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Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Hydrocodone CP, Tussionex Pennkinetic, Hydrocodone HD, Chlor-Trimeton, Triaminic, Coricidin HBP Cold & Flu, Alka-Seltzer Plus Cold, Aller-Chlor, Sinarest, Norel AD, Show all 808 »Allergy Relief, Rondec, Rynatan, Triant-HC, Alka-Seltzer Plus Cold Formula Sparkling Original Effervescent Tablets, TussiCaps, Coricidin HBP Cough & Cold, Coughtuss, Chlorpheniramine (Allergy), Coricidin D, PCM, Zutripro, Tuzistra XR, Chlorphen, Sudafed PE Sinus & Allergy, NoHist DM, Tylenol Cold, Dexodryl, Tanoral, Sinucon, Codeprex, Coldamine, Tylenol Allergy Multi-Symptom, Simplet, Coldcough Syrup, Hydrocodone GF, Novasus, Demazin, Dihydro-CP, Phenagil CH, Amilon, Cold Medicine Plus, aeroHist, ChlorDex GP, Carepanto, Coricidin HBP Maximum Strength Flu, Alka-Seltzer Plus Cold Formula Orange Zest Effervescent Tablets, Ricotuss, Bronkids, Condrin, Ana-Kit, Stahist, Quad-Tuss, C-Tanna 12, Coldtuss-DR, Neotuss D, C-Phen DM Drops, Tri-Vent DPC, Corfen-DM, Sinutab Ex-Strength, Singlet, Mintuss DR, Dex PC, Allerest Headache Strength, Orlenta, Duotan, Durafed, Deconamine, Clorfed, Triaminic-D Multi-Symptom Cold, Actifed Cold and Allergy, NoHist LQ, Triphenicol, Tritan, Triotann, Triplex AD, Relera, Lohist, Vicks NyQuil Cold & Flu Nighttime Relief (Alcohol Free), Coldex, Effective Strength Cough Syrup, Endacof-C, Brexin LA, AlleRx, Triaminic Multi-Symptom Fever, R-Tanna, Rescon-DM, Dicel DM, Carbaphen CH, Codral Cold and Flu + Cough Day and Night, Chlor-Trimeton Allergy SR, Kophane, ChlorTan, Wal-finate, Ed A-Hist, Kidkare Cough/Cold, Coldcough PD, Duravent, Alka-Seltzer Plus Cold & Flu, Tylenol Sinus Congestion and Pain Cool Burst Day Night, Protid, Dehistine, Duradryl SR, Drize, AH-Chew, Triall, Tylenol Sinus Congestion & Pain Nighttime, GNP Cold Relief Plus, Theraflu Flu, Cold and Cough Powder, Hydron PCS, Histinex PV, Multi Symptom Cold Relief, Advil Allergy Sinus, RespiVent DF, Relief-PE, Pyrroxate, Ryneze, Ralix, AlleRx DF, Klerist-D, Alumadrine, Relasin-HC, Suclor, Chlor-Mes, Chlor-Trimeton Allergy Decongestant, Dicel, Curaler, Allergy AM-PM Dose Pack, ScopoHist, VisRx Dose Pack, KG-Tussin, Tussin-V, Hyphed, Hexatussin, Q-V Tussin, A-G Tussin, Pseudo CM TR, Nolamine, Histatab, Rhinaclear, Xiral SR, P-V-Tussin Syrup, RelCof DN PSE, DuraHist, DryMax, Rhinolar, Hydrotuss HC, Dallergy PSE, Relcof PSE, Time-Hist QD, AllePak, Welltuss HC, Amdry-C, PCM-LA, Mescolor, Hista-Vent PSE, Allergy DN, Pediatex HC, DroTuss-CP, Liquicough HC, Poly-Tussin HD, Z-Cof HC, Maxi-Tuss HCX, Relacon-HC, AccuHist Drops, Neo HC, Tusana-D, Ed A-Hist LA, Rynatan Pediatric, Phenchlor Tannate Pediatric, Histatab Plus, Novahistine