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Chlorpheniramine Drug Interactions

A total of 695 drugs are known to interact with chlorpheniramine.

  • 71 major drug interactions
  • 619 moderate drug interactions
  • 5 minor drug interactions

Show all medications in the database that may interact with chlorpheniramine.

Check for interactions

Type in a drug name to check for interactions with chlorpheniramine.

Most frequently checked interactions

View interaction reports for chlorpheniramine and the medicines listed below.

  • Aleve (naproxen)
  • Allegra (fexofenadine)
  • amoxicillin (Amoxil, Trimox, Apo-Amoxi, Amoxicot, DisperMox, Moxatag, Biomox, Wymox, Moxilin)
  • Aspirin Low Strength (aspirin)
  • Benadryl (diphenhydramine)
  • cetirizine (Zyrtec, Aller-Tec, Equate Allergy Relief, All Day Allergy, Children's Allergy Relief, Children's Zyrtec, Aller-Tec Children's, PediaCare Children's 24-Hour Allergy, All Day Allergy Children's, Zyrtec Hives, Alleroff)
  • Claritin (loratadine)
  • Cymbalta (duloxetine)
  • dextromethorphan (Delsym, Dextromethorphan HBr Adult Formula, Delsym 12 Hour Cough Relief, Cough Syrup DM, Dry Cough, Benylin DM, Robitussin CoughGels Long-Acting, Bisolvon Dry, Calmylin, St. Joseph Cough Suppressant, Sucrets Cough, Vicks Formula 44, Delsym 12 Hour Cough Relief for Children & Adults, Strepsils Cough, Creomulsion, Buckley's DM, Hold, DexAlone, PediaCare Children's Long-Acting Cough, Vicks Dayquil Cough, Babee Cof, Silphen DM, Pertussin DM, Vicks Formula 44 Custom Care Dry Cough Suppressant, Balminil DM, Novahistine DM, Covonia Bronchial Balsam, Robitussin Cough Long-Acting, Triaminic Thin Strips Long Acting Cough, Benadryl for the Family Dry Forte, Theraflu Thin Strips Cough, Neocitran Thin Strips Cough, Contac Cough, Robafen Cough Liquidgels, Jack & Jill Thin Strips Cough, Tussinol for Dry Coughs, Bisolvon Dry Junior, Dristan DM, Dexi-Tuss, Nucosef DM, Strepsils Cough Relief, Delsym Children's 12-Hour Cough Relief, Buckleys Mixture, Pedia Relief, Triaminic Long Acting Cough, Creomulsion Children, Buckley's Mixture Cough Suppressant, Tussin Cough Gels (Long Acting), Vicks Nature Fusion Cough, Duract Max Strength Cough, Scot-Tussin Diabetes, Lloydspharmacy Dry Adult Cough, 12 Hour Cough Relief, Triaminic Thin Strips Cough, Robitussin 12-Hour Cough Relief, ElixSure Cough, Scot-Tussin DM Cough Chasers, Hold DM, Pertussin CS Childrens, Robitussin Children's Cough Long-Acting, Pertussin ES, Tussin Pediatric, Robafen Pediatric Cough & Cold)
  • diphenhydramine (Benadryl, Banophen, Benadryl Allergy, ZzzQuil, Sleep, Unisom SleepGels, Benadryl Children's Allergy, Sominex, Dicopanol, Diphen, Sleep Tabs, Simply Sleep, Diphedryl, Diphenadryl, Quenalin, Diphenyl, Hydramine, Diphenydramine Quick Melt, Unisom SleepMelts, Nytol, Dormin, Sleepwell 2-nite, Diphenhist, 40 Winks, Diphen Cough, DPH, Calm-Aid, Sleep Tab II, Altaryl, Snooze Fast, Sominex Maximum Strength Caplet, Unisom SleepMinis, Unisom Liquid, Triaminic Thin Strips Allergy, ConRx Allergy, Buckley's Bedtime, Hyrexin, Hydramine Cough Syrup, Bydramine, Diphen AF, Aler-Dryl, Allergia-C, Benahist-10, Benahist-50, Benoject-50, Genahist, Alka-Seltzer Plus Allergy, Q-Dryl, Aller-G-Time, Sleep-Eze-3, Somnicaps, Nytol QuickCaps, Total Allergy, Trux-adryl, Valu-Dryl, Triaminic Thin Strips Cough & Runny Nose, Beldin, Belix, Vicks QlearQuil Nighttime Allergy Relief, Siladryl, Siladryl DAS, Siladyl SA, Silphen Cough, Sleep-ettes, Tusstat, Diphenylin, Hydramine Compound, Pardryl, Nervine, Nu-Med, Nytol Caplet, Compoz Nighttime Sleep Aid, Sleepinal, Help I Can't Sleep, Allermax, Diphendryl, Twilite, Banaril, Aler-Tab, Siladryl Allergy, Theraflu Thin Strips Multi Symptom, Sleep-ettes D, Uni-Tann, Q-Dryl A/F, Diphenmax, Nightime Sleepaid, Ben-Tann, Dytan, Vanamine PD, Pharbedryl, Histaprin, Z-Sleep, Tranquil Nighttime Sleep Aid, PediaCare Children's Allergy, Truxadryl, Complete Allergy Relief, Dytuss, Miles Nervine, Scot-Tussin Allergy)
