pediatric, Rynatan-S Pediatric, R-Tannate Pediatric, Gelhist Pediatric, R-Tannate, Triotann-S, R-Tannamine Pediatric, Tanoral Pediatric, Tussive HC, Cyndal HD, Duradal HD, Tannate 12 S, Ru-Tuss, Respa-AR, SymPak II, Tustan 12S, Tussi-12S, Tannic-12 S, Tussi-12, Tussizone-12 RF, C-Tanna 12, Bellahist-D LA, Quad-Tuss, Rynatuss Pediatric, Quadratuss, Rynatuss, Rentamine Pediatric, Tuss Tan, Tuss Tan Pediatric, Tetra Tannate Pediatric, Quad Tuss Pediatric, Histacol LA, AccuHist LA, Tannic-12, Actifed Cold & Sinus, Tylenol Allergy Sinus, Sinutab Ex-Strength, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Triaminicin, Sinutab Maximum Strength Caplets, Allergy Sinus Maximum Strength, Rolatuss, Ex-Tuss, Quelidrine, Alka-Seltzer Plus Flu Formula (old formulation), Alka-Seltzer Plus Cold & Cough Formula Effervescent Tablets, Alka-Seltzer Plus Cold Formula Orange Zest Effervescent Tablets, Alka-Seltzer Plus Cold Formula Cherry Burst Effervescent Tablets, Atrohist Plus, Deconhist LA, Rolatuss-SR, Protuss Tablet, Quad Tann Pediatric, Carbaphen 12, Kolephrin, CapCof, Z-Tuss AC, Zodryl AC, Codar AR, TL-Hist CM, Cotab A, Cotab AX, Lexuss 210, Notuss-AC, Endacof-C, Endal CD, Ed Chlor Ped Jr., T- Koff, Pedituss, Demi-Cof, Dihistine DH, Tricode AR, Zodryl DAC, Phenylhistine DH, Decohistine DH, Codehist DH, Chlor-Phenit, Allergy Time, Tannate-12, TanaHist-PD, XiraTuss, Tanni-Hist 12 RF, Exratuss, Tussi-12 (old formulation), Carbaphen CH, DryMax AF, Ricobid H, Aller-Chlor, P-Tann, Ed-Chlortan, Ed Chlor-Tan, Topco Allergy, Pharbechlor, Teldrin HBP Allergy, C.P.M., Chlor-Mal, Chlo-Amine, Chlor-Trimeton Allergy SR, PediaTan, ChlorTan, Allerest Sinus, Codimal, Co-Histine DH, Alka-Seltzer Plus Flu Formula, Theraflu Nighttime Severe Cold & Cough Caplets, Tylenol Cold Head Congestion Day and Night, Comtrex Nighttime Cold & Cough, XL-3 Xtra Cold and Cough, Cold Multi-Symptom (Nighttime), Multi Symptom Cold (Night Formula), Multi Symptom Cold Relief, Alka-Seltzer Plus Severe Cold & Flu Formula Effervescent Tablets, Alka-Seltzer Plus Severe Sinus & Cold Hot Drink Mix, Tylenol Cold Head Congestion Nighttime, Dimetapp Children's Nighttime Flu, Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets, Triaminic Multi-Symptom Fever & Cold, Comtrex Cold and Flu Maximum Strength, Comtrex Maximum Strength Cold Relief, Contac Severe Cold and Flu Maximum Stength, Theraflu Flu, Cold and Cough Powder, Comtrex Day and Night, Cough Formula M Multi-Symptom, Comtrex Cold & Cough Day Night, Tylenol Cold Multi-Symptom Nighttime, Comtrex Cold and Flu Maximum Strength Liquid, Coricidin HBP Multi-Symptom Cold (Night), 999 Cold Remedy Granular, Cotabflu, Colrex Compound, Vicks NyQuil Cold & Flu Nighttime Relief (Alcohol Free), PediaCare Cough & Runny Nose Plus Acetaminophen, Coricidin HBP Maximum Strength Flu, Mapap Cough & Sinus Formula, Vicks Formula 44 Custom Care Cough & Cold PM, Flu Relief BP, Tylenol Plus Children's Cough & Runny Nose, Codral Cold and Flu + Cough Day and Night, Coricidin HBP Day & Night Multi-Symptom Cold, Tylenol Cold and Flu Severe Day & Night, Dimetapp Children's Multi-Symptom Cold & Flu (old formulation), Tylenol Plus Children's Multi-Symptom Cold, Tylenol Plus Children's Flu, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, PediaCare Multi-Symptom Cold Plus Acetaminophen, Alka-Seltzer Plus Cold & Cough Formula Liquid, PediaCare Flu Plus Acetaminophen, Comtrex Cold and Flu Maximum Strength Tablet, Genacol Maximum Strength, Comtrex Allergy Sinus, Dryphen, Comtrex Severe Cold & Sinus, Comtrex Flu Therapy, Tylenol Plus Children's Cold, Protid, Hybrid CF, Sine-Off Sinus/Cold, Tylenol Sinus Congestion and Pain Cool Burst Day Night, Alka-Seltzer Plus Cold & Flu, HEB Allergy, Covangesic, Tylenol Allergy Multi-Symptom, Norel SR, Trital