Chlorpheniramine Side Effects
Medically reviewed by Drugs.com. Last updated on Oct 27, 2020.
For the Consumer
Applies to chlorpheniramine: oral syrup, oral tablet, oral tablet extended release
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
What are some other side effects of this drug?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Feeling sleepy.
- Feeling nervous and excitable.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
For Healthcare Professionals
Applies to chlorpheniramine: compounding powder, injectable solution, oral capsule extended release, oral liquid, oral suspension extended release, oral syrup, oral tablet, oral tablet chewable, oral tablet extended release
Very common (10% or more): Sedation, somnolence
Nearly all patients treated with chlorpheniramine experience drowsiness. This drowsiness may subside in some patients with extended use.
Few cases of dyskinesias and tremors, often of the face, have been reported in patients whose chronic use of chlorpheniramine extended over a period of 3 to 10 years. Some of these cases were only partially relieved by discontinuation of the drug. Haloperidol was successful in relieving symptoms.[Ref]
Common (1% to 10%): Blurred vision[Ref]
Common (1% to 10%): Nausea, dry mouth
Common (1% to 10%): Fatigue
A fatal case of agranulocytosis has been reported in a patient taking chlorpheniramine, pseudoephedrine, acetaminophen, dextromethorphan, phenylpropanolamine, and aspirin. Chlorpheniramine was felt to be the cause.[Ref]
Frequency not reported: Thickening of bronchial secretions[Ref]
Frequency not reported: Anorexia[Ref]
1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
More about chlorpheniramine
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Pricing & Coupons
- 33 Reviews
- Drug class: antihistamines
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.