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Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Tussionex Pennkinetic, Allergy Relief, Coricidin HBP Cold & Flu, Coricidin HBP Cough & Cold, Theraflu Flu & Cough, Tylenol Cold, Comtrex Cold and Flu Maximum Strength Tablet, Coldcough Syrup, Norel AD, R-Tanna, Show all 812 »Triaminic, Sudafed PE Sinus & Allergy, Sinarest, Sinus & Allergy PE, Chlor-Trimeton, Chlorphen, Alka-Seltzer Plus Cold, Phenagil, XL-3 Cold Medicine, Childrens Tylenol Cold Plus Cough, Rynatan, Ed A-Hist, NoHist, TussiCaps, Hydrocodone HD, Advil Allergy Sinus, Hydrocodone CP, Dristan Cold Multi Symptom Formula, Rondec, LoHist-D, Phenagil CH, Tuzistra XR, Ed A-Hist DM, Theraflu Nighttime Severe Cold & Cough Caplets, Singlet, Novahistine DH, Coricidin HBP Maximum Strength Flu, Curaler, Clorfed, Kronofed-A-Jr, Tylenol Sinus Congestion & Pain Nighttime, Isophen-DF, Ornade Spansules, Teldrin, Decongex-3, Dicel, Aller-Chlor Decongestant, Triac, Coricidin D, Sinulin, Norel SR, R-Tannamine, Vituz, Tanoral, Allergy DN PE, Wal-finate, Chlor-Trimeton Allergy SR, Rolatuss, Hycomine Compound, Cyndal HD, Tricodene Sugar Free, Congestant, Reme Tussin DM, Colrex Compound, Trigofen DM Drops, Tylenol Children’s Cold + Cough + Runny Nose, Corfen-DM, Rhinosyn-DM, CPM-PSE DM Drops, Trionate, Cold Multi-Symptom (Nighttime), SymPak II, Ventuss Syrup, Stahist, Actifed Cold and Allergy, Phenylhistine DH Expectorant, Coughtuss, Relasin-HC, Coldcough PD, Sinucon, Cough Formula M Multi-Symptom, Comtrex Day and Night, Naldecon, Rondex, Ceron, Denaze, Durahist PE, Extendryl Seniors, Dallergy ER, Ah-chew Ultra, Redur-PCM, Histatab PH, Chlor-Mes, Norel SD, Omnihist II LA, PCM, Ralix, AlleRx Dose Pack PE (PM Dose), Extendryl JR, Re-Drylex Jr, QV-Allergy, AH-Chew II, Aerokid, Rescon Extended Release, PCM Allergy, Allergy DN, DriHist, AlleRx, Nolamine, Lohist, Nuhist, Novahistine, Dallergy JR, Relera, NoHist LQ, Sonahist, Histatab, Ricobid NR, Suphedrine PE Sinus & Allergy, BP Allergy JR, Allerest PE, Virdec, Ny-Tannic, Rhinatate-NF, Trigofen Drops, Amilon, VisRx Dose Pack, AlleRx Dose Pack, Hista-Vent PSE, Rhinolar, DryMax, DuraHist, Xiral SR, RelCof DN PSE, Dallergy PSE, Relcof PSE, Mescolor, PCM-LA, Allergy AM-PM Dose Pack, Amdry-C, Time-Hist QD, AllePak, Rhinaclear, WE Allergy, Pseudo CM TR, Coldamine, ScopoHist, Chlor-Mes D, SymPak PDX, Ex-Histine, A-G Tussin, JayCof-HC, Pediatex HC, Tussend, Welltuss HC, Hexatussin, Hyphed, Tussin-V, Q-V Tussin, KG-Tussin, Detuss, P-V-Tussin Syrup, Hydrotuss HC, Hydron PCS, Hydrocof-HC, Cordron-HC, Cordron-HC NR, Atuss HD, Atuss HS, Advil Multi-Symptom Cold & Flu, Histinex PV, Notuss, Advil Children's Allergy Sinus, Phendal-HD, Hydron CP, De-Chlor HD, De-Chlor HC, Atuss MS, Hydro-PC II