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Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Chlor-Trimeton, Tussionex Pennkinetic, Hydrocodone CP, Coricidin HBP Cold & Flu, Chlorpheniramine (Allergy), Alka-Seltzer Plus Cold, Allergy Relief, Allerest Maximum Strength, Tylenol Cold, Tuzistra XR, Show all 813 »Triaminic, Sinarest, Hydrocodone HD, Sudafed PE Sinus & Allergy, Norel AD, Aller-Chlor, Coricidin HBP Cough & Cold, Singlet, Rindal-HD, Coughtuss, Coricidin D, Hydrocodone GF, Medicidin-D, XL-3 Cold Medicine, Childrens Tylenol Cold Plus Cough, Phenagil, Rynatan, Triant-HC, Zutripro, Triplex AD, Chlorex A, Deconamine, Anaplex, Chlor-Trimeton Allergy Decongestant, Codral Cold and Flu + Cough Day and Night, Chlortox, Chlorafed HS Timecelles, Suclor, Rhinacon A, Ralix, Triall, Dehistine, Chlorphen, Lexuss 210, Relief-PE, Onset Forte, Tylenol Allergy Multi-Symptom, Xiral SR, Chlor-Mal, C.P.M., Condrin, Ordrine, Genamin, TussiCaps, Teldrin, Simplet, ChlorTan D, Trionate, Tylenol Children’s Cold + Cough + Runny Nose, Balamine DM, NoHist DM, Stahist, Robitussin Children's Cough & Cold Long-Acting, Tylenol Cold Head Congestion Nighttime, AllerTan, Kidcare Cough and Cold, Tanamine, Dicel DM, Actifed Cold and Allergy, Hydron PCS, Children's Nyquil, Relasin-HC, CapCof, Ceron, Sinus & Allergy PE, Cold Medicine Plus, Cyndal HD, Rondec, Esocor P, Amilon, Tanoral, Allpanto-S, Hydron CP, Chlorphen HD, Omnihist II LA, Ah-chew Ultra, PCM, Re-Drylex Jr, Extendryl JR, Durahist PE, Norel SD, AH-Chew II, Dallergy ER, Redur-PCM, Denaze, Aerokid, Histatab PH, Extendryl Seniors, QV-Allergy, Rescon Extended Release, PCM Allergy, Chlor-Mes, AlleRx Dose Pack PE (PM Dose), Amdry-C, DriHist, Sonahist, Lohist, Nuhist, Novahistine, Dallergy JR, Relera, NoHist LQ, AlleRx, Ricobid NR, Histatab, Suphedrine PE Sinus & Allergy, BP Allergy JR, Allerest PE, Virdec, Ny-Tannic, Rhinatate-NF, Trigofen Drops, AccuHist Drops, Nolamine, VisRx Dose Pack, AlleRx Dose Pack, Hista-Vent PSE, Rhinolar, DryMax, DuraHist, RelCof DN PSE, Dallergy PSE, Relcof PSE, Mescolor, PCM-LA, Allergy AM-PM Dose Pack, WE Allergy, Time-Hist QD, AllePak, Rhinaclear, Allergy DN, Pseudo CM TR, Coldamine, ScopoHist, Chlor-Mes D, Hycomine Compound, Ex-Histine, Tussin-V, Detuss, Histinex PV, JayCof-HC, Pediatex HC, Tussend, Welltuss HC, Hexatussin, Hyphed, Q-V Tussin, Notuss-Forte, A-G Tussin, KG-Tussin, P-V-Tussin Syrup, Hydrotuss HC, Hydrocof-HC, Cordron-HC, Cordron-HC NR, Atuss HD, Atuss HS, Notuss, Relacon-HC, Advil Allergy Sinus, Uni-Tricof HC, Duradal HD, Liquitussin HC Syrup, Tussive HC, B-Tuss, Hydro-PC II, De-Chlor HD, De-Chlor HC, Atuss MS, Hydro-PC II Plus, Rindal HD Plus, Maxi-Tuss HCX, Echotuss-HC, Phendal-HD, Relacon-HC NR, Tusana-D, Neo HC, Poly-Tussin HD, Liquicough HC, DroTuss-CP, Z-Cof