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Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Hydrocodone CP, Tussionex Pennkinetic, Coricidin HBP Cold & Flu, Chlor-Trimeton, Chlorpheniramine (Allergy), Alka-Seltzer Plus Cold, Coricidin HBP Cough & Cold, Sinarest, Allergy Relief, Coldcough Syrup, Show all 814 »Triaminic, CapCof, Codral Cold and Flu + Cough Day and Night, Norel AD, Tylenol Cold, Coricidin D, Robitussin Cough & Allergy, Hydron PCS, Ed A-Hist, Phenagil, Advil Allergy Sinus, Hydrocodone HD, PCM, Allerest Maximum Strength, CP Dec, Sudafed PE Sinus & Allergy, Rondec, Ceron, Cold & Cough, Sinutab Ex-Strength, Triant-HC, TussiCaps, Endotuss-HD, Deconamine, Mintuss DR, NoHist DM, Codeprex, Tuzistra XR, Alka-Seltzer Plus Cold Formula Sparkling Original Effervescent Tablets, Phenagil CH, Naldecon, Ru-Hist Forte, Nalex A 12, Chlorphen, Aller-Chlor, Phenylhistine DH, Triplex AD, Rentamine, Tritan, Phenylhistine DH Expectorant, Children's Nyquil, Tanoral, Mescolor, AccuHist LA, Anaplex, Lexuss 210, Triaminicin, Simplet, Singlet, De-Chlor DR, Brexin LA, Triac, Duravent, Klerist-D, SudoGest Sinus & Allergy, Demazin, Mintex, Pseudoephedrine Plus, Clorfed, Duralex, Poly-Tussin DM, Highland HC, Cold Multi-Symptom (Nighttime), Theraflu Flu & Cough, Childrens Tylenol Cold Plus Cough, Cough Formula M Multi-Symptom, Vicks Children’s NyQuil Cold & Cough, Effective Strength Cough Syrup, Hydro-PC II, Zutripro, Theraflu Nighttime Severe Cold & Cough Caplets, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, ChlorDex GP, Coricidin HBP Multi-Symptom Cold (Night), Coricidin HBP Maximum Strength Flu, Triaminic Multi-Symptom Fever, Vicks NyQuil Cold & Flu Nighttime Relief (Alcohol Free), Ed A-Hist DM, Balamine DM, Allpanto-S, Cheracol Plus, Rynatan, Allergy Multi-Symptom, Allerest PE, Advil Allergy and Congestion Relief, Suphedrine PE Sinus & Allergy, Dexodryl, Tylenol Sinus Congestion and Pain Cool Burst Day Night, XL-3 Cold Medicine, Relasin-HC, Comtrex Flu Therapy, Medicidin-D, DriHist, AlleRx Dose Pack, ScopoHist, Rhinolar, Ed A-Hist LA, DryMax, Histatab Plus, Novahistine Elixir, AlleRx Dose Pack PE (PM Dose), Nasohist Pediatric, Rynatan Pediatric, R-Tanna, Phenchlor Tannate Pediatric, DuraHist, Dallergy Drops, Extendryl JR, Re-Drylex Jr, PCM Allergy, Chlor-Mes, Histatab PH, Ah-chew Ultra, Redur-PCM, Phenylhistine, Xiral SR, AccuHist Drops, Ricobid NR, Allergy AM-PM Dose Pack, VisRx Dose Pack, Histatab, Amilon, Lohist, Nuhist, Novahistine, Nolamine, Dallergy JR, Relera, NoHist LQ, AlleRx, Sonahist, BP Allergy JR, Coldamine, Pseudo CM TR, Allergy DN, Virdec, Rhinaclear, Ny-Tannic, Trigofen Drops, AllePak, Time-Hist QD, Amdry-C, PCM-LA, Hista-Vent PSE, Relcof PSE, Dallergy PSE, RelCof DN PSE, Rhinatate-NF, Hycomine Compound, Rescon Extended