Plus, Triant-HC, Uni-Tricof HC, Rindal HD Plus, Echotuss-HC, Relacon-HC NR, Notuss-Forte, Tusana-D, Neo HC, Poly-Tussin HD, Liquicough HC, DroTuss-CP, Z-Cof HC, Maxi-Tuss HCX, Relacon-HC, Zutripro, Advil Allergy and Congestion Relief, RelCof CPM, Drysec, Extendryl Chews, CPM-PE-MSC, Ah-Chew Ultra Tannate, Triall, Phenylhistine, ScopoHist-PE, Sinodec, Extendryl SR, Prehist D, DA Chewable, Duradryl SR, Omnihist L.A., Duravent DA, Hista-Vent DA, DA II, Liqui-Allergy, AH-Chew, Duradryl, Duradryl JR, Drize, Dallergy PE, Aerohist Plus, AlleRx DF, Dehistine, Allergy DN II, NoHist EXT, RespiVent DF, aeroHist, Allerx Dose Pack DF, Dexodryl Suspension, Dexodryl, Ryneze, Duravent, DriHist SR, Duradryl Chewable, Nohist PE, RelCof DN PE, RelCof PE, ScopoHist Syrup, AlleRx Dose Pack (PM Dose), DuraTan PE, Nohist Plus, Nohist Plus Jr, Dallergy SR, AccuHist Drops, Triaminic Cold & Allergy, Novahistine Elixir, Dura-Tap/PD, Deconamine SR, Novafed A, Duratuss DA, Histalet, Fedahist, Tanafed, Chlorafed HS Timecelles, Codimal-LA, Fedahist Timecaps, Biohist LA (old formulation), Orlenta, Chlorphedrin SR, Colfed-A, D-Amine-SR, Deconomed SR, Pseudocot-C, Duralex, Rinade-BID, Suphenamine-SR, Deconamine, Durafed, ND Clear, Chlornade, MyHist-PD, Triplex AD, Rhinolar-EX 12, Dura-Vent/A, Resaid, Or-Phen-Ade, Demazin, Contac 12 Hour, ARM Allergy Relief, Condrin, Duotan, Ordrine, Equi-Nade, Gencold, Rhinolar-EX, Genamin, Allerest 12 Hour, Vanex Forte-R, Histade CR, Chlor-Trimeton Decongestant, Kronofed-A, Chlordrine SR, Poly Hist PD (old formulation), Sudal-12, Allerest Maximum Strength, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, Dynahist-ER Pediatric, CP-Tannic, Histade, Mintex, Suclor, Re2+30, Pediox Chewable, Suphedrine Plus, C-Phed Tannate, De-Congestine, Sudal-12 Chewable, Sudal-12 Tannate, SudaHist, AccuHist Drops (old formulation), Triaminic Softchews Cold and Allergy, Pseudoephedrine Plus, Qdall, Atrohist Pediatric Capsule, Hayfebrol Liquid, Anamine TD, Codimal-LA Half, Time-Hist, Chlorafed Timecelles, Brexin LA, Rescon-Ed, Pseudochlor, Cophene No 2, Anaplex, Anamine, Klerist-D, Fedahist Gyrocaps, SudoGest Sinus & Allergy, Clorfed II, Chlorafed, Histafed LA, Chlor-Trimeton Allergy Decongestant, Sudogest Plus, Neutrahist Drops, Ryna Liquid, Sudogest Cold & Allergy, Genaphed Plus, Phena-S 12, Pyrichlor PE, Histatab Plus, Hista-Vadrin, ChlorTan D, Rinate Pediatric, Ed ChlorPed D, Cardec, Sildec-PE Drops, Acta-Tabs PE, Sildec-PE, Maxichlor PEH, Ry-Tann, Nalphen, P-Tann D, Nalda-Relief Pediatric, Nalgestic Pediatric, Sinucon Pediatric, Nalgest, West-Decon, Nalspan, Uni Decon, Prop-A-Hist, Naldelate, B-Tuss, Cardec Drops, Histalet Forte, Allan Tannate Pediatric, Ed A-Hist LA, Rynatan Pediatric, Phenchlor Tannate Pediatric, Nasohist Pediatric, Dallergy