HC, Advil Allergy and Congestion Relief, Advil Children's Allergy Sinus, Drysec, Extendryl Chews, Dallergy PE, CPM-PE-MSC, Ed A-Hist, Ah-Chew Ultra Tannate, SymPak PDX, ScopoHist-PE, Sinodec, Extendryl SR, Prehist D, DA Chewable, Aerohist Plus, Omnihist L.A., Duravent DA, Hista-Vent DA, DA II, Liqui-Allergy, AH-Chew, Duradryl, Duradryl JR, Drize, Duradryl SR, Duradryl Chewable, RelCof CPM, Duravent, AlleRx DF, Allergy DN II, NoHist EXT, RespiVent DF, aeroHist, Allerx Dose Pack DF, Dexodryl Suspension, Dexodryl, Ryneze, DriHist SR, Dallergy SR, Nohist PE, RelCof DN PE, RelCof PE, ScopoHist Syrup, AlleRx Dose Pack (PM Dose), Allergy DN PE, DuraTan PE, Nohist Plus, Nohist Plus Jr, Phenylhistine, CP Dec, Novahistine Elixir, Fedahist Timecaps, Duratuss DA, Clorfed, Histalet, Fedahist, Tanafed, Codimal-LA, Kronofed-A-Jr, Dura-Tap/PD, Orlenta, Deconamine SR, Chlorphedrin SR, Colfed-A, D-Amine-SR, Deconomed SR, Pseudocot-C, Duralex, Rinade-BID, Suphenamine-SR, Isophen-DF, Novafed A, Biohist LA (old formulation), ND Clear, Chlornade, MyHist-PD, Rhinolar-EX 12, Dura-Vent/A, Ornade Spansules, Resaid, Or-Phen-Ade, Demazin, Contac 12 Hour, ARM Allergy Relief, Decongex-3, Durafed, Equi-Nade, Gencold, Rhinolar-EX, Triac, Allerest 12 Hour, Vanex Forte-R, Histade CR, Chlor-Trimeton Decongestant, Duotan, Kronofed-A, Chlordrine SR, Poly Hist PD (old formulation), C-Phed Tannate, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, Dynahist-ER Pediatric, CP-Tannic, Histade, Mintex, Re2+30, Sudal-12, Pediox Chewable, De-Congestine, Suphedrine Plus, Sudal-12 Chewable, Dicel, Sudal-12 Tannate, SudaHist, AccuHist Drops (old formulation), LoHist-D, Triaminic Softchews Cold and Allergy, Pseudoephedrine Plus, Qdall, Atrohist Pediatric Capsule, Hayfebrol Liquid, Anamine TD, Fedahist Gyrocaps, Time-Hist, Chlorafed Timecelles, Brexin LA, Rescon-Ed, Pseudochlor, Cophene No 2, Anamine, Klerist-D, Codimal-LA Half, Clorfed II, SudoGest Sinus & Allergy, Curaler, Chlorafed, Histafed LA, Aller-Chlor Decongestant, Sudogest Plus, Neutrahist Drops, Ryna Liquid, Sudogest Cold & Allergy, Genaphed Plus, Phena-S 12, Pyrichlor PE, Histatab Plus, Maxichlor PEH, P-Tann D, Triaminic Cold & Allergy, Rinate Pediatric, Ed ChlorPed D, Cardec, Sildec-PE Drops, Acta-Tabs PE, Sildec-PE, NoHist, Ry-Tann, Quindal HD, Hista-Vadrin, Nalphen, Nalda-Relief Pediatric, Nalgestic Pediatric, Sinucon Pediatric, Nalgest, West-Decon, Nalspan, Uni Decon, Cardec Drops, PediaTan D, Sinucon, Tanahist-D, Ed A-Hist LA, Rynatan Pediatric, R-Tanna, Phenchlor Tannate Pediatric, Nasohist Pediatric, Dallergy Drops, PD-Hist D Drops, Ceron Drops, PD-Hist D, Allan Tannate Pediatric, Histadec, CP Dec Drops, Chlor-Mes Jr, Rondex, Rondex Drops, Dec-Chlorphen, Dec-Chlorphen Drops, C Phen Drops, C Phen, Tannate