Release, Atuss HD, Tussin-V, Q-V Tussin, A-G Tussin, KG-Tussin, P-V-Tussin Syrup, Hydrotuss HC, Hydrocof-HC, Cordron-HC, Cordron-HC NR, Atuss HS, Hexatussin, Advil Multi-Symptom Cold & Flu, Advil Children's Allergy Sinus, RelCof CPM, AlleRx DF, Allergy DN II, NoHist EXT, RespiVent DF, aeroHist, Allerx Dose Pack DF, Hyphed, Welltuss HC, Ryneze, Liquicough HC, Hydro-PC II Plus, Uni-Tricof HC, Rindal HD Plus, Echotuss-HC, Phendal-HD, Relacon-HC NR, Tusana-D, Neo HC, Poly-Tussin HD, DroTuss-CP, Tussend, Z-Cof HC, Maxi-Tuss HCX, Relacon-HC, Notuss-Forte, Notuss, Detuss, Histinex PV, JayCof-HC, Pediatex HC, Dexodryl Suspension, Dehistine, QV-Allergy, WE Allergy, Hista-Vent DA, DA II, Liqui-Allergy, AH-Chew, Duradryl, Duradryl JR, Drize, Drysec, Ex-Histine, Chlor-Mes D, Omnihist L.A., Norel SD, Durahist PE, Omnihist II LA, AH-Chew II, Ralix, Denaze, Aerokid, Dallergy ER, Extendryl Seniors, Duravent DA, DA Chewable, DriHist SR, Dallergy SR, Nohist PE, RelCof DN PE, RelCof PE, ScopoHist Syrup, AlleRx Dose Pack (PM Dose), Allergy DN PE, DuraTan PE, Nohist Plus, Nohist Plus Jr, Duradryl Chewable, Prehist D, Aerohist Plus, Duradryl SR, Dallergy PE, CPM-PE-MSC, Ah-Chew Ultra Tannate, Triall, SymPak PDX, ScopoHist-PE, Sinodec, Extendryl SR, Extendryl Chews, Sildec-PE Drops, Sinus & Allergy PE, Kronofed-A-Jr, Deconamine SR, Novafed A, Duratuss DA, Histalet, Fedahist, Tanafed, Chlorafed HS Timecelles, Codimal-LA, Dura-Tap/PD, Durafed, Fedahist Timecaps, Orlenta, Chlorphedrin SR, Colfed-A, D-Amine-SR, Deconomed SR, Pseudocot-C, Rinade-BID, Suphenamine-SR, Biohist LA (old formulation), Duotan, Kronofed-A, Chlornade, Rhinolar-EX 12, Dura-Vent/A, Ornade Spansules, Resaid, Or-Phen-Ade, Contac 12 Hour, ARM Allergy Relief, Teldrin, Condrin, Chlor-Trimeton Decongestant, Ordrine, Decongex-3, Equi-Nade, Gencold, Rhinolar-EX, Genamin, Allerest 12 Hour, Vanex Forte-R, Histade CR, Isophen-DF, ND Clear, Phena-S 12, Pediox Chewable, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, Dynahist-ER Pediatric, CP-Tannic, Histade, Suclor, Re2+30, Sudal-12, C-Phed Tannate, Suphedrine Plus, De-Congestine, Sudal-12 Chewable, Dicel, Sudal-12 Tannate, SudaHist, AccuHist Drops (old formulation), LoHist-D, Triaminic Softchews Cold and Allergy, Qdall, Atrohist Pediatric Capsule, Hayfebrol Liquid, Chlordrine SR, Fedahist Gyrocaps, Anamine TD, Time-Hist, Chlorafed Timecelles, Rescon-Ed, Pseudochlor, Cophene No 2, Anamine, Codimal-LA Half, Clorfed II, Genaphed Plus, Curaler, Chlorafed, Histafed LA, Chlor-Trimeton Allergy Decongestant, Aller-Chlor Decongestant, Sudogest Plus, Neutrahist Drops, Ryna Liquid, Sudogest Cold & Allergy, MyHist-PD, Poly Hist PD (old formulation), PD-Hist D Drops, Nalda-Relief Pediatric, De-Chlor HC, Acta-Tabs PE, Sildec-PE, NoHist, Maxichlor PEH, Ry-Tann, Hista-Vadrin, Nalphen, Nalgestic