Drops, PD-Hist D Drops, Ceron Drops, PD-Hist D, Tanahist-D, CP Dec Drops, CP Dec, Chlor-Mes Jr, Rondex Drops, Dec-Chlorphen, Dec-Chlorphen Drops, C Phen Drops, C Phen, Tannate Pediatric, Histadec, PediaTan D, Andecon Pediatric Drops, Vanex Forte, Conal, Ru-Hist Forte, Tanamine Pediatric, Tri-Tannate Pediatric, Rhinatate Pediatric, Rhinatate, Url-Tannate Pediatric, Tritan, Tanamine, URL-Tannate, Triotann, Histatan, Triple Tannate Pediatric, Phena-S, Triotann Pediatric, Chlorex-A 12, Tri-Gestan S, Tri-Hist Pediatric, Phena-Plus, Tri Tann Pediatric, Nalex A 12, AllerTan, Tri-Tannate, Equitan Pediatric, NoHist-A, Chlorex A, Nalex-A, Rhinacon A, Comhist, Linhist-LA, Comhist LA, Q-Hist LA, Chlortox, C-Hist-SR, Nalex-A SR, Coldex, Tanoral Pediatric, West-Decon M, Atrohist Pediatric, Rynatan-S Pediatric, R-Tannate Pediatric, Gelhist Pediatric, R-Tannate, Triotann-S, R-Tannamine Pediatric, Triotann-S Pediatric, Hydro-PC II, Tuss-PD, Tussive HC, Quad Tuss Pediatric, Rynatuss Pediatric, Quadratuss, Rynatuss, Rentamine Pediatric, Rentamine, Tuss Tan, Tuss Tan Pediatric, Tetra Tannate Pediatric, Quad Tann Pediatric, C-Tanna 12, Quad Tann, Tannic-12, Carbaphen 12, Tannate-12, XiraTuss, Tanni-Hist 12 RF, Exratuss, Tussi-12 (old formulation), Carbaphen CH, Quad-Tuss, Tannate 12 S, Ricobid H, Protuss Tablet, Quelidrine, Alka-Seltzer Plus Flu Formula (old formulation), Alka-Seltzer Plus Cold & Cough Formula Effervescent Tablets, Alka-Seltzer Plus Cold Formula Sparkling Original Effervescent Tablets, Alka-Seltzer Plus Cold Formula Orange Zest Effervescent Tablets, Alka-Seltzer Plus Cold Formula Cherry Burst Effervescent Tablets, Atrohist Plus, Deconhist LA, Rolatuss-SR, Ex-Tuss, Tussizone-12 RF, AccuHist LA, Bellahist-D LA, Histacol LA, Ru-Tuss, Respa-AR, Tustan 12S, Tussi-12S, Tannic-12 S, Tussi-12, DryMax AF, Aller-Chlor, Cold Medicine Plus, Demi-Cof, Codeprex, Notuss-AC, Endacof-C, CapCof, Endal CD, T- Koff, Pediacof, Pedituss, Dihistine DH, Cotab AX, Tricode AR, Zodryl DAC, Phenylhistine DH, Decohistine DH, Codehist DH, Novadyne DH, Co-Histine DH, Ryna-C, Codahistine-DH Elixir, Lexuss 210, Cotab A, P-Tann, PediaTan, TanaHist-PD, Ed ChlorPed, Ed-Chlortan, Topco Allergy, Pharbechlor, Teldrin HBP Allergy, C.P.M., Chlor-Mal, Chlo-Amine, Chlorpheniramine (Allergy), TL-Hist CM, ChlorTan, Ed Chlor-Tan, Allergy Time, Ed Chlor Ped Jr., Chlor-Phenit, Z-Tuss AC, Zodryl AC, Tuxarin ER, Codar AR, Actifed Cold & Sinus, Allergy Sinus Maximum Strength, QC Cough/Cold, Comtrex Cold and Flu Maximum Strength, Multi Symptom Cold (Night Formula), Multi Symptom Cold Relief, Alka-Seltzer Plus Maximum Strength Cold & Cough Liquid Gels, Alka-Seltzer Plus Severe Cold & Flu Formula Effervescent Tablets, Alka-Seltzer Plus Severe Sinus & Cold Hot Drink Mix, Dimetapp Children's