Pediatric, Prop-A-Hist, Naldelate, Conal, Triotann, Tri-Tannate, Tanamine Pediatric, Tri-Tannate Pediatric, Rhinatate Pediatric, Rhinatate, Url-Tannate Pediatric, Tritan, R-Tannamine, URL-Tannate, Ru-Hist Forte, Equitan Pediatric, Histatan, Phena-S, Triotann Pediatric, Chlorex-A 12, Tri-Gestan S, Tri-Hist Pediatric, Phena-Plus, Tri Tann Pediatric, Nalex A 12, Triple Tannate Pediatric, Tanoral Pediatric, Andecon Pediatric Drops, C-Hist-SR, Naldecon, Histalet Forte, Vanex Forte, NoHist-A, Nalex-A, Comhist, Linhist-LA, Comhist LA, Q-Hist LA, Nalex-A SR, Triotann-S Pediatric, Coldex, West-Decon M, Atrohist Pediatric, Rynatan-S Pediatric, R-Tannate Pediatric, Gelhist Pediatric, R-Tannate, Triotann-S, R-Tannamine Pediatric, Hi-Tuss HC, Iotussin HC, Quindal HD Plus, Rynatuss, Tannic-12 S, Tussi-12, Tussizone-12 RF, Tannate 12 S, C-Tanna 12, Quad-Tuss, Rynatuss Pediatric, Quadratuss, Rentamine Pediatric, Tustan 12S, Rentamine, Tuss Tan, Tuss Tan Pediatric, Tetra Tannate Pediatric, Quad Tuss Pediatric, Quad Tann Pediatric, Quad Tann, Tannic-12, Carbaphen 12, Tussi-12S, SymPak II, XiraTuss, Alka-Seltzer Plus Cold Formula Orange Zest Effervescent Tablets, Triaminicin, Sinutab Maximum Strength Caplets, Allergy Sinus Maximum Strength, Actifed Cold & Sinus, Rolatuss, Quelidrine, Alka-Seltzer Plus Flu Formula (old formulation), Alka-Seltzer Plus Cold & Cough Formula Effervescent Tablets, Alka-Seltzer Plus Cold Formula Sparkling Original Effervescent Tablets, Alka-Seltzer Plus Cold Formula Cherry Burst Effervescent Tablets, Respa-AR, Atrohist Plus, Deconhist LA, Rolatuss-SR, Protuss Tablet, Ex-Tuss, AccuHist LA, Bellahist-D LA, Histacol LA, Ru-Tuss, Tannate-12, Tanni-Hist 12 RF, Allerest Headache Strength, Pediacof, Codar AR, TL-Hist CM, Cotab A, Cotab AX, Codeprex, Notuss-AC, Endacof-C, Endal CD, T- Koff, Pedituss, Zodryl AC, Demi-Cof, Dihistine DH, Tricode AR, Zodryl DAC, Phenylhistine DH, Decohistine DH, Codehist DH, Phenylhistine DH Expectorant, Novadyne DH, Tuxarin ER, Z-Tuss AC, Exratuss, Topco Allergy, Tussi-12 (old formulation), Phenagil CH, Carbaphen CH, DryMax AF, Ricobid H, P-Tann, TanaHist-PD, Ed ChlorPed, Ed-Chlortan, Pharbechlor, Chlor-Phenit, Teldrin HBP Allergy, Chlo-Amine, Chlor-Trimeton Allergy SR, PediaTan, Wal-finate, ChlorTan, Ed Chlor-Tan, Allergy Time, Ed Chlor Ped Jr., Sinarest Extra Strength, Comtrex Allergy Sinus Night and Day, Ryna-C, Dimetapp Children's Nighttime Flu, Comtrex Nighttime Cold & Cough, XL-3 Xtra Cold and Cough, Cold Multi-Symptom (Nighttime), Multi Symptom Cold (Night Formula), Multi Symptom Cold Relief, Alka-Seltzer Plus Maximum Strength Cold & Cough Liquid Gels, Alka-Seltzer Plus Severe Cold & Flu Formula Effervescent Tablets, Alka-Seltzer Plus Flu Formula, Alka-Seltzer Plus Severe Sinus & Cold Hot Drink