Pediatric, Ed ChlorPed D, Sinucon Pediatric, Nalgest, West-Decon, Nalspan, Uni Decon, Prop-A-Hist, Sinucon, Naldelate, Andecon Pediatric Drops, Cardec, Rinate Pediatric, Vanex Forte, Dec-Chlorphen, Ceron Drops, PD-Hist D, Tanahist-D, Allan Tannate Pediatric, CP Dec Drops, Chlor-Mes Jr, Rondex, Rondex Drops, Dec-Chlorphen Drops, Actifed Cold and Allergy, C Phen Drops, C Phen, Tannate Pediatric, Histadec, PediaTan D, Cardec Drops, P-Tann D, Triaminic Cold & Allergy, ChlorTan D, Histalet Forte, NoHist-A, Pyrichlor PE, Triotann, Tanamine Pediatric, Tri-Tannate Pediatric, Rhinatate Pediatric, Rhinatate, Url-Tannate Pediatric, Tanamine, R-Tannamine, URL-Tannate, Histatan, Triple Tannate Pediatric, Phena-S, Triotann Pediatric, Chlorex-A 12, Tri-Gestan S, Tri-Hist Pediatric, Phena-Plus, Tri Tann Pediatric, AllerTan, Conal, Tri-Tannate, Equitan Pediatric, Nalex-A, Chlorex A, Rhinacon A, Comhist, Linhist-LA, Comhist LA, Q-Hist LA, Chlortox, C-Hist-SR, Nalex-A SR, Coldex, Tanoral Pediatric, West-Decon M, Atrohist Pediatric, Rynatan-S Pediatric, R-Tannate Pediatric, Gelhist Pediatric, R-Tannate, Triotann-S, R-Tannamine Pediatric, Triotann-S Pediatric, Atuss MS, Ed-Tuss HC, De-Chlor HD, Quad Tuss Pediatric, Quad-Tuss, Rynatuss Pediatric, Quadratuss, Rynatuss, Rentamine Pediatric, Tuss Tan, Tuss Tan Pediatric, Tetra Tannate Pediatric, Quad Tann Pediatric, Trionate, Quad Tann, Tannic-12, Carbaphen 12, Tannate-12, XiraTuss, Tanni-Hist 12 RF, Exratuss, Tussi-12 (old formulation), Carbaphen CH, C-Tanna 12, Tannate 12 S, Ricobid H, Ex-Tuss, Alka-Seltzer Plus Flu Formula (old formulation), Alka-Seltzer Plus Cold & Cough Formula Effervescent Tablets, Alka-Seltzer Plus Cold Formula Orange Zest Effervescent Tablets, Alka-Seltzer Plus Cold Formula Cherry Burst Effervescent Tablets, Atrohist Plus, Deconhist LA, Rolatuss-SR, Protuss Tablet, Bellahist-D LA, Tussizone-12 RF, Histacol LA, Stahist, Ru-Tuss, Respa-AR, SymPak II, Tustan 12S, Tussi-12S, Tannic-12 S, Tussi-12, DryMax AF, P-Tann, Rolatuss, Zodryl DAC, Endacof-C, Endal CD, T- Koff, Pediacof, Pedituss, Demi-Cof, Dihistine DH, Tricode AR, Decohistine DH, Cotab AX, Codehist DH, Novadyne DH, Co-Histine DH, Ryna-C, Codahistine-DH Elixir, Tricodene SF, QC Cough/Cold, Primatuss 4, Tricodene Sugar Free, Notuss-AC, Cotab A, TanaHist-PD, PediaTan, Ed ChlorPed, Ed-Chlortan, Topco Allergy, Pharbechlor, Teldrin HBP Allergy, C.P.M., Chlor-Mal, Chlo-Amine, Chlor-Trimeton Allergy SR, Wal-finate, TL-Hist CM, ChlorTan, Ed Chlor-Tan, Allergy Time, Ed Chlor Ped Jr., Chlor-Phenit, Z-Tuss AC, Zodryl AC, Tuxarin ER, Codar AR, Quelidrine, Actifed Cold & Sinus, Dimetapp Children's Long Acting Cough Plus Cold, Comtrex Cold and Flu Maximum Strength, Multi Symptom Cold Relief, Alka-Seltzer Plus Maximum Strength Cold & Cough