Elixir, Relacon-HC NR, Phenylhistine, Trigofen Drops, Rhinatate-NF, Notuss-Forte, Nuhist, Novahistine, Notuss, Detuss, Hydrocof-HC, JayCof-HC, Dallergy JR, Sonahist, Virdec, Ny-Tannic, Allerest PE, BP Allergy JR, Ricobid NR, Suphedrine PE Sinus & Allergy, Tussend, AlleRx Dose Pack, DA Chewable, Omnihist L.A., Duravent DA, Extendryl Chews, Nasohist Pediatric, Dexodryl Suspension, Prehist D, Hista-Vent DA, Allerx Dose Pack DF, Drysec, Ex-Histine, WE Allergy, Duradryl JR, Duradryl, DA II, Liqui-Allergy, Extendryl SR, Sinodec, Aerohist Plus, Dallergy PE, CPM-PE-MSC, DuraTan PE, Duradryl Chewable, Nohist Plus, Dallergy SR, Allergy DN PE, AlleRx Dose Pack (PM Dose), LoHist-D, ScopoHist-PE, SymPak PDX, Ah-Chew Ultra Tannate, ScopoHist Syrup, RelCof PE, Chlor-Mes D, Norel SD, Nohist PE, Advil Children's Allergy Sinus, Advil Allergy and Congestion Relief, Ah-chew Ultra, Redur-PCM, Rescon Extended Release, AlleRx Dose Pack PE (PM Dose), Atuss HS, Atuss HD, DriHist, Nohist Plus Jr, Cordron-HC NR, Extendryl JR, Re-Drylex Jr, Histatab PH, PCM Allergy, DriHist SR, Pseudoephedrine Plus, Aerokid, Dallergy ER, Extendryl Seniors, Denaze, AH-Chew II, Durahist PE, Omnihist II LA, NoHist EXT, Allergy DN II, Dynahist ER, Qdall, RelCof DN PE, QV-Allergy, RelCof CPM, Triaminic Softchews Cold and Allergy, Cordron-HC, Triaminic Cold & Allergy, Histade CR, Chlor-Trimeton Decongestant, Biohist LA (old formulation), Deconamine SR, De-Congestine, Vanex Forte-R, Rhinolar-EX, Triac, Genamin, Allerest 12 Hour, Novafed A, Duratuss DA, Kronofed-A-Jr, Dura-Tap/PD, Fedahist Timecaps, Chlorphedrin SR, Codimal-LA, Chlorafed HS Timecelles, Histalet, Fedahist, Tanafed, Gencold, Equi-Nade, Phena-S 12, MyHist-PD, Sudal-12 Tannate, Rhinolar-EX 12, Poly Hist PD (old formulation), Pyrichlor PE, Nalex A 12, AllerTan, Conal, Dura-Vent/A, Ornade Spansules, Teldrin, Chlornade, Ordrine, Decongex-3, ARM Allergy Relief, Contac 12 Hour, Resaid, Sudal-12 Chewable, Or-Phen-Ade, Colfed-A, D-Amine-SR, Sudogest Cold & Allergy, Genaphed Plus, SudoGest Sinus & Allergy, Hayfebrol Liquid, Ryna Liquid, Neutrahist Drops, Chlorafed, Histafed LA, Aller-Chlor Decongestant, Sudogest Plus, Suphedrine Plus, Atrohist Pediatric Capsule, Histade, Mintex, Re2+30, Sudal-12, CP-Tannic, Dynahist-ER Pediatric, Allerest Maximum Strength, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, Clorfed II, Fedahist Gyrocaps, Rinade-BID, Suphenamine-SR, Isophen-DF, Kronofed-A, Pediox Chewable, C-Phed Tannate, Deconomed SR, Pseudocot-C, Duralex, ND Clear, Chlordrine SR, Cophene No 2, Anaplex, Anamine, Codimal-LA Half, Pseudochlor, Rescon-Ed, Anamine TD, Time-Hist, Chlorafed Timecelles, Tri Tann Pediatric, Phena-Plus, Sildec-PE, NoHist, Maxichlor PEH, Ry-Tann, Phendal-HD, Acta-Tabs