SR, Rhinogesic, Duadacin, Sinulin, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Simplet, Tricom, Tylenol Sinus Congestion & Pain Nighttime, Dristan Cold Multi Symptom Formula, Childrens Tylenol Cold Plus Cough, ConRx Allergy Sinus, Contac Cold and Flu Maximum Strength, Theraflu Flu & Cough, Allpanto-S, Co-Apap, Theracaps Multi-Symptom Cough & Cold Reliever, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Triaminic Flu, Cough & Fever, Gelpirin-CCF, Medicidin-D, Allergy Pain Relief, Gendecon, Allergy Sinus PE Pain Relief, PX Allergy Sinus PE, Allergy Multi-Symptom, Pyrroxate, Robitussin Peak Cold Nighttime Nasal Relief, Relief-PE, Onset Forte, GNP Cold Relief Plus, Super Strength Sinadrin, Novadyne DH, Ryna-C, Chlorphen HD, Despec-PD, Triaminic-D Multi-Symptom Cold, Allres DS, Duotan DM, T-Tanna DM, Novahistine DH, DiHydro-PE, Coldcough PD, Pancof-PD, Duohist DH, Esocor P, Tusscough DHC, Pancof, Tricof, Hydro-Tussin DHC, Dihydro-CP, Uni-Cof, Coldcough Syrup, Bronkotuss, Ana-Kit, Mesehist DM, CPM-PSE DM Drops, SymPak, Rescon-DM, Tricodene NN, Therahist, Kophane, Threamine DM, Rhinosyn-DM, Vicks 44M Pediatric, Creomulsion Pediatric, Kidcare Cough and Cold, Children's Nyquil, Tanafed-DM, AccuHist PDX Drops, C-Phed DM, M-End DM, Atuss-12 DM, Dicel DM, Atuss DS, Entre-S, Maxichlor PSE DM, Kidkare Cough/Cold, Neutrahist PDX Drops, Z-Tuss 2, P Chlor GG, Dex PC, Histinex HC, Chemtussin HC, Exo-Tuss, Endal-HD Plus, Enplus-HD, Comtussin HC, Tuss-HC, Ventuss Syrup, Maxi-Tuss SA, Maxi-Tuss HC, KG-Dal HD Plus, Endotuss-HD, Highland HC, Uni Tuss HC, H-C Tussive, Cytuss HC, Tuss-DS, Efasin-HD Plus, Quindal HD Plus, Quindal HD, Hi-Tuss HC, Ditussin-HC, KG-Dal HD, Donatussin Pediatric, Efasin-HD, Qual-Tussin Pediatric, Lemohist Plus, HyTan, Novasus, Endagen-HD, Chemdal HD, Iodal HD, Rindal-HD, Ed-TLC, Guiaphen HD, Tuss-PD, Mintuss MS, Vanex-HD, Chemdal HD Plus, Nasatuss, Iotussin HC, Chlorgest HD, Ed-Tuss HC, Sinapils, Hyphen-HD, Tricodene Forte, P Chlor DM, Codahistine-DH Elixir, CP Dec DM, Rondec-DM, Donatussin DM, Ceron-DM Drops, Ceron-DM, Rondex-DM, Rondex-DM Drops, Dec-Chlorphen DM, Dec-Chlorphen DM Drops, HistadecDM, Neo DM Drops, Neotuss D, Nasohist-DM Pediatric, Cardec DM Drops, Balamine DM, Reme Tussin DM, NoHist DM, Tussplex DM, Norel CS, Cardec DM, C-Phen DM, Extendryl DM, Zotex-DM, C-Phen DM Drops, Carepanto, Vicks Children’s NyQuil Cold & Cough, Tricodene SF, QC Cough/Cold, Primatuss 4, Tricodene Sugar Free, Triaminic Softchews Cough & Runny Nose, Dimetapp Children's Long Acting Cough Plus Cold, Robitussin Children's Cough & Cold Long-Acting, Robitussin Cough & Cold Long-Acting, Cold & Cough, Quartuss, Vicks Pediatric Formula 44m Cough & Cold Relief, Triaminic Night Time Cough & Runny Nose, Scot-Tussin DM, St. Joseph HBP Cough & Cold, Robitussin Children's Nighttime Cough Long-Acting DM, SymPak DM, Broncopectol, ChlorDex GP, Qual-Tussin, Robitussin Cough & Allergy, Sildec-PE DM Drops, Trital DM, Atuss DM, Quartuss DM, Statuss DM, NoHist-PDX, Relahist-DM, Albatussin SR, Cerose DM, Maxiphen ADT, Tussar DM, Liquituss R-DM, Father John's Medicine Plus, PD-Cof, NeoTuss Plus, De-Chlor DM, De-Chlor DR, Coldtuss-DR, Tri-Vent DPC, Atuss DR, Corfen-DM, Uni-Tuss DM, Mintuss DR, Zotex-12D, PD-Cof Drops, Sildec-PE DM, Virdec DM, DCP Drops, EndaCof Drops, PE-Hist DM, Maxichlor PEH DM, ED DM, Poly-Tussin DM, Tri-Dex PE, Z-Dex 12 D, Trigofen DM Drops, Zoden DM Drops, CP Dec-DM Drops, Phenabid DM, Re DCP, Sonahist-DM, RE DCP Drops, Nohist-DMX, Bronkids, Donatussin DM Drops, Nasohist-DM, DM-PE-Chlor, Dynahist ER

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as spseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Effects on Lactation and Breastmilk

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

64

Last Revision Date

20170110

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