Liquid Gels, Alka-Seltzer Plus Severe Cold & Flu Formula Effervescent Tablets, Alka-Seltzer Plus Flu Formula, Alka-Seltzer Plus Severe Sinus & Cold Hot Drink Mix, Dimetapp Children's Nighttime Flu, Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets, Triaminic Multi-Symptom Fever & Cold, Comtrex Maximum Strength Cold Relief, XL-3 Xtra Cold and Cough, Contac Severe Cold and Flu Maximum Stength, Theraflu Flu, Cold and Cough Powder, Comtrex Day and Night, Comtrex Cold and Flu Maximum Strength Tablet, Comtrex Cold and Flu Maximum Strength Liquid, Genacol Maximum Strength, Contac Cold and Flu Maximum Strength, Co-Apap, Theracaps Multi-Symptom Cough & Cold Reliever, Multi Symptom Cold (Night Formula), Comtrex Nighttime Cold & Cough, Gelpirin-CCF, Flu Relief BP, Congestant, 999 Cold Remedy Granular, Cotabflu, Colrex Compound, Colrex, Tylenol Children’s Cold + Cough + Runny Nose, PediaCare Cough & Runny Nose Plus Acetaminophen, Mapap Cough & Sinus Formula, Vicks Formula 44 Custom Care Cough & Cold PM, Coricidin HBP Day & Night Multi-Symptom Cold, Tylenol Cold Head Congestion Day and Night, Tylenol Cold and Flu Severe Day & Night, Dimetapp Children's Multi-Symptom Cold & Flu (old formulation), Tylenol Children’s Cold + Flu, PediaCare Multi-Symptom Cold Plus Acetaminophen, Alka-Seltzer Plus Cold & Cough Formula Liquid, PediaCare Flu Plus Acetaminophen, Tylenol Cold Multi-Symptom Nighttime, Tylenol Cold Head Congestion Nighttime, Comtrex Cold & Cough Day Night, Triaminic Flu, Cough & Fever, Contac Cold + Flu (Night Formula), Cold Medicine Plus, Comtrex Allergy Sinus, Rhinogesic, Alumadrine, Duadacin, Sinulin, Chlor-Trimeton Sinus, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Tricom, Codimal, Norel SR, Kolephrin, Allerest Sinus, Tylenol Allergy Sinus, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Sinutab Maximum Strength Caplets, Allergy Sinus Maximum Strength, Trital SR, Covangesic, ConRx Allergy Sinus, Gendecon, Allergy Pain Relief, Allergy Sinus PE Pain Relief, PX Allergy Sinus PE, Pyrroxate, Robitussin Peak Cold Nighttime Nasal Relief, Relief-PE, Onset Forte, GNP Cold Relief Plus, Super Strength Sinadrin, Dristan Cold Multi Symptom Formula, Dryphen, Tylenol Allergy Multi-Symptom, Tylenol Sinus Congestion & Pain Nighttime, Comtrex Severe Cold & Sinus, Tylenol Plus Children's Cold, Protid, Hybrid CF, Sine-Off Sinus/Cold, Alka-Seltzer Plus Cold & Flu, HEB Allergy, Triaminic Softchews Cough & Runny Nose, Robitussin Children's Cough & Cold Long-Acting, Hydron CP, Ana-Kit, Duohist DH, Tusscough DHC, Pancof, Tricof, Hydro-Tussin DHC, Dihydro-CP, Uni-Cof, Bronkotuss, Allfen A, Pancof-PD, Z-Tuss 2, SymPak, P Chlor GG, Donatussin Pediatric, Qual-Tussin Pediatric, Lemohist Plus, Hydrocodone GF, S-T Forte 2, HyTan, Despec-PD, Coldcough PD, Vituz, Neutrahist