PE, Rinate Pediatric, Ed ChlorPed D, Cardec, Sildec-PE Drops, Hista-Vadrin, Nalphen, Nalspan, Uni Decon, Prop-A-Hist, Naldelate, West-Decon, Nalgest, Nalda-Relief Pediatric, Nalgestic Pediatric, Sinucon Pediatric, ChlorTan D, P-Tann D, Tanahist-D, Allan Tannate Pediatric, CP Dec Drops, Chlor-Mes Jr, PD-Hist D, Ceron Drops, Sinus & Allergy PE, Ceron, PD-Hist D Drops, Rondex, Rondex Drops, Histadec, PediaTan D, CP Dec, Cardec Drops, Tannate Pediatric, C Phen, Dec-Chlorphen, Dec-Chlorphen Drops, C Phen Drops, Andecon Pediatric Drops, Naldecon, Tanamine Pediatric, Tri-Tannate Pediatric, Rhinatate Pediatric, Rhinatate, Tri-Tannate, Triple Tannate Pediatric, R-Tannamine Pediatric, Triotann-S Pediatric, Tanoral Pediatric, Equitan Pediatric, Url-Tannate Pediatric, Tanamine, Triotann Pediatric, Chlorex-A 12, Tri-Gestan S, Tri-Hist Pediatric, Phena-S, Histatan, R-Tannamine, URL-Tannate, Ru-Hist Forte, Triotann-S, SudaHist, Comhist, Linhist-LA, Comhist LA, Q-Hist LA, Rhinacon A, Nalex-A, Histalet Forte, Vanex Forte, NoHist-A, Chlortox, C-Hist-SR, R-Tannate Pediatric, Gelhist Pediatric, R-Tannate, AccuHist Drops (old formulation), Rynatan-S Pediatric, Atrohist Pediatric, Nalex-A SR, Chlorex A, West-Decon M, Dallergy Drops, Hyphen-HD, Tuss Tan Pediatric, Tetra Tannate Pediatric, Quad Tuss Pediatric, Quad Tann Pediatric, Tuss Tan, Rentamine, Rynatuss Pediatric, Quadratuss, Rynatuss, Rentamine Pediatric, Quad Tann, Tannic-12, Tussi-12 (old formulation), DryMax AF, Ricobid H, P-Tann, Exratuss, Tanni-Hist 12 RF, Carbaphen 12, Tannate-12, XiraTuss, Trionate, Tannate 12 S, Deconhist LA, Rolatuss-SR, Protuss Tablet, Ex-Tuss, Atrohist Plus, Alka-Seltzer Plus Cold Formula Cherry Burst Effervescent Tablets, Rolatuss, Quelidrine, Alka-Seltzer Plus Flu Formula (old formulation), Alka-Seltzer Plus Cold & Cough Formula Effervescent Tablets, AccuHist LA, Bellahist-D LA, Tussi-12S, Tannic-12 S, Tussi-12, Tussizone-12 RF, Tustan 12S, SymPak II, Histacol LA, Ru-Tuss, Respa-AR, TanaHist-PD, Ed ChlorPed, Zodryl DAC, Phenylhistine DH, Decohistine DH, Codehist DH, Tricode AR, Dihistine DH, T- Koff, Pediacof, Pedituss, Demi-Cof, Phenylhistine DH Expectorant, Novadyne DH, QC Cough/Cold, Primatuss 4, Tricodene Sugar Free, Triaminic Softchews Cough & Runny Nose, Tricodene SF, Vicks Children’s NyQuil Cold & Cough, Co-Histine DH, Ryna-C, Codahistine-DH Elixir, Endal CD, CapCof, Chlo-Amine, PediaTan, Ed Chlor-Tan, Allergy Time, Chlor-Mal, C.P.M., Ed-Chlortan, Topco Allergy, Pharbechlor, Teldrin HBP Allergy, Ed Chlor Ped Jr., Chlor-Phenit, Cotab A, Cotab AX, Lexuss 210, Notuss-AC, TL-Hist CM, Codar AR, Z-Tuss AC, Zodryl AC, Tuxarin ER, Actifed Cold & Sinus, Allergy Sinus Maximum Strength, Alka-Seltzer Plus Flu Formula, Alka-Seltzer