Mix, Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets, Theraflu Nighttime Severe Cold & Cough Caplets, Triaminic Multi-Symptom Fever & Cold, Comtrex Cold and Flu Maximum Strength, Comtrex Maximum Strength Cold Relief, Contac Severe Cold and Flu Maximum Stength, Theraflu Flu, Cold and Cough Powder, Comtrex Day and Night, Cough Formula M Multi-Symptom, Comtrex Cold and Flu Maximum Strength Tablet, Comtrex Cold and Flu Maximum Strength Liquid, Tylenol Cold Head Congestion Day and Night, Comtrex Cold & Cough Day Night, Contac Cold and Flu Maximum Strength, Mapap Cough & Sinus Formula, Congestant, 999 Cold Remedy Granular, Cotabflu, Colrex Compound, Colrex, Vicks NyQuil Cold & Flu Nighttime Relief (Alcohol Free), Triaminic Multi-Symptom Fever, PediaCare Cough & Runny Nose Plus Acetaminophen, Coricidin HBP Maximum Strength Flu, Vicks Formula 44 Custom Care Cough & Cold PM, Tylenol Cold Multi-Symptom Nighttime, Flu Relief BP, Coricidin HBP Multi-Symptom Cold (Night), Coricidin HBP Day & Night Multi-Symptom Cold, Tylenol Cold and Flu Severe Day & Night, Dimetapp Children's Multi-Symptom Cold & Flu (old formulation), Tylenol Children’s Cold + Flu, PediaCare Multi-Symptom Cold Plus Acetaminophen, Alka-Seltzer Plus Cold & Cough Formula Liquid, PediaCare Flu Plus Acetaminophen, Genacol Maximum Strength, Theraflu Flu & Cough, Comtrex Allergy Sinus Maximum Strength, Sinulin, Alka-Seltzer Plus Cold & Flu, HEB Allergy, Dryphen, Covangesic, Norel SR, Trital SR, Rhinogesic, Alumadrine, Duadacin, Chlor-Trimeton Sinus, Sine-Off Sinus/Cold, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Tricom, Comtrex Allergy Sinus, Codimal, Kolephrin, Allerest Sinus, Tylenol Allergy Sinus, Sinutab Ex-Strength, Tylenol Sinus Congestion and Pain Cool Burst Day Night, Hybrid CF, Co-Apap, Allergy Multi-Symptom, Theracaps Multi-Symptom Cough & Cold Reliever, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Triaminic Flu, Cough & Fever, Gelpirin-CCF, Contac Cold + Flu (Night Formula), ConRx Allergy Sinus, Allergy Pain Relief, Allergy Sinus PE Pain Relief, PX Allergy Sinus PE, Pyrroxate, Protid, Robitussin Peak Cold Nighttime Nasal Relief, GNP Cold Relief Plus, Super Strength Sinadrin, Gendecon, Dristan Cold Multi Symptom Formula, Tylenol Sinus Congestion & Pain Nighttime, Comtrex Severe Cold & Sinus, Comtrex Flu Therapy, Tylenol Plus Children's Cold, Co-Histine DH, Codahistine-DH Elixir, Efasin-HD Plus, Coldcough PD, Mesehist DM, Triaminic-D Multi-Symptom Cold, Allres DS, Duotan DM, T-Tanna DM, Pedia Relief Cough-Cold, Novahistine DH, DiHydro-PE, Pancof-PD, AccuHist PDX Drops, Despec-PD, Duohist DH, Tusscough DHC, Pancof, Tricof, Hydro-Tussin DHC, Dihydro-CP, Uni-Cof, Coldcough Syrup, CPM-PSE DM Drops, Neutrahist PDX Drops, Ana-Kit, Vicks 44M Pediatric, Dex PC, Tricodene