PDX Drops, Tanafed-DM, C-Phed DM, M-End DM, Atuss-12 DM, Dicel DM, Atuss DS, Entre-S, Maxichlor PSE DM, Kidkare Cough/Cold, AccuHist PDX Drops, DiHydro-PE, CPM-PSE DM Drops, Esocor P, Mesehist DM, Triaminic-D Multi-Symptom Cold, Allres DS, Duotan DM, T-Tanna DM, Pedia Relief Cough-Cold, Novahistine DH, Novasus, Endagen-HD, Kidcare Cough and Cold, Cytuss HC, Maxi-Tuss SA, Maxi-Tuss HC, Histinex HC, Coughtuss, KG-Dal HD Plus, Uni Tuss HC, H-C Tussive, Histussin HC Liquid, Tuss-DS, Tuss-HC, Efasin-HD Plus, Quindal HD Plus, Quindal HD, Hi-Tuss HC, Chlorphen HD, Duradal HD, Liquitussin HC Syrup, Tussive HC, B-Tuss, Ventuss Syrup, Comtussin HC, Chemdal HD, Iotussin HC, Iodal HD, Rindal-HD, Ed-TLC, Efasin-HD, Guiaphen HD, Mintuss MS, Vanex-HD, Chemdal HD Plus, Nasatuss, Chlorgest HD, Enplus-HD, Sinapils, Cyndal HD, Hyphen-HD, Tuss-PD, KG-Dal HD, Ditussin-HC, Chemtussin HC, Exo-Tuss, Endal-HD Plus, Rescon-DM, Creomulsion Pediatric, Robitussin Cough & Cold Long-Acting, C-Phen DM Drops, Neo DM Drops, Nasohist-DM Pediatric, Cardec DM Drops, Reme Tussin DM, Tussplex DM, Norel CS, Cardec DM, C-Phen DM, Sildec-PE DM Drops, HistadecDM, Sildec-PE DM, DCP Drops, EndaCof Drops, PE-Hist DM, Maxichlor PEH DM, ED DM, Ricotuss, Tri-Dex PE, Z-Dex 12 D, CP Dec DM, Dec-Chlorphen DM Drops, Virdec DM, Quartuss, Carepanto, Vicks Pediatric Formula 44m Cough & Cold Relief, Triaminic Night Time Cough & Runny Nose, Scot-Tussin DM, St. Joseph HBP Cough & Cold, Robitussin Children's Nighttime Cough Long-Acting DM, SymPak DM, Broncopectol, Qual-Tussin, Genelan NF, Dec-Chlorphen DM, Zotex-DM, Neotuss D, Extendryl DM, Rondec-DM, Donatussin DM, Ceron-DM Drops, Ceron-DM, Rondex-DM, Rondex-DM Drops, Trigofen DM Drops, Zoden DM Drops, Creomulsion Cough/Cold/Allergy, Trital DM, Norel DM, NeoTuss Plus, De-Chlor DM, Coldtuss-DR, Tri-Vent DPC, Atuss DR, Corfen-DM, Uni-Tuss DM, P Chlor DM, Atuss DM, Dex PC, Tricodene Forte, Tricodene NN, Therahist, Triphenicol, Kophane, Threamine DM, Rhinosyn-DM, Vicks 44M Pediatric, Father John's Medicine Plus, Centergy DM, Phenabid DM, PD-Cof Drops, Re DCP, Sonahist-DM, RE DCP Drops, Nohist-DMX, Bronkids, Donatussin DM Drops, Nasohist-DM, DM-PE-Chlor, CP Dec-DM Drops, PD-Cof, Liquituss R-DM, Zotex-12D, Quartuss DM, Statuss DM, NoHist-PDX, Relahist-DM, Albatussin SR, Cerose DM, Maxiphen ADT, Tussar DM, Dynahist ER

Medically reviewed on Jul 5, 2018

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as spseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Effects on Lactation and Breastmilk

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Breast Feeding

Lactation

Antihistamines

Administrative Information

LactMed Record Number

64

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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