  • fexofenadine (Allegra, Allegra Allergy, Mucinex Allergy, Allegra Hives, Aller-Ease, Allegra ODT)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • Flonase (fluticasone nasal)
  • hydrocodone (Hysingla ER, Zohydro ER, Vantrela ER)
  • ibuprofen (Advil, Motrin, IBU, Advil Liqui-Gels, Children's Motrin, Proprinal, Motrin IB, Childrens Ibuprofen Berry, Advil Children's, Ibuprofen PMR, Ibu-8, Rufen, IBU-200, Motrin Childrens, Advil Migraine, Caldolor, Ibu-Tab, Menadol, Midol Maximum Strength Cramp Formula, Motrin Migraine Pain, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Motrin Pediatric, Genpril, Haltran, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Nuprin, Advil Junior Strength, Actiprofen, Addaprin, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, Motrin Junior Strength, Motrin Infant Drops, NeoProfen, Help I Have An Aching Body, Children's ElixSure IB, Advil Infant's Concentrated Drops, Cap-Profen, Advil Film-Coated)
  • loratadine (Claritin, Alavert, Claritin 24 Hour Allergy, Loratadine Reditab, Allergy Relief 24 Hour, Claritin Reditabs, Allergy Relief Tablets, Wal-itin, Children's Claritin Allergy, Children's Allergy Relief 24 Hour, Vicks QlearQuil All Day & All Night 24 Hour Allergy Relief, Help I Have Allergies, ohm Allergy Relief, Clear-Atadine, Claritin Hives Relief, Dimetapp Children's ND Non-Drowsy Allergy, Clear-Atadine Children's, Bactimicina Allergy, Tavist ND)
  • Lyrica (pregabalin)
  • Nexium (esomeprazole)
  • Norco (acetaminophen / hydrocodone)
  • Panadol (acetaminophen)
  • Paracetamol (acetaminophen)
  • phenylephrine (Neo-Synephrine, Sudafed PE Congestion, Suphedrine PE, Nasal Decongestant PE, Help I Have A Stuffy Nose, Sudogest PE, Dimetapp Toddler's Drops Decongestant, Vazculep, Sudafed PE Children's Nasal Decongestant, Despec-SF, Nasop12, Triaminic Thin Strips Cold with Stuffy Nose, Phenyl-T, Congest Aid II, AH-Chew D, Gilchew IR, Little Colds Decongestant, Lusonal, Contac-D, Nasop, Ricobid-D, PediaCare Children's Decongestant)
  • phenylpropanolamine (Dexatrim, Propan, Phenyldrine, Propagest, Control, Acutrim 16 Hour, Acutrim II, Maximum Strength, Rhindecon, Acutrim Late Day, Empro, Mega-Trim, Westrim, Westrim LA, Dexatrim Caffeine Free)
  • prednisone (Deltasone, Rayos, Sterapred, Prednicot, Meticorten, Sterapred DS, Liquid Pred, Orasone, Prednicen-M)
  • ProAir HFA (albuterol)
  • pseudoephedrine (Sudafed Congestion, Sudafed 12-Hour, SudoGest, Entex, Sudafed 24-Hour, Silfedrine, Sudafed Children's Nasal Decongestant, Contac Cold, Suphedrin, Chlor-Trimeton Nasal Decongestant, Nexafed Nasal Decongestant, nasofed, Suphedrine, ElixSure Congestion, Children's Dimetapp Decongestant Infant, Allermed, Novafed, Cenafed, Genaphed, Ridafed, Seudotabs, Sudrine, Superfed, Afrinol, Zephrex-D, Decofed Liquid, Efidac, Decofed, Kid Kare Drops, Myfedrine, Sudodrin, Elixsure Decongestant, Unifed, Drixoral Decongestant Non-Drowsy, SudoGest 12 Hour, 12 Hour Decongestant, 12 Hour Nasal Decongestant)
  • sertraline (Zoloft)
  • Singulair (montelukast)
  • Synthroid (levothyroxine)
  • Tylenol (acetaminophen)
  • Vitamin B Complex 100 (multivitamin)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)
  • warfarin (Coumadin, Jantoven)
  • Xanax (alprazolam)
  • Zyrtec (cetirizine)

Chlorpheniramine alcohol/food interactions

There is 1 alcohol/food interaction with chlorpheniramine

Chlorpheniramine disease interactions

There are 4 disease interactions with chlorpheniramine which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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