Plus Severe Sinus & Cold Hot Drink Mix, Dimetapp Children's Nighttime Flu, Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets, Alka-Seltzer Plus Severe Cold & Flu Formula Effervescent Tablets, Multi Symptom Cold (Night Formula), Tylenol Cold Head Congestion Day and Night, Comtrex Nighttime Cold & Cough, XL-3 Xtra Cold and Cough, Cold Multi-Symptom (Nighttime), Triaminic Multi-Symptom Fever & Cold, Comtrex Cold and Flu Maximum Strength, Comtrex Cold and Flu Maximum Strength Liquid, Genacol Maximum Strength, Childrens Tylenol Cold Plus Cough, Contac Cold and Flu Maximum Strength, Comtrex Cold and Flu Maximum Strength Tablet, Cough Formula M Multi-Symptom, Comtrex Maximum Strength Cold Relief, Contac Severe Cold and Flu Maximum Stength, Comtrex Day and Night, Theraflu Nighttime Severe Cold & Cough Caplets, Comtrex Cold & Cough Day Night, Mapap Cough & Sinus Formula, Vicks Formula 44 Custom Care Cough & Cold PM, Flu Relief BP, Coricidin HBP Multi-Symptom Cold (Night), PediaCare Cough & Runny Nose Plus Acetaminophen, Colrex, Sinapils, Congestant, Cotabflu, Colrex Compound, Tylenol Plus Children's Cough & Runny Nose, Coricidin HBP Day & Night Multi-Symptom Cold, Alka-Seltzer Plus Cold & Cough Formula Liquid, PediaCare Flu Plus Acetaminophen, Tylenol Cold Multi-Symptom Nighttime, Tylenol Cold Head Congestion Nighttime, PediaCare Multi-Symptom Cold Plus Acetaminophen, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, Dimetapp Children's Multi-Symptom Cold & Flu (old formulation), Tylenol Plus Children's Multi-Symptom Cold, Tylenol Plus Children's Flu, Theraflu Flu & Cough, Allpanto-S, Sinulin, Chlor-Trimeton Sinus, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Duadacin, Rhinogesic, Dryphen, Covangesic, Norel SR, Trital SR, Tricom, Comtrex Allergy Sinus, Comtrex Allergy Sinus Night and Day, Sinarest Extra Strength, Triaminicin, Sinutab Maximum Strength Caplets, Comtrex Allergy Sinus Maximum Strength, Tylenol Allergy Sinus, Codimal, Kolephrin, Allerest Sinus, HEB Allergy, Sine-Off Sinus/Cold, Medicidin-D, ConRx Allergy Sinus, Allergy Pain Relief, Allergy Sinus PE Pain Relief, Contac Cold + Flu (Night Formula), Gelpirin-CCF, Co-Apap, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Triaminic Flu, Cough & Fever, PX Allergy Sinus PE, Allergy Multi-Symptom, Comtrex Flu Therapy, Tylenol Plus Children's Cold, XL-3 Cold Medicine, Hybrid CF, Comtrex Severe Cold & Sinus, Dristan Cold Multi Symptom Formula, Robitussin Peak Cold Nighttime Nasal Relief, Onset Forte, Gendecon, Dimetapp Children's Long Acting Cough Plus Cold, Robitussin Children's Cough & Cold Long-Acting, P Chlor GG, Donatussin Pediatric, Qual-Tussin Pediatric, Lemohist Plus, SymPak, Z-Tuss 2, Hydro-Tussin