Nighttime Flu, Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets, Triaminic Multi-Symptom Fever & Cold, Comtrex Maximum Strength Cold Relief, XL-3 Xtra Cold and Cough, Contac Severe Cold and Flu Maximum Stength, Theraflu Flu, Cold and Cough Powder, Comtrex Cold and Flu Maximum Strength Liquid, Genacol Maximum Strength, Contac Cold and Flu Maximum Strength, Allpanto-S, Co-Apap, Theracaps Multi-Symptom Cough & Cold Reliever, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Alka-Seltzer Plus Maximum Strength Cold & Cough, Comtrex Nighttime Cold & Cough, Gelpirin-CCF, Coricidin HBP Multi-Symptom Cold (Night), 999 Cold Remedy Granular, Cotabflu, Colrex, Vicks NyQuil Cold & Flu Nighttime Relief (Alcohol Free), Triaminic Multi-Symptom Fever, PediaCare Cough & Runny Nose Plus Acetaminophen, Mapap Cough & Sinus Formula, Vicks Formula 44 Custom Care Cough & Cold PM, Flu Relief BP, Coricidin HBP Day & Night Multi-Symptom Cold, Tylenol Cold Head Congestion Day and Night, Tylenol Cold and Flu Severe Day & Night, Dimetapp Children's Multi-Symptom Cold & Flu (old formulation), Tylenol Children’s Cold + Flu, PediaCare Multi-Symptom Cold Plus Acetaminophen, PediaCare Flu Plus Acetaminophen, Codral Cold and Flu + Cough Day and Night, Tylenol Cold Multi-Symptom Nighttime, Tylenol Cold Head Congestion Nighttime, Comtrex Cold & Cough Day Night, Triaminic Flu, Cough & Fever, Contac Cold + Flu (Night Formula), Sinutab Maximum Strength Caplets, Comtrex Allergy Sinus, Trital SR, Rhinogesic, Alumadrine, Duadacin, Chlor-Trimeton Sinus, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Simplet, Tricom, Codimal, Dryphen, Kolephrin, Allerest Sinus, Tylenol Allergy Sinus, Sinutab Ex-Strength, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Triaminicin, Covangesic, HEB Allergy, Medicidin-D, Onset Forte, BC Sinus Pain & Congestion, ConRx Allergy Sinus, Allergy Pain Relief, Allergy Sinus PE Pain Relief, PX Allergy Sinus PE, Allergy Multi-Symptom, Pyrroxate, Robitussin Peak Cold Nighttime Nasal Relief, Relief-PE, GNP Cold Relief Plus, Tylenol Sinus Congestion and Pain Cool Burst Day Night, Super Strength Sinadrin, Gendecon, Tylenol Allergy Multi-Symptom, Comtrex Severe Cold & Sinus, Comtrex Flu Therapy, Tylenol Plus Children's Cold, Protid, Hybrid CF, Sine-Off Sinus/Cold, Vicks Children’s NyQuil Cold & Cough, Effective Strength Cough Syrup, Liquitussin HC Syrup, Pancof, Duotan DM, T-Tanna DM, Pedia Relief Cough-Cold, DiHydro-PE, Pancof-PD, Despec-PD, Duohist DH, Tusscough DHC, Tricof, Triaminic-D Multi-Symptom Cold, Hydro-Tussin DHC, Dihydro-CP, Uni-Cof, Bronkotuss, Ana-Kit, Allfen A, Z-Tuss 2, SymPak, P Chlor GG, Allres DS, Mesehist DM, Qual-Tussin Pediatric, Tanafed-DM, Triphenicol, Kophane, Threamine DM, Vicks 44M