Forte, Tricodene NN, Cheracol Plus, Therahist, Triphenicol, Kophane, Threamine DM, Rhinosyn-DM, Creomulsion Cough/Cold/Allergy, Kidkare Cough/Cold, Creomulsion Pediatric, Rescon-DM, Tanafed-DM, C-Phed DM, M-End DM, Atuss-12 DM, Atuss DS, Entre-S, Maxichlor PSE DM, Bronkotuss, Allfen A, Ed A-Hist DM, Ventuss Syrup, KG-Dal HD, Endotuss-HD, Ditussin-HC, Chemtussin HC, Exo-Tuss, Endal-HD Plus, Enplus-HD, Comtussin HC, Tuss-HC, Maxi-Tuss SA, Hyphen-HD, Maxi-Tuss HC, Histinex HC, KG-Dal HD Plus, Highland HC, Uni Tuss HC, H-C Tussive, Histussin HC Liquid, Cytuss HC, Tuss-DS, Tuss-PD, Ed-Tuss HC, Z-Tuss 2, Endagen-HD, SymPak, P Chlor GG, Donatussin Pediatric, Qual-Tussin Pediatric, Lemohist Plus, S-T Forte 2, HyTan, Novasus, Vituz, Chemdal HD, Chlorgest HD, Iodal HD, Ed-TLC, Efasin-HD, Guiaphen HD, Mintuss MS, Vanex-HD, Chemdal HD Plus, Nasatuss, Sinapils, P Chlor DM, Trital DM, Vicks Children’s NyQuil Cold & Cough, CP Dec DM, Rondec-DM, Donatussin DM, Ceron-DM Drops, Ceron-DM, Rondex-DM, Rondex-DM Drops, Dec-Chlorphen DM, Dec-Chlorphen DM Drops, HistadecDM, Neo DM Drops, Neotuss D, Nasohist-DM Pediatric, Cardec DM Drops, Reme Tussin DM, Tussplex DM, Norel CS, Cardec DM, C-Phen DM, Robitussin Cough & Allergy, C-Phen DM Drops, Extendryl DM, Zotex-DM, Sildec-PE DM, Cold & Cough, Tricodene SF, QC Cough/Cold, Effective Strength Cough Syrup, Primatuss 4, Tricodene Sugar Free, Triaminic Softchews Cough & Runny Nose, Dimetapp Children's Long Acting Cough Plus Cold, Robitussin Cough & Cold Long-Acting, Carepanto, Vicks Pediatric Formula 44m Cough & Cold Relief, Genelan NF, Triaminic Night Time Cough & Runny Nose, Scot-Tussin DM, St. Joseph HBP Cough & Cold, Robitussin Children's Nighttime Cough Long-Acting DM, SymPak DM, Broncopectol, ChlorDex GP, Qual-Tussin, Quartuss, Sildec-PE DM Drops, DCP Drops, Mintuss DR, Atuss DM, Statuss DM, NoHist-PDX, Relahist-DM, Albatussin SR, Cerose DM, Maxiphen ADT, Tussar DM, Liquituss R-DM, Centergy DM, Father John's Medicine Plus, Zotex-12D, Norel DM, NeoTuss Plus, De-Chlor DM, De-Chlor DR, Coldtuss-DR, Tri-Vent DPC, Atuss DR, Corfen-DM, Uni-Tuss DM, Quartuss DM, PD-Cof, EndaCof Drops, Zoden DM Drops, PE-Hist DM, Maxichlor PEH DM, ED DM, Poly-Tussin DM, Ricotuss, Tri-Dex PE, Z-Dex 12 D, Trigofen DM Drops, Virdec DM, Phenabid DM, PD-Cof Drops, Re DCP, Sonahist-DM, RE DCP Drops, Nohist-DMX, Bronkids, Donatussin DM Drops, Nasohist-DM, DM-PE-Chlor, CP Dec-DM Drops, Dynahist ER

Medically reviewed on January 10, 2017

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as spseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Effects on Lactation and Breastmilk

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

64

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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