DHC, Uni-Cof, Bronkotuss, Allfen A, S-T Forte 2, HyTan, Ed-TLC, Efasin-HD, Guiaphen HD, Mintuss MS, Rindal-HD, Iodal HD, Vituz, Endagen-HD, Chemdal HD, Tricof, Pancof, Maxichlor PSE DM, Neutrahist PDX Drops, AccuHist PDX Drops, CPM-PSE DM Drops, Entre-S, Atuss DS, Tanafed-DM, C-Phed DM, M-End DM, Atuss-12 DM, Esocor P, Mesehist DM, Pancof-PD, Despec-PD, Duohist DH, Tusscough DHC, DiHydro-PE, Novahistine DH, Allres DS, Duotan DM, T-Tanna DM, Vanex-HD, Chemdal HD Plus, Quindal HD, Hi-Tuss HC, Chlorphen HD, Duradal HD, Quindal HD Plus, Efasin-HD Plus, H-C Tussive, Histussin HC Liquid, Cytuss HC, Tuss-DS, Liquitussin HC Syrup, Tussive HC, Atuss MS, Hydro-PC II Plus, Uni-Tricof HC, Rindal HD Plus, De-Chlor HC, De-Chlor HD, B-Tuss, Hydro-PC II, Hydron CP, Uni Tuss HC, Highland HC, Tuss-PD, KG-Dal HD, Endotuss-HD, Ditussin-HC, Hycomine Compound, Cyndal HD, Nasatuss, Iotussin HC, Chlorgest HD, Ed-Tuss HC, Chemtussin HC, Exo-Tuss, Maxi-Tuss SA, Maxi-Tuss HC, Histinex HC, KG-Dal HD Plus, Ventuss Syrup, Tuss-HC, Endal-HD Plus, Enplus-HD, Comtussin HC, Children's Nyquil, Kidcare Cough and Cold, Tussplex DM, Norel CS, Cardec DM, C-Phen DM, Reme Tussin DM, Balamine DM, CP Dec DM, Neo DM Drops, Nasohist-DM Pediatric, Cardec DM Drops, Robitussin Cough & Allergy, Sildec-PE DM Drops, ED DM, Poly-Tussin DM, Tri-Dex PE, Z-Dex 12 D, Maxichlor PEH DM, PE-Hist DM, Sildec-PE DM, DCP Drops, EndaCof Drops, HistadecDM, Dec-Chlorphen DM Drops, Robitussin Children's Nighttime Cough Long-Acting DM, SymPak DM, Broncopectol, Qual-Tussin, St. Joseph HBP Cough & Cold, Scot-Tussin DM, Robitussin Cough & Cold Long-Acting, Cold & Cough, Vicks Pediatric Formula 44m Cough & Cold Relief, Triaminic Night Time Cough & Runny Nose, Quartuss, Genelan NF, Ceron-DM, Rondex-DM, Rondex-DM Drops, Dec-Chlorphen DM, Ceron-DM Drops, Donatussin DM, Zotex-DM, Extendryl DM, Rondec-DM, Trigofen DM Drops, Virdec DM, De-Chlor DR, Atuss DR, Uni-Tuss DM, Trital DM, De-Chlor DM, NeoTuss Plus, Centergy DM, Atuss DM, Father John's Medicine Plus, Norel DM, Ed A-Hist DM, P Chlor DM, Rhinosyn-DM, Vicks 44M Pediatric, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Threamine DM, Therahist, Tricodene Forte, Tricodene NN, Cheracol Plus, Liquituss R-DM, Tussar DM, Nohist-DMX, Donatussin DM Drops, Nasohist-DM, DM-PE-Chlor, RE DCP Drops, Sonahist-DM, Zoden DM Drops, Phenabid DM, Re DCP, CP Dec-DM Drops, PD-Cof Drops, Relahist-DM, Albatussin SR, Cerose DM, Maxiphen ADT, NoHist-PDX, Statuss DM, PD-Cof, Zotex-12D, Quartuss DM, Echotuss-HC

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Effects on Lactation and Breastmilk

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

64

Last Revision Date

20150310

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