Pediatric, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Kidcare Cough and Cold, Children's Nyquil, Rescon-DM, C-Phed DM, Esocor P, M-End DM, Atuss-12 DM, Dicel DM, Atuss DS, Entre-S, Maxichlor PSE DM, Kidkare Cough/Cold, Neutrahist PDX Drops, AccuHist PDX Drops, Donatussin Pediatric, Lemohist Plus, Cheracol Plus, Uni Tuss HC, Endal-HD Plus, Enplus-HD, Comtussin HC, Tuss-HC, Maxi-Tuss SA, Maxi-Tuss HC, Histinex HC, KG-Dal HD Plus, Highland HC, H-C Tussive, Chemtussin HC, Histussin HC Liquid, Cytuss HC, Tuss-DS, Efasin-HD Plus, Quindal HD Plus, Quindal HD, Hi-Tuss HC, Chlorphen HD, Duradal HD, Exo-Tuss, Ditussin-HC, Hydrocodone GF, Guiaphen HD, S-T Forte 2, HyTan, Novasus, Endagen-HD, Chemdal HD, Iodal HD, Rindal-HD, Ed-TLC, Efasin-HD, Mintuss MS, Endotuss-HD, Vanex-HD, Chemdal HD Plus, Nasatuss, Iotussin HC, Chlorgest HD, Ed-Tuss HC, Hyphen-HD, Sinapils, KG-Dal HD, Therahist, Tricodene NN, Primatuss 4, NoHist DM, Dec-Chlorphen DM, Dec-Chlorphen DM Drops, HistadecDM, CP Dec DM, Neo DM Drops, Nasohist-DM Pediatric, Cardec DM Drops, Balamine DM, Tussplex DM, Rondex-DM, Norel CS, Cardec DM, C-Phen DM, Robitussin Cough & Allergy, C-Phen DM Drops, Sildec-PE DM Drops, Sildec-PE DM, DCP Drops, EndaCof Drops, Rondex-DM Drops, Ceron-DM, Maxichlor PEH DM, SymPak DM, Triaminic Softchews Cough & Runny Nose, Dimetapp Children's Long Acting Cough Plus Cold, Robitussin Children's Cough & Cold Long-Acting, Robitussin Cough & Cold Long-Acting, Carepanto, Triaminic Night Time Cough & Runny Nose, Scot-Tussin DM, St. Joseph HBP Cough & Cold, Robitussin Children's Nighttime Cough Long-Acting DM, Broncopectol, Ceron-DM Drops, ChlorDex GP, Qual-Tussin, Quartuss, Genelan NF, Zotex-DM, Neotuss D, Extendryl DM, Rondec-DM, Donatussin DM, PE-Hist DM, ED DM, Tricodene Forte, NeoTuss Plus, Albatussin SR, Cerose DM, Maxiphen ADT, Tussar DM, Liquituss R-DM, Centergy DM, Atuss DM, Father John's Medicine Plus, Norel DM, De-Chlor DM, NoHist-PDX, De-Chlor DR, Coldtuss-DR, Tri-Vent DPC, Atuss DR, Uni-Tuss DM, Mintuss DR, Trital DM, P Chlor DM, Dex PC, Relahist-DM, Giltuss Allergy Plus, Poly-Tussin DM, Nohist-DMX, Ricotuss, Tri-Dex PE, Z-Dex 12 D, Virdec DM, Zoden DM Drops, Phenabid DM, Re DCP, Sonahist-DM, RE DCP Drops, Bronkids, Gencontuss, Donatussin DM Drops, Nasohist-DM, DM-PE-Chlor, CP Dec-DM Drops, PD-Cof Drops, PD-Cof, Zotex-12D, Quartuss DM, Statuss DM, Dynahist ER

Medically reviewed by Drugs.com. Last updated on Mar 14, 2020.

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as spseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Effects on Lactation and Breastmilk

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Breast Feeding

Lactation

Antihistamines

Administrative Information

LactMed Record Number

64

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.